4-aminopyridine has been researched along with Seizures in 183 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study examined temporal activation patterns of rat cerebellar cortical neurons in 4-aminopyridine induced seizures, using c-fos protein as a marker of neuronal activity." | 7.91 | Differential expression of the c-fos protein and synaptophysin in zebrin II positive and zebrin II negative cerebellar cortical areas in 4-aminopyridine seizures. ( Krisztin-Péva, B; Mihály, A; Tóth, Z, 2019) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 7.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " To study this hypothesis, we chose an animal model comprising focal unilateral hippocampal injection of 4-aminopyridine (4-AP), which produced focal recurrent hippocampal seizures with secondary generalization in awake, behaving rats." | 7.85 | Mortality with brainstem seizures from focal 4-aminopyridine-induced recurrent hippocampal seizures. ( Carlen, PL; Del Campo, M; Devinsky, O; Genov, R; Montandon, G; Salam, MT, 2017) |
| " Seizures were induced with one of Pentelyntetrazole (PTZ), 4-Aminopyridine (AP) and Strychnine (STR)." | 7.85 | Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats. ( Desalu, OO; Kolo, PM; Olarinoye, JK; Olatunji, LA; Sanya, EO; Soladoye, AO, 2017) |
| "), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine." | 7.78 | The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. ( Aldana, BI; Gómez, CD; Nekrassov, V; Sitges, M, 2012) |
| "Distribution and time course of the occurrence of "dark" neurons were compared with the EEG activity and behavior of rats during 4-aminopyridine (4-AP) induced epileptic seizures." | 7.74 | Generalization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat. ( Baracskay, P; Czurkó, A; Juhász, G; Orbán, G; Szepesi, Z, 2008) |
| " Focal seizures in rats were induced by neocortical injections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels." | 7.74 | Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. ( Rensing, N; Rothman, SM; Thio, LL; Weisenfeld, AE; Wong, M; Xu, L; Yamada, KA; Yang, XF; Zhang, HX, 2008) |
| "In this study, the immunolocalization of FosB transcription factor was investigated in acute and chronic experimental models of seizures induced by 4-aminopyridine." | 7.74 | Late expression of FosB transcription factor in 4-aminopyridine-induced seizures in the rat cerebral cortex. ( Bagosi, A; Bakos, M; Krisztin-Péva, B; Mihály, A, 2008) |
| " Anticonvulsant effects were evaluated against seizures induced by both 14 mg/kg of 4-aminopyridine and 110 mg/kg of pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 7.72 | Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Bravo, J; Cuadrado, A, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 7.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " Using this device, we have found that the microdialysis infusion of 4-aminopyridine (4-AP) in the motor cerebral cortex produces intense behavioral convulsions and EEG seizures in both the infused and the contralateral cortex." | 7.70 | Cortical catecholamine changes and seizures induced by 4-aminopyridine in awake rats, studied with a dual microdialysis-electrical recording technique. ( López-Pérez, S; Medina-Ceja, L; Morales-Villagrán, A; Tapia, R, 1999) |
| "Systemic injections of 4-aminopyridine precipitate epileptiform generalized seizures characterized mainly by shivering of the body, tail movements and tonic-clonic convulsions in rats and mice." | 7.70 | Acute 4-aminopyridine seizures increase the regional cerebral blood flow in the thalamus and neocortex, but not in the entire allocortex of the mouse brain. ( Ayesha, A; Gopinath, S; Mathew, M; Mihály, A; Owunwanne, A; Shihab-Eldeen, A, 2000) |
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 7.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| "Systemic administration of pilocarpine to adult rats induces an acute status epilepticus followed by spontaneous recurrent seizures after a 1-2-week silent period." | 7.69 | Interictal discharges in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Gloor, P; Nagao, T, 1994) |
| "Pilocarpine injection into rodents leads to the development of chronic limbic seizures that follow an initial status epilepticus and a seizure-free interval." | 7.69 | Extracellular potassium elevations in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Köhling, R; Lücke, A; Nagao, T; Speckmann, EJ, 1995) |
| "We investigated the influence of NG-nitro-L-arginine (NNA), the inhibitor of nitric oxide synthese, on seizures induced by 4-aminopyridine (4-AP), the K+ channel antagonist, in mice NNA (5, 10 and 40 mg/kg, i." | 7.69 | NG-nitro-L-arginine sensitizes mice to 4-aminopyridine-induced seizures. ( Kleinrok, Z; Młynarczyk, M; Tutka, P; Zółkowska, D, 1996) |
| "The susceptibility of rats made deficient of taurine by treatment with guanidinoethane sulfonate (GES), to seizures induced by 4-aminopyridine was examined." | 7.67 | Higher susceptibility of taurine-deficient rats to seizures induced by 4-aminopyridine. ( Arzate, ME; Huxtable, RJ; Pasantes-Morales, H; Quesada, O, 1987) |
| "In epilepsy, seizures are generated by abnormal synchronous activity in neurons." | 5.42 | Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus. ( Alberto, MV; Anne, S; Laura, MC; Xóchitl, FP, 2015) |
| "Seizures were prevented in 50% and 75% of the animals by chronic CBZ and VPC, respectively." | 5.35 | Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine. ( Nekrassov, V; Sitges, M, 2008) |
| "The GYKI 52466-pretreatment did not prevent the astrocyte swelling in the investigated cortical areas; thus we conclude that the AMPA-receptors have little if any involvement in the in the mediation of neuropathological alterations in acute convulsions." | 5.35 | Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling. ( Krisztin-Péva, B; Mihály, A; Weiczner, R, 2008) |
| "These results suggest that seizure activity induced by 4-aminopyridine is due to a combined action of excitatory amino acid release and direct stimulation of neuronal firing, whereas neuronal death is related to the increased glutamate release but is independent of seizure activity." | 5.30 | Relationships among seizures, extracellular amino acid changes, and neurodegeneration induced by 4-aminopyridine in rat hippocampus: a microdialysis and electroencephalographic study. ( Peña, F; Tapia, R, 1999) |
| "4-aminopyridine, particularly the tonic convulsions, but were less effective against those produced by i." | 5.29 | Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine. ( Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME, 1996) |
| "Pretreatment with nifedipine (7." | 5.28 | Seizures and wet-dog shakes induced by 4-aminopyridine, and their potentiation by nifedipine. ( Alvarado, R; Fragoso-Veloz, J; Massieu, L; Tapia, R, 1990) |
| "Serial sections of the whole seizure focus were evaluated in the light microscope, and the areas of protein extravasation were measured planimetrically." | 5.28 | Vasogenic brain edema in focal 4-aminopyridine seizures: the role of neuronal hyperactivity. ( Joó, F; Mihály, A; Szente, M, 1990) |
| "Focal seizure was induced in rat and cat neocortex by the topical application of aminopyridines." | 5.27 | Neocortical cytopathology in focal aminopyridine seizures as related to the intracortical diffusion of [3H] 4-aminopyridine. Electrophysiologic and light-microscopic studies. ( Joó, F; Mihály, A; Szente, M; Tóth, G, 1985) |
| " Furthermore, real-time measurement of lactate and oxygen concentration dynamics concurrently with network electrical activity during status epilepticus induced by 4-aminopyridine (4-AP) demonstrated phasic changes in lactate levels that correlated with bursts of electrical activity, while tonic levels of lactate remained stable during seizures." | 4.84 | Amperometric bio-sensing of lactate and oxygen concurrently with local field potentials during status epilepticus. ( Barbosa, RM; Fernandes, E; Gerhardt, GA; Ledo, A, 2024) |
| "4-Aminopyridine was used in both in vivo and in vitro preparation to trigger seizures or epileptiform activity." | 4.02 | Neural recruitment by ephaptic coupling in epilepsy. ( Chiang, CC; Couturier, NH; Durand, DM; Pakalapati, N; Shivacharan, RS; Subramanian, M; Wei, X, 2021) |
| "We performed combined in vivo 2-photon calcium imaging from different targeted neuronal subpopulations and extracellular electrophysiological recordings during 4-aminopyridine-induced neocortical spikes and seizures." | 3.96 | Layer- and Cell-Specific Recruitment Dynamics during Epileptic Seizures In Vivo. ( Aeed, F; Schiller, Y; Shnitzer, T; Talmon, R, 2020) |
| "The present study examined temporal activation patterns of rat cerebellar cortical neurons in 4-aminopyridine induced seizures, using c-fos protein as a marker of neuronal activity." | 3.91 | Differential expression of the c-fos protein and synaptophysin in zebrin II positive and zebrin II negative cerebellar cortical areas in 4-aminopyridine seizures. ( Krisztin-Péva, B; Mihály, A; Tóth, Z, 2019) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 3.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " To study this hypothesis, we chose an animal model comprising focal unilateral hippocampal injection of 4-aminopyridine (4-AP), which produced focal recurrent hippocampal seizures with secondary generalization in awake, behaving rats." | 3.85 | Mortality with brainstem seizures from focal 4-aminopyridine-induced recurrent hippocampal seizures. ( Carlen, PL; Del Campo, M; Devinsky, O; Genov, R; Montandon, G; Salam, MT, 2017) |
| " Seizures were induced with one of Pentelyntetrazole (PTZ), 4-Aminopyridine (AP) and Strychnine (STR)." | 3.85 | Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats. ( Desalu, OO; Kolo, PM; Olarinoye, JK; Olatunji, LA; Sanya, EO; Soladoye, AO, 2017) |
