Compounds > 4-aminopyridine
Page last updated: 2024-10-21

4-aminopyridine and Benign Psychomotor Epilepsy, Childhood

4-aminopyridine has been researched along with Benign Psychomotor Epilepsy, Childhood in 24 studies

Research Excerpts

ExcerptRelevanceReference
" In this study we used the pilocarpine-induced status epilepticus model of TLE (i."3.91Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy. ( Derera, ID; Smith, BN; Smith, KC, 2019)
"Limbic seizures can be mimicked in vitro using preparations of combined hippocampus-entorhinal cortex slices perfused with artificial cerebrospinal fluid containing convulsants or nominally zero Mg(2+), in order to produce epileptiform synchronization."2.41Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. ( Avoli, M; Biagini, G; D'Antuono, M; D'Arcangelo, G; Köhling, R; Louvel, J; Pumain, R; Tancredi, V, 2002)
"To investigate the abortion of seizure generation using "minimal" intervention in hippocampi using two rat models of human temporal lobe epilepsy."1.42Rapid brief feedback intracerebral stimulation based on real-time desynchronization detection preceding seizures stops the generation of convulsive paroxysms. ( Genov, R; Kassiri, H; Perez Velazquez, JL; Salam, MT, 2015)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (12.50)18.2507
2000's10 (41.67)29.6817
2010's9 (37.50)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Scalmani, P1
Paterra, R1
Mantegazza, M1
Avoli, M11
de Curtis, M1
Kong, S1
Chen, TX1
Jia, XL1
Cheng, XL1
Zeng, ML1
Liang, JY1
He, XH1
Yin, J1
Han, S1
Liu, WH1
Fan, YT1
Zhou, T1
Liu, YM1
Peng, BW1
Derera, ID1
Smith, KC1
Smith, BN1
Lévesque, M1
Salami, P1
Behr, C1
Tang, Y1
Durand, DM2
Grosser, S1
Queenan, BN1
Lalchandani, RR1
Vicini, S1
Salam, MT1
Kassiri, H1
Genov, R1
Perez Velazquez, JL1
Ahn, S1
Jun, SB1
Lee, HW1
Lee, S1
Panuccio, G1
D'Antuono, M5
de Guzman, P1
De Lannoy, L1
Biagini, G3
Jung, S1
Yang, H1
Kim, BS1
Chu, K1
Lee, SK1
Jeon, D1
Toprani, S1
Moe, MC1
Berg-Johnsen, J2
Larsen, GA1
Røste, GK2
Vinje, ML2
Louvel, J3
Köhling, R2
Pumain, R3
D'Arcangelo, G3
Tancredi, V3
Niittykoski, M1
Nissinen, J1
Penttonen, M1
Pitkänen, A1
Mattia, D2
Bernasconi, A2
Olivier, A3
Turak, B2
Devaux, A1
Bernard, C1
Anderson, A1
Becker, A1
Poolos, NP1
Beck, H1
Johnston, D1
Gigout, S1
Kawasaki, H1
Armand, V1
Kurcewicz, I1
Laschet, J1
Devaux, B1
Sudbury, JR1
Barbarosie, M2
Valø, ET1
Hwa, GG1
Ohno, K1
Higashima, M1
Benini, R1

Reviews

1 review available for 4-aminopyridine and Benign Psychomotor Epilepsy, Childhood

ArticleYear
Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro.
    Progress in neurobiology, 2002, Volume: 68, Issue:3

    Topics: 4-Aminopyridine; Action Potentials; Animals; Electric Stimulation; Electrophysiology; Entorhinal Cor

2002

Trials

1 trial available for 4-aminopyridine and Benign Psychomotor Epilepsy, Childhood

ArticleYear
Sevoflurane reduces synaptic glutamate release in human synaptosomes.
    Journal of neurosurgical anesthesiology, 2002, Volume: 14, Issue:3

    Topics: 4-Aminopyridine; Adult; Anesthetics, Inhalation; Calcium; Cytosol; Epilepsy, Temporal Lobe; Glutamic

2002

Other Studies

22 other studies available for 4-aminopyridine and Benign Psychomotor Epilepsy, Childhood

ArticleYear
Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal Cortex
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023, 03-15, Volume: 43, Issue:11

    Topics: 4-Aminopyridine; Action Potentials; Animals; Entorhinal Cortex; Epilepsy, Temporal Lobe; Interneuron

2023
Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.
    Journal of neuroinflammation, 2023, Oct-25, Volume: 20, Issue:1

    Topics: 4-Aminopyridine; Animals; Astrocytes; Brain; Central Nervous System; Epilepsy; Epilepsy, Temporal Lo

2023
Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy.
    Journal of neurophysiology, 2019, 01-01, Volume: 121, Issue:1

    Topics: 4-Aminopyridine; Action Potentials; Animals; Brugada Syndrome; Disease Models, Animal; Epilepsy, Tem

