4-aminopyridine has been researched along with Status Epilepticus in 18 studies
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "2 channel and of its major modulator, voltage-dependent potassium channel-interacting protein (KChIP1), is altered following lithium-pilocarpine induced status epilepticus (SE) and the chronic-epilepsy phase in the rat model." | 7.74 | Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus. ( Cong, WD; Deng, WY; Liao, WP; Long, YS; Luo, AH; Su, T; Sun, WW, 2008) |
| "We investigated the effects of valproate (VPA) on an in vivo model of status epilepticus (SE) induced by intrahippocampal application of 4-aminopyridine (4-AP)." | 7.72 | Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region. ( Martín, ED; Pozo, MA, 2003) |
| " Furthermore, real-time measurement of lactate and oxygen concentration dynamics concurrently with network electrical activity during status epilepticus induced by 4-aminopyridine (4-AP) demonstrated phasic changes in lactate levels that correlated with bursts of electrical activity, while tonic levels of lactate remained stable during seizures." | 4.84 | Amperometric bio-sensing of lactate and oxygen concurrently with local field potentials during status epilepticus. ( Barbosa, RM; Fernandes, E; Gerhardt, GA; Ledo, A, 2024) |
| " In this study we used the pilocarpine-induced status epilepticus model of TLE (i." | 3.91 | Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy. ( Derera, ID; Smith, BN; Smith, KC, 2019) |
| "2 channel and of its major modulator, voltage-dependent potassium channel-interacting protein (KChIP1), is altered following lithium-pilocarpine induced status epilepticus (SE) and the chronic-epilepsy phase in the rat model." | 3.74 | Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus. ( Cong, WD; Deng, WY; Liao, WP; Long, YS; Luo, AH; Su, T; Sun, WW, 2008) |
| "We investigated the potential of 4-AP (50-100 microM) to induce seizure-like events (SLEs) in combined entorhinal cortex-hippocampal slices from Sprague Dawley rats which developed spontaneous limbic seizures following kainic acid induced status epilepticus." | 3.74 | Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats. ( Derst, C; Gruber, C; Heinemann, U; Tolner, EA; Veh, RW; Zahn, RK, 2008) |
| "We investigated the effects of valproate (VPA) on an in vivo model of status epilepticus (SE) induced by intrahippocampal application of 4-aminopyridine (4-AP)." | 3.72 | Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region. ( Martín, ED; Pozo, MA, 2003) |
| "Status epilepticus (SE) is defined as a seizure lasting more than 5min or a period of recurrent seizures without recovery between them." | 1.43 | High frequency oscillations can pinpoint seizures progressing to status epilepticus. ( Avoli, M; Lévesque, M; Salami, P, 2016) |
| "IL-1R1 knockout or IL-1RA enhanced the seizure refractory phenomenon without influencing the baseline seizure threshold in intermittent MES model." | 1.42 | The Pro-inflammatory Cytokine Interleukin-1β is a Key Regulatory Factor for the Postictal Suppression in Mice. ( Chen, B; Chen, Z; Hu, WW; Shi, LY; Tang, YS; Tao, AF; Wang, Y; Wu, XH; Xu, CL; Xu, ZH; Zhang, J; Zhang, SH; Zhao, HW, 2015) |
| "The behavioral signs of the developing epileptic seizures were scored in all rats." | 1.35 | Status epilepticus affects the gigantocellular network of the pontine reticular formation. ( Baracskay, P; Czurkó, A; Juhász, G; Kékesi, KA; Kiglics, V, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Maghbooli, M | 2 |
| Jourahmad, Z | 2 |
| Golizadeh, M | 2 |
| Fernandes, E | 1 |
| Ledo, A | 1 |
| Gerhardt, GA | 1 |
| Barbosa, RM | 1 |
| Lisgaras, CP | 1 |
| Mikroulis, A | 1 |
| Psarropoulou, C | 1 |
| Van Looy, E | 1 |
| Van Dycke, A | 1 |
| Vanopdenbosch, L | 1 |
| Panicucci, E | 1 |
| Cohen, M | 1 |
| Bourg, V | 1 |
| Rocher, F | 1 |
| Thomas, P | 1 |
| Lebrun, C | 1 |
| Farrell, R | 1 |
| Derera, ID | 1 |
| Smith, KC | 1 |
| Smith, BN | 1 |
| Tao, AF | 1 |
| Xu, ZH | 1 |
| Chen, B | 1 |
| Wang, Y | 1 |
| Wu, XH | 1 |
| Zhang, J | 1 |
| Tang, YS | 1 |
| Xu, CL | 1 |
| Zhao, HW | 1 |
| Hu, WW | 1 |
| Shi, LY | 1 |
| Zhang, SH | 1 |
| Chen, Z | 1 |
| Salami, P | 1 |
| Lévesque, M | 1 |
