4-aminopyridine has been researched along with Pregnancy in 52 studies
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Exposure of vessels from NP animals to 4-aminopyridine, which inhibits the activity of K(v) channels, mimicked the effects of pregnancy by increasing pressure-induced depolarization, elevation of [Ca(2+)](i), and development of myogenic tone." | 3.74 | Decreased function of voltage-gated potassium channels contributes to augmented myogenic tone of uterine arteries in late pregnancy. ( Bonev, AD; Goecks, T; Gokina, NI; Osol, G; Telezhkin, V, 2008) |
| "Methyl palmitate is thought to cause relaxation in vascular smooth muscle by opening voltage-activated potassium channels." | 1.40 | The effects of methyl palmitate, a putative regulator from perivascular fat, on the contractility of pregnant human myometrium. ( Crankshaw, DJ; Morrison, JJ; Walsh, JM, 2014) |
| "A successful pregnancy is dependent on liberal placental perfusion via the maternal and fetal circulations." | 1.33 | Reactivity of human placental chorionic plate vessels from pregnancies complicated by intrauterine growth restriction (IUGR). ( Baker, PN; Fyfe, GK; Greenwood, SL; Wareing, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (5.77) | 18.7374 |
| 1990's | 11 (21.15) | 18.2507 |
| 2000's | 25 (48.08) | 29.6817 |
| 2010's | 12 (23.08) | 24.3611 |
| 2020's | 1 (1.92) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, J | 1 |
| Qi, L | 1 |
| He, Y | 1 |
| Li, N | 1 |
| Zhang, Z | 1 |
| Zhou, X | 1 |
| Su, H | 1 |
| Zheng, Q | 1 |
| Zhang, Y | 1 |
| Tao, J | 1 |
| Xu, Z | 1 |
| Kalinina, DS | 1 |
| Vasilev, DS | 1 |
| Volnova, AB | 1 |
| Nalivaeva, NN | 1 |
| Zhuravin, IA | 1 |
| Lv, Y | 1 |
| Tang, LL | 1 |
| Wei, JK | 1 |
| Xu, XF | 1 |
| Gu, W | 1 |
| Fu, LC | 1 |
| Zhang, LY | 1 |
| Du, LZ | 1 |
| Wang, J | 1 |
| Qian, W | 1 |
| Liu, J | 2 |
| Zhao, J | 1 |
| Yu, P | 1 |
| Jiang, L | 1 |
| Zhou, J | 1 |
| Gao, R | 1 |
| Xiao, H | 1 |
| Crankshaw, DJ | 1 |
| Walsh, JM | 1 |
| Morrison, JJ | 2 |
| Al-Jarallah, A | 1 |
| Oriowo, MA | 1 |
| Díaz, P | 1 |
| Sibley, CP | 2 |
| Greenwood, SL | 4 |
| Maillart, E | 1 |
| Gout, O | 1 |
| Lubetzki, C | 1 |
| Carpentier, B | 1 |
| Nizard, J | 1 |
| Williams, JL | 1 |
| Fyfe, GK | 3 |
| Baker, PN | 3 |
| Greenwood, IA | 1 |
| Yeung, SY | 1 |
| Tribe, RM | 1 |
| Ohya, S | 1 |
| Konduri, GG | 1 |
| Bakhutashvili, I | 1 |
| Eis, A | 1 |
| Gauthier, KM | 1 |
| Porto, NP | 1 |
| Jucá, DM | 1 |
| Lahlou, S | 1 |
| Coelho-de-Souza, AN | 1 |
| Duarte, GP | 1 |
| Magalhães, PJ | 1 |
| Chen, L | 1 |
| Xu, C | 1 |
| Keblesh, J | 1 |
| Zang, W | 1 |
| Xiong, H | 1 |
| Kaufman, AM | 1 |
| Milnerwood, AJ | 1 |
| Sepers, MD | 1 |
| Coquinco, A | 1 |
| She, K | 1 |
| Wang, L | 1 |
| Lee, H | 1 |
| Craig, AM | 1 |
| Cynader, M | 1 |
| Raymond, LA | 1 |
| López-Pérez, SJ | 1 |
| Morales-Villagrán, A | 1 |
| Ventura-Valenzuela, J | 1 |