| "Our results firmly establish that under a similar experimental condition (ie, bath application of 4-aminopyridine), the initiation of low-voltage, fast and of hypersynchronous onset seizures in the entorhinal cortex depends on the preponderant involvement of interneuronal and principal cell networks, respectively." | 3.83 | Activation of specific neuronal networks leads to different seizure onset types. ( Avoli, M; Lévesque, M; Manseau, F; Shiri, Z; Williams, S, 2016) |
| " Approximately 3-4 wk later recurrent electrographic seizures were evoked by local application of the chemoconvulsant 4-aminopyridine (4-AP); the ECoG and unit activity were monitored with extracellular silicone electrodes; and PV interneurons were activated optogenetically during the ictal and interictal phases." | 3.83 | The antiepileptic and ictogenic effects of optogenetic neurostimulation of PV-expressing interneurons. ( Assaf, F; Schiller, Y, 2016) |
| " Generalized seizures were induced by means of intraperitoneal 4-aminopyridine injections." | 3.81 | Immunohistochemistry of cerebellar seizures: mossy fiber afferents play an important role in seizure spread and initiation in the rat. ( Kopniczky, Z; Krisztin-Péva, B; Mihály, A; Molnár, G; Morvai, M; Tóth, Z, 2015) |
| " Ripples (80-200 Hz) and fast ripples (250-500 Hz) have been linked to each pattern, with ripples predominating during LVF seizures and fast ripples predominating during HYP seizures in the rat pilocarpine model." | 3.81 | Distinct EEG seizure patterns reflect different seizure generation mechanisms. ( Avoli, M; Gotman, J; Lévesque, M; Salami, P, 2015) |
| " Local application of 4-aminopyridine (4-AP) into the CA1 region was used to induce focal motor seizures in different animal age groups representing young, late-middle aged and elderly humans." | 3.80 | Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure. ( Bensalem-Owen, M; Davis, VA; Deel, ME; Gerhardt, GA; Huettl, P; Pomerleau, F; Slevin, J; Stephens, ML; Williamson, A, 2014) |
| " After seizures had been induced by 4-aminopyridine treatment, on-off control stimulation was used to suppress the seizures at 20 s intervals." | 3.79 | On-off control of burst high frequency electrical stimulation to suppress 4-AP induced seizures. ( Chiang, CC; Ju, MS; Lin, CC, 2013) |
| "), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine." | 3.78 | The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. ( Aldana, BI; Gómez, CD; Nekrassov, V; Sitges, M, 2012) |
| " CBD (1, 10, and 100 mg/kg) effects were also examined in vivo using the pentylenetetrazole model of generalized seizures." | 3.76 | Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. ( Bevan, SA; Hill, AJ; Jones, NA; Smith, I; Stephens, GJ; Whalley, BJ; Williams, CM, 2010) |
| "This study investigated the in vitro antioxidant activity of (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD), the anticonvulsant effect of BPD on seizures induced by pilocarpine (PC), pentylenetetrazole (PTZ) and 4-aminopyridine (4-AMP) and the mechanism involved." | 3.76 | Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Roman, SS; Wilhelm, EA, 2010) |
| " Consistent with these observations, acetoacetate reduced quantal size at hippocampal synapses and suppresses glutamate release and seizures evoked with 4-aminopyridine in the brain." | 3.76 | Metabolic control of vesicular glutamate transport and release. ( Edwards, RH; Gray, JA; Hara, C; Inoue, T; Juge, N; Miyaji, T; Moriyama, Y; Nicoll, RA; Omote, H; Uneyama, H, 2010) |
| " platyphylla stem bark were studied on pentylenetetrazole-, strychnine- and maximal electroshock seizures in mice." | 3.75 | Anticonvulsant properties of saponins from Ficus platyphylla stem bark. ( Adamu, SS; Amos, S; Anuka, JA; Chindo, BA; Connelly, WK; Gamaniel, KS; Lees, G; McNeil, L; Yaro, AH, 2009) |
| " Daily repeated epileptic seizures were induced for 12 days by intraperitoneal administration of 4-aminopyridine (4-AP; 4." | 3.75 | Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures. ( Bakos, M; Borbély, S; Czégé, D; Dobó, E; Mihály, A; Molnár, E; Szucs, B; Világi, I; Vincze, A, 2009) |
| "Distribution and time course of the occurrence of "dark" neurons were compared with the EEG activity and behavior of rats during 4-aminopyridine (4-AP) induced epileptic seizures." | 3.74 | Generalization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat. ( Baracskay, P; Czurkó, A; Juhász, G; Orbán, G; Szepesi, Z, 2008) |
| "Excessive release of L-glutamic acid (glu) has been associated with seizures and epilepsy." | 3.74 | Simultaneous glutamate and EEG activity measurements during seizures in rat hippocampal region with the use of an electrochemical biosensor. ( López-Pérez, SJ; Medina-Ceja, L; Morales-Villagrán, A, 2008) |
| " Focal seizures in rats were induced by neocortical injections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels." | 3.74 | Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. ( Rensing, N; Rothman, SM; Thio, LL; Weisenfeld, AE; Wong, M; Xu, L; Yamada, KA; Yang, XF; Zhang, HX, 2008) |
| "In this study, the immunolocalization of FosB transcription factor was investigated in acute and chronic experimental models of seizures induced by 4-aminopyridine." | 3.74 | Late expression of FosB transcription factor in 4-aminopyridine-induced seizures in the rat cerebral cortex. ( Bagosi, A; Bakos, M; Krisztin-Péva, B; Mihály, A, 2008) |
| " We report that application of 4-aminopyridine (4-AP) to immature (P6-P9) neocortical slices generates layer-specific interictal seizures (IISs) that transform after recurrent seizures to ictal seizures (ISs)." | 3.74 | Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses. ( Ben-Ari, Y; Represa, A; Rheims, S; Zilberter, Y, 2008) |
| "The effect of acute brief seizures on neocortical c-fos expression was investigated in rats injected with 5 mg/kg 4-aminopyridine." | 3.73 | Neocortical c-fos mRNA transcription in repeated, brief, acute seizures: is c-fos a coincidence detector? ( Bagosi, A; Borbély, S; Détári, L; Kopniczky, Z; Krisztin-Péva, B; Mihály, A; Világi, I; Weiczner, R; Zádor, E; Zádor, Z, 2005) |
| " Here we analysed the effects of one-sided lateral EC (LEC) and temporoammonic (alvear) path lesion on the development and properties of 4-aminopyridine-induced seizures." | 3.73 | Lateral entorhinal cortex lesions rearrange afferents, glutamate receptors, increase seizure latency and suppress seizure-induced c-fos expression in the hippocampus of adult rat. ( Bagosi, A; Borbély, S; Détári, L; Dobó, E; Kopniczky, Z; Krisztin-Péva, B; Mihály, A; Molnár, E; Világi, I, 2005) |
| "The selective contribution of neuronal gap junction (GJ) communication via connexin 36 (Cx36) channels to epileptogenesis and to the maintenance and propagation of seizures was investigated in both the primary focus and the mirror focus by using pharmacologic approaches with the 4-aminopyridine in vivo epilepsy model." | 3.73 | Quinine, a blocker of neuronal cx36 channels, suppresses seizure activity in rat neocortex in vivo. ( Blazsó, G; Gajda, Z; Szente, M; Szupera, Z, 2005) |
| "Focal neocortical seizures, induced by injection of 4-aminopyridine, were imaged in the rat neocortex using the intrinsic optical signal, with incident light at various wavelengths." | 3.73 | Intrinsic optical signal imaging of neocortical seizures: the 'epileptic dip'. ( Bahar, S; Schwartz, TH; Suh, M; Zhao, M, 2006) |
| "The functional significance of gap-junction (GJ) channels in seizure susceptibility and induction and maintenance of seizures in the developing rat brain was investigated on the 4-aminopyridine (4-AP) in vivo epilepsy model." | 3.73 | The functional significance of gap junction channels in the epileptogenicity and seizure susceptibility of juvenile rats. ( Gajda, Z; Gyengési, E; Hermesz, E; Szente, M; Szupera, Z, 2006) |
| "We examined the effects of dexamethasone on the expression of the inducible transcription factor c-fos in 4-aminopyridine (4-AP) seizures." | 3.73 | Alterations of seizure-induced c-fos immunolabelling and gene expression in the rat cerebral cortex following dexamethasone treatment. ( Fazekas, I; Janka, Z; Juhász, A; Krisztin-Péva, B; Mihály, A; Szakács, R; Zádor, Z, 2006) |
| " Anticonvulsant effects were evaluated against seizures induced by both 14 mg/kg of 4-aminopyridine and 110 mg/kg of pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 3.72 | Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Bravo, J; Cuadrado, A, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 3.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " After creating a cranial window in anesthetized rats, we induced seizures by injecting artificial cerebrospinal fluid containing 4-aminopyridine (4-AP), a potassium channel blocker." | 3.71 | Focal cooling rapidly terminates experimental neocortical seizures. ( Rothman, SM; Yang, XF, 2001) |
| "We induced focal neocortical seizures in halothane-anesthetized rats by the microinjection of 4-aminopyridine (4-AP) into the motor cortex." | 3.71 | Neocortical seizure termination by focal cooling: temperature dependence and automated seizure detection. ( Duffy, DW; Morley, RE; Rothman, SM; Yang, XF, 2002) |
| " AR-R 15896AR prevented tonic seizures in rodents for up to 6 to 8 h in response to maximal electroshock (MES), 4-aminopyridine, bicuculline, or strychnine, as well as characteristic seizures following injections of N-methyl-DL-aspartic or kainic acids." | 3.70 | [S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties. ( Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML, 1999) |
| " We compared the epileptiform activities induced by 4-aminopyridine (4-AP) induced in hippocampal-entorhinal cortex slices from genetic absence epilepsy rats of Strasbourg (GAERS, age 6 months) in which absence seizures have been present for about 4 months and from control non epileptic rats (NE)." | 3.70 | Epileptiform activity induced by 4-aminopyridine in entorhinal cortex hippocampal slices of rats with a genetically determined absence epilepsy (GAERS). ( Armand, V; Heinemann, U; Hoffmann, P; Vergnes, M, 1999) |