| Avoli, M | 1 |
| Su, T | 1 |
| Cong, WD | 1 |
| Long, YS | 1 |
| Luo, AH | 1 |
| Sun, WW | 1 |
| Deng, WY | 1 |
| Liao, WP | 1 |
| Burton, JM | 1 |
| Bell, CM | 1 |
| Walker, SE | 1 |
| O'Connor, PW | 1 |
| Baracskay, P | 1 |
| Kiglics, V | 1 |
| Kékesi, KA | 1 |
| Juhász, G | 1 |
| Czurkó, A | 1 |
| de Gusmao, CM | 1 |
| Ortega, MR | 1 |
| Wallace, DM | 1 |
| Martín, ED | 2 |
| Pozo, MA | 2 |
| Ceña, V | 1 |
| Zahn, RK | 1 |
| Tolner, EA | 1 |
| Derst, C | 1 |
| Gruber, C | 1 |
| Veh, RW | 1 |
| Heinemann, U | 1 |
| Hochman, DW | 1 |
| Baraban, SC | 1 |
| Owens, JW | 1 |
| Schwartzkroin, PA | 1 |
| Giménez-Llort, L | 1 |
| De Vera, N | 1 |
| Martínez, E | 1 |
1 review available for 4-aminopyridine and Status Epilepticus
17 other studies available for 4-aminopyridine and Status Epilepticus
| Article | Year |
|---|---|
Amperometric bio-sensing of lactate and oxygen concurrently with local field potentials during status epilepticus.
Topics: 4-Aminopyridine; Animals; Biosensing Techniques; Brain; Epilepsy; Humans; Lactic Acid; Oxygen; Rats; | 2024 |
Region-specific Effects of Early-life Status Epilepticus on the Adult Hippocampal CA3 - Medial Entorhinal Cortex Circuitry In vitro: Focus on Interictal Spikes and Concurrent High-frequency Oscillations.
Topics: 4-Aminopyridine; Animals; Entorhinal Cortex; Hippocampus; Pentylenetetrazole; Rats; Status Epileptic | 2021 |
Two related cases of super-refractory status epilepticus due to 4-aminopyridine intoxication and an overview of the literature.
Topics: 4-Aminopyridine; Anticonvulsants; Humans; Status Epilepticus | 2021 |
De novo convulsive status epilepticus in patients with multiple sclerosis treated with dalfampridine.
Topics: 4-Aminopyridine; Adult; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Multiple Sclerosis, R | 2019 |
Clinical commentary on "De novo convulsive status epilepticus in patients with multiple sclerosis treated with dalfampridine".
Topics: 4-Aminopyridine; Humans; Multiple Sclerosis; Potassium Channel Blockers; Status Epilepticus | 2019 |
Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Brugada Syndrome; Disease Models, Animal; Epilepsy, Tem | 2019 |
The Pro-inflammatory Cytokine Interleukin-1β is a Key Regulatory Factor for the Postictal Suppression in Mice.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Electroshock; Hippocampus; Humans; Interleukin 1 R | 2015 |
High frequency oscillations can pinpoint seizures progressing to status epilepticus.
Topics: 4-Aminopyridine; Animals; Brain Waves; Disease Models, Animal; Disease Progression; Electroencephalo | 2016 |
Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus.
Topics: 4-Aminopyridine; Animals; Calcium; Disease Models, Animal; Extracellular Fluid; Female; Gene Express | 2008 |
4-aminopyridine toxicity with unintentional overdose in four patients with multiple sclerosis.
Topics: 4-Aminopyridine; Canada; Chromatography, Liquid; Critical Care; Drug Compounding; Drug Overdose; Fem | 2008 |
Status epilepticus affects the gigantocellular network of the pontine reticular formation.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cell Shape; Electrodes, Implanted; Electroencephalograp | 2009 |
Status epilepticus associated with dalfampridine in a patient with multiple sclerosis.
Topics: 4-Aminopyridine; Cocaine; Humans; Male; Middle Aged; Multiple Sclerosis; Potassium Channel Blockers; | 2012 |
Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region.
Topics: 4-Aminopyridine; Animals; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2003 |
Cholinergic modulation of status epilepticus in the rat barrel field region of primary somatosensory cortex.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Disease Models, Animal; Electroencephalography; Electromyog | 2005 |
Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats.
Topics: 4-Aminopyridine; Animals; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2008 |
Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Entorhinal Cortex; Ext | 1995 |
Analysis of chemically-induced alterations of the motor activity in rats.
Topics: 4-Aminopyridine; Animals; Convulsants; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Motor Activity; Pe | 1998 |