4-aminopyridine has been researched along with Epilepsy, Temporal Lobe in 24 studies
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study we used the pilocarpine-induced status epilepticus model of TLE (i." | 3.91 | Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy. ( Derera, ID; Smith, BN; Smith, KC, 2019) |
| "Limbic seizures can be mimicked in vitro using preparations of combined hippocampus-entorhinal cortex slices perfused with artificial cerebrospinal fluid containing convulsants or nominally zero Mg(2+), in order to produce epileptiform synchronization." | 2.41 | Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. ( Avoli, M; Biagini, G; D'Antuono, M; D'Arcangelo, G; Köhling, R; Louvel, J; Pumain, R; Tancredi, V, 2002) |
| "To investigate the abortion of seizure generation using "minimal" intervention in hippocampi using two rat models of human temporal lobe epilepsy." | 1.42 | Rapid brief feedback intracerebral stimulation based on real-time desynchronization detection preceding seizures stops the generation of convulsive paroxysms. ( Genov, R; Kassiri, H; Perez Velazquez, JL; Salam, MT, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Scalmani, P | 1 |
| Paterra, R | 1 |
| Mantegazza, M | 1 |
| Avoli, M | 11 |
| de Curtis, M | 1 |
| Kong, S | 1 |
| Chen, TX | 1 |
| Jia, XL | 1 |
| Cheng, XL | 1 |
| Zeng, ML | 1 |
| Liang, JY | 1 |
| He, XH | 1 |
| Yin, J | 1 |
| Han, S | 1 |
| Liu, WH | 1 |
| Fan, YT | 1 |
| Zhou, T | 1 |
| Liu, YM | 1 |
| Peng, BW | 1 |
| Derera, ID | 1 |
| Smith, KC | 1 |
| Smith, BN | 1 |
| Lévesque, M | 1 |
| Salami, P | 1 |
| Behr, C | 1 |
| Tang, Y | 1 |
| Durand, DM | 2 |
| Grosser, S | 1 |
| Queenan, BN | 1 |
| Lalchandani, RR | 1 |
| Vicini, S | 1 |
| Salam, MT | 1 |
| Kassiri, H | 1 |
| Genov, R | 1 |
| Perez Velazquez, JL | 1 |
| Ahn, S | 1 |
| Jun, SB | 1 |
| Lee, HW | 1 |
| Lee, S | 1 |
| Panuccio, G | 1 |
| D'Antuono, M | 5 |
| de Guzman, P | 1 |
| De Lannoy, L | 1 |
| Biagini, G | 3 |
| Jung, S | 1 |
| Yang, H | 1 |
| Kim, BS | 1 |
| Chu, K | 1 |
| Lee, SK | 1 |
| Jeon, D | 1 |
| Toprani, S | 1 |
| Moe, MC | 1 |
| Berg-Johnsen, J | 2 |
| Larsen, GA | 1 |
| Røste, GK | 2 |
| Vinje, ML | 2 |
| Louvel, J | 3 |
| Köhling, R | 2 |
| Pumain, R | 3 |
| D'Arcangelo, G | 3 |
| Tancredi, V | 3 |
| Niittykoski, M | 1 |
| Nissinen, J | 1 |
| Penttonen, M | 1 |
| Pitkänen, A | 1 |
| Mattia, D | 2 |
| Bernasconi, A | 2 |
| Olivier, A | 3 |
| Turak, B | 2 |
| Devaux, A | 1 |
| Bernard, C | 1 |
| Anderson, A | 1 |
| Becker, A | 1 |
| Poolos, NP | 1 |
| Beck, H | 1 |
| Johnston, D | 1 |
| Gigout, S | 1 |
| Kawasaki, H | 1 |
| Armand, V | 1 |
| Kurcewicz, I | 1 |
| Laschet, J | 1 |
| Devaux, B | 1 |
| Sudbury, JR | 1 |
| Barbarosie, M | 2 |
| Valø, ET | 1 |
| Hwa, GG | 1 |
| Ohno, K | 1 |
| Higashima, M | 1 |
| Benini, R | 1 |
1 review available for 4-aminopyridine and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Electric Stimulation; Electrophysiology; Entorhinal Cor | 2002 |
1 trial available for 4-aminopyridine and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Sevoflurane reduces synaptic glutamate release in human synaptosomes.