| " Using this device, we have found that the microdialysis infusion of 4-aminopyridine (4-AP) in the motor cerebral cortex produces intense behavioral convulsions and EEG seizures in both the infused and the contralateral cortex." | 3.70 | Cortical catecholamine changes and seizures induced by 4-aminopyridine in awake rats, studied with a dual microdialysis-electrical recording technique. ( López-Pérez, S; Medina-Ceja, L; Morales-Villagrán, A; Tapia, R, 1999) |
| "Systemic injections of 4-aminopyridine precipitate epileptiform generalized seizures characterized mainly by shivering of the body, tail movements and tonic-clonic convulsions in rats and mice." | 3.70 | Acute 4-aminopyridine seizures increase the regional cerebral blood flow in the thalamus and neocortex, but not in the entire allocortex of the mouse brain. ( Ayesha, A; Gopinath, S; Mathew, M; Mihály, A; Owunwanne, A; Shihab-Eldeen, A, 2000) |
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 3.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| "Systemic administration of pilocarpine to adult rats induces an acute status epilepticus followed by spontaneous recurrent seizures after a 1-2-week silent period." | 3.69 | Interictal discharges in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Gloor, P; Nagao, T, 1994) |
| "Seizures may be induced in mice in response to stimulation of subtypes of glutamate receptors by kainic acid or inhibition of certain voltage-dependent potassium channels by 4-aminopyridine (4-AP)." | 3.69 | Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of anti-epileptic agents and calcium antagonists. ( Cramer, CL; Knowles, MA; Palmer, GC; Stagnitto, ML, 1994) |
| "Pilocarpine injection into rodents leads to the development of chronic limbic seizures that follow an initial status epilepticus and a seizure-free interval." | 3.69 | Extracellular potassium elevations in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Köhling, R; Lücke, A; Nagao, T; Speckmann, EJ, 1995) |
| "The relative ability of derivatives of 2-piperidinecarboxylic acid (2-PC; pipecolic acid) and 3-piperidinecarboxylic acid (3-PC; nipecotic acid) to block maximal electroshock (MES)-induced seizures, elevate the threshold for electroshock-induced seizures and be neurotoxic in mice was investigated." | 3.69 | Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats. ( Andersen, PH; Burns, CM; Chang, H; Crider, AM; el-Assadi, AA; Hinko, CN; Ho, B; Kliem, MA; Klitgaard, H; Seo, TH; Steinmiller, CL; Tietz, EI; Venkatarangan, P, 1996) |
| "We investigated the influence of NG-nitro-L-arginine (NNA), the inhibitor of nitric oxide synthese, on seizures induced by 4-aminopyridine (4-AP), the K+ channel antagonist, in mice NNA (5, 10 and 40 mg/kg, i." | 3.69 | NG-nitro-L-arginine sensitizes mice to 4-aminopyridine-induced seizures. ( Kleinrok, Z; Młynarczyk, M; Tutka, P; Zółkowska, D, 1996) |
| " GYKI 52466 was also protective against seizures and lethality induced by 4-aminopyridine, kainate and AMPA, but not by NMDA, whereas NBQX was ineffective in these chemoconvulsant tests." | 3.68 | Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models. ( Donevan, SD; Rogawski, MA; Yamaguchi, S, 1993) |
| "Using electroencephalographic (EEG) recordings in freely moving rats and extracellular neuronal firing-rate recordings in hippocampal slices, we examined the effects of riluzole (RP 54274), a compound with anti-glutamate properties, against the convulsive seizures and the cellular hyperexcitability produced by the mast-cell degranulating peptide (MCD), dendrotoxin I (DTXi) and 4-aminopyridine (4-AP)." | 3.68 | Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat. ( Blanchard, JC; Böhme, GA; Gandolfo, G; Gottesmann, C; Laduron, PM; Lafforgue, J; Lazdunski, M; Stutzmann, JM, 1991) |
| "Intracerebroventricular injection of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), 3 blockers of a subclass of K+ channel, produces seizures and convulsions." | 3.67 | Subtypes of K+ channels differentiated by the effect of K+ channel openers upon K+ channel blocker-induced seizures. ( Bidard, JN; Gandolfo, G; Gottesmann, C; Lazdunski, M, 1989) |
| "The susceptibility of rats made deficient of taurine by treatment with guanidinoethane sulfonate (GES), to seizures induced by 4-aminopyridine was examined." | 3.67 | Higher susceptibility of taurine-deficient rats to seizures induced by 4-aminopyridine. ( Arzate, ME; Huxtable, RJ; Pasantes-Morales, H; Quesada, O, 1987) |
| " Strict adherence to the prescribed dosing regimen is essential." | 2.48 | Clinical overview of the seizure risk of dalfampridine. ( Bienen, EJ; Haut, SR; Miller, A, 2012) |
| "Medication used to treat multiple sclerosis (MS) can be categorized as disease-modifying therapies, symptomatic therapies, or treatment of acute exacerbations." | 2.48 | Clinical overview of dalfampridine: an agent with a novel mechanism of action to help with gait disturbances. ( Bainbridge, JL; Egeberg, MD; Oh, CY, 2012) |
| "Limbic seizures can be mimicked in vitro using preparations of combined hippocampus-entorhinal cortex slices perfused with artificial cerebrospinal fluid containing convulsants or nominally zero Mg(2+), in order to produce epileptiform synchronization." | 2.41 | Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. ( Avoli, M; Biagini, G; D'Antuono, M; D'Arcangelo, G; Köhling, R; Louvel, J; Pumain, R; Tancredi, V, 2002) |
| "During epileptic seizures, neuronal network activity is hyper synchronized whereby GABAergic parvalbumin-interneurons may have a key role." | 1.91 | Cell-specific switch for epileptiform activity: critical role of interneurons in the mouse subicular network. ( Andersson, M; Kokaia, M; Ledri, M; Wickham, J, 2023) |
| "Greater seizure power and area of recruitment predicted SD." | 1.62 | Spreading depression as an innate antiseizure mechanism. ( Ayata, C; Chung, DY; de Morais, AL; Endres, M; Loonen, ICM; Misra, A; Qin, T; Schiff, SJ; Schlunk, F; Tamim, I, 2021) |
| "We find that the seizure focus elicits a rapid alteration in triggering, initiation, and propagation of burst suppression events." | 1.51 | Burst suppression uncovers rapid widespread alterations in network excitability caused by an acute seizure focus. ( Baird-Daniel, E; Daniel, A; Liou, JY; Ma, H; Schevon, CA; Schwartz, TH; Zhao, M, 2019) |
| "Recent evidence shows that seizures propagate primarily through supragranular cortical layers." | 1.51 | In Vivo Femtosecond Laser Subsurface Cortical Microtransections Attenuate Acute Rat Focal Seizures. ( Baird-Daniel, E; Fetcho, R; Lieberman, S; Liu, L; Ma, H; Nagappan, S; Nguyen, J; Nishimura, N; Radwanski, RE; Schaffer, CB; Schwartz, TH; Zhao, M, 2019) |
| "Epilepsy is a group of neurological disorders which affects millions of people worldwide." | 1.51 | Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice. ( Kaszas, A; Malliaras, GG; Proctor, CM; Slezia, A; Williamson, A, 2019) |
| "Rosmarinic acid (RA) is an ester of caffeic acid and 3,4-dihydroxyphenylactic acid that prevents cell damage caused by free radicals, acting as an antioxidant." | 1.51 | Rosmarinic acid improves oxidative stress parameters and mitochondrial respiratory chain activity following 4-aminopyridine and picrotoxin-induced seizure in mice. ( da Rosa, MS; Gonçalves, D; Leipnitz, G; Luft, JG; Morás, AM; Moura, DJ; Pereira, P; Pflüger, PF; Regner, GG; Steffens, L, 2019) |
| "Traditionally, seizure activity is believed to arise from the breakdown of this delicate balance in favor of excitation with loss of inhibition." | 1.48 | Role of KCC2-dependent potassium efflux in 4-Aminopyridine-induced Epileptiform synchronization. ( Avoli, M; Bazhenov, M; González, OC; Krishnan, GP; Myers, TL; Shiri, Z; Williams, S, 2018) |
| "Generalized seizures were precipitated by the intraperitoneal injection of 4-aminopyridine." | 1.48 | Non-competitive antagonists of NMDA and AMPA receptors decrease seizure-induced c-fos protein expression in the cerebellum and protect against seizure symptoms in adult rats. ( Krisztin-Péva, B; Mátyás, A; Mihály, A; Tóth, Z, 2018) |
| "Focal seizure propagation is classically thought to be spatially contiguous." | 1.48 | Role of inhibitory control in modulating focal seizure spread. ( Baird-Daniel, E; Daniel, A; Emerson, R; Liou, JY; Ma, H; Schevon, CA; Schwartz, TH; Smith, EH; Wenzel, M; Yuste, R; Zhao, M, 2018) |
| "Secondarily generalized seizures in the hippocampus were eliminated when seizures in the cortical focus were suppressed." | 1.48 | Corpus callosum low-frequency stimulation suppresses seizures in an acute rat model of focal cortical seizures. ( Couturier, NH; Durand, DM, 2018) |
| "We induced focal neocortical seizures using microinjection of 4-aminopyridine into premotor cortex in five anesthetized cynomolgus monkeys." | 1.46 | Rapid focal cooling attenuates cortical seizures in a primate epilepsy model. ( Fu, Y; Gan, Y; Li, D; Ren, G; Tao, G; Wang, L; Wang, W; Yan, J; Yan, X; Yang, X; Yue, F; Zhang, Z, 2017) |
| "Seizures are accompanied by an exacerbated activation of cerebral ion channels." | 1.43 | Effect of the Anti-depressant Sertraline, the Novel Anti-seizure Drug Vinpocetine and Several Conventional Antiepileptic Drugs on the Epileptiform EEG Activity Induced by 4-Aminopyridine. ( Aldana, BI; Reed, RC; Sitges, M, 2016) |
| "Status epilepticus (SE) is defined as a seizure lasting more than 5min or a period of recurrent seizures without recovery between them." | 1.43 | High frequency oscillations can pinpoint seizures progressing to status epilepticus. ( Avoli, M; Lévesque, M; Salami, P, 2016) |
| "In addition, both types of seizures presented with higher ripple than fast ripple rates." | 1.42 | Interneuron activity leads to initiation of low-voltage fast-onset seizures. ( Avoli, M; Lévesque, M; Manseau, F; Shiri, Z; Williams, S, 2015) |
| "Seizures were induced by daily administration of 4-aminopyridine (4-AP)." | 1.42 | Repeated application of 4-aminopyridine provoke an increase in entorhinal cortex excitability and rearrange AMPA and kainate receptors. ( Borbély, S; Czégé, D; Dobó, E; Mihály, A; Molnár, E; Világi, I, 2015) |