| Medina-Ceja, L | 1 |
| Hu, XQ | 1 |
| Xiao, D | 1 |
| Zhu, R | 1 |
| Huang, X | 1 |
| Yang, S | 1 |
| Wilson, SM | 1 |
| Zhang, L | 1 |
| Smyth, MD | 1 |
| Barbaro, NM | 1 |
| Baraban, SC | 3 |
| Olschewski, A | 1 |
| Hong, Z | 1 |
| Linden, BC | 1 |
| Porter, VA | 1 |
| Weir, EK | 1 |
| Cornfield, DN | 1 |
| Hampl, V | 1 |
| Bíbová, J | 1 |
| Stranák, Z | 1 |
| Wu, X | 1 |
| Michelakis, ED | 2 |
| Hashimoto, K | 2 |
| Archer, SL | 2 |
| Marcotti, W | 1 |
| Johnson, SL | 1 |
| Holley, MC | 1 |
| Kros, CJ | 1 |
| Liu, B | 1 |
| Arulkumaran, S | 1 |
| Hill, SJ | 1 |
| Khan, RN | 2 |
| Lin, MT | 1 |
| Hessinger, DA | 1 |
| Pearce, WJ | 1 |
| Longo, LD | 1 |
| Milesi, V | 1 |
| Raingo, J | 1 |
| Rebolledo, A | 1 |
| Grassi de Gende, AO | 1 |
| Mhaouty-Kodja, S | 1 |
| Houdeau, E | 1 |
| Legrand, C | 1 |
| Thébaud, B | 1 |
| Wu, XC | 1 |
| Moudgil, R | 1 |
| Kuzyk, M | 1 |
| Dyck, JR | 1 |
| Harry, G | 1 |
| Haromy, A | 1 |
| Rebeyka, I | 1 |
| Bisseling, TM | 1 |
| Versteegen, MG | 1 |
| van der Wal, S | 1 |
| Copius Peereboom-Stegeman, JJ | 1 |
| Borggreven, JM | 1 |
| Steegers, EA | 1 |
| van der Laak, JA | 1 |
| Russel, FG | 1 |
| Smits, P | 1 |
| Pelufo-Pellicer, A | 1 |
| Monte-Boquet, E | 1 |
| Romá-Sánchez, E | 1 |
| Casanova-Sorní, C | 1 |
| Poveda-Andrés, JL | 1 |
| Wareing, M | 2 |
| Bai, X | 1 |
| Seghier, F | 1 |
| Turner, CM | 1 |
| Taggart, MJ | 1 |
| Smith, RC | 1 |
| McClure, MC | 1 |
| Smith, MA | 1 |
| Abel, PW | 1 |
| Bradley, ME | 1 |
| Telezhkin, V | 1 |
| Goecks, T | 1 |
| Bonev, AD | 1 |
| Osol, G | 1 |
| Gokina, NI | 1 |
| Ninomiya, JG | 1 |
| Suzuki, H | 1 |
| Yokel, RA | 1 |
| Allen, DD | 1 |
| Meyer, JJ | 1 |
| Liljelund, P | 1 |
| Ghosh, P | 1 |
| van den Pol, AN | 1 |
| Inoue, Y | 1 |
| Shimamura, K | 1 |
| Sperelakis, N | 1 |
| Mienville, JM | 1 |
| Barker, JL | 1 |
| Smith, SK | 1 |
| Ashford, ML | 1 |
| Wang, SY | 1 |
| Yoshino, M | 1 |
| Sui, JL | 1 |
| Wakui, M | 1 |
| Kao, PN | 1 |
| Kao, CY | 1 |
| Pacher, P | 1 |
| Ungvári, Z | 1 |
| Nánási, PP | 1 |
| Mucha, I | 1 |
| Kecskeméti, V | 1 |
| Losonczy, G | 1 |
| Knock, GA | 1 |
| Smirnov, SV | 1 |
| Aaronson, PI | 1 |
| Seifert, G | 1 |
| Kuprijanova, E | 1 |
| Zhou, M | 1 |
| Steinhäuser, C | 1 |
| Wenzel, HJ | 1 |
| Hochman, DW | 1 |
| Schwartzkroin, PA | 1 |
| Martin-Caraballo, M | 1 |
| Greer, JJ | 1 |
| Thompson, LP | 1 |
| Aguan, K | 1 |
| Pinkas, G | 1 |
| Weiner, CP | 1 |
| Gosche, JR | 1 |
| Castro, PA | 1 |
| Cooper, EC | 1 |
| Lowenstein, DH | 1 |
| Bychkov, R | 1 |
| Glowinski, J | 1 |
| Giaume, C | 1 |
| López, E | 1 |
| Oset-Gasque, MJ | 1 |
| Figueroa, S | 1 |
| Albarrán, JJ | 1 |
| González, MP | 1 |
| Rizzo, MA | 1 |
| Nonner, W | 1 |
| Zona, C | 1 |
| Tancredi, V | 1 |
| Palma, E | 1 |
| Pirrone, GC | 1 |
| Avoli, M | 1 |
| Wilde, DW | 1 |
| Marshall, JM | 1 |
| Mironneau, J | 1 |
| Savineau, JP | 1 |
