4-aminopyridine has been researched along with Paralysis in 12 studies
Paralysis: A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)
| Excerpt | Relevance | Reference |
|---|---|---|
| "4-Aminopyridine and guanidine were administered intraperitoneally to mice during the complete flaccid paralysis induced by treatment with ruthenium red (RuR)." | 7.66 | Antagonism of the ruthenium red-induced paralysis in mice by 4-aminopyridine, guanidine and lanthanum. ( Tapia, R, 1982) |
| " Utilizing drugs with known neuromuscular actions to provoke hyperactivity (4-aminopyridine, AP) and either rigid (decamethonium bromide, DMB) or flaccid (pancuronium bromide, PB) paralysis, we have examined the role of movement in joint, osteochondral and muscle development." | 4.83 | Early effects of embryonic movement: 'a shot out of the dark'. ( Pitsillides, AA, 2006) |
| "In the isolated phrenic nerve-hemidiaphragm preparation from the rat, thallium acetate induced a dose-dependent irreversible paralysis." | 3.67 | The action of thallium acetate on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation. ( Csicsaky, M; Krämer, U; Wiegand, H, 1984) |
| "4-Aminopyridine and 3,4-diaminopyridine were evaluated for their abilities to delay the onset of paralysis due to botulinum neurotoxin types A, B, and E." | 3.67 | A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism. ( Simpson, LL, 1986) |
| "4-Aminopyridine and guanidine were administered intraperitoneally to mice during the complete flaccid paralysis induced by treatment with ruthenium red (RuR)." | 3.66 | Antagonism of the ruthenium red-induced paralysis in mice by 4-aminopyridine, guanidine and lanthanum. ( Tapia, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lima, SC | 1 |
| Porta, LC | 1 |
| Lima, ÁDC | 1 |
| Campeiro, JD | 1 |
| Meurer, Y | 1 |
| Teixeira, NB | 1 |
| Duarte, T | 1 |
| Oliveira, EB | 1 |
| Picolo, G | 1 |
| Godinho, RO | 1 |
| Silva, RH | 1 |
| Hayashi, MAF | 1 |
| Lim, JH | 1 |
| Muguet-Chanoit, AC | 1 |
| Smith, DT | 1 |
| Laber, E | 1 |
| Olby, NJ | 1 |
| Adler, M | 3 |
| Deshpande, SS | 2 |
| Apland, JP | 1 |
| Murray, B | 1 |
| Borrell, A | 1 |
| Pitsillides, AA | 1 |
| Morbiato, L | 1 |
| Carli, L | 1 |
| Johnson, EA | 1 |
| Montecucco, C | 1 |
| Molgó, J | 1 |
| Rossetto, O | 1 |
| Tapia, R | 1 |
| Wiegand, H | 1 |
| Csicsaky, M | 1 |
| Krämer, U | 1 |
| Blair, KL | 1 |
| Bennett, JL | 1 |
| Pax, RA | 1 |
| Macdonald, DA | 1 |
| Sellin, LC | 1 |
| Parker, GW | 1 |
| Capacio, B | 1 |
| Harris, JB | 1 |
| Pollard, SL | 1 |
| Simpson, LL | 1 |
1 review available for 4-aminopyridine and Paralysis
| Article | Year |
|---|---|
Early effects of embryonic movement: 'a shot out of the dark'.
Topics: 4-Aminopyridine; Animals; Bone Development; Cartilage, Articular; Chick Embryo; Congenital Abnormali | 2006 |
1 trial available for 4-aminopyridine and Paralysis
| Article | Year |
|---|---|
Potassium channel antagonists 4-aminopyridine and the T-butyl carbamate derivative of 4-aminopyridine improve hind limb function in chronically non-ambulatory dogs; a blinded, placebo-controlled trial.
Topics: 4-Aminopyridine; Animals; Demyelinating Diseases; Dogs; Double-Blind Method; Female; Gait; Hindlimb; | 2014 |
10 other studies available for 4-aminopyridine and Paralysis
| Article | Year |
|---|---|
Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles.
Topics: 4-Aminopyridine; Animals; Crotalid Venoms; Dose-Response Relationship, Drug; Hindlimb; Male; Mice; M | 2018 |
Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins, Type A; Diaphragm; Male; Mice; Paralysis; | 2012 |
Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins; Botulinum Toxins, Type A; Drug Resistance | 2007 |
Antagonism of the ruthenium red-induced paralysis in mice by 4-aminopyridine, guanidine and lanthanum.
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Guanidine; Guanidines; Lanthanum; Mice; Mus | 1982 |
The action of thallium acetate on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Diaphragm; Female; Guanidine; Guanidines; Kinetic | 1984 |
Serotonin and acetylcholine: further analysis of praziquantel-induced contraction of magnesium-paralysed Schistosoma mansoni.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Amifampridine; Animals; Arecoline; Carbachol; Colforsi | 1993 |
Effect of 3,4-diaminopyridine on rat extensor digitorum longus muscle paralyzed by local injection of botulinum neurotoxin.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins; Drug Interactions; Male; Muscle, Skeletal | 1996 |
Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins, Type A; Drug Delivery Systems; Hindlimb; | 2000 |
Reversal of paralysis in nerve-muscle preparations isolated from animals with hereditary motor endplate disease.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Mice; Motor Endplate; Neuromuscular Diseases; Neuromuscula | 1985 |
A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Botulinum Toxins; Botulism; Dose-Response R | 1986 |