| "The long-term effects of DCS on seizures were not influenced by the depotentiation blocker FK-506." | 1.42 | Treatment with direct-current stimulation against cingulate seizure-like activity induced by 4-aminopyridine and bicuculline in an in vitro mouse model. ( Chang, WP; Lu, HC; Shyu, BC, 2015) |
| "Interictal spikes in models of focal seizures and epilepsies are sustained by the synchronous activation of glutamatergic and GABAergic networks." | 1.42 | Synchronous inhibitory potentials precede seizure-like events in acute models of focal limbic seizures. ( Breschi, GL; de Curtis, M; Gnatkovsky, V; Taverna, S; Uva, L, 2015) |
| "IL-1R1 knockout or IL-1RA enhanced the seizure refractory phenomenon without influencing the baseline seizure threshold in intermittent MES model." | 1.42 | The Pro-inflammatory Cytokine Interleukin-1β is a Key Regulatory Factor for the Postictal Suppression in Mice. ( Chen, B; Chen, Z; Hu, WW; Shi, LY; Tang, YS; Tao, AF; Wang, Y; Wu, XH; Xu, CL; Xu, ZH; Zhang, J; Zhang, SH; Zhao, HW, 2015) |
| "To investigate the abortion of seizure generation using "minimal" intervention in hippocampi using two rat models of human temporal lobe epilepsy." | 1.42 | Rapid brief feedback intracerebral stimulation based on real-time desynchronization detection preceding seizures stops the generation of convulsive paroxysms. ( Genov, R; Kassiri, H; Perez Velazquez, JL; Salam, MT, 2015) |
| "In epilepsy, seizures are generated by abnormal synchronous activity in neurons." | 1.42 | Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus. ( Alberto, MV; Anne, S; Laura, MC; Xóchitl, FP, 2015) |
| "The seizures were refractory to benzodiazepines, barbiturates and phenytoin." | 1.42 | A Massive Overdose of Dalfampridine. ( Fil, LJ; Sattler, S; Sud, P, 2015) |
| "Hydrogen sulfide (H2 S) is a gas transmitter that may mediate cerebral ischemic injury." | 1.40 | Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability. ( Chen, JG; Guan, XL; He, JG; Hu, ZL; Luo, Y; Wang, F; Wu, PF; Xiao, W; Zhang, JT; Zhou, J, 2014) |
| "A closed-loop seizure control system was then implemented based on optimal eTBS parameters." | 1.40 | Suppression of acute seizures by theta burst electrical stimulation of the hippocampal commissure using a closed-loop system. ( Chiang, CC; Ju, MS; Lin, CC; Siah, BH, 2014) |
| "Seizures were induced by global hypoxia (5-7% O2 for 15 min) in rat pups on postnatal day 10." | 1.39 | Decreased A-currents in hippocampal dentate granule cells after seizure-inducing hypoxia in the immature rat. ( He, XH; Justice, JA; Peng, BW; Sanchez, RM, 2013) |
| "To study the spatial extent of seizure suppression by HFS applied on the tract and focus site in an in vivo experiment." | 1.39 | High frequency stimulation can suppress globally seizures induced by 4-AP in the rat hippocampus: an acute in vivo study. ( Chiang, CC; Durand, DM; Ju, MS; Lin, CC, 2013) |
| "Epilepsy is a neurological disorder produced by an imbalance between excitatory and inhibitory neurotransmission, in which transporters of both glutamate and GABA have been implicated." | 1.38 | Rapid compensatory changes in the expression of EAAT-3 and GAT-1 transporters during seizures in cells of the CA1 and dentate gyrus. ( López-Pérez, SJ; Medina-Ceja, L; Morales-Villagrán, A; Sandoval-García, F, 2012) |
| "Perfusion of LM/HK produced seizure-like events (SLEs) or stimulus-evoked primary afterdischarges (PADs) with amplitudes of 0." | 1.37 | Isovaline, a rare amino acid, has anticonvulsant properties in two in vitro hippocampal seizure models by increasing interneuronal activity. ( Calos, M; Carlen, PL; Puil, E; Shin, DS; Sutton, A; Yu, W, 2011) |
| "In addition, seizure onset and propagation are difficult to determine in vivo in ACC." | 1.37 | Spatiotemporal organization and thalamic modulation of seizures in the mouse medial thalamic-anterior cingulate slice. ( Chang, WP; Lee, CM; Shyu, BC; Vogt, BA; Wu, JS, 2011) |
| "Because our seizure model is very severe, it is probable that this technique would have a robust effect in human focal epilepsy." | 1.36 | Optical suppression of experimental seizures in rat brain slices. ( Rode, DL; Rothman, SM; Schmidt, BF; Yang, XF, 2010) |
| "Seizures were prevented in 50% and 75% of the animals by chronic CBZ and VPC, respectively." | 1.35 | Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine. ( Nekrassov, V; Sitges, M, 2008) |
| "The behavioral signs of the developing epileptic seizures were scored in all rats." | 1.35 | Status epilepticus affects the gigantocellular network of the pontine reticular formation. ( Baracskay, P; Czurkó, A; Juhász, G; Kékesi, KA; Kiglics, V, 2009) |
| "The GYKI 52466-pretreatment did not prevent the astrocyte swelling in the investigated cortical areas; thus we conclude that the AMPA-receptors have little if any involvement in the in the mediation of neuropathological alterations in acute convulsions." | 1.35 | Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling. ( Krisztin-Péva, B; Mihály, A; Weiczner, R, 2008) |
| "They show, in two rodent seizure models, that leptin administered directly to the brain or nasal epithelium suppresses seizures via direct effects on glutamate neurotransmission in the hippocampus." | 1.35 | Anticonvulsant effects of leptin in epilepsy. ( Diano, S; Horvath, TL, 2008) |
| "We determine that, in the model system, seizures result from increased connectivity between excitatory and inhibitory cell populations, or from decreased connectivity within either excitatory or inhibitory cell populations." | 1.34 | Mechanisms of seizure propagation in a cortical model. ( Kirsch, HE; Kramer, MA; Sleigh, JW; Szeri, AJ, 2007) |
| "Within an hour of induction, seizure activity caused both a significant decrease in F-actin labeling, indicating depolymerization of F-actin, and a corresponding decrease in phosphorylated cofilin, signifying an increase in cofilin activity." | 1.34 | Hippocampal seizures cause depolymerization of filamentous actin in neurons independent of acute morphological changes. ( Erbayat-Altay, E; Hu, XY; Lee, JM; Ouyang, Y; Wong, M; Yang, XF; Zeng, LH, 2007) |
| "In addition, convulsive seizure activity was induced by systemic administration of either 4-aminopyridine (4-AP; 10 mg/kg, i." | 1.33 | Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel. ( Henry, M; Hescheler, J; Kamp, M; Krieger, A; Radhakrishnan, K; Schneider, T; Weiergräber, M, 2006) |
| "Practical devices to inhibit seizure activity may only need to induce small temperature drops, if the cooling can be applied sufficiently rapidly." | 1.33 | Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy models. ( Lesser, RP; Motamedi, GK; Ortinski, PI; Rogawski, MA; Salazar, P; Smith, EL; Vicini, S; Webber, WR, 2006) |
| "Unexpectedly, seizure-like events in 4AP were desynchronous events, both in comparison with interictal periods preceding the seizure without bursts (cut Schaffer collateral tract) and in comparison with bursts preceding the seizures (intact Schaffer collateral tract)." | 1.31 | Decreased neuronal synchronization during experimental seizures. ( Netoff, TI; Schiff, SJ, 2002) |
| "Because focal seizures produce an increase in local cerebral metabolism and blood flow, we wanted to determine whether they might lead to changes in brain temperature." | 1.31 | Intracerebral temperature alterations associated with focal seizures. ( Chang, JH; Rothman, SM; Yang, XF, 2002) |
| "In this model of limbic seizures, ictal discharges disappear over time and are reestablished after Schaffer collateral cut, a procedure that blocks interictal propagation from CA3 to EC." | 1.31 | Hippocampus-entorhinal cortex loop and seizure generation in the young rodent limbic system. ( Avoli, M; Barbarosie, M; Calcagnotto, ME, 2000) |
| "Alaproclate and GEA-857 antagonized seizures induced by NMDA, 200 mg/kg subcutaneously at doses similar to those antagonizing the harmaline- and NMDA-induced elevation of cerebellar cGMP." | 1.30 | NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857. ( Hu, PS; Ross, SB, 1997) |
| "During seizure-like events (SLEs), intracellular Ca2+ concentration ([Ca2+]i) increases causing depolarization of the mitochondrial membrane and subsequent intramitochondrial accumulation of Ca2+." | 1.30 | A relative energy failure is associated with low-Mg2+ but not with 4-aminopyridine induced seizure-like events in entorhinal cortex. ( Buchheim, K; Heinemann, U; Meierkord, H; Schuchmann, S, 1999) |
| "K+ channel blockers are known to induce seizures, but the specific K channel types that can serve as convulsant targets are not well defined." | 1.30 | Induction of seizures by the potent K+ channel-blocking scorpion venom peptide toxins tityustoxin-K(alpha) and pandinustoxin-K(alpha). ( Blaustein, MP; Juhng, KN; Kim, BY; Kokate, TG; Rogawski, MA; Rogowski, RS; Yamaguchi, S, 1999) |
| "These results suggest that seizure activity induced by 4-aminopyridine is due to a combined action of excitatory amino acid release and direct stimulation of neuronal firing, whereas neuronal death is related to the increased glutamate release but is independent of seizure activity." | 1.30 | Relationships among seizures, extracellular amino acid changes, and neurodegeneration induced by 4-aminopyridine in rat hippocampus: a microdialysis and electroencephalographic study. ( Peña, F; Tapia, R, 1999) |
| "Most baclofen effects were reversed by the GABA(B) receptor antagonist CGP 35348 (1 mM; n = 4)." | 1.30 | GABA(B) receptor activation promotes seizure activity in the juvenile rat hippocampus. ( Avoli, M; Kurcewicz, I; Louvel, J; Motalli, R; Pumain, R; Tancredi, V; Wan-Chow-Wah, D, 1999) |
| "With 40 rabbits, the occurrence of convulsion at this dose level was 100%." | 1.29 | [Intracerebral-ventricular injection of 4-aminopyridine induced convulsion in rabbits]. ( Cao, H; Xu, JH; Zheng, JH, 1993) |
| "This class of compounds caused convulsions in American cockroaches when injected." | 1.29 | Effect of the insect growth regulators, N-tert-butyl-N, N'-dibenzoylhydrazines, on neural activity of the American cockroach. ( Nakagawa, Y; Nishimura, K; Tada, T, 1996) |
