4-aminopyridine has been researched along with Nerve Degeneration in 10 studies
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 7.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| "These results suggest that seizure activity induced by 4-aminopyridine is due to a combined action of excitatory amino acid release and direct stimulation of neuronal firing, whereas neuronal death is related to the increased glutamate release but is independent of seizure activity." | 5.30 | Relationships among seizures, extracellular amino acid changes, and neurodegeneration induced by 4-aminopyridine in rat hippocampus: a microdialysis and electroencephalographic study. ( Peña, F; Tapia, R, 1999) |
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 3.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| "These results suggest that seizure activity induced by 4-aminopyridine is due to a combined action of excitatory amino acid release and direct stimulation of neuronal firing, whereas neuronal death is related to the increased glutamate release but is independent of seizure activity." | 1.30 | Relationships among seizures, extracellular amino acid changes, and neurodegeneration induced by 4-aminopyridine in rat hippocampus: a microdialysis and electroencephalographic study. ( Peña, F; Tapia, R, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Honsa, P | 1 |
| Pivonkova, H | 1 |
| Anderova, M | 1 |
| Ayala, GX | 2 |
| Tapia, R | 5 |
| Ricciardi, TN | 1 |
| Malouf, AT | 1 |
| Zona, C | 1 |
| Ferri, A | 1 |
| Gabbianelli, R | 1 |
| Mercuri, NB | 1 |
| Bernardi, G | 1 |
| Rotilio, G | 1 |
| Carri, MT | 1 |
| Peña, F | 2 |
| Shi, R | 1 |
| Pryor, JD | 1 |
| Chiu, SY | 1 |
| Wilson, GF | 1 |
1 review available for 4-aminopyridine and Nerve Degeneration
| Article | Year |
|---|---|
Release and uptake of glutamate as related to excitotoxicity.
Topics: 4-Aminopyridine; Cell Culture Techniques; Glutamic Acid; N-Methylaspartate; Nerve Degeneration | 1996 |
9 other studies available for 4-aminopyridine and Nerve Degeneration
| Article | Year |
|---|---|
Focal cerebral ischemia induces the neurogenic potential of mouse Dach1-expressing cells in the dorsal part of the lateral ventricles.
Topics: 4-Aminopyridine; Adult Stem Cells; Animals; Cell Count; Cell Differentiation; Disease Models, Animal | 2013 |
Expression of heat shock protein 70 induced by 4-aminopyridine through glutamate-mediated excitotoxic stress in rat hippocampus in vivo.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Cell Count; Chromatography, High Pressure Liquid; Dizocil | 2003 |
Late N-methyl-D-aspartate receptor blockade rescues hippocampal neurons from excitotoxic stress and death after 4-aminopyridine-induced epilepsy.
Topics: 4-Aminopyridine; Animals; Cell Count; Cell Death; Chelating Agents; Disease Models, Animal; Dizocilp | 2005 |
Differential effects of zinc on hyperpolarizing and depolarizing GABAA synaptic potentials in hippocampal slice cultures.
Topics: 4-Aminopyridine; Animals; Culture Techniques; Electrophysiology; Excitatory Amino Acid Antagonists; | 1995 |
Voltage-activated sodium currents in a cell line expressing a Cu,Zn superoxide dismutase typical of familial ALS.
Topics: 4-Aminopyridine; Amyotrophic Lateral Sclerosis; Cadmium; Calcium; Electric Stimulation; Humans; Ion | 1998 |
Relationships among seizures, extracellular amino acid changes, and neurodegeneration induced by 4-aminopyridine in rat hippocampus: a microdialysis and electroencephalographic study.
Topics: 4-Aminopyridine; Amino Acids; Animals; Dose-Response Relationship, Drug; Electroencephalography; Ext | 1999 |
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
Topics: 4-Aminopyridine; Animals; Epilepsy; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonis | 2000 |
Pathological changes of isolated spinal cord axons in response to mechanical stretch.
Topics: 4-Aminopyridine; Action Potentials; Animals; Axons; Cell Membrane; Cell Membrane Permeability; Disea | 2002 |
The role of potassium channels in Schwann cell proliferation in Wallerian degeneration of explant rabbit sciatic nerves.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Female; | 1989 |