4-aminopyridine has been researched along with Muscular Atrophy, Spinal in 4 studies
Muscular Atrophy, Spinal: A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hereditary Canine Spinal Muscular Atrophy (HCSMA) is an autosomal dominant disorder of motor neurons that shares features with human motor neuron disease." | 1.30 | Effects of 4-aminopyridine on muscle and motor unit force in canine motor neuron disease. ( Cope, TC; Cork, LC; Pinter, MJ; Waldeck, RF, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chiriboga, CA | 1 |
| Marra, J | 1 |
| LaMarca, NM | 1 |
| Young, SD | 1 |
| Weimer, LH | 1 |
| Levin, B | 1 |
| McCabe, B | 1 |
| Simon, CM | 1 |
| Blanco-Redondo, B | 1 |
| Buettner, JM | 1 |
| Pagiazitis, JG | 1 |
| Fletcher, EV | 1 |
| Sime Longang, JK | 1 |
| Mentis, GZ | 1 |
| Sleigh, JN | 1 |
| Buckingham, SD | 1 |
| Esmaeili, B | 1 |
| Viswanathan, M | 1 |
| Cuppen, E | 1 |
| Westlund, BM | 1 |
| Sattelle, DB | 1 |
| Pinter, MJ | 1 |
| Waldeck, RF | 1 |
| Cope, TC | 1 |
| Cork, LC | 1 |
1 trial available for 4-aminopyridine and Muscular Atrophy, Spinal
| Article | Year |
|---|---|
Lack of effect on ambulation of dalfampridine-ER (4-AP) treatment in adult SMA patients.
Topics: 4-Aminopyridine; Adult; Cross-Over Studies; Double-Blind Method; Fatigue; Female; Humans; Male; Midd | 2020 |
3 other studies available for 4-aminopyridine and Muscular Atrophy, Spinal
| Article | Year |
|---|---|
Chronic Pharmacological Increase of Neuronal Activity Improves Sensory-Motor Dysfunction in Spinal Muscular Atrophy Mice.
Topics: 4-Aminopyridine; Animals; Cell Death; Mice; Mice, Knockout; Motor Neurons; Movement Disorders; Muscu | 2021 |
A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds.
Topics: 4-Aminopyridine; Alleles; Amino Acid Sequence; Animals; Caenorhabditis elegans; Disease Models, Anim | 2011 |
Effects of 4-aminopyridine on muscle and motor unit force in canine motor neuron disease.
Topics: 4-Aminopyridine; Animals; Calcium; Disease Models, Animal; Dogs; Electromyography; Female; Homozygot | 1997 |