4-aminopyridine has been researched along with Muscle Contraction in 157 studies
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the mechanisms of melatonin-induced inhibition of the ileal smooth muscle contraction." | 3.69 | Apamin blocks the direct relaxant effect of melatonin on rat ileal smooth muscle. ( García-Segoviano, JA; Naranjo-Rodríguez, EB; Prieto-Gómez, B; Reyes-Vázquez, C; Trujillo-Santana, JT, 1997) |
| "The antagonisms to the d-tubocurarine-induced neuromuscular blockade by neostigmine and 3,4-diaminopyridine (DAP) were studied quantitatively in the isolated phrenic nerve-diaphragm preparation of mice in vitro and in lethality of mice in vivo by assaying concentrations of d-tubocurarine needed to produce 70% block of indirect muscle contraction and LD50, respectively." | 3.67 | Potentiation between neostigmine and 3,4-diaminopyridine in antagonizing the neuromuscular block induced by D-tubocurarine. ( Chang, CC; Hong, SJ; Lin, HL; Shieh, BH; Su, MJ, 1984) |
| "In the isolated phrenic nerve-hemidiaphragm preparation from the rat, thallium acetate induced a dose-dependent irreversible paralysis." | 3.67 | The action of thallium acetate on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation. ( Csicsaky, M; Krämer, U; Wiegand, H, 1984) |
| " 3 Quinidine, which like 4AP and TEA produced some increase to twitch height, did not reduce responses to the various agonists, indicating that an increased muscle contraction was not itself responsible for the reduced responses." | 3.66 | The effects of 4-aminopyridine on the isolated vas deferens and its effects on the inhibitory properties of adenosine, morphine, noradrenaline and gamma-aminobutyric acid. ( Stone, TW, 1981) |
| "Ischemia-reperfusion injury is the major complication of abdominal aortic surgery, and it mainly affects the lower extremities and remote organs." | 1.46 | Electrophysiological alterations in diaphragm muscle caused by abdominal ischemia-reperfusion. ( Burat, I; Dalkilic, N; Tuncer, S, 2017) |
| "In nicardipine pretreated condition, the concentration-response curves for the negative inotropic effect of potassium channel blockers were shifted to the right by the increasing concentration of carbachol from 0." | 1.32 | Inhibitory effects of potassium channel blockers on carbachol-induced contraction in rat detrusor muscle. ( Ahn, SC; Oh, SJ, 2003) |
| "To examine the action(s) of 4-AP in demyelinating disorders, the drug was administered at clinical doses, both in vivo and in vitro, to rat dorsal column axons which had been experimentally demyelinated by the intraspinal injection of ethidium bromide." | 1.31 | Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension. ( Felts, PA; John, GR; Smith, KJ, 2000) |
| "The guanidine-induced NMB was reverted by increasing the Ca2+ concentration (1." | 1.30 | Novel effects of guanidine on the neuromuscular junction. ( Ballejo, G; Corrado, AP; Cruz-Höfling, MA; Heluany, NF; Leite, GB; Prado-Franceschi, J; Rodrigues-Simioni, L; Silva-Carvalho, I, 1997) |
| "Hereditary Canine Spinal Muscular Atrophy (HCSMA) is an autosomal dominant disorder of motor neurons that shares features with human motor neuron disease." | 1.30 | Effects of 4-aminopyridine on muscle and motor unit force in canine motor neuron disease. ( Cope, TC; Cork, LC; Pinter, MJ; Waldeck, RF, 1997) |
| " A bell-shaped dose-response relation was obtained for evoked [3H] overflow over the same concentration range, with maximum effects occurring at 10 microM for 4M2AP (163 +/- 31% increase) and 100 microM for 4AP (154 +/- 16% increase)." | 1.30 | Effects of 4-methyl-2-aminopyridine on [3H]-noradrenaline overflow and contractility of isolated rabbit arteries. ( Fryer, MW; Glover, WE, 1997) |
| " Since the GLU receptors present at NMJ have been reported to be predominantly N-methyl-D-aspartate (NMDA) subtype, some non-competitive and competitive NMDA receptor blockers, MK801, ketamine, dextromethorphan and CGP 37849, and GLU release inhibitors, clonidine, guanfacine, tizanidine were used at their optimum concentrations in medium after having found them from dose-response curves." | 1.30 | N-methyl-D-aspartate antagonists, glutamate release inhibitors, 4-aminopyridine at neuromuscular transmission. ( Günel, MA; Kara, I; Koyuncuoğlu, H; Nurten, A; Yamantürk, P, 1998) |
| "Adenosine has previously been shown to stimulate K(+)-efflux and to block L-type calcium channels in atrial myocytes." | 1.30 | Effects of K(+)-channel blockers on A1-adenosine receptor-mediated negative inotropy and chronotropy of guinea-pig isolated left and right atria. ( Broadley, KJ; Ford, WR, 1999) |
| "Nifedipine was also effective in these models, but propranolol was not." | 1.29 | Antianginal effects of YM-16151-4 in various experimental angina models. ( Asano, M; Shibasaki, K; Takenaka, T; Uchida, W, 1993) |
