4-aminopyridine has been researched along with Hypoxia in 50 studies
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DuP 996, 3,3-bis(4-pyrindinylmethyl)-1-phenylindolin-2-one, physostigmine (PH), tetrahydroaminoacridine (THA) and 3,4-diaminopyridine (3,4-DAP) were compared for their ability to protect against hypoxia-induced performance deficits in a passive avoidance (PA) task." | 7.68 | Comparison of DuP 996, with physostigmine, THA and 3,4-DAP on hypoxia-induced amnesia in rats. ( Cook, L; DeNoble, KF; DeNoble, VJ; Johnson, LC; Myers, MJ; Scribner, RM; Spencer, KR, 1990) |
| " Whole-cell patch-clamp studies showed that 4-aminopyridine-sensitive K(+) current density was increased significantly in rat smooth muscle cells (rSMCs) cocultured under hypoxia with PGI2-EPCs (7." | 3.78 | Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells. ( Cheng, J; Dixon, RA; Liu, Q; Liu, X; Mohite, A; Ruan, KH; So, SP; Terry, T; Willerson, JT; Wu, G; Xi, Y; Zhang, J, 2012) |
| "During hypoxia, the level of adenosine in the carotid bodies increases as a result of ATP catabolism and adenosine efflux via adenosine transporters." | 3.73 | Adenosine stimulates depolarization and rise in cytoplasmic [Ca2+] in type I cells of rat carotid bodies. ( Tse, A; Tse, FW; Xu, F; Xu, J, 2006) |
| " In adult male Sprague Dawley rats, constrictions to hypoxia, the Kv blocker 4-aminopyridine (4-AP), and correolide, a Kv1." | 3.72 | Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. ( Archer, SL; Bonnet, S; Harry, G; Hashimoto, K; McMurtry, MS; Michelakis, ED; Nsair, A; Thébaud, B; Tyrrell, B; Wu, XC, 2004) |
| " Presynaptic depression of evoked EPSCs by hypoxia or adenosine was significantly larger in alpha-Syn knockout than in wild-type mice, further supporting the hypothesis of regulation of synaptic transmission by alpha-Syn." | 3.72 | Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice. ( Ceña, V; Fariñas, I; González-García, C; Martín, ED; Milán, M, 2004) |
| "The principal finding of the present study with rat spinal cord slices was the novel demonstration of the [Ca2+]o-independent effect of ischemia on norepinephrine release and its antagonism by tetrodotoxin and low temperature (10 degrees C)." | 3.70 | Na+ channel block prevents the ischemia-induced release of norepinephrine from spinal cord slices. ( Bencsics, A; Nakai, T; Sato, T; Uchihashi, Y; Umeda, E; Vizi, ES, 1998) |
| "Exposing rats to chronic hypoxia increased the 4-aminopyridine (4-AP) sensitivity of pulmonary arteries." | 3.70 | Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle. ( Alexander, D; Gurney, AM; MacLean, MR; Osipenko, ON, 1998) |
| "The effects of the outward rectifying potassium channel blocker, 4-aminopyridine, on contractile tone and on contractile responses to the spasmogens, 5-hydroxytryptamine and endothelin-1, were examined in pulmonary arteries (main and intralobar) and systemic vessels (aorta and mesenteric artery) from rats with and without hypoxic pulmonary hypertension." | 3.70 | Functional effects of 4-aminopyridine (4-AP) on pulmonary and systemic vessels from normoxic control and hypoxic pulmonary hypertensive rats. ( Doggrell, SA; Gambino, A; Wanstall, JC, 1999) |
