4-aminopyridine has been researched along with Stroke in 7 studies
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using a conditional transgenic mouse model, selective ablation of adult neural stem and progenitor cells in the subventricular zone induced a dramatic increase in morbidity and mortality of central nervous system disorders characterized by excitotoxicity-induced cell death accompanied by reactive inflammation, such as 4-aminopyridine-induced epilepsy and ischaemic stroke." | 3.78 | Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. ( Bacigaluppi, M; Bari, M; Brambilla, E; Butti, E; Cambiaghi, M; Cebrian Silla, A; Centonze, D; Comi, G; D'Adamo, P; De Ceglia, R; De Chiara, V; Garcia-Verdugo, JM; Leocani, L; Maccarrone, M; Martino, G; Musella, A; Muzio, L; Quattrini, A; Rossi, S; Teneud, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Simpson, DM | 1 |
| Goldenberg, J | 1 |
| Kasner, S | 1 |
| Nash, M | 1 |
| Reding, MJ | 1 |
| Zweifler, RM | 1 |
| Suarez, G | 1 |
| Zhao, P | 1 |
| Henney, HR | 1 |
| Rabinowicz, AL | 1 |
| Carrazana, E | 1 |
| Tauskela, JS | 1 |
| Aylsworth, A | 1 |
| Hewitt, M | 1 |
| Brunette, E | 1 |
| Blondeau, N | 1 |
| Vazana, U | 1 |
| Veksler, R | 1 |
| Pell, GS | 1 |
| Prager, O | 1 |
| Fassler, M | 1 |
| Chassidim, Y | 1 |
| Roth, Y | 1 |
| Shahar, H | 1 |
| Zangen, A | 1 |
| Raccah, R | 1 |
| Onesti, E | 1 |
| Ceccanti, M | 1 |
| Colonnese, C | 1 |
| Santoro, A | 1 |
| Salvati, M | 1 |
| D'Elia, A | 1 |
| Nucciarelli, V | 1 |
| Inghilleri, M | 1 |
| Friedman, A | 1 |
| Butti, E | 1 |
| Bacigaluppi, M | 1 |
| Rossi, S | 1 |
| Cambiaghi, M | 1 |
| Bari, M | 1 |
| Cebrian Silla, A | 1 |
| Brambilla, E | 1 |
| Musella, A | 1 |
| De Ceglia, R | 1 |
| Teneud, L | 1 |
| De Chiara, V | 1 |
| D'Adamo, P | 1 |
| Garcia-Verdugo, JM | 1 |
| Comi, G | 1 |
| Muzio, L | 1 |
| Quattrini, A | 1 |
| Leocani, L | 1 |
| Maccarrone, M | 1 |
| Centonze, D | 1 |
| Martino, G | 1 |
| Sadanaga, T | 1 |
| Ohya, Y | 1 |
| Ohtsubo, T | 1 |
| Goto, K | 1 |
| Fujii, K | 1 |
| Abe, I | 1 |
| Johnson, NC | 1 |
| Morgan, MW | 1 |
| Bains, JS | 1 |
| Follwell, MJ | 1 |
| Latchford, KJ | 1 |
| Anderson, JW | 1 |
| Ferguson, AV | 1 |
1 trial available for 4-aminopyridine and Stroke
| Article | Year |
|---|---|
Dalfampridine in chronic sensorimotor deficits after ischemic stroke: A proof of concept study.
Topics: 4-Aminopyridine; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Cross-Over Studies; Do | 2015 |
6 other studies available for 4-aminopyridine and Stroke
| Article | Year |
|---|---|
Failure and rescue of preconditioning-induced neuroprotection in severe stroke-like insults.
Topics: 4-Aminopyridine; Animals; Aspartic Acid; Bicuculline; Cell Hypoxia; Cells, Cultured; Cerebral Cortex | 2016 |
Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery.
Topics: 4-Aminopyridine; Adult; Aged; Animals; Blood-Brain Barrier; Brain Neoplasms; Disease Models, Animal; | 2016 |
Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
Topics: 4-Aminopyridine; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Corpus Striatu | 2012 |
Decreased 4-aminopyridine sensitive K+ currents in endothelial cells from hypertensive rats.
Topics: 4-Aminopyridine; Animals; Aorta; Apamin; Charybdotoxin; Drug Combinations; Endothelium, Vascular; Ge | 2002 |
An unusual case of 4-aminopyridine toxicity.
Topics: 4-Aminopyridine; Accidents; Atrial Fibrillation; Diagnosis, Differential; Drug Overdose; Drugs, Gene | 2006 |
Slowly inactivating potassium conductance (I(D)): a potential target for stroke therapy.
Topics: 4-Aminopyridine; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cell Death; Cells, Cultu | 2001 |