| " These results indicate that prolonged paralysis after long-term administration of high-dose pancuronium is caused primarily by failure of neuromuscular transmission, most likely caused by the persistent plasma concentrations of the drug in the pharmacologically active range." | 1.29 | Prolonged paralysis after long-term, high-dose infusion of pancuronium in anaesthetized cats. ( Agoston, S; den Hertog, A; Henning, RH; Houwertjes, MC; Scaf, AH, 1993) |
| "Droperidol caused no increase in twitch, but it depressed the twitch by 50% at concentrations of 9." | 1.27 | Myoneural effects of pethidine and droperidol. ( Boros, M; Chaudhry, IA; Duncalf, RM; Foldes, FF; Nagashima, H; Sherman, EH, 1984) |
| " Serum data best fit a three-compartment pharmacokinetic model." | 1.27 | Pharmacokinetics and pharmacodynamics of 4-aminopyridine in anesthetized dogs. ( Castagnoli, N; Fisher, DM; Miller, RD; Rupp, SM; Shinohara, Y, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (36.94) | 18.7374 |
| 1990's | 55 (35.03) | 18.2507 |
| 2000's | 29 (18.47) | 29.6817 |
| 2010's | 14 (8.92) | 24.3611 |
| 2020's | 1 (0.64) | 2.80 |
| Authors | Studies |
|---|---|
| Amberg, GC | 1 |
| Lee, JY | 1 |
| Koh, SD | 1 |
| Sanders, KM | 1 |
| Danylovych, IuV | 1 |
| Chunikhin, OIu | 1 |
| Danylovych, HV | 1 |
| Gal, V | 1 |
| Platiša, MM | 1 |
| Nestorović, Z | 1 |
| Labudović Borović, M | 1 |
| Vuksanović, V | 1 |
| Gojković Bukarica, L | 1 |
| Lv, Y | 1 |
| Tang, LL | 1 |
| Wei, JK | 1 |
| Xu, XF | 1 |
| Gu, W | 1 |
| Fu, LC | 1 |
| Zhang, LY | 1 |
| Du, LZ | 1 |
| Sung, DJ | 1 |
| Noh, HJ | 1 |
| Kim, JG | 1 |
| Park, SW | 1 |
| Kim, B | 1 |
| Cho, H | 1 |
| Bae, YM | 1 |
| Kun, A | 1 |
| Seprényi, G | 1 |
| Varró, A | 1 |
| Papp, JG | 1 |
| Pataricza, J | 1 |
| Hou, X | 1 |
| Liu, Y | 2 |
| Niu, L | 1 |
| Cui, L | 1 |
| Zhang, M | 1 |
| Vasconcelos, LH | 1 |
| Correia, AC | 1 |
| de Souza, IL | 1 |
| Silva, Mda C | 1 |
| Paredes-Gamero, EJ | 1 |
| Santos, BV | 1 |
| Cavalcante, Fde A | 1 |
| da Silva, BA | 1 |
| Jensen, HB | 1 |
| Nielsen, JL | 1 |
| Ravnborg, M | 1 |
| Dalgas, U | 1 |
| Aagaard, P | 1 |
| Stenager, E | 1 |
| Tuncer, S | 1 |
| Dalkilic, N | 1 |
| Burat, I | 1 |
| Khin, PP | 1 |
| Zaw, TS | 1 |
| Sohn, UD | 1 |
| Hyvelin, JM | 1 |
| Gautier, M | 1 |
| Lemaire, MC | 1 |
| Bonnet, P | 1 |
| Eder, V | 1 |
| Ning Lo, W | 1 |
| Liang, W | 1 |
| Adaramoye, OA | 1 |
| Medeiros, IA | 1 |
| Thyagarajan, B | 1 |
| Potian, JG | 1 |
| Garcia, CC | 1 |
| Hognason, K | 1 |
| Capková, K | 1 |
| Moe, ST | 1 |
| Jacobson, AR | 1 |
| Janda, KD | 1 |
| McArdle, JJ | 2 |
| Sordi, R | 1 |
| Fernandes, D | 1 |
| Assreuy, J | 1 |
| Uchida, Y | 5 |
| Maezawa, Y | 2 |
| Nakamura, F | 1 |
| Amobi, NI | 1 |
| Guillebaud, J | 1 |
| Smith, IC | 1 |
| van Lunteren, E | 7 |
| Moyer, M | 7 |
| Sasaki, K | 1 |
| Fujisawa, Y | 1 |
| Morishita, F | 1 |
| Matsushima, O | 1 |
| Furukawa, Y | 1 |
| Orekhova, IV | 1 |
| Alexeeva, V | 1 |
| Church, PJ | 1 |
| Weiss, KR | 2 |
| Brezina, V | 2 |
| Queiroz, RN | 1 |
| Ramos, ER | 1 |
| Alves-Do-Prado, W | 1 |
| Oh, SJ | 1 |
| Ahn, SC | 1 |
| Bruce, J | 1 |
| Taggart, M | 1 |
| Austin, C | 1 |
| Mora, TC | 1 |
| Suarez-Kurtz, G | 1 |
| Dong, DL | 1 |
| Wang, QH | 1 |
| Chen, W | 1 |
| Fan, JJ | 1 |
| Mu, JW | 1 |
| Ke, J | 1 |
| Yang, BF | 1 |
| Cogolludo, A | 1 |
| Moreno, L | 1 |
| Lodi, F | 1 |
| Tamargo, J | 1 |
| Perez-Vizcaino, F | 2 |
| Bubolz, AH | 1 |
| Li, H | 1 |
| Wu, Q | 1 |
| Yeung, SY | 1 |
| Greenwood, IA | 1 |
| Myung, SC | 1 |
| Keum, EM | 1 |
| Park, SY | 1 |
| Lee, MY | 1 |
| Kim, SC | 1 |
| Agren, P | 1 |
| Cogolludo, AL | 1 |
| Kessels, CG | 1 |
| De Mey, JG | 1 |
| Blanco, CE | 1 |
| Villamor, E | 1 |
| Armstrong, ML | 1 |
| Dua, AK | 1 |
| Murrant, CL | 1 |
| Morbiato, L | 1 |
| Carli, L | 1 |
| Johnson, EA | 1 |
| Montecucco, C | 1 |
| Molgó, J | 2 |
| Rossetto, O | 1 |
| Ionno, M | 1 |
| Pollarine, J | 1 |
| Chang, CC | 2 |
| Su, MJ | 1 |
| Shieh, BH | 1 |
| Lin, HL | 1 |
| Hong, SJ | 2 |
| Zetler, G | 2 |
| Sowoidnich, T | 1 |
| Sakanashi, M | 1 |
| Rokutanda, M | 1 |
| Takeo, S | 1 |
| Higuchi, M | 1 |
| Kromer, W | 1 |
| Scheiblhuber, E | 1 |
| Illes, P | 1 |
| Papasova, M | 2 |
| Bonev, A | 2 |
| Boev, K | 2 |
| Zafirov, D | 1 |
| Gachilova, S | 1 |
| Khan, RA | 1 |
| Lemeignan, M | 3 |
| Wiegand, H | 1 |
| Csicsaky, M | 1 |
| Krämer, U | 1 |
| Savage, AO | 3 |
| Donati, F | 1 |
| Bevan, JC | 1 |
| Bevan, DR | 1 |
| Stein, PG | 1 |
| Driska, SP | 1 |
| Ekelund, MC | 1 |
| Fukushima, K | 1 |
| Aoki, T | 1 |
| Ishikawa, J | 1 |
| Boros, M | 1 |
| Chaudhry, IA | 1 |
| Nagashima, H | 1 |
| Duncalf, RM | 1 |
| Sherman, EH | 1 |
| Foldes, FF | 1 |
| Louttit, JB | 1 |
| Downing, OA | 1 |
| Wilson, KA | 1 |
| Arzate, ME | 1 |
| Ponce, H | 1 |
| Pasantes-Morales, H | 1 |
| Miledi, R | 1 |
| Parker, I | 1 |
| Zhu, PH | 1 |
| Carlsson, C | 1 |
| Rosén, I | 1 |
| Nilsson, E | 1 |
| Rupp, SM | 1 |
| Shinohara, Y | 1 |
| Fisher, DM | 1 |
| Miller, RD | 1 |
| Castagnoli, N | 1 |
| Anraku, M | 1 |
| Hashimura, S | 1 |
| Rezvani, A | 1 |
| Huidobro-Toro, JP | 1 |
| Way, EL | 1 |
| Davis, C | 1 |
| Kannan, MS | 1 |
| Jones, TR | 1 |
| Daniel, EE | 1 |