2019
Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats.
    Epilepsia, 2013, Volume: 54, Issue:4

    Topics: 4-Aminopyridine; Animals; Behavior, Animal; CA3 Region, Hippocampal; Electrodes, Implanted; Electroe

2013
A novel electrical stimulation paradigm for the suppression of epileptiform activity in an in vivo model of mesial temporal lobe status epilepticus.
    International journal of neural systems, 2012, Volume: 22, Issue:3

    Topics: 4-Aminopyridine; Animals; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy, Tempor

2012
Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Epilepsy, Temporal Lobe; gamma-Aminobutyric Ac

2014
Rapid brief feedback intracerebral stimulation based on real-time desynchronization detection preceding seizures stops the generation of convulsive paroxysms.
    Epilepsia, 2015, Volume: 56, Issue:8

    Topics: 4-Aminopyridine; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electric Stimulation; Ele

2015
Computational modeling of epileptiform activities in medial temporal lobe epilepsy combined with in vitro experiments.
    Journal of computational neuroscience, 2016, Volume: 41, Issue:2

    Topics: 4-Aminopyridine; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; In Vitro

2016
In vitro ictogenesis and parahippocampal networks in a rodent model of temporal lobe epilepsy.
    Neurobiology of disease, 2010, Volume: 39, Issue:3

    Topics: 4-Aminopyridine; Action Potentials; Amygdala; Animals; Disease Models, Animal; Electrophysiology; Ep

2010
The immunosuppressant cyclosporin A inhibits recurrent seizures in an experimental model of temporal lobe epilepsy.
    Neuroscience letters, 2012, Nov-07, Volume: 529, Issue:2

    Topics: 4-Aminopyridine; Animals; Cyclosporine; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus

2012
Fiber tract stimulation can reduce epileptiform activity in an in-vitro bilateral hippocampal slice preparation.
    Experimental neurology, 2013, Volume: 240

    Topics: 4-Aminopyridine; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Electric Stimulation The

2013
Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats.
    Neuroscience, 2004, Volume: 124, Issue:2

    Topics: 4-Aminopyridine; Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Electroencephalogr

2004
GABAA receptor-dependent synchronization leads to ictogenesis in the human dysplastic cortex.
    Brain : a journal of neurology, 2004, Volume: 127, Issue:Pt 7

    Topics: 4-Aminopyridine; Adolescent; Adult; Analysis of Variance; Baclofen; Child; Electrophysiology; Epilep

2004
Acquired dendritic channelopathy in temporal lobe epilepsy.
    Science (New York, N.Y.), 2004, Jul-23, Volume: 305, Issue:5683

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Action Potentials; Animals; Butadien

2004
Effects of gap junction blockers on human neocortical synchronization.
    Neurobiology of disease, 2006, Volume: 22, Issue:3

    Topics: 4-Aminopyridine; Adolescent; Adult; Aged; Brain Diseases; Carbenoxolone; Child; Cortical Synchroniza

2006
Epileptiform synchronization in the rat insular and perirhinal cortices in vitro.
    The European journal of neuroscience, 2007, Volume: 26, Issue:12

    Topics: 4-Aminopyridine; Action Potentials; Animals; Cerebral Cortex; Cortical Synchronization; Epilepsy, Te

2007
CA3-driven hippocampal-entorhinal loop controls rather than sustains in vitro limbic seizures.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Dec-01, Volume: 17, Issue:23

    Topics: 4-Aminopyridine; Action Potentials; Animals; Convulsants; Dentate Gyrus; Electric Stimulation; Entor

1997
Measured increase in intracellular Ca(2+) during stimulated release of endogenous glutamate from human cerebrocortical synaptosomes.
    Brain research, 1999, Oct-02, Volume: 843, Issue:1-2

    Topics: 4-Aminopyridine; Animals; Calcium; Cerebral Cortex; Cytosol; Epilepsy, Temporal Lobe; Glutamic Acid;

1999
Epileptiform discharges in the human dysplastic neocortex: in vitro physiology and pharmacology.
    Annals of neurology, 1999, Volume: 46, Issue:6

    Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; Anticonvulsants; Cerebral

1999
Intrinsic optical signals and electrographic seizures in the rat limbic system.
    Neurobiology of disease, 2001, Volume: 8, Issue:6

    Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Axotomy; Electric Stimulation; Electro

2001
Effects of antiepileptic drugs on afterdischarge generation in rat hippocampal slices.
    Brain research, 2002, Jan-04, Volume: 924, Issue:1

    Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Bicuculline; Carbamazepine; Dose-Respo

2002
Limbic network interactions leading to hyperexcitability in a model of temporal lobe epilepsy.
    Journal of neurophysiology, 2002, Volume: 87, Issue:1

    Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippoc

2002