| "4-aminopyridine, particularly the tonic convulsions, but were less effective against those produced by i." | 1.29 | Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine. ( Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME, 1996) |
| "Pretreatment with nifedipine (7." | 1.28 | Seizures and wet-dog shakes induced by 4-aminopyridine, and their potentiation by nifedipine. ( Alvarado, R; Fragoso-Veloz, J; Massieu, L; Tapia, R, 1990) |
| "Serial sections of the whole seizure focus were evaluated in the light microscope, and the areas of protein extravasation were measured planimetrically." | 1.28 | Vasogenic brain edema in focal 4-aminopyridine seizures: the role of neuronal hyperactivity. ( Joó, F; Mihály, A; Szente, M, 1990) |
| "Morphine dependence was induced in 90-day-old mice (weighing 29 to 32 g) by a 6-day schedule of twice daily i." | 1.27 | Effect of different convulsant drugs on some seizure parameters in morphine-dependent mice. ( Aleman, V; de Muñoz, DM, 1983) |
| "In five rats with demyelination, slowed conduction velocity through the lesion was partially reversed at dose levels of 5." | 1.27 | Effects of 4-aminopyridine in experimental CNS demyelination. ( Kaji, R; Sumner, AJ, 1988) |
| "Focal seizure was induced in rat and cat neocortex by the topical application of aminopyridines." | 1.27 | Neocortical cytopathology in focal aminopyridine seizures as related to the intracortical diffusion of [3H] 4-aminopyridine. Electrophysiologic and light-microscopic studies. ( Joó, F; Mihály, A; Szente, M; Tóth, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (4.92) | 18.7374 |
| 1990's | 32 (17.49) | 18.2507 |
| 2000's | 52 (28.42) | 29.6817 |
| 2010's | 81 (44.26) | 24.3611 |
| 2020's | 9 (4.92) | 2.80 |
| Authors | Studies |
|---|---|
| Wickham, J | 1 |
| Ledri, M | 1 |
| Andersson, M | 1 |
| Kokaia, M | 1 |
| Scalmani, P | 1 |
| Paterra, R | 1 |
| Mantegazza, M | 1 |
| Avoli, M | 24 |
| de Curtis, M | 6 |
| Fernandes, E | 1 |
| Ledo, A | 1 |
| Gerhardt, GA | 2 |
| Barbosa, RM | 1 |
| Liou, JY | 2 |
| Baird-Daniel, E | 3 |
| Zhao, M | 8 |
| Daniel, A | 2 |
| Schevon, CA | 2 |
| Ma, H | 7 |
| Schwartz, TH | 8 |
| Krisztin-Péva, B | 8 |
| Mihály, A | 15 |
| Tóth, Z | 3 |
| Aeed, F | 1 |
| Shnitzer, T | 1 |
| Talmon, R | 1 |
| Schiller, Y | 2 |
| Etemadifar, M | 1 |
| Saboori, M | 1 |
| Chitsaz, A | 1 |
| Nouri, H | 1 |
| Salari, M | 1 |
| Khorvash, R | 1 |
| Sheibani Tehrani, D | 1 |
| Aghababaee, A | 1 |
| Villasana-Salazar, B | 2 |
| Hernández-Soto, R | 1 |
| Guerrero-Gómez, ME | 1 |
| Ordaz, B | 1 |
| Manrique-Maldonado, G | 1 |
| Salgado-Puga, K | 1 |
| Peña-Ortega, F | 2 |
| Tamim, I | 1 |
| Chung, DY | 1 |
| de Morais, AL | 1 |
| Loonen, ICM | 1 |
| Qin, T | 1 |
| Misra, A | 1 |
| Schlunk, F | 1 |
| Endres, M | 1 |
| Schiff, SJ | 3 |
| Ayata, C | 1 |
| Shivacharan, RS | 1 |
| Chiang, CC | 4 |
| Wei, X | 1 |
| Subramanian, M | 1 |
| Couturier, NH | 2 |
| Pakalapati, N | 1 |
| Durand, DM | 3 |
| Ragot, A | 1 |
| Luhmann, HJ | 2 |
| Dipper-Wawra, M | 1 |
| Heinemann, U | 8 |
| Holtkamp, M | 1 |
| Fidzinski, P | 1 |
| Ren, G | 1 |
| Yan, J | 1 |
| Tao, G | 1 |
| Gan, Y | 1 |
| Li, D | 1 |
| Yan, X | 1 |
| Fu, Y | 1 |
| Wang, L | 1 |
| Wang, W | 1 |
| Zhang, Z | 1 |
| Yue, F | 1 |
| Yang, X | 1 |
| Ha, Y | 2 |
| Lee, Y | 2 |
| Suh, M | 4 |
| Salam, MT | 2 |
| Montandon, G | 1 |
| Genov, R | 2 |
| Devinsky, O | 1 |
| Del Campo, M | 1 |
| Carlen, PL | 3 |
| González, OC | 1 |
| Shiri, Z | 3 |
| Krishnan, GP | 1 |
| Myers, TL | 1 |
| Williams, S | 3 |
| Bazhenov, M | 1 |
| Mátyás, A | 1 |
| Wenzel, M | 1 |
| Smith, EH | 1 |
| Emerson, R | 1 |
| Yuste, R | 1 |
| Nagappan, S | 1 |
| Liu, L | 1 |
| Fetcho, R | 1 |
| Nguyen, J | 2 |
| Nishimura, N | 2 |
| Radwanski, RE | 1 |
| Lieberman, S | 1 |
| Schaffer, CB | 2 |
| Islas-Espinoza, AM | 1 |
| Campos-Rodriguez, C | 1 |
| San Juan, ER | 1 |
| Kalinina, DS | 1 |
| Vasilev, DS | 1 |
| Volnova, AB | 1 |
| Nalivaeva, NN | 1 |
| Zhuravin, IA | 1 |
| Slezia, A | 1 |
| Proctor, CM | 1 |
| Kaszas, A | 1 |
| Malliaras, GG | 1 |
| Williamson, A | 2 |
| Luft, JG | 1 |
| Steffens, L | 1 |
| Morás, AM | 1 |
| da Rosa, MS | 1 |
| Leipnitz, G | 1 |
| Regner, GG | 1 |
| Pflüger, PF | 1 |
| Gonçalves, D | 1 |
| Moura, DJ | 1 |
| Pereira, P | 1 |
| Foschi, M | 1 |
| Lugaresi, A | 1 |
| Chen, LY | 1 |
| Lévesque, M | 8 |
| Alcantara-Gonzalez, D | 1 |
| Uva, L | 5 |
| Trombin, F | 1 |
| Carriero, G | 2 |
| Tsytsarev, V | 1 |
| Rao, B | 1 |
| Maslov, KI | 1 |
| Li, L | 1 |
| Wang, LV | 1 |
| Lin, CC | 3 |
| Ju, MS | 3 |
| Peng, BW | 1 |
| Justice, JA | 1 |
| He, XH | 1 |
| Sanchez, RM | 1 |
| Yu, W | 2 |
| Smith, AB | 1 |
| Pilitsis, J | 1 |
| Shin, DS | 2 |
| Sharopov, S | 1 |
| Chen, R | 1 |
| Sun, H | 1 |
| Kolbaev, SN | 1 |
| Kirischuk, S | 1 |
| Kilb, W | 1 |
| Luo, Y | 1 |
| Wu, PF | 1 |
| Zhou, J | 1 |
| Xiao, W | 1 |
| He, JG | 1 |
| Guan, XL | 1 |
| Zhang, JT | 1 |
| Hu, ZL | 1 |
| Wang, F | 1 |
| Chen, JG | 1 |
| Harris, S | 1 |
| Boorman, L | 1 |
| Zheng, Y | 1 |
| Kennerley, A | 1 |
| Bruyns-Haylett, M | 1 |
| Overton, PG | 1 |
| Berwick, J | 1 |
| Wijayatunge, R | 1 |
| Chen, LF | 1 |
| Cha, YM | 1 |
| Zannas, AS | 1 |
| Frank, CL | 1 |
| West, AE | 1 |
| Salar, S | 1 |
| Maslarova, A | 1 |
| Lippmann, K | 1 |
| Nichtweiss, J | 1 |
| Weissberg, I | 1 |
| Sheintuch, L | 1 |
| Kunz, WS | 1 |
| Shorer, Z | 1 |
| Friedman, A | 3 |
| Hsiao, MC | 1 |
| Yu, PN | 1 |
| Song, D | 1 |
| Liu, CY | 1 |
| Heck, CN | 1 |
| Millett, D | 1 |
| Berger, TW | 1 |
| Stephens, ML | 1 |
| Deel, ME | 1 |
| Bensalem-Owen, M | 1 |
| Davis, VA | 1 |
| Slevin, J | 1 |
| Pomerleau, F | 1 |
| Huettl, P | 1 |
| Bazzigaluppi, P | 1 |
| Dufour, S | 1 |
| Siah, BH | 1 |
| Molnár, G | 1 |
| Morvai, M | 1 |
| Kopniczky, Z | 3 |
| Manseau, F | 2 |
| Borbély, S | 4 |
| Czégé, D | 2 |
| Molnár, E | 3 |
| Dobó, E | 3 |
| Világi, I | 5 |
| Cao, Z | 1 |
| Zou, X | 1 |
| Cui, Y | 1 |
| Hulsizer, S | 1 |
| Lein, PJ | 1 |
| Wulff, H | 1 |
| Pessah, IN | 1 |
| Salami, P | 2 |
| Gotman, J | 2 |
| Chang, WP | 2 |
| Lu, HC | 1 |
| Shyu, BC | 2 |
| Breschi, GL | 1 |
| Gnatkovsky, V | 2 |
| Taverna, S | 1 |
| Medina-Ceja, L | 6 |
| Pardo-Peña, K | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double Blind, Placebo Controlled, Parallel Design Phase II b Study of Safety and Efficacy of MGCND00EP1 as an Add on Treatment in Children and Adolescents With Resistant Epilepsies[NCT04406948] | Phase 2 | 103 participants (Anticipated) | Interventional | 2023-08-31 | Not yet recruiting | ||
| Rett Syndrome, MECP2 Duplication, and Rett-Related Disorders Consortium, Rare Disease Clinical Research Network: Neurophysiologic Correlates[NCT03077308] | 185 participants (Actual) | Observational | 2017-01-02 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for 4-aminopyridine and Seizures
| Article | Year |
|---|---|
Clinical overview of the seizure risk of dalfampridine.
Topics: 4-Aminopyridine; Electroencephalography; Humans; Multiple Sclerosis; Patient Selection; Potassium Ch | 2012 |
Clinical overview of dalfampridine: an agent with a novel mechanism of action to help with gait disturbances.
Topics: 4-Aminopyridine; Animals; Drug Costs; Drug Interactions; Gait; Gait Disorders, Neurologic; Humans; M | 2012 |
Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Electric Stimulation; Electrophysiology; Entorhinal Cor | 2002 |
Do interictal discharges promote or control seizures? Experimental evidence from an in vitro model of epileptiform discharge.
Topics: 4-Aminopyridine; Animals; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Electroenceph | 2001 |
179 other studies available for 4-aminopyridine and Seizures
| Article | Year |
|---|---|
Cell-specific switch for epileptiform activity: critical role of interneurons in the mouse subicular network.
Topics: 4-Aminopyridine; Animals; Epilepsy; Hippocampus; Interneurons; Limbic System; Mice; Parvalbumins; Se | 2023 |
Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal Cortex
Topics: 4-Aminopyridine; Action Potentials; Animals; Entorhinal Cortex; Epilepsy, Temporal Lobe; Interneuron | 2023 |
Amperometric bio-sensing of lactate and oxygen concurrently with local field potentials during status epilepticus.
Topics: 4-Aminopyridine; Animals; Biosensing Techniques; Brain; Epilepsy; Humans; Lactic Acid; Oxygen; Rats; | 2024 |
Burst suppression uncovers rapid widespread alterations in network excitability caused by an acute seizure focus.
Topics: 4-Aminopyridine; Animals; Brain; Disease Models, Animal; Electroencephalography; Isoflurane; Male; N | 2019 |
Differential expression of the c-fos protein and synaptophysin in zebrin II positive and zebrin II negative cerebellar cortical areas in 4-aminopyridine seizures.
Topics: 4-Aminopyridine; Animals; Axons; Cerebellar Cortex; Cerebellum; Immunohistochemistry; Male; Nerve Ti | 2019 |
Layer- and Cell-Specific Recruitment Dynamics during Epileptic Seizures In Vivo.
Topics: 4-Aminopyridine; Action Potentials; Algorithms; Animals; Female; Interneurons; Machine Learning; Mal | 2020 |
The effect of fampridine on the risk of seizure in patients with multiple sclerosis.
Topics: 4-Aminopyridine; Cohort Studies; Humans; Multiple Sclerosis; Potassium Channel Blockers; Seizures | 2020 |
Chronic intermittent hypoxia transiently increases hippocampal network activity in the gamma frequency band and 4-Aminopyridine-induced hyperexcitability in vitro.
Topics: 4-Aminopyridine; Animals; Chronic Disease; Gamma Rhythm; Hippocampus; Hypoxia, Brain; Male; Nerve Ne | 2020 |
Spreading depression as an innate antiseizure mechanism.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Stem; Cortical Spreading Depression; Depression; Female | 2021 |
Neural recruitment by ephaptic coupling in epilepsy.
Topics: 4-Aminopyridine; Animals; Cerebral Cortex; Computer Simulation; Convulsants; Electromagnetic Fields; | 2021 |
Pathology-selective antiepileptic effects in the focal freeze-lesion rat model of malformation of cortical development.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bumetanide; Cerebral Cortex; Cryosurgery; Male; Malformat | 2021 |
Rapid focal cooling attenuates cortical seizures in a primate epilepsy model.
