4-aminopyridine has been researched along with Muscle Spasticity in 7 studies
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The Ashworth scale of spasticity was significantly (p2 < 0." | 2.69 | Randomized double-blind crossover trial of fampridine-SR (sustained release 4-aminopyridine) in patients with incomplete spinal cord injury. ( Brunnemann, SR; Delaney, GA; Hayes, KC; Hsieh, JT; Mason, D; Potter, PJ; Segal, JL; Tierney, DS, 1998) |
| "Severity of spasticity and H-reflex threshold might allow prediction of response." | 1.51 | Predictors of Response to 4-Aminopyridine in Chronic Canine Spinal Cord Injury. ( Laber, E; Lewis, MJ; Olby, NJ, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Selcuk Muhtaroglu, F | 1 |
| Belgen Kaygisiz, B | 1 |
| Usar Incirli, S | 1 |
| Kahraman, T | 1 |
| Lewis, MJ | 1 |
| Laber, E | 1 |
| Olby, NJ | 1 |
| Wiener, J | 1 |
| Hsieh, J | 1 |
| McIntyre, A | 1 |
| Teasell, R | 1 |
| Cardenas, DD | 1 |
| Ditunno, JF | 1 |
| Graziani, V | 1 |
| McLain, AB | 1 |
| Lammertse, DP | 1 |
| Potter, PJ | 3 |
| Alexander, MS | 1 |
| Cohen, R | 1 |
| Blight, AR | 1 |
| Zafonte, R | 1 |
| Lombard, L | 1 |
| Elovic, E | 1 |
| Hayes, KC | 2 |
| Hsieh, JT | 2 |
| Delaney, GA | 2 |
| Segal, JL | 2 |
| Brunnemann, SR | 1 |
| Tierney, DS | 1 |
| Mason, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Quality of Life, Efficacy and Safety of High Doses of 4-aminopyridine in Patients With Clinically Complete Chronic Spinal Cord Injury: Multicenter, Randomized, Double Blind, Placebo Controlled Clinical Trial[NCT03899584] | Phase 3 | 150 participants (Actual) | Interventional | 2019-07-17 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 4-aminopyridine and Muscle Spasticity
| Article | Year |
|---|---|
Effectiveness of 4-Aminopyridine for the Management of Spasticity in Spinal Cord Injury: A Systematic Review.
Topics: 4-Aminopyridine; Humans; Muscle Relaxants, Central; Muscle Spasticity; Potassium Channel Blockers; S | 2018 |
Antispasticity medications: uses and limitations of enteral therapy.
Topics: 4-Aminopyridine; Acetates; Adrenergic alpha-Agonists; Amines; Baclofen; Benzodiazepines; Cyclohexane | 2004 |
3 trials available for 4-aminopyridine and Muscle Spasticity
| Article | Year |
|---|---|
Dalfampridine as a promising agent in the management of hereditary spastic paraplegia: A triple-blinded, randomized, placebo-controlled pilot trial.
Topics: 4-Aminopyridine; Humans; Muscle Spasticity; Pilot Projects; Spastic Paraplegia, Hereditary; Walking | 2023 |
Two phase 3, multicenter, randomized, placebo-controlled clinical trials of fampridine-SR for treatment of spasticity in chronic spinal cord injury.
Topics: 4-Aminopyridine; Adult; Canada; Double-Blind Method; Female; Humans; Male; Muscle Spasticity; Potass | 2014 |
Randomized double-blind crossover trial of fampridine-SR (sustained release 4-aminopyridine) in patients with incomplete spinal cord injury.
Topics: 4-Aminopyridine; Adult; Analysis of Variance; Chi-Square Distribution; Cross-Over Studies; Delayed-A | 1998 |
2 other studies available for 4-aminopyridine and Muscle Spasticity
| Article | Year |
|---|---|
Predictors of Response to 4-Aminopyridine in Chronic Canine Spinal Cord Injury.
Topics: 4-Aminopyridine; Animals; Dogs; Evoked Potentials, Motor; Female; H-Reflex; Male; Motor Neurons; Mus | 2019 |
Sustained improvements in neurological function in spinal cord injured patients treated with oral 4-aminopyridine: three cases.
Topics: 4-Aminopyridine; Administration, Oral; Adult; Evoked Potentials, Motor; Female; Humans; Male; Middle | 1998 |