| " The changes induced by hyperglycaemic hypoxia in low bicarbonate could be mimicked by exposure of the roots either to 100% CO2 or to a combination of 3 mM tetraethylammonium chloride and 3 mM 4-aminopyridine, to block both fast and slow potassium channels." | 3.69 | The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons. ( Bostock, H; Grafe, P; Schneider, U, 1994) |
| "DuP 996, 3,3-bis(4-pyrindinylmethyl)-1-phenylindolin-2-one, physostigmine (PH), tetrahydroaminoacridine (THA) and 3,4-diaminopyridine (3,4-DAP) were compared for their ability to protect against hypoxia-induced performance deficits in a passive avoidance (PA) task." | 3.68 | Comparison of DuP 996, with physostigmine, THA and 3,4-DAP on hypoxia-induced amnesia in rats. ( Cook, L; DeNoble, KF; DeNoble, VJ; Johnson, LC; Myers, MJ; Scribner, RM; Spencer, KR, 1990) |
| "To test the hypothesis that decreased acetylcholine (ACh) metabolism during hypoxia is behaviorally important, the effects of cholinergic drugs and 4-aminopyridine, an enhancer of ACh release, were examined in hypoxic mice." | 3.66 | Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits. ( Gibson, GE; Pelmas, CJ; Peterson, C, 1983) |
| "Seizures were induced by global hypoxia (5-7% O2 for 15 min) in rat pups on postnatal day 10." | 1.39 | Decreased A-currents in hippocampal dentate granule cells after seizure-inducing hypoxia in the immature rat. ( He, XH; Justice, JA; Peng, BW; Sanchez, RM, 2013) |
| "Rett syndrome is a neurodevelopmental disorder caused by mutations in the X-chromosomal MECP2 gene encoding for the transcriptional regulator methyl CpG binding protein 2 (MeCP2)." | 1.35 | Enhanced hypoxia susceptibility in hippocampal slices from a mouse model of rett syndrome. ( Fischer, M; Gerich, FJ; Hägele, S; Hildebrandt, B; Katschinski, D; Müller, M; Reuter, J, 2009) |
| "Baseline and anoxia-stimulated (1 min duration; PO2 of approximately 0 Torr at nadir) levels were quantified." | 1.29 | Effect of Na+ and K+ channel blockade on baseline and anoxia-induced catecholamine release from rat carotid body. ( Donnelly, DF; Doyle, TP, 1994) |
| "1." | 1.28 | Ionic basis of membrane potential changes induced by anoxia in rat dorsal vagal motoneurones. ( Cowan, AI; Martin, RL, 1992) |
| "Reversible effects of brief periods of anoxia (replacing 95% O2-5% CO2 with 95% N2-5% CO2 for 2-4 min) were studied in CA1 neurons in hippocampal slices (from Sprague-Dawley rats), kept in an interface-type chamber at 33." | 1.28 | Hypoxic changes in hippocampal neurons. ( Krnjevic, K; Leblond, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (14.00) | 18.7374 |
| 1990's | 18 (36.00) | 18.2507 |
| 2000's | 20 (40.00) | 29.6817 |
| 2010's | 5 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, BW | 1 |
| Justice, JA | 1 |
| He, XH | 1 |
| Sanchez, RM | 1 |
| Accorsi-Mendonça, D | 1 |
| Almado, CE | 1 |
| Bonagamba, LG | 1 |
| Castania, JA | 1 |
| Moraes, DJ | 1 |
| Machado, BH | 1 |
| Wang, D | 1 |
| Liu, Y | 1 |
| Lu, P | 1 |
| Zhu, D | 1 |
