4-aminopyridine has been researched along with Spinocerebellar Ataxias in 3 studies
Spinocerebellar Ataxias: A group of predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We further found that chronic administration of the FDA-approved drug 4-aminopyridine (4-AP), which targets potassium channels, alleviated motor coordination deficits and restored cerebellar Purkinje cell firing precision to wildtype (WT) levels in SCA6(84Q/84Q) mice both in acute slices and in vivo." | 1.43 | 4-aminopyridine reverses ataxia and cerebellar firing deficiency in a mouse model of spinocerebellar ataxia type 6. ( Chang, HH; Cullen, KE; Jayabal, S; Watt, AJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jayabal, S | 1 |
| Chang, HH | 1 |
| Cullen, KE | 1 |
| Watt, AJ | 1 |
| Tsunemi, T | 1 |
| Ishikawa, K | 1 |
| Tsukui, K | 1 |
| Sumi, T | 1 |
| Kitamura, K | 1 |
| Mizusawa, H | 1 |
| Hopkins, AL | 1 |
| Clarke, J | 1 |
3 other studies available for 4-aminopyridine and Spinocerebellar Ataxias
| Article | Year |
|---|---|
4-aminopyridine reverses ataxia and cerebellar firing deficiency in a mouse model of spinocerebellar ataxia type 6.
Topics: 4-Aminopyridine; Animals; Cerebellum; Disease Models, Animal; Electrophysiology; Female; Heterozygot | 2016 |
The effect of 3,4-diaminopyridine on the patients with hereditary pure cerebellar ataxia.
Topics: 4-Aminopyridine; Amifampridine; Ataxia; Drug Administration Schedule; Female; Genetic Predisposition | 2010 |
Episodic cerebellar dysfunction in a bichon frise: a canine case of episodic ataxia?
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Cerebellar Diseases; Dog Diseases; Dogs; Magnetic Resonan | 2010 |