| Stone, TW | 1 |
| Moritoki, H | 1 |
| Su, C | 1 |
| Hara, Y | 1 |
| Kitamura, K | 1 |
| Kuriyama, H | 1 |
| Lee, C | 1 |
| Durant, NN | 1 |
| Au, E | 1 |
| Katz, RL | 1 |
| Lang, RJ | 1 |
| Zhang, Y | 1 |
| Blair, KL | 1 |
| Bennett, JL | 1 |
| Pax, RA | 1 |
| Kanwal, S | 1 |
| Trachte, GJ | 1 |
| Poli, E | 1 |
| Pozzoli, C | 1 |
| Coruzzi, G | 1 |
| Bertaccini, G | 1 |
| Røed, A | 2 |
| Herlofson, BB | 1 |
| Huang, Y | 2 |
| Uchida, W | 2 |
| Shibasaki, K | 2 |
| Asano, M | 2 |
| Takenaka, T | 2 |
| Constantin, B | 1 |
| Cognard, C | 1 |
| Rivet-Bastide, M | 1 |
| Raymond, G | 1 |
| Maggi, CA | 3 |
| Lecci, A | 1 |
| Garret, C | 1 |
| Giuliani, S | 2 |
| Kontani, H | 1 |
| Ginkawa, M | 1 |
| Sakai, T | 1 |
| Kelly, G | 1 |
| Sun, YD | 1 |
| Benishin, CG | 1 |
| Vafaie, H | 1 |
| Braga, MF | 1 |
| Rowan, EG | 1 |
| Harvey, AL | 2 |
| Bowman, WC | 1 |
| Fleischmann, BK | 1 |
| Washabau, RJ | 1 |
| Kotlikoff, MI | 1 |
| Schwörer, H | 1 |
| Clemens, A | 1 |
| Katsoulis, S | 1 |
| Köhler, H | 1 |
| Creutzfeldt, W | 1 |
| Schmidt, WE | 1 |
| Henning, RH | 1 |
| Houwertjes, MC | 1 |
| Scaf, AH | 1 |
| den Hertog, A | 2 |
| Agoston, S | 1 |
| Gilly, WF | 1 |
| Scheuer, T | 1 |
| Ishida, Y | 2 |
| Honda, H | 2 |
| Sadraei, H | 1 |
| Beech, DJ | 1 |
| Yuan, XJ | 1 |
| Tod, ML | 1 |
| Rubin, LJ | 1 |
| Blaustein, MP | 1 |
| Greensmith, L | 1 |
| Dick, J | 1 |
| Emanuel, AO | 1 |
| Vrbová, G | 1 |
| Reyes-Vázquez, C | 1 |
| Naranjo-Rodríguez, EB | 1 |
| García-Segoviano, JA | 1 |
| Trujillo-Santana, JT | 1 |
| Prieto-Gómez, B | 1 |
| Rodrigues-Simioni, L | 1 |
| Silva-Carvalho, I | 1 |
| Heluany, NF | 1 |
| Leite, GB | 1 |
| Prado-Franceschi, J | 1 |
| Cruz-Höfling, MA | 1 |
| Ballejo, G | 1 |
| Corrado, AP | 1 |
| Pinter, MJ | 1 |
| Waldeck, RF | 1 |
| Cope, TC | 1 |
| Cork, LC | 1 |
| Zagorodnyuk, V | 1 |
| Santicioli, P | 1 |
| Velasco, A | 1 |
| Maroto, M | 1 |
| Dueñas, A | 1 |
| Carvajal, A | 1 |
| Fernández de la Gándara, F | 1 |
| Nieto, A | 1 |
| Prieto, D | 1 |
| Buus, C | 1 |
| Mulvany, MJ | 1 |
| Nilsson, H | 1 |
| Arai, Y | 1 |
| Okazaki, T | 1 |
| Fryer, MW | 1 |
| Glover, WE | 1 |
| Scott, ML | 1 |
| Ishikawa, T | 1 |
| Eckman, DM | 1 |
| Keef, KD | 1 |
| Koyuncuoğlu, H | 1 |
| Kara, I | 1 |
| Günel, MA | 1 |
| Nurten, A | 1 |
| Yamantürk, P | 1 |
| Maddison, P | 1 |
| Newsom-Davis, J | 1 |
| Mills, KR | 1 |
| Peng, W | 1 |
| Michael, JR | 1 |
| Hoidal, JR | 1 |
| Karwande, SV | 1 |
| Farrukh, IS | 1 |
| Yuan, YM | 1 |
| Yang, HH | 1 |
| Hu, GY | 1 |
| Ford, WR | 1 |
| Broadley, KJ | 1 |
| Wade, GR | 1 |
| Laurier, LG | 1 |
| Preiksaitis, HG | 1 |
| Sims, SM | 1 |
| Mistry, DK | 1 |
| Garland, CJ | 1 |
| Smith, KJ | 1 |
| Felts, PA | 1 |
| John, GR | 1 |
| Peuler, JD | 1 |
| Lee, JM | 1 |
| Smith, JM | 1 |
| Adler, M | 1 |
| Capacio, B | 1 |
| Deshpande, SS | 1 |
| Mukerji, MS | 1 |
| Leathard, HL | 1 |
| Huddart, H | 1 |
| Long, W | 1 |
| Zhang, L | 1 |
| Longo, LD | 1 |
| Gomez, JP | 1 |
| Ghisdal, P | 1 |
| Morel, N | 1 |
| Imai, T | 1 |
| Okamoto, T | 1 |
| Yamamoto, Y | 1 |
| Tanaka, H | 1 |
| Koike, K | 1 |
| Shigenobu, K | 1 |
| Tanaka, Y | 1 |
| Salapatek, AM | 1 |
| Ji, J | 1 |
| Diamant, NE | 1 |
| Gwee, MC | 1 |
| Cheah, LS | 1 |
| Okamoto, M | 1 |
| Walewski, JL | 1 |
| Artusio, JF | 1 |
| Riker, WF | 1 |
| Gelband, CH | 1 |
| Hume, JR | 1 |
| Watanabe, TX | 1 |
| Nasledov, GA | 1 |
| Lukyanenko, WI | 1 |
| Katina, IE | 1 |
| Lonsky, AV | 1 |
| Ram, JL | 1 |
| Liu, LX | 1 |
| Morita, K | 1 |
| Barrett, EF | 1 |
| Gonzalez-Ramirez, D | 1 |
| Morales-Aguilera, A | 2 |
| Usune, S | 1 |
| Katsuragi, T | 1 |
| Furukawa, T | 1 |
| Lydrup, ML | 1 |
| Fujino, K | 1 |
| Nakaya, S | 1 |
| Wakatsuki, T | 1 |
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| Nakaya, Y | 1 |
| Mori, H | 1 |
| Inoue, I | 1 |
| Gage, PW | 1 |
| Saint, DA | 1 |
| Black, JL | 1 |
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| Armour, CL | 1 |
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| Sugimoto, T | 2 |
| Bilbaut, A | 1 |
| Hernandez-Nicaise, ML | 1 |
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| Meech, RW | 1 |
| Cook, NS | 1 |
| Nishimura, M | 1 |
| Ohtani, H | 1 |
| Yagasaki, O | 1 |
| Kaschube, M | 1 |
| Ebong, OO | 1 |
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| Hsu, SY | 1 |
| Shen, CL | 1 |
| Marshall, DL | 1 |
| Fu, WM | 1 |
| Lin, RH | 1 |
| Lin-Shiau, SY | 1 |
| Khan, AR | 1 |
| Gibb, AJ | 1 |
| Marshall, IG | 1 |
| Lee, HS | 1 |
| Go, ML | 1 |
| Kuromaru, O | 1 |
| Sakai, K | 1 |
| Zacharias, J | 1 |
| Guerrero, S | 1 |
| Uchiyama, T | 1 |
| Lechat, P | 1 |
| Gonzalez, DR | 1 |
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| Zhang, YP | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fampyra Outcome Measures Study: a Study of Different Outcome Measures on the Effect of Fampyra[NCT01656148] | Phase 4 | 108 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 4-aminopyridine and Muscle Contraction
| Article | Year |
|---|---|
Neuromuscular blocking drugs in anaesthesia.