Topics: 4-Aminopyridine; Animals; Cold Temperature; Convulsants; Electroencephalography; Epilepsy; Macaca fa | 2017 |
Insertable NO/CO Microsensors Recording Gaseous Vasomodulators Reflecting Differential Neuronal Activation Level with Respect to Seizure Focus.
Topics: 4-Aminopyridine; Animals; Biosensing Techniques; Brain; Brain Chemistry; Carbon Monoxide; Dendrites; | 2017 |
Mortality with brainstem seizures from focal 4-aminopyridine-induced recurrent hippocampal seizures.
Topics: 4-Aminopyridine; Animals; Brain Stem; Electroencephalography; Hippocampus; Male; Rats; Rats, Wistar; | 2017 |
Role of KCC2-dependent potassium efflux in 4-Aminopyridine-induced Epileptiform synchronization.
Topics: 4-Aminopyridine; Animals; Cortical Synchronization; Entorhinal Cortex; Epilepsy; Female; Interneuron | 2018 |
Non-competitive antagonists of NMDA and AMPA receptors decrease seizure-induced c-fos protein expression in the cerebellum and protect against seizure symptoms in adult rats.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Exci | 2018 |
Role of inhibitory control in modulating focal seizure spread.
Topics: 4-Aminopyridine; Animals; Calcium; Electric Stimulation; Electroencephalography; Epilepsy; Interneur | 2018 |
In Vivo Femtosecond Laser Subsurface Cortical Microtransections Attenuate Acute Rat Focal Seizures.
Topics: 4-Aminopyridine; Animals; Cerebral Cortex; Disease Models, Animal; Electrophysiological Phenomena; F | 2019 |
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Comb | 2018 |
Corpus callosum low-frequency stimulation suppresses seizures in an acute rat model of focal cortical seizures.
Topics: 4-Aminopyridine; Animals; Convulsants; Corpus Callosum; Electric Stimulation Therapy; Electrodes, Im | 2018 |
Age-Dependent Electrocorticogram Dynamics and Epileptogenic Responsiveness in Rats Subjected to Prenatal Hypoxia.
Topics: 4-Aminopyridine; Animals; Convulsants; Electrocorticography; Female; Fetal Hypoxia; Neurotransmitter | 2019 |
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice.
Topics: 4-Aminopyridine; Animals; Brain; Craniotomy; Disease Models, Animal; Electrophoresis; Epilepsy; gamm | 2019 |
Rosmarinic acid improves oxidative stress parameters and mitochondrial respiratory chain activity following 4-aminopyridine and picrotoxin-induced seizure in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Cinnamates; Depsides; Dis | 2019 |
Evaluating dalfampridine for the treatment of relapsing-remitting multiple sclerosis: does it add to the treatment armamentarium?
Topics: 4-Aminopyridine; Clinical Trials as Topic; Cognitive Dysfunction; Cost-Benefit Analysis; Databases, | 2019 |
KCC2 antagonism increases neuronal network excitability but disrupts ictogenesis in vitro.
Topics: 4-Aminopyridine; Animals; Electroencephalography; Electrophysiological Phenomena; Entorhinal Cortex; | 2019 |
Single amyloid-beta injection exacerbates 4-aminopyridine-induced seizures and changes synaptic coupling in the hippocampus.
Topics: 4-Aminopyridine; Amyloid beta-Peptides; Animals; Cisterna Magna; Excitatory Postsynaptic Potentials; | 2019 |
Seizure-like discharges induced by 4-aminopyridine in the olfactory system of the in vitro isolated guinea pig brain.
Topics: 4-Aminopyridine; Animals; Extracellular Space; Guinea Pigs; In Vitro Techniques; Limbic System; Memb | 2013 |
Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Epilepsy; Mice; Photoacoustic Techniques; Potassiu | 2013 |
On-off control of burst high frequency electrical stimulation to suppress 4-AP induced seizures.
Topics: 4-Aminopyridine; Action Potentials; Algorithms; Animals; Biological Clocks; Computer Simulation; Ele | 2013 |
Decreased A-currents in hippocampal dentate granule cells after seizure-inducing hypoxia in the immature rat.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Biophysics; Disease Models, Animal; E | 2013 |
Isovaline attenuates epileptiform activity and seizure behavior in 4-aminopyridine treated rats.
Topics: 4-Aminopyridine; Action Potentials; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Hip | 2014 |
Inhibition of different GABA transporter systems is required to attenuate epileptiform activity in the CA3 region of the immature rat hippocampus.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; CA3 Region, Hippocampal; GABA Antagon | 2014 |
Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Hydrogen Sulfide; Magnesium Def | 2014 |
Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures.
Topics: 4-Aminopyridine; Animals; Blood Volume; Cerebrovascular Circulation; Convulsants; Electroencephalogr | 2014 |
The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival.
Topics: 4-Aminopyridine; Animals; Astrocytes; Bicuculline; Cell Survival; Cells, Cultured; Disease Models, A | 2014 |
Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Blood-Brain Barrier; Drug Resistance; Hippocampus; Inject | 2014 |
An in vitro seizure model from human hippocampal slices using multi-electrode arrays.
Topics: 4-Aminopyridine; Action Potentials; Dose-Response Relationship, Drug; Electrodes; Hippocampus; Human | 2015 |
Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure.
Topics: 4-Aminopyridine; Aging; Animals; Behavior, Animal; CA1 Region, Hippocampal; Glutamic Acid; Hippocamp | 2014 |
Wide field fluorescent imaging of extracellular spatiotemporal potassium dynamics in vivo.
Topics: 4-Aminopyridine; Animals; Brain Chemistry; Cerebral Cortex; Cisterna Magna; Convulsants; Electric St | 2015 |
Suppression of acute seizures by theta burst electrical stimulation of the hippocampal commissure using a closed-loop system.
Topics: 4-Aminopyridine; Acute Disease; Animals; Disease Models, Animal; Electric Stimulation Therapy; Forni | 2014 |
Immunohistochemistry of cerebellar seizures: mossy fiber afferents play an important role in seizure spread and initiation in the rat.
Topics: 4-Aminopyridine; Animals; Cerebral Cortex; Gene Expression Regulation; Immunohistochemistry; Male; N | 2015 |
Interneuron activity leads to initiation of low-voltage fast-onset seizures.
Topics: 4-Aminopyridine; Animals; Electrophysiological Phenomena; Entorhinal Cortex; GABAergic Neurons; gamm | 2015 |
Repeated application of 4-aminopyridine provoke an increase in entorhinal cortex excitability and rearrange AMPA and kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Benzodiazepines; Entorhinal Cortex; Excitator | 2015 |
Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium; Cells, Cultured; High-Throughput Screening Assay | 2015 |
Distinct EEG seizure patterns reflect different seizure generation mechanisms.
Topics: 4-Aminopyridine; Animals; Brain; Brain Mapping; Disease Models, Animal; Electroencephalography; Male | 2015 |
Treatment with direct-current stimulation against cingulate seizure-like activity induced by 4-aminopyridine and bicuculline in an in vitro mouse model.
Topics: 4-Aminopyridine; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Gyrus Cinguli; | 2015 |
Synchronous inhibitory potentials precede seizure-like events in acute models of focal limbic seizures.
Topics: 4-Aminopyridine; Action Potentials; Animals; Bicuculline; Computer Simulation; Convulsants; Disease | 2015 |
Increase in the extracellular glutamate level during seizures and electrical stimulation determined using a high temporal resolution technique.
Topics: 4-Aminopyridine; Animals; Bicuculline; Calibration; Catheters, Indwelling; Convulsants; Dialysis; El | 2015 |
The Pro-inflammatory Cytokine Interleukin-1β is a Key Regulatory Factor for the Postictal Suppression in Mice.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Electroshock; Hippocampus; Humans; Interleukin 1 R | 2015 |
Rapid brief feedback intracerebral stimulation based on real-time desynchronization detection preceding seizures stops the generation of convulsive paroxysms.
Topics: 4-Aminopyridine; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electric Stimulation; Ele | 2015 |
Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus.
Topics: 4-Aminopyridine; Animals; Astrocytes; Connexins; Gene Expression Regulation; Hippocampus; Male; Neur | 2015 |
Measurement of Local Partial Pressure of Oxygen in the Brain Tissue under Normoxia and Epilepsy with Phosphorescence Lifetime Microscopy.
Topics: 4-Aminopyridine; Angiography; Animals; Brain; Epilepsy; Luminescent Measurements; Male; Mice, Inbred | 2015 |
Activation of specific neuronal networks leads to different seizure onset types.
Topics: 4-Aminopyridine; Animals; Cortical Synchronization; Entorhinal Cortex; Interneurons; Mice; Nerve Net | 2016 |
Hypersynchronous ictal onset in the perirhinal cortex results from dynamic weakening in inhibition.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cations, Monovale | 2016 |
Interneurons spark seizure-like activity in the entorhinal cortex.
Topics: 4-Aminopyridine; Action Potentials; Animals; Disease Models, Animal; Entorhinal Cortex; Excitatory A | 2016 |
A Massive Overdose of Dalfampridine.
Topics: 4-Aminopyridine; Adult; Anticonvulsants; Benzodiazepines; Drug Overdose; Humans; Male; Multiple Scle | 2015 |
Effect of the Anti-depressant Sertraline, the Novel Anti-seizure Drug Vinpocetine and Several Conventional Antiepileptic Drugs on the Epileptiform EEG Activity Induced by 4-Aminopyridine.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antidepressive Agents; Dose-Response Relationship, Drug; | 2016 |
Insertable Fast-Response Amperometric NO/CO Dual Microsensor: Study of Neurovascular Coupling During Acutely Induced Seizures of Rat Brain Cortex.
Topics: 4-Aminopyridine; Animals; Biosensing Techniques; Carbon Monoxide; Cerebral Cortex; Nitric Oxide; Rat | 2016 |
Neocortical slices from adult chronic epileptic rats exhibit discharges of higher voltages and broader spread.
Topics: 4-Aminopyridine; Animals; Chronic Disease; Disease Models, Animal; Electrocorticography; Epilepsy; I | 2016 |
High frequency oscillations can pinpoint seizures progressing to status epilepticus.
Topics: 4-Aminopyridine; Animals; Brain Waves; Disease Models, Animal; Disease Progression; Electroencephalo | 2016 |
Compromising KCC2 transporter activity enhances the development of continuous seizure activity.
Topics: 4-Aminopyridine; Action Potentials; Animals; Hippocampus; K Cl- Cotransporters; Male; Mice; Mice, In | 2016 |
Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery.
Topics: 4-Aminopyridine; Adult; Aged; Animals; Blood-Brain Barrier; Brain Neoplasms; Disease Models, Animal; | 2016 |
The antiepileptic and ictogenic effects of optogenetic neurostimulation of PV-expressing interneurons.
Topics: 4-Aminopyridine; Action Potentials; Animals; Disease Models, Animal; Electrocorticography; Epilepsy; | 2016 |
High-frequency oscillations and seizure-like discharges in the entorhinal cortex of the in vitro isolated guinea pig brain.
