4-aminopyridine has been researched along with Neuroblastoma in 18 studies
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The steady-state effects and rate of action of 4-aminopyridine (4-AP) on normal and chloramine-T (CL-T)-modified voltage-dependent potassium (K) currents were studied in neuroblastoma cells with the whole-cell voltage-clamp current recording technique." | 7.68 | Interaction of 4-aminopyridine with normal and chloramine-T-modified K channels of neuroblastoma cells. ( Dubois, JM; Rouzaire-Dubois, B, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 15 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baskaran, P | 1 |
| Thyagarajan, B | 1 |
| Miyake, M | 1 |
| Kurihara, K | 1 |
| Toral, J | 1 |
| Hu, W | 1 |
| Yi, L | 1 |
| Barrett, JE | 1 |
| Sokol, PT | 1 |
| Ziai, MR | 1 |
| Basavappa, S | 1 |
| Romano-Silva, MA | 1 |
| Mangel, AW | 1 |
| Laro, D | 1 |
| Campbell, I | 1 |
| Brammer, M | 1 |
| García-Guzmán, M | 1 |
| Sala, F | 1 |
| Criado, M | 1 |
| Sala, S | 1 |
| Lee, YS | 1 |
| Sayeed, MM | 1 |
| Wurster, RD | 1 |
| Verheugen, JA | 1 |
| Oortgiesen, M | 1 |
| Vijverberg, HP | 1 |
| Hirsh, JK | 1 |
| Quandt, FN | 2 |
| Hu, Q | 2 |
| Shi, YL | 1 |
| Huang, F | 1 |
| Shi, Y | 1 |
| Rouzaire-Dubois, B | 3 |
| Dubois, JM | 3 |
| Zona, C | 1 |
| Ferri, A | 1 |
| Gabbianelli, R | 1 |
| Mercuri, NB | 1 |
| Bernardi, G | 1 |
| Rotilio, G | 1 |
| Carri, MT | 1 |
| Reeve, HL | 1 |
| Vaughan, PF | 1 |
| Peers, C | 1 |
| Smith-Maxwell, CJ | 1 |
| Eatock, RA | 1 |
| Begenisich, T | 1 |
| Robbins, J | 1 |
| Sim, JA | 1 |
18 other studies available for 4-aminopyridine and Neuroblastoma
| Article | Year |
|---|---|
Acute and chronic effects of botulinum neurotoxin a on the mammalian neuromuscular junction.
Topics: 4-Aminopyridine; Acetylcholine; Acetylcholinesterase; Amifampridine; Animals; Botulinum Toxins, Type | 2014 |
Resting potential of the mouse neuroblastoma cells. I. The presence of K+ channels activated at high K+ concentration but closed at low K+ concentration including the physiological concentration.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Cell Line; Electrophysiology; Ion Channels; Membrane Poten | 1983 |
Use of cultured human neuroblastoma cells in rapid discovery of the voltage-gated potassium-channel blockers.
Topics: 4-Aminopyridine; Barium; Charybdotoxin; Humans; Membrane Potentials; Neuroblastoma; Neurons; Potassi | 1994 |
Inhibition of K+ channel activity by 4-AP stimulates N-type Ca2+ channels in CHP-100 cells.
Topics: 4-Aminopyridine; Brain Neoplasms; Calcium; Calcium Channel Agonists; Calcium Channels; Cell Membrane | 1994 |
A delayed rectifier potassium channel cloned from bovine adrenal medulla. Functional analysis after expression in Xenopus oocytes and in a neuroblastoma cell line.
Topics: 4-Aminopyridine; Adrenal Medulla; Amino Acid Sequence; Animals; Base Sequence; Cattle; Cloning, Mole | 1994 |
Inhibition of cell growth by K+ channel modulators is due to interference with agonist-induced Ca2+ release.
Topics: 4-Aminopyridine; Astrocytoma; Brain Neoplasms; Calcium; Cell Division; Diazoxide; Humans; In Vitro T | 1993 |
Veratridine blocks voltage-gated potassium current in human T lymphocytes and in mouse neuroblastoma cells.
Topics: 4-Aminopyridine; Animals; Cadmium; Dose-Response Relationship, Drug; Drug Interactions; Electrophysi | 1994 |
Aminopyridine block of potassium channels in mouse neuroblastoma cells.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Binding Sites; Mice; Neuroblastoma; Potassium Channels; Tu | 1993 |
Characterization of an inward-rectifying potassium current in NG108-15 neuroblastoma x glioma cells.
Topics: 4-Aminopyridine; Barium; Bucladesine; Cadmium; Calcium; Cell Differentiation; Cesium; Cobalt; Cyclic | 1997 |
Inhibition of Toosendanin on the delayed rectifier potassium current in neuroblastoma x glioma NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
K+ channel block-induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation.
Topics: 4-Aminopyridine; Anti-Bacterial Agents; Cell Division; Cesium; Culture Media; Drug Combinations; Neu | 1998 |
Voltage-activated sodium currents in a cell line expressing a Cu,Zn superoxide dismutase typical of familial ALS.
Topics: 4-Aminopyridine; Amyotrophic Lateral Sclerosis; Cadmium; Calcium; Electric Stimulation; Humans; Ion | 1998 |
Glibenclamide inhibits a voltage-gated K+ current in the human neuroblastoma cell line SH-SY5Y.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Cadmium; Cell Line; Glyburide; Humans; Kinetics; Membrane P | 1992 |
Induction of K-channel expression in a neuroblastoma cell line.
Topics: 4-Aminopyridine; Animals; Cell Line; Dimethyl Sulfoxide; Gene Expression; Membranes; Mice; Nervous S | 1991 |
Interaction of 4-aminopyridine with normal and chloramine-T-modified K channels of neuroblastoma cells.
Topics: 4-Aminopyridine; Chloramines; Dose-Response Relationship, Drug; Electrophysiology; Neuroblastoma; Po | 1991 |
Modification of electrophysiological and pharmacological properties of K channels in neuroblastoma cells induced by the oxidant chloramine-T.
Topics: 4-Aminopyridine; Animals; Calcium Channels; Chloramines; Electrophysiology; Glioma; Hybrid Cells; Io | 1990 |
A transient outward current in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: 4-Aminopyridine; Action Potentials; Adrenergic Fibers; Animals; Barium; Calcium; Elapid Venoms; Glio | 1990 |
Three kinetically distinct potassium channels in mouse neuroblastoma cells.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Calcium; Ion Channels; Kinetics; Mice; | 1988 |