Topics: 4-Aminopyridine; Acid-Base Equilibrium; Adult; Age Factors; Aminopyridines; Atropine; Child; Choline | 1984 |
1 trial available for 4-aminopyridine and Muscle Contraction
| Article | Year |
|---|---|
Effect of slow release-Fampridine on muscle strength, rate of force development, functional capacity and cognitive function in an enriched population of MS patients. A randomized, double blind, placebo controlled study.
Topics: 4-Aminopyridine; Arm; Cognition; Double-Blind Method; Female; Humans; Leg; Male; Middle Aged; Multip | 2016 |
155 other studies available for 4-aminopyridine and Muscle Contraction
| Article | Year |
|---|---|
Characterization of the A-type potassium current in murine gastric fundus smooth muscles.
Topics: 4-Aminopyridine; Animals; Gastric Fundus; Gastrointestinal Motility; Kinetics; Male; Membrane Potent | 2021 |
[Investigation of the changes in uterine myocytes size depending on contractile activity modulators by photon correlation spectroscopy].
Topics: 4-Aminopyridine; Animals; Calcimycin; Calcium; Calcium Ionophores; Cell Size; Enzyme Inhibitors; Fem | 2013 |
Contractions of the whole and longitudinally cut rat's portal vein.
Topics: 4-Aminopyridine; Animals; Endothelium, Vascular; Entropy; Muscle Contraction; Portal Vein; Potassium | 2013 |
Decreased Kv1.5 expression in intrauterine growth retardation rats with exaggerated pulmonary hypertension.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Barium Compounds; Cell Hypoxia; Cells, Cultured; Chlorides; | 2013 |
Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cult | 2013 |
Neurogenic contraction induced by the antiarrhythmic compound, AVE 0118, in rat small mesenteric arteries.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Biphenyl Compounds; Electric Stimulation; Immunohi | 2014 |
Enhancement of voltage-gated K+ channels and depression of voltage-gated Ca2+ channels are involved in quercetin-induced vasorelaxation in rat coronary artery.
Topics: 4-Aminopyridine; Aniline Compounds; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L- | 2014 |
Flavonoid galetin 3,6-dimethyl ether attenuates guinea pig ileum contraction through K(+) channel activation and decrease in cytosolic calcium concentration.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2015 |
Electrophysiological alterations in diaphragm muscle caused by abdominal ischemia-reperfusion.
Topics: 4-Aminopyridine; Action Potentials; Analysis of Variance; Animals; Biophysics; Diaphragm; Disease Mo | 2017 |
Signal Transduction Underlying the Inhibitory Mechanism of Fluoxetine on Electrical Field Stimulation Response in Rat Ileal Smooth Muscle.
Topics: 4-Aminopyridine; Amides; Animals; Atropine; Azepines; Benzophenanthridines; Bicuculline; Calcimycin; | 2017 |
Adaptative modifications of right coronary myocytes voltage-gated K+ currents in rat with hypoxic pulmonary hypertension.
Topics: 4-Aminopyridine; Animals; Coronary Vessels; Hypertension, Pulmonary; Hypoxia; Male; Membrane Potenti | 2009 |
Blockade of voltage-sensitive K+ channels increases contractility more in transverse than in longitudinal rat detrusor strips.
Topics: 4-Aminopyridine; Animals; Female; Male; Muscle Contraction; Muscle, Smooth; Potassium Channel Blocke | 2009 |
Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds, in rat superior mesenteric arteries.
Topics: 4-Aminopyridine; Animals; Calcium; Calcium Channels, L-Type; Charybdotoxin; Chelating Agents; Dose-R | 2009 |
Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Animals; Antidotes; Botulinum Toxins, Type A; Calcium | 2010 |
Differential involvement of potassium channel subtypes in early and late sepsis-induced hyporesponsiveness to vasoconstrictors.
Topics: 4-Aminopyridine; Animals; Apamin; Blood Pressure; Female; Glyburide; Muscle Contraction; Muscle, Smo | 2010 |
Role of calcium-activated potassium channels in the genesis of 3,4-diaminopyridine-induced periodic contractions in isolated canine coronary artery smooth muscles.
Topics: 4-Aminopyridine; Adrenergic beta-Agonists; Amifampridine; Animals; Calcium Channel Agonists; Calcium | 2011 |
Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Amides; Apamin; Calcium Channel Agonists; Calcium Channels, | 2012 |
Improvement of dy/dy dystrophic diaphragm by 3,4-diaminopyridine.
Topics: 4-Aminopyridine; Amifampridine; Animals; Diaphragm; Disease Models, Animal; Electric Stimulation; Ho | 2002 |
The enterins inhibit the contractile activity of the anterior aorta of Aplysia kurodai.
Topics: 4-Aminopyridine; Animals; Aorta; Aplysia; Invertebrate Hormones; Membrane Potentials; Muscle Contrac | 2002 |
Multiple presynaptic and postsynaptic sites of inhibitory modulation by myomodulin at ARC neuromuscular junctions of Aplysia.
Topics: 4-Aminopyridine; Animals; Aplysia; Drug Interactions; Electrophysiology; Motor Neurons; Mouth; Muscl | 2003 |
Wheel-running exercise alters rat diaphragm action potentials and their regulation by K+ channels.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Animals; Diaphragm; Male; Motor Activity; Muscle | 2003 |
Sternohyoid muscle fatigue properties of dy/dy dystrophic mice, an animal model of merosin-deficient congenital muscular dystrophy.