| Mironneau, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253] | Phase 3 | 44 participants (Anticipated) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
52 other studies available for 4-aminopyridine and Pregnancy
| Article | Year |
|---|---|
In vitro fertilization with frozen embryo transfer increased histamine-mediated contractile sensitivity via PKCβ in human umbilical vein.
Topics: 4-Aminopyridine; Embryo Transfer; Female; Fertilization in Vitro; Histamine; Humans; Pregnancy; Umbi | 2023 |
Age-Dependent Electrocorticogram Dynamics and Epileptogenic Responsiveness in Rats Subjected to Prenatal Hypoxia.
Topics: 4-Aminopyridine; Animals; Convulsants; Electrocorticography; Female; Fetal Hypoxia; Neurotransmitter | 2019 |
Decreased Kv1.5 expression in intrauterine growth retardation rats with exaggerated pulmonary hypertension.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Barium Compounds; Cell Hypoxia; Cells, Cultured; Chlorides; | 2013 |
Effect of methamphetamine on the microglial damage: role of potassium channel Kv1.3.
Topics: 4-Aminopyridine; Amines; Animals; Central Nervous System Stimulants; Female; In Situ Nick-End Labeli | 2014 |
The effects of methyl palmitate, a putative regulator from perivascular fat, on the contractility of pregnant human myometrium.
Topics: 4-Aminopyridine; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Myometrium; | 2014 |
Loss of Anticontractile Effect of Perivascular Adipose Tissue on Pregnant Rats: A Potential Role of Tumor Necrosis Factor-α.
Topics: 4-Aminopyridine; Adipose Tissue; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Female; | 2016 |
Oxygen-Sensitive K+ Channels Modulate Human Chorionic Gonadotropin Secretion from Human Placental Trophoblast.
Topics: 4-Aminopyridine; Chorionic Gonadotropin; Chorionic Villi; Female; Humans; Hydrogen Peroxide; L-Lacta | 2016 |
Favorable outcome of a pregnancy after fampridine exposition during the first month.
Topics: 4-Aminopyridine; Adult; Female; Humans; Multiple Sclerosis, Relapsing-Remitting; Potassium Channel B | 2016 |
K+ channel inhibition modulates the biochemical and morphological differentiation of human placental cytotrophoblast cells in vitro.
Topics: 4-Aminopyridine; Arachidonic Acids; Barium Compounds; Calcium Channel Blockers; Cell Differentiation | 2008 |
Loss of functional K+ channels encoded by ether-à-go-go-related genes in mouse myometrium prior to labour onset.
Topics: 4-Aminopyridine; Animals; Chlorobenzenes; Cresols; Electric Stimulation; Electrophysiological Phenom | 2009 |
Impaired voltage gated potassium channel responses in a fetal lamb model of persistent pulmonary hypertension of the newborn.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; 4-Aminopyridine; Adenosine Triphosphate; Ani | 2009 |
Effects of K+channels inhibitors on the cholinergic relaxation of the isolated aorta of adult offspring rats exposed to maternal diabetes.