| Zhu, Y | 1 |
| Hyvelin, JM | 1 |
| Gautier, M | 1 |
| Lemaire, MC | 1 |
| Bonnet, P | 1 |
| Eder, V | 1 |
| Fischer, M | 1 |
| Reuter, J | 1 |
| Gerich, FJ | 1 |
| Hildebrandt, B | 1 |
| Hägele, S | 1 |
| Katschinski, D | 1 |
| Müller, M | 1 |
| Liu, Q | 1 |
| Xi, Y | 1 |
| Terry, T | 1 |
| So, SP | 1 |
| Mohite, A | 1 |
| Zhang, J | 1 |
| Wu, G | 1 |
| Liu, X | 1 |
| Cheng, J | 1 |
| Ruan, KH | 1 |
| Willerson, JT | 1 |
| Dixon, RA | 1 |
| Hu, XQ | 1 |
| Xiao, D | 1 |
| Zhu, R | 1 |
| Huang, X | 1 |
| Yang, S | 1 |
| Wilson, SM | 1 |
| Zhang, L | 1 |
| St -John, WM | 1 |
| Rybak, IA | 1 |
| Paton, JF | 1 |
| Michelakis, ED | 4 |
| Rebeyka, I | 2 |
| Wu, X | 3 |
| Nsair, A | 3 |
| Thébaud, B | 2 |
| Hashimoto, K | 4 |
| Dyck, JR | 1 |
| Haromy, A | 1 |
| Harry, G | 2 |
| Barr, A | 1 |
| Archer, SL | 4 |
| Hampl, V | 2 |
| Bíbová, J | 1 |
| Stranák, Z | 1 |
| Ishizaki, T | 1 |
| Sakai, A | 1 |
| Koizumi, T | 1 |
| Ruan, Z | 1 |
| Wang, ZG | 1 |
| Wu, XC | 1 |
| Bonnet, S | 2 |
| Tyrrell, B | 1 |
| McMurtry, MS | 1 |
| Bruce, J | 1 |
| Taggart, M | 1 |
| Austin, C | 1 |
| Martín, ED | 1 |
| González-García, C | 1 |
| Milán, M | 1 |
| Fariñas, I | 1 |
| Ceña, V | 1 |
| Campanucci, VA | 1 |
| Nurse, CA | 2 |
| Xu, F | 1 |
| Xu, J | 1 |
| Tse, FW | 1 |
| Tse, A | 1 |
| Wasicko, MJ | 1 |
| Breitwieser, GE | 1 |
| Kim, I | 1 |
| Carroll, JL | 1 |
| Fike, CD | 1 |
| Kaplowitz, MR | 1 |
| Zhang, Y | 1 |
| Madden, JA | 1 |
| Spöhr, F | 1 |
| Busch, CJ | 1 |
| Reich, C | 1 |
| Motsch, J | 1 |
| Gebhard, MM | 1 |
| Kuebler, WM | 1 |
| Bloch, KD | 1 |
| Weimann, J | 1 |
| Gibson, GE | 4 |
| Pelmas, CJ | 1 |
| Peterson, C | 3 |
| Pokorski, M | 1 |
| Lahiri, S | 2 |
| McMurtry, IF | 1 |
| Grafe, P | 2 |
| Bostock, H | 1 |
| Schneider, U | 2 |
| Doyle, TP | 1 |
| Donnelly, DF | 2 |
| Quasthoff, S | 1 |
| Mitrović, N | 1 |
| Smirnov, SV | 1 |
| Robertson, TP | 1 |
| Ward, JP | 1 |
| Aaronson, PI | 1 |
| Longo, R | 1 |
| Zeng, YC | 1 |
| Sagratella, S | 1 |
| Buckler, KJ | 2 |
| Van Lunteren, E | 1 |
| Torres, A | 1 |
| Moyer, M | 1 |
| Roy, A | 1 |
| Rozanov, C | 1 |
| Buerk, DG | 1 |
| Mokashi, A | 1 |
| Uchihashi, Y | 1 |
| Bencsics, A | 1 |
| Umeda, E | 1 |
| Nakai, T | 1 |
| Sato, T | 1 |
| Vizi, ES | 1 |
| Barman, SA | 1 |
| Osipenko, ON | 1 |
| Alexander, D | 1 |
| MacLean, MR | 1 |
| Gurney, AM | 1 |
| Fu, XW | 1 |
| Wang, YT | 1 |
| Cutz, E | 1 |
| Doggrell, SA | 1 |
| Wanstall, JC | 1 |
| Gambino, A | 1 |
| Cornfield, DN | 1 |
| Saqueton, CB | 1 |
| Porter, VA | 1 |
| Herron, J | 1 |
| Resnik, E | 1 |
| Haddad, IY | 1 |
| Reeve, HL | 1 |
| Michelakis, E | 1 |
| Bateson, J | 1 |
| Olley, P | 1 |
| Puttagunta, L | 2 |
| Archer, S | 1 |
| Malvin, GM | 1 |
| Walker, BR | 1 |
| Goirand, F | 1 |
| Bardou, M | 1 |
| Dumas, J | 1 |
| Rochette, L | 1 |
| Dumas, M | 1 |
| London, B | 1 |
| Waite, RE | 1 |
| Dubuis, E | 1 |
| Vandier, C | 1 |
| Martin, S | 1 |
| Marthan, R | 1 |
| Savineau, JP | 1 |
| Cowan, AI | 1 |
| Martin, RL | 1 |
| Aitken, PG | 1 |
| Jing, J | 1 |
| Young, J | 1 |
| Somjen, GG | 1 |
| DeNoble, VJ | 1 |
| DeNoble, KF | 1 |
| Spencer, KR | 1 |
| Johnson, LC | 1 |