Topics: 4-Aminopyridine; Animals; Bicuculline; Convulsants; Entorhinal Cortex; Female; Guinea Pigs; In Vitro | 2017 |
Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats.
Topics: 4-Aminopyridine; Animal Nutritional Physiological Phenomena; Animals; Biomarkers; Blood Glucose; Die | 2017 |
Generalization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat.
Topics: 4-Aminopyridine; Animals; Behavior, Animal; Electroencephalography; Hippocampus; Male; Microinjectio | 2008 |
Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine.
Topics: 4-Aminopyridine; Acoustic Stimulation; Animals; Anticonvulsants; Auditory Threshold; Carbamazepine; | 2008 |
Anticonvulsant properties of saponins from Ficus platyphylla stem bark.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Cells, Cultured; Electroshock; Female; Ficus; Male | 2009 |
Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Action Potentials; Animals; Benzodiazepines; Biophysic | 2009 |
Diphenyl diselenide and diphenyl ditelluride increase the latency for 4-aminopyridine-induced chemical seizure and prevent death in mice.
Topics: 4-Aminopyridine; Animals; Benzene Derivatives; Dose-Response Relationship, Drug; Male; Mice; Organom | 2009 |
Spatiotemporal dynamics of perfusion and oximetry during ictal discharges in the rat neocortex.
Topics: 4-Aminopyridine; Algorithms; Animals; Cerebrovascular Circulation; Data Interpretation, Statistical; | 2009 |
Facilitation of glutamate release from rat cerebral cortex nerve terminal by subanesthetic concentration propofol.
Topics: 4-Aminopyridine; Anesthetics, Intravenous; Animals; Cerebral Cortex; Dose-Response Relationship, Dru | 2009 |
Optical suppression of experimental seizures in rat brain slices.
Topics: 4-Aminopyridine; Animals; Convulsants; Disease Models, Animal; Epilepsies, Partial; GABA Agents; gam | 2010 |
Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Brain; Carbamazepine; Convulsants; Dis | 2010 |
Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; F | 2010 |
Status epilepticus affects the gigantocellular network of the pontine reticular formation.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cell Shape; Electrodes, Implanted; Electroencephalograp | 2009 |
Independent epileptiform discharge patterns in the olfactory and limbic areas of the in vitro isolated Guinea pig brain during 4-aminopyridine treatment.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Brain; Cerebral Cortex; Entorhinal Cortex; Ep | 2010 |
An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
Topics: 4-Aminopyridine; Action Potentials; Adenosine Triphosphate; Animals; Astrocytes; Calcium; Chelating | 2010 |
Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Dose-Respons | 2010 |
Metabolic control of vesicular glutamate transport and release.
Topics: 4-Aminopyridine; Acetoacetates; Animals; Astrocytes; Behavior, Animal; Cells, Cultured; Chlorides; C | 2010 |
Age- and region-specific effects of anticonvulsants and bumetanide on 4-aminopyridine-induced seizure-like events in immature rat hippocampal-entorhinal cortex slices.
Topics: 4-Aminopyridine; Action Potentials; Age Factors; Animals; Animals, Newborn; Anticonvulsants; Bumetan | 2011 |
Isovaline, a rare amino acid, has anticonvulsant properties in two in vitro hippocampal seizure models by increasing interneuronal activity.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Convulsants; Dose-Response Relationshi | 2011 |
Preictal and ictal neurovascular and metabolic coupling surrounding a seizure focus.
Topics: 4-Aminopyridine; Animals; Blood Volume; Cerebral Cortex; Cerebrovascular Circulation; Disease Models | 2011 |
L-pGlu-(2-propyl)-L-His-L-ProNH₂ attenuates 4-aminopyridine-induced epileptiform activity and sodium current: a possible action of new thyrotropin-releasing hormone analog for its anticonvulsant potential.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Convulsants; Epilepsy; Ganglia, Spinal | 2011 |
Allopregnanolone potentiates the glutamate-mediated seizures induced by 4-aminopyridine in rat hippocampus in vivo.
Topics: 4-Aminopyridine; Animals; Drug Interactions; Electroencephalography; Glutamic Acid; Hippocampus; Mal | 2012 |
Spatiotemporal organization and thalamic modulation of seizures in the mouse medial thalamic-anterior cingulate slice.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Biol | 2011 |
Short- and long-term changes in extracellular glutamate and acetylcholine concentrations in the rat hippocampus following hypoxia.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Animals, Newborn; Brain Chemistry; Extracellular Space; Fem | 2012 |
Dynamic neurovascular coupling and uncoupling during ictal onset, propagation, and termination revealed by simultaneous in vivo optical imaging of neural activity and local blood volume.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cerebrovascular Circulation; Hemodynamics; Male; Models | 2013 |
High frequency stimulation can suppress globally seizures induced by 4-AP in the rat hippocampus: an acute in vivo study.
Topics: 4-Aminopyridine; Animals; Electric Stimulation; Hippocampus; Neurons; Rats; Rats, Sprague-Dawley; Se | 2013 |
Rapid compensatory changes in the expression of EAAT-3 and GAT-1 transporters during seizures in cells of the CA1 and dentate gyrus.
Topics: 4-Aminopyridine; Animals; Behavior, Animal; CA1 Region, Hippocampal; Catheters; Dentate Gyrus; Elect | 2012 |
The immunosuppressant cyclosporin A inhibits recurrent seizures in an experimental model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Animals; Cyclosporine; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus | 2012 |
Dalfampridine: is the seizure risk greater than previously thought?
Topics: 4-Aminopyridine; Donepezil; Follow-Up Studies; Humans; Indans; Middle Aged; Multiple Sclerosis; Pipe | 2013 |
The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Electroence | 2012 |
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events.
Topics: 4-Aminopyridine; Animals; Excitatory Postsynaptic Potentials; Hippocampus; Inhibitory Postsynaptic P | 2013 |
Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Waves; Disease Models, Animal; Excitatory Amino Acid Ag | 2013 |
Two different interictal spike patterns anticipate ictal activity in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Brain Waves; Entorhinal Cortex; Male; Rats; Rats, Sprag | 2013 |
Decreased neuronal synchronization during experimental seizures.
Topics: 4-Aminopyridine; Animals; Cortical Synchronization; Hippocampus; In Vitro Techniques; Membrane Poten | 2002 |
Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice.
Topics: 4-Aminopyridine; Animals; Bicuculline; Binding, Competitive; Brain; Convulsants; Dose-Response Relat | 2002 |
Far field effects of seizure like events induced by application of 4-AP in combined entorhinal cortex hippocampal slices.
Topics: 4-Aminopyridine; Entorhinal Cortex; Evoked Potentials; Hippocampus; Neural Pathways; Organ Culture T | 2002 |
Intracerebral temperature alterations associated with focal seizures.
Topics: 4-Aminopyridine; Animals; Blood Flow Velocity; Body Temperature; Brain; Disease Models, Animal; Elec | 2002 |
Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Synergism; | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Anima | 2003 |
Initiation of electrographic seizures by neuronal networks in entorhinal and perirhinal cortices in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Entorhinal Cortex; Excitatory Amino Acid Antagonists; H | 2004 |
Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats.
Topics: 4-Aminopyridine; Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Electroencephalogr | 2004 |
Neocortical c-fos mRNA transcription in repeated, brief, acute seizures: is c-fos a coincidence detector?
Topics: 4-Aminopyridine; Animals; Cell Nucleus; Electrophysiology; Immunohistochemistry; Male; Neocortex; Pr | 2005 |
Anticonvulsant activity of androsterone and etiocholanolone.
Topics: 4-Aminopyridine; Androsterone; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; D | 2005 |
Lateral entorhinal cortex lesions rearrange afferents, glutamate receptors, increase seizure latency and suppress seizure-induced c-fos expression in the hippocampus of adult rat.
Topics: 4-Aminopyridine; Afferent Pathways; Animals; Brain Diseases; Disease Susceptibility; Electroencephal | 2005 |
Quinine, a blocker of neuronal cx36 channels, suppresses seizure activity in rat neocortex in vivo.
Topics: 4-Aminopyridine; Animals; Astrocytes; Carbenoxolone; Cerebral Cortex; Connexins; Dose-Response Relat | 2005 |
Effects in vitro and in vivo of a gap junction blocker on epileptiform activities in a genetic model of absence epilepsy.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbenoxolone; Cerebral Cortex; Disease Models, Animal; E | 2006 |
Intrinsic optical signal imaging of neocortical seizures: the 'epileptic dip'.
Topics: 4-Aminopyridine; Animals; Data Interpretation, Statistical; Electrophysiology; Epilepsies, Partial; | 2006 |
Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel.
Topics: 4-Aminopyridine; Animals; Blotting, Western; Calcium Channels; Calcium Channels, T-Type; Disease Mod | 2006 |
Expression of pannexin1 in the CNS of adult mouse: cellular localization and effect of 4-aminopyridine-induced seizures.
Topics: 4-Aminopyridine; Animals; Blotting, Western; Central Nervous System; Connexins; Eye Proteins; Gap Ju | 2006 |
Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy models.
Topics: 4-Aminopyridine; Animals; Bicuculline; Cerebrospinal Fluid; Cryotherapy; Disease Models, Animal; Ele | 2006 |
The functional significance of gap junction channels in the epileptogenicity and seizure susceptibility of juvenile rats.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Carbenoxolone; Connexins; Cortical Synchronization; Dise | 2006 |
Cyclothiazide prolongs low [Mg2+]-induced seizure-like events.
Topics: 4-Aminopyridine; Animals; Benzodiazepines; Benzothiadiazines; Diuretics; Excitatory Amino Acid Antag | 2006 |
Mechanisms of seizure propagation in a cortical model.
Topics: 4-Aminopyridine; Adult; Anticonvulsants; Benzodiazepines; Cerebral Cortex; Electroencephalography; E | 2007 |
Alterations of seizure-induced c-fos immunolabelling and gene expression in the rat cerebral cortex following dexamethasone treatment.
Topics: 4-Aminopyridine; Animals; Anti-Inflammatory Agents; Dexamethasone; Gene Expression Regulation; Hippo | 2006 |
Hippocampal seizures cause depolymerization of filamentous actin in neurons independent of acute morphological changes.
Topics: 4-Aminopyridine; Actin Cytoskeleton; Actin Depolymerizing Factors; Animals; Dendritic Spines; Diseas | 2007 |
Inwardly rectifying K(+) (Kir) channels antagonize ictal-like epileptiform activity in area CA1 of the rat hippocampus.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Barium; Cesium; Dizocilpine Maleate; | 2007 |
Simultaneous glutamate and EEG activity measurements during seizures in rat hippocampal region with the use of an electrochemical biosensor.
Topics: 4-Aminopyridine; Animals; Behavior, Animal; Biosensing Techniques; Disease Models, Animal; Electroch | 2008 |
Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Astrocytes; Behavior, Animal; Benzodiazepines; Brain | 2008 |
Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents.