Topics: 4-Aminopyridine; Amifampridine; Animals; Disease Models, Animal; Electric Stimulation; Humans; In Vi | 2003 |
4-Aminopyridine inhibits the neuromuscular effects of nitric oxide and 8-Br-cGMP.
Topics: 4-Aminopyridine; Animals; Cyclic GMP; Diaphragm; Electric Stimulation; Endothelium-Dependent Relaxin | 2003 |
Inhibitory effects of potassium channel blockers on carbachol-induced contraction in rat detrusor muscle.
Topics: 4-Aminopyridine; Animals; Calcium; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, | 2003 |
Contractile responses of isolated rat mesenteric arteries to acute episodes of severe hypoxia and subsequent reoxygenation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Adenosine Triph | 2004 |
Effects of NS1608, a BK(Ca) channel agonist, on the contractility of guinea-pig urinary bladder in vitro.
Topics: 4-Aminopyridine; Animals; Apamin; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smoo | 2005 |
Contrasting effects of tetraethylammonium and 4-aminopyridine on the gastrointestinal function of mice.
Topics: 4-Aminopyridine; Animals; Duodenum; Gastric Acid; Gastric Fundus; Gastric Mucosa; Gastrointestinal M | 2005 |
Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Aging; Amides; | 2005 |
Enhanced oxidative stress impairs cAMP-mediated dilation by reducing Kv channel function in small coronary arteries of diabetic rats.
Topics: 4-Aminopyridine; Animals; Antioxidants; Blood Glucose; Body Weight; Colforsin; Coronary Vessels; Cyc | 2005 |
Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells.
Topics: 4-Aminopyridine; Animals; Anthracenes; Chromans; Dose-Response Relationship, Drug; Female; In Vitro | 2005 |
Vasomotor action of insulin on the rabbit normal cavernous smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2006 |
Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Animals; Blood | 2007 |
Potassium initiates vasodilatation induced by a single skeletal muscle contraction in hamster cremaster muscle.
Topics: 4-Aminopyridine; Amifampridine; Animals; Arterioles; Barium Compounds; Chlorides; Cricetinae; Electr | 2007 |
Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins; Botulinum Toxins, Type A; Drug Resistance | 2007 |
Inotropic effects of the K+ channel blocker 3,4-diaminopyridine on fatigued diaphragm muscle.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Animals; Diaphragm; Electric Stimulation; Electro | 2008 |
Potentiation between neostigmine and 3,4-diaminopyridine in antagonizing the neuromuscular block induced by D-tubocurarine.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Drug Synergism; Female; Male; Mice; Muscle | 1984 |
Substance P, bethanechol, 4-aminopyridine, and potassium antagonize the depressing effects of low-frequency stimulation, tetrodotoxin, procaine, and of magnesium on the field-stimulated guinea-pig vas deferens.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Bethanechol Compounds; Electric Stimulation; Guinea Pigs; | 1980 |
Effects of 4-aminopyridine and tetraethylammonium on relaxant responses of isolated dog coronary arteries to 2-nicotinamidoethyl nitrate (SG-75).
Topics: 4-Aminopyridine; Aminopyridines; Animals; Coronary Vessels; Dinoprost; Dogs; Female; In Vitro Techni | 1982 |
Functional antagonism by calcium of an intrinsic opioid mechanism in the guinea-pig isolated ileum.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Female; Guinea Pigs; Ileum; In Vitro Techniques; | 1980 |
Effect of 4-aminopyridine on neurotransmission in smooth muscle.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Cats; In Vitro Techniques; Male; Muscle Contraction; Muscl | 1982 |
Effects of 3,4-diaminopyridine on mechanical and electrical responses of frog single muscle fibres.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; In Vitro Techniques; Ion | 1983 |
The action of thallium acetate on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Diaphragm; Female; Guanidine; Guanidines; Kinetic | 1984 |
Contractile effects of 4-aminopyridine on isolated frog rectus abdominis muscles.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Dose-Response Relationship, Drug; In Vitro Techni | 1984 |
Histamine-induced rhythmic contraction of hog carotid artery smooth muscle.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Carotid Arteries; Electrophysiology; Female; Hist | 1984 |
The influence of dantrolene, diazepam, pentobarbital and 4-aminopyridine on shortening induced depression in isolated muscle fibres of the frog.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Dantrolene; Diazepam; Muscle Contraction; Muscles | 1983 |
[Antagonistic effects of neostigmine, 4-aminopyridine and 3,4-diaminopyridine on muscle relaxing effects of d-tubocurarine].
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Muscle Contraction; Muscle Relaxation; Neos | 1983 |
Myoneural effects of pethidine and droperidol.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Droperidol; Drug Interactions; Electric Stimulation; In Vi | 1984 |
Differential effects of strychnine on two types of vascular muscle.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Aorta, Thoracic; Cardiovascular Agents; Male; Muscle Contr | 1984 |
Antagonistic effects of taurine and 4-aminopyridine on guinea pig ileum.
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Atropine; Calcium; Female; Guinea Pigs; Ile | 1984 |
Extracellular ions and excitation-contraction coupling in frog twitch muscle fibres.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Arsenazo III; Calcium; C | 1984 |
Can 4-aminopyridine be used to reverse anaesthesia and muscle relaxation?
Topics: 4-Aminopyridine; Adolescent; Adult; Aminopyridines; Anesthetics; Drug Evaluation; Electrocardiograph | 1983 |
Pharmacokinetics and pharmacodynamics of 4-aminopyridine in anesthetized dogs.
Topics: 4-Aminopyridine; Aminopyridines; Anesthesia; Animals; Dogs; Half-Life; Kinetics; Muscle Contraction; | 1983 |
Contraction of the frog muscle in 4-aminopyridine by rapid cooling.
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Caffeine; Cold Temperature; Dose-Response R | 1981 |
Effect of 4-aminopyridine and verapamil on the inhibitory action of normorphine on the guinea-pig ileum.
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Calcium; Drug Interactions; Guinea Pigs; Il | 1982 |
Control of human airway smooth muscle: in vitro studies.
Topics: 4-Aminopyridine; Aminopyridines; Arachidonic Acids; Dopamine; Electric Stimulation; Histamine; Human | 1982 |
The effects of 4-aminopyridine on the isolated vas deferens and its effects on the inhibitory properties of adenosine, morphine, noradrenaline and gamma-aminobutyric acid.
Topics: 4-Aminopyridine; Adenosine; Aminopyridines; Animals; Calcium; Dose-Response Relationship, Drug; GABA | 1981 |
Potentiating effects of 5-hydroxytryptamine and histamine on nerve stimulation-induced contractions of the rabbit mesenteric artery.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Drug Interactions; Electric Stimulation; Female; Histamine | 1981 |
Actions of 4-aminopyridine on vascular smooth muscle tissues of the guinea-pig.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Electric Stimulation; Female; Guinea Pigs; In Vitro Techni | 1980 |
Reversal of dantrolene sodium-induced depression of skeletal muscle in the cat.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium Chloride; Cats; Cevanes; Dantrolene; Electromyogra | 1981 |
The effects of K+ channel blockers on the spontaneous electrical and contractile activity in the proximal renal pelvis of the guinea pig.