Topics: 4-Aminopyridine; Acetylcholine; Aging; Animals; Aorta; Blood Glucose; Body Weight; Diabetes Mellitus | 2010 |
HIV-1gp120 induces neuronal apoptosis through enhancement of 4-aminopyridine-senstive outward K+ currents.
Topics: 4-Aminopyridine; Animals; Apoptosis; Caspase 3; Cells, Cultured; Cerebral Cortex; Drug Synergism; En | 2011 |
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Bicuculline; Calcium Channel Blockers; Cells, Cultur | 2012 |
Short- and long-term changes in extracellular glutamate and acetylcholine concentrations in the rat hippocampus following hypoxia.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Animals, Newborn; Brain Chemistry; Extracellular Space; Fem | 2012 |
Chronic hypoxia suppresses pregnancy-induced upregulation of large-conductance Ca2+-activated K+ channel activity in uterine arteries.
Topics: 4-Aminopyridine; Acclimatization; Altitude; Animals; Blotting, Western; Cells, Cultured; Chronic Dis | 2012 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disea | 2002 |
Contribution of the K(Ca) channel to membrane potential and O2 sensitivity is decreased in an ovine PPHN model.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Disease Models, Animal; Female; Gestational Age; Hyperte | 2002 |
Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition.
Topics: 4-Aminopyridine; Arteries; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Humans; Hypercapnia | 2002 |
Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells.
Topics: 4-Aminopyridine; Algorithms; Animals; Animals, Newborn; Calcium Channels; Cochlea; Electrophysiology | 2003 |
Comparison of potassium currents in human decidua before and after the onset of labor.
Topics: 4-Aminopyridine; Adult; Cesarean Section; Decidua; Delivery, Obstetric; Female; Fluorescent Antibody | 2003 |
Developmental differences in Ca2+-activated K+ channel activity in ovine basilar artery.
Topics: 4-Aminopyridine; Age Factors; Animals; Basilar Artery; Calcium; Female; Fetus; Ion Channel Gating; M | 2003 |
Potassium channels in human umbilical artery cells.
Topics: 4-Aminopyridine; Calcium; Electric Conductivity; Female; Humans; Membrane Potentials; Muscle, Smooth | 2003 |
Regulation of myometrial phospholipase C system and uterine contraction by beta-adrenergic receptors in midpregnant rat.
Topics: 4-Aminopyridine; Adrenergic beta-Agonists; Animals; Cell Membrane; Colforsin; Female; In Vitro Techn | 2004 |
Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus.
Topics: 4-Aminopyridine; Adenoviridae; Animals; Animals, Newborn; Ductus Arteriosus; Ductus Arteriosus, Pate | 2004 |
Impaired KATP channel function in the fetoplacental circulation of patients with type 1 diabetes mellitus.
Topics: 4-Aminopyridine; Charybdotoxin; Diabetes Mellitus, Type 1; Endothelial Cells; Female; Glyburide; Hum | 2005 |
Fetal exposure to 3,4-diaminopyridine in a pregnant woman with congenital myasthenia syndrome.
Topics: 4-Aminopyridine; Adult; Amifampridine; Apgar Score; Drug Therapy, Combination; Female; Fetal Develop | 2006 |
Reactivity of human placental chorionic plate vessels from pregnancies complicated by intrauterine growth restriction (IUGR).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Adolescent; Adu | 2006 |
Expression and function of potassium channels in the human placental vasculature.
Topics: 4-Aminopyridine; Adolescent; Adult; Female; Humans; Placenta; Potassium Channel Blockers; Potassium | 2006 |
The role of voltage-gated potassium channels in the regulation of mouse uterine contractility.
Topics: 4-Aminopyridine; Animals; Dose-Response Relationship, Drug; Female; Large-Conductance Calcium-Activa | 2007 |
Decreased function of voltage-gated potassium channels contributes to augmented myogenic tone of uterine arteries in late pregnancy.
Topics: 4-Aminopyridine; Animals; Arteries; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cal | 2008 |
Electrical responses of smooth muscle cells of the mouse uterus to adenosine triphosphate.
Topics: 4-Aminopyridine; Action Potentials; Adenosine Triphosphate; Aminopyridines; Animals; Apamin; Dose-Re | 1983 |
Studies of aluminum neurobehavioral toxicity in the intact mammal.
