4-aminopyridine has been researched along with Palsy in 12 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "4-Aminopyridine and guanidine were administered intraperitoneally to mice during the complete flaccid paralysis induced by treatment with ruthenium red (RuR)." | 7.66 | Antagonism of the ruthenium red-induced paralysis in mice by 4-aminopyridine, guanidine and lanthanum. ( Tapia, R, 1982) |
| " Utilizing drugs with known neuromuscular actions to provoke hyperactivity (4-aminopyridine, AP) and either rigid (decamethonium bromide, DMB) or flaccid (pancuronium bromide, PB) paralysis, we have examined the role of movement in joint, osteochondral and muscle development." | 4.83 | Early effects of embryonic movement: 'a shot out of the dark'. ( Pitsillides, AA, 2006) |
| "In the isolated phrenic nerve-hemidiaphragm preparation from the rat, thallium acetate induced a dose-dependent irreversible paralysis." | 3.67 | The action of thallium acetate on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation. ( Csicsaky, M; Krämer, U; Wiegand, H, 1984) |
| "4-Aminopyridine and 3,4-diaminopyridine were evaluated for their abilities to delay the onset of paralysis due to botulinum neurotoxin types A, B, and E." | 3.67 | A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism. ( Simpson, LL, 1986) |
| "4-Aminopyridine and guanidine were administered intraperitoneally to mice during the complete flaccid paralysis induced by treatment with ruthenium red (RuR)." | 3.66 | Antagonism of the ruthenium red-induced paralysis in mice by 4-aminopyridine, guanidine and lanthanum. ( Tapia, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lima, SC | 1 |
| Porta, LC | 1 |
| Lima, ÁDC | 1 |
| Campeiro, JD | 1 |
| Meurer, Y | 1 |
| Teixeira, NB | 1 |
| Duarte, T | 1 |
| Oliveira, EB | 1 |
| Picolo, G | 1 |
| Godinho, RO | 1 |
| Silva, RH | 1 |
| Hayashi, MAF | 1 |
| Lim, JH | 1 |
| Muguet-Chanoit, AC | 1 |
| Smith, DT | 1 |
| Laber, E | 1 |
| Olby, NJ | 1 |
| Adler, M | 3 |
| Deshpande, SS | 2 |
| Apland, JP | 1 |
| Murray, B | 1 |
| Borrell, A | 1 |
| Pitsillides, AA | 1 |
| Morbiato, L | 1 |
| Carli, L | 1 |
| Johnson, EA | 1 |
| Montecucco, C | 1 |
| Molgó, J | 1 |
| Rossetto, O | 1 |
| Tapia, R | 1 |
| Wiegand, H | 1 |
| Csicsaky, M | 1 |
| Krämer, U | 1 |
| Blair, KL | 1 |
| Bennett, JL | 1 |
| Pax, RA | 1 |
| Macdonald, DA | 1 |
| Sellin, LC | 1 |
| Parker, GW | 1 |
| Capacio, B | 1 |
| Harris, JB | 1 |
| Pollard, SL | 1 |
| Simpson, LL | 1 |
1 review available for 4-aminopyridine and Palsy
| Article | Year |
|---|---|
Early effects of embryonic movement: 'a shot out of the dark'.
Topics: 4-Aminopyridine; Animals; Bone Development; Cartilage, Articular; Chick Embryo; Congenital Abnormali | 2006 |
1 trial available for 4-aminopyridine and Palsy
| Article | Year |
|---|---|
Potassium channel antagonists 4-aminopyridine and the T-butyl carbamate derivative of 4-aminopyridine improve hind limb function in chronically non-ambulatory dogs; a blinded, placebo-controlled trial.
Topics: 4-Aminopyridine; Animals; Demyelinating Diseases; Dogs; Double-Blind Method; Female; Gait; Hindlimb; | 2014 |
10 other studies available for 4-aminopyridine and Palsy
| Article | Year |
|---|---|
Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles.
Topics: 4-Aminopyridine; Animals; Crotalid Venoms; Dose-Response Relationship, Drug; Hindlimb; Male; Mice; M | 2018 |
Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins, Type A; Diaphragm; Male; Mice; Paralysis; | 2012 |
Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins; Botulinum Toxins, Type A; Drug Resistance | 2007 |
Antagonism of the ruthenium red-induced paralysis in mice by 4-aminopyridine, guanidine and lanthanum.
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Guanidine; Guanidines; Lanthanum; Mice; Mus | 1982 |
The action of thallium acetate on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Diaphragm; Female; Guanidine; Guanidines; Kinetic | 1984 |
Serotonin and acetylcholine: further analysis of praziquantel-induced contraction of magnesium-paralysed Schistosoma mansoni.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Amifampridine; Animals; Arecoline; Carbachol; Colforsi | 1993 |
Effect of 3,4-diaminopyridine on rat extensor digitorum longus muscle paralyzed by local injection of botulinum neurotoxin.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins; Drug Interactions; Male; Muscle, Skeletal | 1996 |
Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins, Type A; Drug Delivery Systems; Hindlimb; | 2000 |
Reversal of paralysis in nerve-muscle preparations isolated from animals with hereditary motor endplate disease.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Mice; Motor Endplate; Neuromuscular Diseases; Neuromuscula | 1985 |
A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Botulinum Toxins; Botulism; Dose-Response R | 1986 |