Topics: 4-Aminopyridine; Action Potentials; Animals; Apamin; Charybdotoxin; Female; Glyburide; Guinea Pigs; | 1996 |
Serotonin and acetylcholine: further analysis of praziquantel-induced contraction of magnesium-paralysed Schistosoma mansoni.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Amifampridine; Animals; Arecoline; Carbachol; Colforsi | 1993 |
Potassium channel inhibitors attenuate neuromodulatory effects of atrial natriuretic factor in the rabbit isolated vas deferens.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Atrial Natriuretic Factor; Benzopyrans; Charybdoto | 1994 |
Signal transducing mechanisms coupled to histamine H3 receptors and alpha-2 adrenoceptors in the guinea pig duodenum: possible involvement of N-type Ca++ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Inhibitory effects of HgCl2 on excitation-secretion coupling at the motor nerve terminal and excitation-contraction coupling in the muscle cell.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Caffeine; Calcium; Dantrolene; Diaphragm; Electric Stimulat | 1994 |
4-Aminopyridine-induced phasic contractions in rat caudal epididymis are mediated through release of noradrenaline.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Epididymis; In Vitro Techniques; Male; Muscle Cont | 1995 |
Antianginal effects of YM-16151-4 in various experimental angina models.
Topics: 4-Aminopyridine; Amifampridine; Angina Pectoris; Animals; Arginine Vasopressin; Atrioventricular Nod | 1993 |
Activation of a slow outward current by the calcium released during contraction of cultured rat skeletal muscle cells.
Topics: 4-Aminopyridine; Animals; Apamin; Caffeine; Calcium; Cells, Cultured; Cesium; Charybdotoxin; Egtazic | 1993 |
Spinal effects of selective NK-1 and NK-2 receptor antagonists on bladder motility in anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Afferent Pathways; Animals; Capsaicin; Indoles; Isoind | 1993 |
A simple method for measurement of ureteric peristaltic function in vivo and the effects of drugs acting on ion channels applied from the ureter lumen in anesthetized rats.
Topics: 4-Aminopyridine; Anesthesia; Animals; Benzopyrans; Cromakalim; Glyburide; Ion Channels; Lidocaine; M | 1993 |
Ability of some K+ channel blockers to reverse inhibition of electrically evoked contractions of longitudinal muscle-myenteric plexus.
Topics: 4-Aminopyridine; Adenosine; Animals; Electric Stimulation; Guinea Pigs; Male; Muscle Contraction; My | 1995 |
Changes in pharyngeal respiratory muscle force produced by K+ channel blockade.
Topics: 4-Aminopyridine; Animals; Diaphragm; Electric Stimulation; In Vitro Techniques; Isometric Contractio | 1995 |
Interactions between suxamethonium and non-depolarizing neuromuscular blocking drugs.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Animals; Cats; Drug Interactions; Female; In Vitr | 1994 |
Control of resting membrane potential by delayed rectifier potassium currents in ferret airway smooth muscle cells.
Topics: 4-Aminopyridine; Animals; Atropine; Electrophysiology; Female; Ferrets; In Vitro Techniques; Indicat | 1993 |
Pituitary adenylate cyclase-activating peptide is a potent modulator of human colonic motility.
Topics: 4-Aminopyridine; Apamin; Arginine; Carbachol; Colon, Sigmoid; Gastrointestinal Motility; Humans; In | 1993 |
Prolonged paralysis after long-term, high-dose infusion of pancuronium in anaesthetized cats.
Topics: 4-Aminopyridine; Animals; Cats; Hemodynamics; Infusions, Intravenous; Male; Muscle Contraction; Neos | 1993 |
Voltage-dependent calcium and potassium conductances in striated muscle fibers from the scorpion, Centruroides sculpturatus.
Topics: 4-Aminopyridine; Amifampridine; Animals; Barium; Calcium; Calcium Channels; Cell Membrane; Electric | 1993 |
Inhibitory action of 4-aminopyridine on Ca(2+)-ATPase of the mammalian sarcoplasmic reticulum.
Topics: 4-Aminopyridine; Animals; Calcium; Calcium-Transporting ATPases; Guinea Pigs; In Vitro Techniques; M | 1993 |
BaCl2- and 4-aminopyridine-evoked phasic contractions in the rat vas deferens.
Topics: 4-Aminopyridine; Animals; Barium Compounds; Calcium Channel Blockers; Chlorides; In Vitro Techniques | 1995 |
Ionic currents and inhibitory effects of glibenclamide in seminal vesicle smooth muscle cells.
Topics: 4-Aminopyridine; Amifampridine; Animals; Barium; Biological Transport, Active; Cadmium; Calcium; Cal | 1995 |
NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Cell Membrane; Cells, Cultured; Ion Channel Ga | 1996 |
Induction of transmitter release at the neuromuscular junction prevents motoneuron death after axotomy in neonatal rats.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Axons; Cell Death; Female; Male; Motor Neurons; Muscle C | 1996 |
Apamin blocks the direct relaxant effect of melatonin on rat ileal smooth muscle.
Topics: 4-Aminopyridine; Adrenergic alpha-Antagonists; Animals; Apamin; Calcium; Calcium Channel Blockers; C | 1997 |
Novel effects of guanidine on the neuromuscular junction.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Calcium; Chickens; Cromakalim; Electric Stimulation; Electrom | 1997 |
Effects of 4-aminopyridine on muscle and motor unit force in canine motor neuron disease.
Topics: 4-Aminopyridine; Animals; Calcium; Disease Models, Animal; Dogs; Electromyography; Female; Homozygot | 1997 |
Sequential activation of the triple excitatory transmission to the circular muscle of guinea-pig colon.
Topics: 4-Aminopyridine; Animals; Atropine; Colon; Electric Stimulation; Guinea Pigs; In Vitro Techniques; M | 1997 |
Pharmacological modulation of electromechanical coupling in the proximal and distal regions of the guinea-pig renal pelvis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Effect of 4-aminopyridine and 3,4-diaminopyridine on guinea-pig isolated ileum.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Animals; Atropine; Calcium Channel Blockers; Diazoxid | 1997 |
Interactions between neuropeptide Y and the adenylate cyclase pathway in rat mesenteric small arteries: role of membrane potential.
Topics: 4-Aminopyridine; Acetylcholine; Adenylyl Cyclases; Animals; Charybdotoxin; Colforsin; Cyclic AMP-Dep | 1997 |
Antianginal effects of YM430, a novel calcium entry-blocking and beta-adrenoceptor-blocking agent in several experimental angina models.