Topics: 4-Aminopyridine; Administration, Intranasal; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2008 |
Anticonvulsant effects of leptin in epilepsy.
Topics: 4-Aminopyridine; Administration, Intranasal; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2008 |
Late expression of FosB transcription factor in 4-aminopyridine-induced seizures in the rat cerebral cortex.
Topics: 4-Aminopyridine; Animals; Cell Nucleus; Cerebral Cortex; Gene Expression Regulation; Hippocampus; Im | 2008 |
NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus.
Topics: 4-Aminopyridine; Animals; Blotting, Western; Chlorides; Electrophysiology; Extracellular Space; GABA | 2008 |
An analytical flow injection system to measure glutamate in microdialysis samples based on an enzymatic reaction and electrochemical detection.
Topics: 4-Aminopyridine; Animals; Chromatography, High Pressure Liquid; Electrochemistry; Electroencephalogr | 2008 |
Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Animals, Newborn; | 2008 |
Effect of different convulsant drugs on some seizure parameters in morphine-dependent mice.
Topics: 3-Mercaptopropionic Acid; 4-Aminopyridine; Aminopyridines; Animals; Bicuculline; Brain; Convulsants; | 1983 |
The effects of aminopyridines on the cortical evoked potentials.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Cats; Cerebral Cortex; Evoked Potentials, S | 1984 |
Evaluation of 4-aminopyridine and 3,4-diaminopyridine penetrability into cerebrospinal fluid in anesthetized rats.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Blood-Brain Barrier; Chromatography, High P | 1984 |
Effect of taurine on seizures induced by 4-aminopyridine.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Cerebral Cortex; Dose-Response Relationship, Drug | 1981 |
Laminar pattern of synaptic inhibition during convulsive activity induced by 4-aminopyridine in neocortical slices.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cerebral Cortex; Cortical Synchronization; Electric Sti | 1995 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Age | 1993 |
Identification of distinct components, with different time courses, of the changes in response to convulsive stimuli during ethanol withdrawal.
Topics: 4-Aminopyridine; Aminophylline; Animals; Ethanol; Kainic Acid; Male; Mice; Receptors, GABA-A; Recept | 1995 |
Pharmacological inhibition of brain carbonic anhydrase protects against 4-aminopyridine seizures.
Topics: 4-Aminopyridine; Acetazolamide; Animals; Brain; Brain Chemistry; Carbonic Anhydrase Inhibitors; Carb | 1994 |
Interictal discharges in the hippocampus of rats with long-term pilocarpine seizures.
Topics: 4-Aminopyridine; Animals; Chronic Disease; Electrophysiology; Evoked Potentials; Hippocampus; In Vit | 1994 |
[Intracerebral-ventricular injection of 4-aminopyridine induced convulsion in rabbits].
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Disease Models, Animal; Female; Haloperidol; Injections, | 1993 |
Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of anti-epileptic agents and calcium antagonists.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium Channel Blockers; Dizocilpine Maleate; Ion Channe | 1994 |
BRL 38227--a potassium channel opener, antagonizes digoxin-induced convulsions.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Brain; Cromakalim; Digoxin; Dose-Response Relationship, Drug; | 1993 |
Effect of the insect growth regulators, N-tert-butyl-N, N'-dibenzoylhydrazines, on neural activity of the American cockroach.
Topics: 4-Aminopyridine; Action Potentials; Animals; Axons; Cockroaches; Hydrazines; Insecta; Insecticides; | 1996 |
Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anticonvulsants; Convulsants; Dizocilpine Mal | 1996 |
Extracellular potassium elevations in the hippocampus of rats with long-term pilocarpine seizures.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Excitatory Amino | 1995 |
NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857.
Topics: 4-Aminopyridine; Alanine; Animals; Behavior, Animal; Cerebellum; Convulsants; Cyclic GMP; Drug Inter | 1997 |
Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats.
Topics: 4-Aminopyridine; Amygdala; Animals; Anticonvulsants; Brain; Convulsants; Kindling, Neurologic; Male; | 1996 |
NG-nitro-L-arginine sensitizes mice to 4-aminopyridine-induced seizures.
Topics: 4-Aminopyridine; Animals; Convulsants; Drug Synergism; Enzyme Inhibitors; Male; Mice; Nitric Oxide S | 1996 |
CA3-driven hippocampal-entorhinal loop controls rather than sustains in vitro limbic seizures.
Topics: 4-Aminopyridine; Action Potentials; Animals; Convulsants; Dentate Gyrus; Electric Stimulation; Entor | 1997 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mic | 1999 |
A relative energy failure is associated with low-Mg2+ but not with 4-aminopyridine induced seizure-like events in entorhinal cortex.
Topics: 4-Aminopyridine; Animals; Convulsants; Energy Metabolism; Entorhinal Cortex; In Vitro Techniques; Ma | 1999 |
Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Carbamates; Convulsants; Electrophysiology; | 1999 |
Induction of seizures by the potent K+ channel-blocking scorpion venom peptide toxins tityustoxin-K(alpha) and pandinustoxin-K(alpha).
Topics: 4-Aminopyridine; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Dizo | 1999 |
Relationships among seizures, extracellular amino acid changes, and neurodegeneration induced by 4-aminopyridine in rat hippocampus: a microdialysis and electroencephalographic study.
Topics: 4-Aminopyridine; Amino Acids; Animals; Dose-Response Relationship, Drug; Electroencephalography; Ext | 1999 |
GABA(B) receptor activation promotes seizure activity in the juvenile rat hippocampus.
Topics: 4-Aminopyridine; Age of Onset; Animals; Baclofen; Convulsants; GABA Agonists; GABA-B Receptor Agonis | 1999 |
Effect of a glutamate receptor antagonist (GYKI 52466) on 4-aminopyridine-induced seizure activity developed in rat cortical slices.
Topics: 4-Aminopyridine; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Electric Stimulatio | 1999 |
Epileptiform activity induced by 4-aminopyridine in entorhinal cortex hippocampal slices of rats with a genetically determined absence epilepsy (GAERS).
Topics: 4-Aminopyridine; Animals; Entorhinal Cortex; Epilepsy, Absence; Evoked Potentials; Hippocampus; In V | 1999 |
Cortical catecholamine changes and seizures induced by 4-aminopyridine in awake rats, studied with a dual microdialysis-electrical recording technique.
Topics: 4-Aminopyridine; Animals; Catecholamines; Cerebral Cortex; Dialysis; Electroencephalography; Male; M | 1999 |
CA3-released entorhinal seizures disclose dentate gyrus epileptogenicity and unmask a temporoammonic pathway.
Topics: 4-Aminopyridine; Animals; Dentate Gyrus; Electrophysiology; Entorhinal Cortex; Epilepsy; Evoked Pote | 2000 |
Hippocampus-entorhinal cortex loop and seizure generation in the young rodent limbic system.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Entorhinal Cortex; Excitatory Amino | 2000 |
Comparison of intrinsic optical signals associated with low Mg2+-and 4-aminopyridine-induced seizure-like events reveals characteristic features in adult rat limbic system.
Topics: 4-Aminopyridine; Adult; Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; L | 2000 |
Acute 4-aminopyridine seizures increase the regional cerebral blood flow in the thalamus and neocortex, but not in the entire allocortex of the mouse brain.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Autoradiography; Carbamazepine; Cerebrovascular Circulati | 2000 |
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
Topics: 4-Aminopyridine; Animals; Epilepsy; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonis | 2000 |
Dopamine D4 receptor-deficient mice display cortical hyperexcitability.
Topics: 4-Aminopyridine; Animals; Bicuculline; Cerebral Cortex; Convulsants; Dopamine; Dopamine D2 Receptor | 2001 |
Focal cooling rapidly terminates experimental neocortical seizures.
Topics: 4-Aminopyridine; Algorithms; Animals; Blood Pressure; Body Temperature; Brain Mapping; Cryotherapy; | 2001 |
Intrinsic optical signals and electrographic seizures in the rat limbic system.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Axotomy; Electric Stimulation; Electro | 2001 |
4-aminopyridine poisoning of crows in the Chicago area.
Topics: 4-Aminopyridine; Animals; Bird Diseases; Fatal Outcome; Female; Potassium Channel Blockers; Seizures | 2001 |
Nitric oxide and convulsions in 4-aminopyridine-treated mice.
Topics: 4-Aminopyridine; Animals; Arginine; Behavior, Animal; Enzyme Inhibitors; Injections, Intraperitoneal | 2002 |
Neocortical seizure termination by focal cooling: temperature dependence and automated seizure detection.
Topics: 4-Aminopyridine; Animals; Automation; Cold Temperature; Electroencephalography; Male; Neocortex; Pot | 2002 |
NMDA receptor antagonists protect against seizures and wet-dog shakes induced by 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Amino Acids; Animals; Behavior, Animal; Male; N-Methyl | 1992 |
Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Male; | 1992 |
Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Elapid Venoms; Electroe | 1991 |
Naltrexone potentiates 4-aminopyridine seizures in the rat.
Topics: 4-Aminopyridine; Animals; Convulsants; Dose-Response Relationship, Drug; Female; Naltrexone; Rats; R | 1990 |
Effects of potassium channel openers on pentylenetetrazole-induced seizures in mice.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Cromakalim; Drug Antagonism; Female; Guanidines; Mice; Pentyl | 1990 |
Seizures and wet-dog shakes induced by 4-aminopyridine, and their potentiation by nifedipine.
Topics: 4-Aminopyridine; Animals; Behavior, Animal; Drug Synergism; Electroencephalography; Hippocampus; Mal | 1990 |
Vasogenic brain edema in focal 4-aminopyridine seizures: the role of neuronal hyperactivity.
Topics: 4-Aminopyridine; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Convulsants; Hor | 1990 |
Effects of potassium channel blockers on baclofen-induced suppression of paroxysmal discharges in rat neo-cortical slices.
Topics: 4-Aminopyridine; Animals; Baclofen; Barium; Cerebral Cortex; Cesium; Magnesium; Potassium Channels; | 1990 |
Subtypes of K+ channels differentiated by the effect of K+ channel openers upon K+ channel blocker-induced seizures.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Elapid Venoms; Injections, Intraventricular; Male; Neuroto | 1989 |
Higher susceptibility of taurine-deficient rats to seizures induced by 4-aminopyridine.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Cerebral Cortex; Rats; Seizures; Taurine | 1987 |
Effects of 4-aminopyridine in experimental CNS demyelination.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Central Nervous System Diseases; Demyelinating Diseases; D | 1988 |
Neocortical cytopathology in focal aminopyridine seizures as related to the intracortical diffusion of [3H] 4-aminopyridine. Electrophysiologic and light-microscopic studies.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Autoradiography; Blood-Brain Barrier; Capillary Permeabili | 1985 |
Spontaneous epileptiform discharges in hippocampal slices induced by 4-aminopyridine.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Female; Hippocampus; In Vitro Techniques; Male; Membrane P | 1985 |