4-aminopyridine has been researched along with Hypertension in 18 studies
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Diminished PAME release and its vasorelaxing activity and increased release of angiotensin II in the PVAT suggest a noble role of PVAT in pathogenesis of hypertension." | 7.77 | Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension. ( Chang, HH; Chen, MF; Chen, PY; Chiang, CL; Kuo, JS; Lee, TJ; Lee, YC; Liu, CH; Yeh, JI, 2011) |
| " Diminished PAME release and its vasorelaxing activity and increased release of angiotensin II in the PVAT suggest a noble role of PVAT in pathogenesis of hypertension." | 3.77 | Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension. ( Chang, HH; Chen, MF; Chen, PY; Chiang, CL; Kuo, JS; Lee, TJ; Lee, YC; Liu, CH; Yeh, JI, 2011) |
| "This study was designed to investigate involvement of potassium channels in the action of nitric oxide facilitating reduction of basal tone by thromboxane A2/prostaglandin H2 receptor blockade with ifetroban in rings of thoracic aorta taken from rats with aortic coarctation-induced hypertension." | 3.70 | Involvement of nitric oxide and potassium channels in the reduction of basal tone produced by blockade of thromboxane A2/prostaglandin H2 receptors in aortic rings of hypertensive rats. ( DelliPizzi, A; Nasjletti, A, 1998) |
| " We tested the effects of inhibitors of calcium-dependent K(+) channels [iberiotoxin (50 nM) and tetraethylammonium (TEA, 1 mM)] on changes in arteriolar diameter during acute hypertension." | 3.70 | Potassium channels modulate cerebral autoregulation during acute hypertension. ( Faraci, FM; Heistad, DD; Paternò, R, 2000) |
| "Nitroxyl anion (HNO) has recently become an emerging candidate in vascular regulation." | 1.46 | Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice. ( Labazi, H; Tostes, RC; Webb, RC; Wynne, BM, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (50.00) | 18.2507 |
| 2000's | 7 (38.89) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wynne, BM | 1 |
| Labazi, H | 1 |
| Tostes, RC | 1 |
| Webb, RC | 2 |
| Gálvez-Prieto, B | 1 |
| Dubrovska, G | 2 |
| Cano, MV | 1 |
| Delgado, M | 1 |
| Aranguez, I | 2 |
| González, MC | 2 |
| Ruiz-Gayo, M | 1 |
| Gollasch, M | 2 |
| Fernández-Alfonso, MS | 1 |
| Badruddin, A | 1 |
| Menon, RS | 1 |
| Reder, AT | 1 |
| Lee, YC | 1 |
| Chang, HH | 1 |
| Chiang, CL | 1 |
| Liu, CH | 1 |
| Yeh, JI | 1 |
| Chen, MF | 1 |
| Chen, PY | 1 |
| Kuo, JS | 1 |
| Lee, TJ | 1 |
| Sadanaga, T | 1 |
| Ohya, Y | 1 |
| Ohtsubo, T | 1 |
| Goto, K | 1 |
| Fujii, K | 1 |
| Abe, I | 1 |
| Berg, T | 1 |
| Kubo, T | 1 |
| Hagiwara, Y | 1 |
| Gálvez, B | 1 |
| de Castro, J | 1 |
| Herold, D | 1 |
| Arribas, S | 1 |
| Luft, FC | 1 |
| Ramos, MP | 1 |
| Fernández Alfonso, MS | 1 |
| Chapleau, MW | 1 |
| Abboud, FM | 1 |
| Hendriks, MG | 1 |
| Pfaffendorf, M | 1 |
| van Zwieten, PA | 1 |
| Takemoto, T | 1 |
| Eda, M | 1 |
| Okada, T | 1 |
| Sakashita, H | 1 |
| Matzno, S | 1 |
| Gohda, M | 1 |
| Ebisu, H | 1 |
| Nakamura, N | 1 |
| Fukaya, C | 1 |
| Hihara, M | 1 |
| Kolias, TJ | 1 |
| Chai, S | 1 |
| Cox, RH | 1 |
| Hohage, H | 1 |
| Hess, K | 1 |
| Jahl, C | 1 |
| Greven, J | 1 |
| Schlatter, E | 1 |
| DelliPizzi, A | 1 |
| Nasjletti, A | 1 |
| Nand, V | 1 |
| Doggrell, SA | 1 |
| Honda, H | 1 |
| Unemoto, T | 1 |
| Kogo, H | 1 |
| Paternò, R | 1 |
| Heistad, DD | 1 |
| Faraci, FM | 1 |
1 review available for 4-aminopyridine and Hypertension
| Article | Year |
|---|---|
Modulation of baroreceptor activity by ionic and paracrine mechanisms: an overview.