Topics: 4-Aminopyridine; Adrenergic beta-Antagonists; Amifampridine; Angina Pectoris; Animals; Calcium Chann | 1997 |
Effects of 4-methyl-2-aminopyridine on [3H]-noradrenaline overflow and contractility of isolated rabbit arteries.
Topics: 4-Aminopyridine; Animals; Arteries; Calcium; Ear; Female; In Vitro Techniques; Male; Muscle Contract | 1997 |
Ion currents and mechanisms of modulation in the radula opener muscles of Aplysia.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 4-Aminopyridine; Acetylcholine; Animals; Aplysia; Ba | 1997 |
Characterization of delayed rectifier K+ currents in rabbit coronary artery cells near resting membrane potential.
Topics: 4-Aminopyridine; Animals; Coronary Vessels; Delayed Rectifier Potassium Channels; In Vitro Technique | 1997 |
N-methyl-D-aspartate antagonists, glutamate release inhibitors, 4-aminopyridine at neuromuscular transmission.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; ATP-Binding | 1998 |
Effect of 3,4-diaminopyridine on the time course of decay of compound muscle action potential augmentation in the Lambert-Eaton myasthenic syndrome.
Topics: 4-Aminopyridine; Action Potentials; Adult; Aged; Amifampridine; Female; Fingers; Humans; Lambert-Eat | 1998 |
Electrophysiologic and inotropic effects of K+-channel blockade in aged diaphragm.
Topics: 4-Aminopyridine; Action Potentials; Adenosine Triphosphate; Aging; Amifampridine; Analysis of Varian | 1998 |
ET-1 modulates KCa-channel activity and arterial tension in normoxic and hypoxic human pulmonary vasculature.
Topics: 4-Aminopyridine; Analysis of Variance; Cell Hypoxia; Cells, Cultured; Charybdotoxin; Dehydroepiandro | 1998 |
Tetraethylammonium and 4-aminopyridine enhancement of 5-HT3 receptor-mediated contraction of guinea pig ileum in vitro.
Topics: 4-Aminopyridine; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, | 1998 |
Effects of K(+)-channel blockers on A1-adenosine receptor-mediated negative inotropy and chronotropy of guinea-pig isolated left and right atria.
Topics: 4-Aminopyridine; Adenosine; Animals; Dose-Response Relationship, Drug; Drug Interactions; Glyburide; | 1999 |
Delayed rectifier and Ca(2+)-dependent K(+) currents in human esophagus: roles in regulating muscle contraction.
Topics: 4-Aminopyridine; Calcium; Charybdotoxin; Delayed Rectifier Potassium Channels; Electric Conductivity | 1999 |
The influence of phenylephrine outward potassium currents in single smooth muscle cells from the rabbit mesenteric artery.
Topics: 4-Aminopyridine; Adrenergic alpha-Antagonists; Amifampridine; Animals; Caffeine; Calcium; Chelating | 1999 |
Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension.
Topics: 4-Aminopyridine; Animals; Axons; Demyelinating Diseases; Male; Muscle Contraction; Muscle, Skeletal; | 2000 |
4-Aminopyridine antagonizes the acute relaxant action of metformin on adrenergic contraction in the ventral tail artery of the rat.
Topics: 4-Aminopyridine; Animals; Arteries; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; I | 1999 |
Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins, Type A; Drug Delivery Systems; Hindlimb; | 2000 |
The effects of potassium channel blockers on progesterone-induced suppression of rat portal vein contractility.
Topics: 4-Aminopyridine; Animals; Barium Compounds; Chlorides; Glyburide; Hypoglycemic Agents; Male; Muscle | 2000 |
Cerebral artery K(ATP)- and K(Ca)-channel activity and contractility: changes with development.
Topics: 4-Aminopyridine; Animals; Benzimidazoles; Calcium; Fetus; In Vitro Techniques; Middle Cerebral Arter | 2000 |
Changes of the potassium currents in rat aortic smooth muscle cells during postnatal development.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Apamin; Barium; Benzimidazoles; Calcium Channel Bl | 2001 |
Auxotonic contractile responses of rat tracheal and bronchial airway smooth muscle.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Culture Techniques; Muscle Contraction; Muscle, Smooth; Pot | 2001 |
Ion channel diversity in the feline smooth muscle esophagus.
Topics: 4-Aminopyridine; Animals; Cats; Chelating Agents; Delayed Rectifier Potassium Channels; Egtazic Acid | 2002 |
Ranitidine inhibits adrenergic transmission in the rat isolated anococcygeus muscle.
Topics: 4-Aminopyridine; Animals; Depression, Chemical; Electric Stimulation; In Vitro Techniques; Male; Mus | 1992 |
Neuromuscular pharmacology in rat neonates: development of responsiveness to prototypic blocking and reversal drugs.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Cholinesterase Inhibitors; Curare; Dose-Response | 1992 |
Ionic currents in single smooth muscle cells of the canine renal artery.
Topics: 4-Aminopyridine; Angiotensin II; Animals; Calcium Channels; Charybdotoxin; Dogs; Electrophysiology; | 1992 |
Ca2+ release from isolated sarcoplasmic reticulum of guinea-pig psoas muscle induced by K(+)-channel blockers.
Topics: 4-Aminopyridine; Animals; Apamin; Calcium; Charybdotoxin; Glyburide; Guinea Pigs; In Vitro Technique | 1992 |
Ionic requirements for the activation of contraction in embryonic frog myoblasts in culture.
Topics: 4-Aminopyridine; Animals; Cells, Cultured; Culture Media; Embryo, Nonmammalian; Ions; Membrane Poten | 1992 |
Voltage-dependent calcium current in dissociated smooth muscle cells of the buccal mass of Aplysia.
Topics: 4-Aminopyridine; Animals; Aplysia; Biological Transport; Calcium; Calcium Channels; Cell Separation; | 1991 |
Evidence for two calcium-dependent potassium conductances in lizard motor nerve terminals.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
The effects of 4-aminopyridine on rabbit spontaneous jejunal contractions are calcium dependent.
Topics: 4-Aminopyridine; Animals; Calcium; In Vitro Techniques; Jejunum; Muscle Contraction; Muscle, Smooth; | 1991 |
Involvement of K(+)-channel opening in endothelin-1 induced suppression of spontaneous contractions in the guinea pig taenia coli.
Topics: 4-Aminopyridine; Action Potentials; Animals; Apamin; Calcium; Colon; Endothelins; Guinea Pigs; In Vi | 1991 |
Role of K+ channels in spontaneous electrical and mechanical activity of smooth muscle in the guinea-pig mesotubarium.
Topics: 4-Aminopyridine; Animals; Apamin; Electrophysiology; Female; Guanidines; Guinea Pigs; In Vitro Techn | 1991 |
Effects of nitroglycerin on ATP-induced Ca(++)-mobilization, Ca(++)-activated K channels and contraction of cultured smooth muscle cells of porcine coronary artery.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Coronary Vessels; Cyclic | 1991 |
Effects of butanedione monoxime on neuromuscular transmission.