Topics: 4-Aminopyridine; Adult; Anesthetics, Inhalation; Calcium; Cytosol; Epilepsy, Temporal Lobe; Glutamic | 2002 |
22 other studies available for 4-aminopyridine and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal Cortex
Topics: 4-Aminopyridine; Action Potentials; Animals; Entorhinal Cortex; Epilepsy, Temporal Lobe; Interneuron | 2023 |
Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.
Topics: 4-Aminopyridine; Animals; Astrocytes; Brain; Central Nervous System; Epilepsy; Epilepsy, Temporal Lo | 2023 |
Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Brugada Syndrome; Disease Models, Animal; Epilepsy, Tem | 2019 |
Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats.
Topics: 4-Aminopyridine; Animals; Behavior, Animal; CA3 Region, Hippocampal; Electrodes, Implanted; Electroe | 2013 |
A novel electrical stimulation paradigm for the suppression of epileptiform activity in an in vivo model of mesial temporal lobe status epilepticus.
Topics: 4-Aminopyridine; Animals; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy, Tempor | 2012 |
Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Epilepsy, Temporal Lobe; gamma-Aminobutyric Ac | 2014 |
Rapid brief feedback intracerebral stimulation based on real-time desynchronization detection preceding seizures stops the generation of convulsive paroxysms.
Topics: 4-Aminopyridine; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electric Stimulation; Ele | 2015 |
Computational modeling of epileptiform activities in medial temporal lobe epilepsy combined with in vitro experiments.
Topics: 4-Aminopyridine; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; In Vitro | 2016 |
In vitro ictogenesis and parahippocampal networks in a rodent model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Amygdala; Animals; Disease Models, Animal; Electrophysiology; Ep | 2010 |
The immunosuppressant cyclosporin A inhibits recurrent seizures in an experimental model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Animals; Cyclosporine; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus | 2012 |
Fiber tract stimulation can reduce epileptiform activity in an in-vitro bilateral hippocampal slice preparation.
Topics: 4-Aminopyridine; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Electric Stimulation The | 2013 |
Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats.
Topics: 4-Aminopyridine; Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Electroencephalogr | 2004 |
GABAA receptor-dependent synchronization leads to ictogenesis in the human dysplastic cortex.
Topics: 4-Aminopyridine; Adolescent; Adult; Analysis of Variance; Baclofen; Child; Electrophysiology; Epilep | 2004 |
Acquired dendritic channelopathy in temporal lobe epilepsy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Action Potentials; Animals; Butadien | 2004 |
Effects of gap junction blockers on human neocortical synchronization.
Topics: 4-Aminopyridine; Adolescent; Adult; Aged; Brain Diseases; Carbenoxolone; Child; Cortical Synchroniza | 2006 |
Epileptiform synchronization in the rat insular and perirhinal cortices in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cerebral Cortex; Cortical Synchronization; Epilepsy, Te | 2007 |
CA3-driven hippocampal-entorhinal loop controls rather than sustains in vitro limbic seizures.
Topics: 4-Aminopyridine; Action Potentials; Animals; Convulsants; Dentate Gyrus; Electric Stimulation; Entor | 1997 |
Measured increase in intracellular Ca(2+) during stimulated release of endogenous glutamate from human cerebrocortical synaptosomes.
Topics: 4-Aminopyridine; Animals; Calcium; Cerebral Cortex; Cytosol; Epilepsy, Temporal Lobe; Glutamic Acid; | 1999 |
Epileptiform discharges in the human dysplastic neocortex: in vitro physiology and pharmacology.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; Anticonvulsants; Cerebral | 1999 |
Intrinsic optical signals and electrographic seizures in the rat limbic system.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Axotomy; Electric Stimulation; Electro | 2001 |
Effects of antiepileptic drugs on afterdischarge generation in rat hippocampal slices.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Bicuculline; Carbamazepine; Dose-Respo | 2002 |
Limbic network interactions leading to hyperexcitability in a model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippoc | 2002 |