Topics: 4-Aminopyridine; Animals; Arteriosclerosis; Blood Pressure; Carotid Sinus; Endothelium, Vascular; Hu | 1994 |
17 other studies available for 4-aminopyridine and Hypertension
| Article | Year |
|---|---|
Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice.
Topics: 4-Aminopyridine; Acetylcholine; Angiotensin II; Animals; Disease Models, Animal; Hypertension; Male; | 2017 |
A reduction in the amount and anti-contractile effect of periadventitial mesenteric adipose tissue precedes hypertension development in spontaneously hypertensive rats.
Topics: 4-Aminopyridine; Adipose Tissue; Animals; Hypertension; Male; Mesenteric Arteries; Nitric Oxide; Nor | 2008 |
4-Aminopyridine toxicity mimics autoimmune-mediated limbic encephalitis.
Topics: 4-Aminopyridine; Diagnosis, Differential; Diagnostic Errors; Drug Overdose; Echocardiography; Electr | 2009 |
Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension.
Topics: 4-Aminopyridine; Adipocytes; Adipose Tissue; Angiotensin II; Animals; Aorta; Calcium; Cells, Culture | 2011 |
Decreased 4-aminopyridine sensitive K+ currents in endothelial cells from hypertensive rats.
Topics: 4-Aminopyridine; Animals; Aorta; Apamin; Charybdotoxin; Drug Combinations; Endothelium, Vascular; Ge | 2002 |
The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats.
Topics: 4-Aminopyridine; Adrenalectomy; Adrenergic Antagonists; Amifampridine; Angiotensin Receptor Antagoni | 2003 |
Protein kinase C activation-induced increases of neural activity are enhanced in the hypothalamus of spontaneously hypertensive rats.
Topics: 4-Aminopyridine; Action Potentials; Angiotensin II; Animals; Dose-Response Relationship, Drug; Enzym | 2005 |
Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats.
Topics: 4-Aminopyridine; Adipocytes; Adipose Tissue; Animals; Blood Vessels; Cell Size; Hypertension; In Vit | 2006 |
The role of nitric oxide and potassium channels in endothelium-dependent vasodilation in SHR.
Topics: 4-Aminopyridine; Animals; Arginine; Biological Factors; Endothelium, Vascular; Hypertension; In Vitr | 1993 |
Novel potassium channel openers: synthesis and pharmacological evaluation of new N-(substituted-3-pyridyl)-N'-alkylthioureas and related compounds.
Topics: 4-Aminopyridine; Amifampridine; Animals; Antihypertensive Agents; Biomechanical Phenomena; Glyburide | 1994 |
Potassium channel antagonists and vascular reactivity in stroke-prone spontaneously hypertensive rats.
Topics: 4-Aminopyridine; Amifampridine; Animals; Apamin; Barium; Cardiovascular System; Carotid Arteries; Ce | 1993 |
Comparison of K+ channel properties in freshly isolated myocytes from thoracic aorta of WKY and SHR.
Topics: 4-Aminopyridine; Animals; Aorta, Thoracic; Hypertension; In Vitro Techniques; Male; Muscle Fibers, S | 1996 |
Renal and blood pressure effects of moxonidine and clonidine in spontaneously hypertensive rats.
Topics: 4-Aminopyridine; Adrenergic alpha-Antagonists; Aminoacridines; Angiotensin Receptor Antagonists; Ani | 1997 |
Involvement of nitric oxide and potassium channels in the reduction of basal tone produced by blockade of thromboxane A2/prostaglandin H2 receptors in aortic rings of hypertensive rats.
Topics: 4-Aminopyridine; Animals; Aorta; Basal Metabolism; Bridged Bicyclo Compounds, Heterocyclic; Hyperten | 1998 |
Effects of tetraethylammonium, 4-aminopyridine and bretylium on cardiovascular tissues from normo- and hypertensive rats.
Topics: 4-Aminopyridine; Action Potentials; Animals; Arteries; Bretylium Compounds; Cardiovascular System; H | 1999 |
Different mechanisms for testosterone-induced relaxation of aorta between normotensive and spontaneously hypertensive rats.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Aorta, Thoracic; Cyclooxygenase Inhibitors; Dose-Response R | 1999 |
Potassium channels modulate cerebral autoregulation during acute hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Acute Disease; | 2000 |