4-aminopyridine has been researched along with Paraplegia in 4 studies
Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A Phase I trial of 4-aminopyridine (4-AP) was carried out in 39 dogs referred to the veterinary teaching hospital with naturally occurring traumatic paraplegia or paraparesis." | 5.07 | The effects of 4-aminopyridine on neurological deficits in chronic cases of traumatic spinal cord injury in dogs: a phase I clinical trial. ( Bauer, MS; Blight, AR; Toombs, JP; Widmer, WR, 1991) |
| " A statistically significant difference in the initial rate and extent of absorption, but not in total 4-AP bioavailability over the 12-hour study period, was evident between tetraplegic patients, 0." | 2.69 | Absorption characteristics of sustained-release 4-aminopyridine (fampridine SR) in patients with chronic spinal cord injury. ( Brunnemann, SR; Hayes, KC; Hsieh, JT; Mason, D; Pathak, MS; Potter, PJ; Segal, JL; Tierney, DS, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Isoda, WC | 1 |
| Segal, JL | 3 |
| Brunnemann, SR | 2 |
| Hayes, KC | 1 |
| Hsieh, JT | 1 |
| Potter, PJ | 1 |
| Pathak, MS | 1 |
| Tierney, DS | 1 |
| Mason, D | 1 |
| Blight, AR | 1 |
| Toombs, JP | 1 |
| Bauer, MS | 1 |
| Widmer, WR | 1 |
4 trials available for 4-aminopyridine and Paraplegia
| Article | Year |
|---|---|
Effects of 4-aminopyridine on cardiac repolarization, PR interval, and heart rate in patients with spinal cord injury.
Topics: 4-Aminopyridine; Adult; Double-Blind Method; Electrocardiography; Female; Heart Conduction System; H | 2003 |
4-Aminopyridine alters gait characteristics and enhances locomotion in spinal cord injured humans.
Topics: 4-Aminopyridine; Administration, Oral; Adult; Gait; Humans; Locomotion; Male; Paraplegia; Quadripleg | 1998 |
Absorption characteristics of sustained-release 4-aminopyridine (fampridine SR) in patients with chronic spinal cord injury.
Topics: 4-Aminopyridine; Absorption; Adult; Area Under Curve; Biological Availability; Chronic Disease; Cros | 2000 |
The effects of 4-aminopyridine on neurological deficits in chronic cases of traumatic spinal cord injury in dogs: a phase I clinical trial.
Topics: 4-Aminopyridine; Animals; Dog Diseases; Dogs; Drug Evaluation; Muscles; Pain; Paraplegia; Propriocep | 1991 |