4-aminopyridine has been researched along with Magnesium Deficiency in 10 studies
Magnesium Deficiency: A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epilepsy is a disease of neuronal hyper-synchrony that can involve both neocortical and hippocampal brain regions." | 1.42 | Coalescence of deep and superficial epileptic foci into larger discharge units in adult rat neocortex. ( Andrade, R; Loeb, JA; Serafini, R, 2015) |
| "Hydrogen sulfide (H2 S) is a gas transmitter that may mediate cerebral ischemic injury." | 1.40 | Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability. ( Chen, JG; Guan, XL; He, JG; Hu, ZL; Luo, Y; Wang, F; Wu, PF; Xiao, W; Zhang, JT; Zhou, J, 2014) |
| "Remacemide is a potential anticonvulsant drug with an active metabolite, desglycinyl-remacemide (DGR)." | 1.31 | Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice. ( Brodie, MJ; Santangeli, S; Sills, GJ; Stone, TW, 2002) |
| "During seizure-like events (SLEs), intracellular Ca2+ concentration ([Ca2+]i) increases causing depolarization of the mitochondrial membrane and subsequent intramitochondrial accumulation of Ca2+." | 1.30 | A relative energy failure is associated with low-Mg2+ but not with 4-aminopyridine induced seizure-like events in entorhinal cortex. ( Buchheim, K; Heinemann, U; Meierkord, H; Schuchmann, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, Y | 1 |
| Wu, PF | 1 |
| Zhou, J | 1 |
| Xiao, W | 1 |
| He, JG | 1 |
| Guan, XL | 1 |
| Zhang, JT | 1 |
| Hu, ZL | 1 |
| Wang, F | 1 |
| Chen, JG | 1 |
| Serafini, R | 1 |
| Andrade, R | 1 |
| Loeb, JA | 1 |
| Hill, AJ | 1 |
| Jones, NA | 1 |
| Williams, CM | 1 |
| Stephens, GJ | 1 |
| Whalley, BJ | 1 |
| Gulyás-Kovács, A | 1 |
| Dóczi, J | 1 |
| Tarnawa, I | 1 |
| Détári, L | 1 |
| Banczerowski-Pelyhe, I | 1 |
| Világi, I | 1 |
| D'Arcangelo, G | 1 |
| D'Antuono, M | 1 |
| Biagini, G | 1 |
| Warren, R | 1 |
| Tancredi, V | 1 |
| Avoli, M | 1 |
| Lasztóczi, B | 1 |
| Kardos, J | 1 |
| Castro-Alamancos, MA | 1 |
| Tawara-Hirata, Y | 1 |
| Schuchmann, S | 2 |
| Buchheim, K | 2 |
| Meierkord, H | 2 |
| Heinemann, U | 2 |
| Siegmund, H | 1 |
| Weissinger, F | 1 |
| Santangeli, S | 1 |
| Sills, GJ | 1 |
| Stone, TW | 1 |
| Brodie, MJ | 1 |
10 other studies available for 4-aminopyridine and Magnesium Deficiency
| Article | Year |
|---|---|
Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Hydrogen Sulfide; Magnesium Def | 2014 |
Coalescence of deep and superficial epileptic foci into larger discharge units in adult rat neocortex.
Topics: 4-Aminopyridine; Animals; Epilepsy; Equipment Design; Magnesium Deficiency; Microelectrodes; Rats; S | 2015 |
Development of multi-electrode array screening for anticonvulsants in acute rat brain slices.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Drug Evaluation | 2010 |
Comparison of spontaneous and evoked epileptiform activity in three in vitro epilepsy models.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicucul | 2002 |
Thalamocortical oscillations in a genetic model of absence seizures.
Topics: 4-Aminopyridine; Action Potentials; Animals; Biological Clocks; Cerebral Cortex; Disease Models, Ani | 2002 |
Cyclothiazide prolongs low [Mg2+]-induced seizure-like events.
Topics: 4-Aminopyridine; Animals; Benzodiazepines; Benzothiadiazines; Diuretics; Excitatory Amino Acid Antag | 2006 |
Area-specific resonance of excitatory networks in neocortex: control by outward currents.
Topics: 4-Aminopyridine; Animals; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Magnesium Defici | 2007 |
A relative energy failure is associated with low-Mg2+ but not with 4-aminopyridine induced seizure-like events in entorhinal cortex.
Topics: 4-Aminopyridine; Animals; Convulsants; Energy Metabolism; Entorhinal Cortex; In Vitro Techniques; Ma | 1999 |
Comparison of intrinsic optical signals associated with low Mg2+-and 4-aminopyridine-induced seizure-like events reveals characteristic features in adult rat limbic system.
Topics: 4-Aminopyridine; Adult; Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; L | 2000 |
Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice.
Topics: 4-Aminopyridine; Acetamides; Action Potentials; Animals; Anticonvulsants; Carbamazepine; Dose-Respon | 2002 |