4-aminopyridine has been researched along with Brain Ischemia in 5 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 mg D-ER, 10 mg D-ER, or placebo, dosed twice-daily for 12 weeks." | 2.94 | A double-blind, randomized, controlled study of two dose strengths of dalfampridine extended release on walking deficits in ischemic stroke. ( Bockbrader, M; El-Feky, WH; Finklestein, SP; Goldstein, M; Kasner, SE; Ning, M; Page, SJ; Roberts, H; Wilson, CA, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Page, SJ | 1 |
| Kasner, SE | 1 |
| Bockbrader, M | 1 |
| Goldstein, M | 1 |
| Finklestein, SP | 1 |
| Ning, M | 1 |
| El-Feky, WH | 1 |
| Wilson, CA | 1 |
| Roberts, H | 1 |
| Takagi, H | 1 |
| Kodama, K | 1 |
| Saito, M | 1 |
| Suzuki, H | 1 |
| Bancila, V | 1 |
| Nikonenko, I | 1 |
| Dunant, Y | 1 |
| Bloc, A | 1 |
| Sperlágh, B | 1 |
| Zsilla, G | 1 |
| Vizi, ES | 1 |
| Schaeffer, P | 1 |
| Lazdunski, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| This is a Multi-center, Double-blind, Three Arm, Parallel Group, Placebo-controlled, Randomized Study Designed to Evaluate the Efficacy, Safety and Tolerability of Dalfampridine.[NCT02271217] | Phase 3 | 377 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Walk-12 is a 12-question questionnaire that asks subjects to rate limitations of their mobility during the preceding two weeks on a 5-point scale (from 1= not at all to 5=extremely). For each visit, the Walk-12 score will be calculated by summing the 12 components and transforming into a scale with a range of 0 to 100. A higher score indicates a greater degree of limitation in walking. A negative change indicates an improvement in walking. 0 = no limitation in mobility to 100 extreme limitation in mobility.~Walk-12 Score = 100 * [(Mean of the 12 items) - 1]/(5-1)" (NCT02271217)
Timeframe: Baseline, week 12
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 45.40 |
| Dalfampridine-ER 7.5 mg | 48.34 |
| Dalfampridine-ER 10mg | 49.26 |
"The 2MinWT measures the distance a subject can walk in 2 minutes. Participants showing at Least a 20% Improvement on the 2MinWT at 12-weeks are considered Responders." (NCT02271217)
Timeframe: Week 12
| Intervention | participants (Number) | ||
|---|---|---|---|
| Responder | Non-Responder | Missing | |
| Dalfampridine-ER 10mg | 23 | 90 | 8 |
| Dalfampridine-ER 7.5 mg | 17 | 96 | 8 |
| Placebo | 17 | 97 | 12 |
1 trial available for 4-aminopyridine and Brain Ischemia
| Article | Year |
|---|---|
A double-blind, randomized, controlled study of two dose strengths of dalfampridine extended release on walking deficits in ischemic stroke.
Topics: 4-Aminopyridine; Adult; Brain Ischemia; Delayed-Action Preparations; Double-Blind Method; Humans; Is | 2020 |
4 other studies available for 4-aminopyridine and Brain Ischemia
| Article | Year |
|---|---|
Presynaptic K+ channel modulation is a crucial ionic basis of neuronal damage induced by ischemia in rat hippocampal CA1 pyramidal neurons.
Topics: 4-Aminopyridine; Animals; Brain Ischemia; Excitatory Postsynaptic Potentials; Hippocampus; Potassium | 2003 |
Zinc inhibits glutamate release via activation of pre-synaptic K channels and reduces ischaemic damage in rat hippocampus.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Brain Ischemia; Chelating Agents; Chlorocebus aethiops; | 2004 |
K(ATP) channel blockers selectively interact with A(1)-adenosine receptor mediated modulation of acetylcholine release in the rat hippocampus.
Topics: 4-Aminopyridine; Acetylcholine; Adenosine; Animals; ATP-Binding Cassette Transporters; Binding, Comp | 2001 |
K+ efflux pathways and neurotransmitter release associated to hippocampal ischemia: effects of glucose and of K+ channel blockers.
Topics: 4-Aminopyridine; Animals; Apamin; Aspartic Acid; Barium; Barium Compounds; Brain Ischemia; Calcium C | 1991 |