4-aminopyridine has been researched along with Myocardial Ischemia in 12 studies
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to elucidate the contribution of adenosine A(2A) and A(2B) receptors to coronary reactive hyperemia and downstream K(+) channels involved." | 3.76 | Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels. ( Berwick, ZC; Dick, GM; Lynch, B; Payne, GA; Sturek, M; Tune, JD, 2010) |
| "Regional myocardial ischemia was produced in an isolated, arterially perfused canine right ventricular wedge preparation." | 1.32 | Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia. ( Guo, D; Hlaing, T; Joshi, A; Kowey, PR; Martin, J; Xu, X; Yan, GX, 2004) |
| "Reactive hyperemia was induced following 30 sec and 300 sec of no-flow ischemia of the heart." | 1.30 | Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts. ( Ito, T; Mokuno, S; Murase, K; Okumura, K; Shinoda, M; Toki, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berwick, ZC | 1 |
| Payne, GA | 1 |
| Lynch, B | 1 |
| Dick, GM | 1 |
| Sturek, M | 1 |
| Tune, JD | 1 |
| Yan, GX | 1 |
| Joshi, A | 1 |
| Guo, D | 1 |
| Hlaing, T | 1 |
| Martin, J | 1 |
| Xu, X | 1 |
| Kowey, PR | 1 |
| Bao, M | 1 |
| Zhang, J | 1 |
| Huang, C | 1 |
| Jiang, H | 1 |
| Liu, J | 1 |
| Zhao, D | 1 |
| Fiszer, M | 1 |
| Kołaciński, Z | 1 |
| Rechciński, T | 1 |
| Mubagwa, K | 1 |
| Flameng, W | 1 |
| Carmeliet, E | 1 |
| Lukas, A | 1 |
| Antzelevitch, C | 1 |
| Perchenet, L | 1 |
| Kreher, P | 1 |
| Shinoda, M | 1 |
| Toki, Y | 1 |
| Murase, K | 1 |
| Mokuno, S | 1 |
| Okumura, K | 1 |
| Ito, T | 1 |
| Shibasaki, K | 1 |
| Arai, Y | 1 |
| Uchida, W | 1 |
| Okazaki, T | 1 |
| Asano, M | 1 |
| Takenaka, T | 1 |
| Kocić, I | 1 |
| Dworakowska, D | 1 |
| Dworakowski, R | 1 |
| Baiardi, G | 1 |
| Carrión, A | 1 |
| Petrich, ER | 1 |
| Zumino, AP | 1 |
| Gwilt, M | 1 |
| Henderson, CG | 1 |
| Orme, J | 1 |
| Rourke, JD | 1 |
12 other studies available for 4-aminopyridine and Myocardial Ischemia
| Article | Year |
|---|---|
Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.
Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Anima | 2010 |
Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia.
Topics: 4-Aminopyridine; Action Potentials; Acute Disease; Animals; Cardiac Complexes, Premature; Cardiac Pa | 2004 |
Abnormal intracellular calcium handling underlying T-wave alternans and its hysteresis.
Topics: 4-Aminopyridine; Animals; Arrhythmias, Cardiac; Calcium; Calcium Signaling; Electrocardiography; End | 2007 |
[The application of 4-aminopyridine in calcium channel inhibitors acute poisoning].
Topics: 4-Aminopyridine; Acute Disease; Adrenergic beta-Antagonists; Adult; Antidotes; Antihypertensive Agen | 2007 |
Resting and action potentials of nonischemic and chronically ischemic human ventricular muscle.
Topics: 4-Aminopyridine; Action Potentials; Chronic Disease; Diacetyl; Epinephrine; Heart; Humans; In Vitro | 1994 |
Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia. Role of the transient outward current.
Topics: 4-Aminopyridine; Action Potentials; Adenosine Triphosphate; Animals; Dogs; Electric Stimulation; Ele | 1993 |
Mechanical and electrophysiological effects of preconditioning in isolated ischemic/reperfused rat hearts.
Topics: 4-Aminopyridine; Action Potentials; Animals; Female; Heart; Myocardial Contraction; Myocardial Ische | 1995 |
Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts.
Topics: 4-Aminopyridine; Adenosine Diphosphate; Animals; Apamin; Charybdotoxin; Glyburide; Hyperemia; In Vit | 1997 |
Antianginal effects of YM430, a novel calcium entry-blocking and beta-adrenoceptor-blocking agent in several experimental angina models.
Topics: 4-Aminopyridine; Adrenergic beta-Antagonists; Amifampridine; Angina Pectoris; Animals; Calcium Chann | 1997 |
4-Aminopyridine induces positive lusitropic effects and prevents the negative inotropic action of phenylephrine in the rat cardiac tissue subjected to ischaemia.
Topics: 4-Aminopyridine; Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Female; In Vitro Tec | 1999 |
4-Aminopyridine: effects on electrical activity during ischemia and reperfusion in perfused rat hearts.
Topics: 4-Aminopyridine; Action Potentials; Animals; Chemotherapy, Cancer, Regional Perfusion; Electric Stim | 2002 |
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease | 1992 |