Topics: 4-Aminopyridine; Acetylcholine; Aging; Aluminum; Alzheimer Disease; Animals; Blinking; Blood-Brain B | 1994 |
Expression of the neural axon adhesion molecule L1 in the developing and adult rat brain.
Topics: 4-Aminopyridine; Animals; Brain; Cell Adhesion Molecules, Neuronal; Cerebellum; Female; Gene Express | 1994 |
Forskolin inhibition of K+ current in pregnant rat uterine smooth muscle cells.
Topics: 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Dose-Response Relations | 1993 |
Potassium current expression during prenatal corticogenesis in the rat.
Topics: 4-Aminopyridine; Age Factors; Animals; Calcium; Cell Differentiation; Cerebral Cortex; Delayed Recti | 1997 |
Ca2+ dependence and pharmacology of large-conductance K+ channels in nonlabor and labor human uterine myocytes.
Topics: 4-Aminopyridine; Barium; Calcium; Cells, Cultured; Charybdotoxin; Female; Humans; Ion Channel Gating | 1997 |
Potassium currents in freshly dissociated uterine myocytes from nonpregnant and late-pregnant rats.
Topics: 4-Aminopyridine; Animals; Apamin; Calcium; Charybdotoxin; Elapid Venoms; Female; In Vitro Techniques | 1998 |
Post-partum prolongation of the atrial repolarization in rabbit.
Topics: 4-Aminopyridine; Action Potentials; Animals; Atrial Function; Electrophysiology; Estrogens; Female; | 1999 |
Voltage-gated K+ currents in freshly isolated myocytes of the pregnant human myometrium.
Topics: 4-Aminopyridine; Adult; Anti-Arrhythmia Agents; Electric Stimulation; Electrophysiology; Female; Hum | 1999 |
Developmental changes in the expression of Shaker- and Shab-related K(+) channels in neurons of the rat trigeminal ganglion.
Topics: 4-Aminopyridine; Animals; Cadmium Chloride; Delayed Rectifier Potassium Channels; Elapid Venoms; Emb | 1999 |
Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Diseases; Choristoma; Convulsants; Electrophysiology; E | 2000 |
Development of potassium conductances in perinatal rat phrenic motoneurons.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Electrophysiology; Female; In Vitro Techniques; Membrane | 2000 |
Chronic hypoxia increases the NO contribution of acetylcholine vasodilation of the fetal guinea pig heart.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Coronary Vessels; Female; Fetal Hypoxia; Gene Expression Re | 2000 |
Oxygen dilation in fetal pulmonary arterioles: role of K(+) channels.
Topics: 4-Aminopyridine; Animals; Arterioles; Charybdotoxin; Female; Fetus; Glyburide; Hypoglycemic Agents; | 2001 |
Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cerebral Cortex; Choristoma; Delayed Rectifier Potassiu | 2001 |
Sequential and opposite regulation of two outward K(+) currents by ET-1 in cultured striatal astrocytes.
Topics: 4-Aminopyridine; Animals; Astrocytes; Calcium; Cells, Cultured; Corpus Striatum; Endothelin-1; Femal | 2001 |
Calcium channel types involved in intrinsic amino acid neurotransmitters release evoked by depolarizing agents in cortical neurons.
Topics: 4-Aminopyridine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Cyto | 2001 |
Transient K current in the somatic membrane of cultured central neurons of embryonic rat.
Topics: 4-Aminopyridine; Animals; Cadmium; Cell Membrane; Cells, Cultured; Cloning, Molecular; Electrophysio | 1992 |
Potassium currents in rat cortical neurons in culture are enhanced by the antiepileptic drug carbamazepine.
Topics: 4-Aminopyridine; Animals; Cadmium; Calcium; Carbamazepine; Cells, Cultured; Cerebral Cortex; Ethanol | 1990 |
Effects of tetraethylammonium and 4-aminopyridine on the plateau potential of circular myometrium from the pregnant rat.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Electrophysiology; Female; Gallopamil; | 1988 |
Effect of indapamide on the electromechanical properties of rat myometrium and rat portal vein.
Topics: 4-Aminopyridine; Acetylcholine; Action Potentials; Aminopyridines; Animals; Diuretics; Dose-Response | 1986 |