| Cook, L | 1 |
| Myers, MJ | 1 |
| Scribner, RM | 1 |
| Leblond, J | 1 |
| Krnjevic, K | 1 |
| Freeman, GB | 1 |
| Mykytyn, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253] | Phase 3 | 44 participants (Anticipated) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
50 other studies available for 4-aminopyridine and Hypoxia
| Article | Year |
|---|---|
Decreased A-currents in hippocampal dentate granule cells after seizure-inducing hypoxia in the immature rat.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Biophysics; Disease Models, Animal; E | 2013 |
Enhanced Firing in NTS Induced by Short-Term Sustained Hypoxia Is Modulated by Glia-Neuron Interaction.
Topics: 4-Aminopyridine; Action Potentials; Afferent Pathways; Amino Acids; Animals; Baroreflex; Bicuculline | 2015 |
15-oxo-ETE-induced internal carotid artery constriction in hypoxic rats is mediated by potassium channels.
Topics: 4-Aminopyridine; Animals; Arachidonic Acids; Carotid Artery, Internal; Glyburide; Hydroxyprostagland | 2016 |
Adaptative modifications of right coronary myocytes voltage-gated K+ currents in rat with hypoxic pulmonary hypertension.
Topics: 4-Aminopyridine; Animals; Coronary Vessels; Hypertension, Pulmonary; Hypoxia; Male; Membrane Potenti | 2009 |
Enhanced hypoxia susceptibility in hippocampal slices from a mouse model of rett syndrome.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Bicuculline; Disease Models, Animal; Disease Susce | 2009 |
Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells.
Topics: 4-Aminopyridine; Animals; Apoptosis; Cell Engineering; Cell Growth Processes; Culture Media, Conditi | 2012 |
Chronic hypoxia suppresses pregnancy-induced upregulation of large-conductance Ca2+-activated K+ channel activity in uterine arteries.
Topics: 4-Aminopyridine; Acclimatization; Altitude; Animals; Blotting, Western; Cells, Cultured; Chronic Dis | 2012 |
Potential switch from eupnea to fictive gasping after blockade of glycine transmission and potassium channels.
Topics: 4-Aminopyridine; Age Factors; Animals; Brachial Plexus; Brain Stem; Glycine; Glycine Agents; Hypoglo | 2002 |
O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor.
Topics: 4-Aminopyridine; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Ductus Arte | 2002 |
Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition.
Topics: 4-Aminopyridine; Arteries; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Humans; Hypercapnia | 2002 |
Blunted effect of the Kv channel inhibitor on pulmonary circulation in Tibetan sheep: a model for studying hypoxia and pulmonary artery pressure regulation.
Topics: 4-Aminopyridine; Altitude; Animals; Atmosphere Exposure Chambers; Disease Models, Animal; Hypoxia; M | 2004 |
Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Cell Hypoxia; Cells, Cultured; Gene Expression Regulation; | 2004 |
Contractile responses of isolated rat mesenteric arteries to acute episodes of severe hypoxia and subsequent reoxygenation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Adenosine Triph | 2004 |
Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice.