Topics: 4-Aminopyridine; Action Potentials; Animals; Butanones; Cholinesterase Reactivators; Diacetyl; In Vi | 1990 |
Neurokinin A with K+ channel blockade potentiates contraction to electrical stimulation in human bronchus.
Topics: 4-Aminopyridine; Acetylcholine; Bronchi; Electric Stimulation; Electrophysiology; Humans; Muscle Con | 1990 |
Effects of 3,4-diaminopyridine and tetraethylammonium on the pre- and post-junctional alpha-adrenoceptor mediated inhibitory actions of noradrenaline in the guinea-pig ileum.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Atropine; Electric Stimulation; Female; Gui | 1985 |
Neural control of gastro-intestinal motility; events following receptor activation.
Topics: 4-Aminopyridine; Acetylcholine; Adenosine Triphosphate; Aminopyridines; Animals; Calcium; Cecum; Gas | 1986 |
The effects of nicorandil on phasic contractions of isolated canine coronary artery.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calmodulin; Coronary Vessels; Dogs; Ergonov | 1987 |
Membrane currents that govern smooth muscle contraction in a ctenophore.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Calcium; Cell Membrane; Cnidaria; Cobal | 1988 |
Effect of some potassium channel blockers on contractile responses of the rabbit aorta.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Aorta, Thoracic; Apamin; Calcium Channel Bl | 1989 |
The influence of ouabain on twitch contractions in the presence of veratridine.
Topics: 4-Aminopyridine; Aconitine; Aminopyridines; Animals; Caffeine; Electric Stimulation; Male; Mice; Mic | 1989 |
Noradrenergic, purinergic, and cholinergic transmission in the mouse vas deferens: influence of field-stimulation parameters, reserpinization, 6-hydroxydopamine and 4-aminopyridine.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Atropine; Electric Stimulation; Hy | 1989 |
Failure of non-adrenergic transmission in the rat vas deferens.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Electric Stimulation; Epididymis; | 1989 |
The effects of tetraethylammonium during twitch and tetanic stimulation of the phrenic nerve diaphragm preparation in the rat.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Calcium; Diaphragm; Electric Stimulatio | 1989 |
4-Aminopyridine induces the release of neuropeptide Y (NPY) to produce an atropine- and tetrodotoxin-resistant contraction in rabbit isolated jejunum.
Topics: 4-Aminopyridine; Animals; Atropine; Drug Resistance; Female; In Vitro Techniques; Jejunum; L-Lactate | 1989 |
A comparison of the actions of 4-aminopyridine, caffeine and quinine on the toad isolated rectus abdominis muscle.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Bufonidae; Caffeine; Egtazic Acid; In Vitro Techniques; Ma | 1989 |
Block of potassium channels and facilitation of acetylcholine release at the neuromuscular junction by the venom of the scorpion, Pandinus imperator.
Topics: 4-Aminopyridine; Acetylcholine; Action Potentials; Amifampridine; Aminopyridines; Animals; Chickens; | 1989 |
Study on the neuromuscular action of 4-aminopyridine in the mouse diaphragm.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Axons; Calcium; Diaphragm; Female; In V | 1987 |
A comparison of the effects of 4-dimethylaminopyridine and 4-aminopyridine on isolated cardiac and skeletal muscle preparations.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Diaphragm; Female; Gallopamil; Guinea Pigs; Heart Atria; H | 1985 |
Effects of toxin II from the sea anemone Anemonia sulcata on contractile and electrical responses of frog skeletal muscle fibres.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Cnidarian Venoms; Formam | 1986 |
Nicotinic antagonists produce differing amounts of tetanic fade in the isolated diaphragm of the rat.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Diaphragm; Electric Stimulation; Erabutoxin | 1986 |
Action of mefloquine on toad isolated rectus abdominis muscle.
Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Antimalarials; Bufonidae; Calcium; In Vitro | 1988 |
Effects of nicorandil on the rhythmic contractile response of isolated miniature pig coronary artery to 3,4-diaminopyridine: comparison with nitroglycerin.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Coronary Vasospasm; Coronary Vessels; Femal | 1986 |
Effects of cholinergic drugs and 4-aminopyridine on cat ciliary muscle contractility.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Atropine; Carbachol; Cats; Ciliary Body; Muscle Contractio | 1985 |
Equipotency of anti-curare activity of 4-aminopyridine and 3,4-diaminopyridine in anesthetized rats.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Anesthesia; Animals; In Vitro Techniques; Male; Musc | 1985 |
Atropine- and tetrodotoxin-resistant motor activity, responsive to 4-aminopyridine, present in isolated rabbit jejunum.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Atropine; Drug Resistance; In Vitro Techniques; Jejunum; M | 1985 |
4-Aminopyridine-induced changes in the electrical and contractile activities of the gastric smooth muscle.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Atropine; Cats; Electric Conductivity; Female; Male; Membr | 1985 |
The effects of hemicholinium-3 (Hc-3) during tetanic (TP) and posttetanic potentiation (PTP) on sympathetic ganglion.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Anura; Calcium; Electric | 1986 |
Epithelial modulation of tracheal smooth muscle response to antigenic stimulation.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Antigens; Atropine; Capsaicin; Epithelium; Male; Microscop | 1986 |
Mechanisms of tetraethylammonium-induced contraction in the canine coronary artery.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Cesium; Chlorides; Coronary Vessels; Dogs; Female | 1986 |
Differential effects of Ca antagonists on the noradrenaline release and contraction evoked by nerve stimulation in the presence of 4-aminopyridine.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium Channel Blockers; Diltiazem; Dogs; Electric Stimul | 1987 |
[Antagonism of the neuromuscular-blocking effect of polymyxin B by 3,4-diaminopyridine].
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Female; Male; Muscle Con | 1987 |
Decreasing potassium conductance--a possible mechanism of phasic coronary vasospasm.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calcium; Coronary Vasospasm; Coronary Vesse | 1985 |
[Effects of 3,4-diaminopyridine on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2].
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Drug Synergism; Guinea Pigs; Histamine; In | 1988 |
Effects of adenosine and calcium entry blockers on 3,4-diaminopyridine-induced rhythmic contractions in dog coronary artery.
Topics: 4-Aminopyridine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amifampridine; Aminopyridines; Animal | 1988 |
Relation between action potential duration and mechanical activity on rat diaphragm fibers. Effects of 3,4-diaminopyridine and tetraethylammonium.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Caffeine; In Vitro Techn | 1987 |
Effects of extracellular calcium and calcium channel blocker on silver-induced contractures in frog skeletal muscle fibers.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calcium; Calcium Channel Blockers; Diltiaze | 1987 |
Pre- and postsynaptic effects of nicotine on the mouse phrenic nerve-diaphragm preparation.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calcium; Diaphragm; Electric Stimulation; F | 1987 |