Topics: 4-Aminopyridine; Adenosine; alpha-Synuclein; Analgesics; Anesthetics, Local; Animals; Blotting, West | 2004 |
Biophysical characterization of whole-cell currents in O2-sensitive neurons from the rat glossopharyngeal nerve.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Cadmium; Calcium Channels; Cells, Cul | 2005 |
Adenosine stimulates depolarization and rise in cytoplasmic [Ca2+] in type I cells of rat carotid bodies.
Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Antagonists; Adenylyl Cyclases; Animals; Calcium; | 2006 |
Postnatal development of carotid body glomus cell response to hypoxia.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Calcium; Carotid Body; Electric Capacitance; Elec | 2006 |
Voltage-gated K+ channels at an early stage of chronic hypoxia-induced pulmonary hypertension in newborn piglets.
Topics: 4-Aminopyridine; Animals; Arterioles; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; In V | 2006 |
4-Aminopyridine restores impaired hypoxic pulmonary vasoconstriction in endotoxemic mice.
Topics: 4-Aminopyridine; Algorithms; Angiotensin II; Animals; Body Weight; Dose-Response Relationship, Drug; | 2007 |
Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Arecoline; Atropine; Behavior, Animal; Cholinesterase Inhi | 1983 |
Presynaptic neurotransmitter and chemosensory responses to natural stimuli.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Atropine; Carbon Dioxide; Carotid Body; Cats; Chemorecepto | 1984 |
3,4-diaminopyridine alters acetylcholine metabolism and behavior during hypoxia.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Aminopyridines; Animals; Behavior, Animal; Brain; Cal | 1982 |
Angiotensin is not required for hypoxic constriction in salt solution-perfused rat lungs.
Topics: 4-Aminopyridine; Aminopyridines; Analysis of Variance; Angiotensin II; Animals; Hypoxia; Male; Perfu | 1984 |
Synaptosomal calcium metabolism during hypoxia and 3,4-diaminopyridine treatment.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calcium; Hypoxia; Male; Mice; Synaptosomes | 1984 |
The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons.
Topics: 4-Aminopyridine; Animals; Diabetic Neuropathies; Electric Stimulation; Hexoses; Hydrogen-Ion Concent | 1994 |
Effect of Na+ and K+ channel blockade on baseline and anoxia-induced catecholamine release from rat carotid body.
Topics: 4-Aminopyridine; Animals; Carotid Body; Catecholamines; Cesium; Electrophysiology; Hypoxia; Potassiu | 1994 |
Hyperglycaemic hypoxia alters after-potential and fast K+ conductance of rat axons by cytoplasmic acidification.
Topics: 4-Aminopyridine; Action Potentials; Animals; Axons; Bicarbonates; Cytoplasm; Ganglia, Spinal; Hydrog | 1993 |
Chronic hypoxia is associated with reduced delayed rectifier K+ current in rat pulmonary artery muscle cells.
Topics: 4-Aminopyridine; Animals; Chronic Disease; Electric Conductivity; Electrophysiology; Glyburide; Hypo | 1994 |
Opposite modulation of 4-aminopyridine and hypoxic hyperexcitability by A1 and A2 adenosine receptor ligands in rat hippocampal slices.
Topics: 4-Aminopyridine; Animals; Epilepsy; Hippocampus; Hypoxia; Purinergic P1 Receptor Antagonists; Rats; | 1995 |
Modulation of glomus cell membrane currents of intact rat carotid body.
Topics: 4-Aminopyridine; Animals; Carotid Body; Cell Membrane; Hypoxia; In Vitro Techniques; Membrane Potent | 1995 |
Role of potassium channels in hypoxic chemoreception in rat carotid body type-I cells.
Topics: 4-Aminopyridine; Action Potentials; Animals; Carotid Body; Charybdotoxin; Hypoxia; Ion Channel Gatin | 1996 |
A novel oxygen-sensitive potassium current in rat carotid body type I cells.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Calcium; Carotid Body; Cell Separation; Electrophysiolog | 1997 |
Effects of hypoxia on diaphragm relaxation rate during fatigue.
Topics: 4-Aminopyridine; Animals; Chloride Channels; Chlorides; Diaphragm; Electric Conductivity; Electric S | 1997 |
Suppression of glomus cell K+ conductance by 4-aminopyridine is not related to [Ca2+]i, dopamine release and chemosensory discharge from carotid body.
Topics: 4-Aminopyridine; Animals; Calcium; Carotid Body; Carotid Sinus; Cats; Chemoreceptor Cells; Dopamine; | 1998 |
Na+ channel block prevents the ischemia-induced release of norepinephrine from spinal cord slices.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Calcium; Calcium Channel Blockers; Cold Temperature; H | 1998 |
Potassium channels modulate hypoxic pulmonary vasoconstriction.
Topics: 4-Aminopyridine; Animals; Blood Pressure; Dogs; Female; Glyburide; Hypoxia; In Vitro Techniques; Mal | 1998 |
Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle.
Topics: 4-Aminopyridine; Animals; Delayed Rectifier Potassium Channels; Hypoxia; In Vitro Techniques; Ion Ch | 1998 |
Selective modulation of membrane currents by hypoxia in intact airway chemoreceptors from neonatal rabbit.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Cadmium; Calcium; Calcium Channels; Carotid Body; Catech | 1999 |
Functional effects of 4-aminopyridine (4-AP) on pulmonary and systemic vessels from normoxic control and hypoxic pulmonary hypertensive rats.
Topics: 4-Aminopyridine; Animals; Aorta; Arteries; Endothelin-1; Hypertension, Pulmonary; Hypoxia; In Vitro | 1999 |
Voltage-gated K(+)-channel activity in ovine pulmonary vasculature is developmentally regulated.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Cells, Cultured; Delayed Rectifier Potassium Chan | 2000 |
Voltage-gated potassium channels in human ductus arteriosus.
Topics: 4-Aminopyridine; Charybdotoxin; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, Pat | 2000 |
Sites and ionic mechanisms of hypoxic vasoconstriction in frog skin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-d | 2001 |
Effects of phosphodiesterase inhibitors on hypoxic pulmonary vasoconstriction. Influence of K(+) channels and nitric oxide.
Topics: 4-Aminopyridine; Animals; Apamin; Charybdotoxin; Dose-Response Relationship, Drug; Enzyme Inhibitors | 2001 |
Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5.
Topics: 3' Untranslated Regions; 4-Aminopyridine; 5' Untranslated Regions; Animals; Drug Resistance; Electri | 2001 |
Reversal of chronic hypoxia-induced alterations in pulmonary artery smooth muscle electromechanical coupling upon air breathing.
Topics: 4-Aminopyridine; Animals; Blood Pressure; Calcium; Cells, Cultured; Chronic Disease; Electrophysiolo | 2002 |
Ionic basis of membrane potential changes induced by anoxia in rat dorsal vagal motoneurones.
Topics: 4-Aminopyridine; Action Potentials; Animals; Apamin; Hypoxia; Ions; Male; Manganese; Membrane Potent | 1992 |
Ion channel involvement in hypoxia-induced spreading depression in hippocampal slices.
Topics: 4-Aminopyridine; Animals; Cortical Spreading Depression; Evoked Potentials; Female; Hippocampus; Hyp | 1991 |
Comparison of DuP 996, with physostigmine, THA and 3,4-DAP on hypoxia-induced amnesia in rats.
Topics: 4-Aminopyridine; Amnesia; Animals; Avoidance Learning; Hypoxia; Indoles; Male; Oxygen Consumption; P | 1990 |
Hypoxic changes in hippocampal neurons.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Apamin; Caffeine; Calcium; Egtazic | 1989 |
Differential alteration of dopamine, acetylcholine, and glutamate release during anoxia and/or 3,4-diaminopyridine treatment.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Aminopyridines; Animals; Calcium; Corpus Striatum; Do | 1987 |