4-aminopyridine has been researched along with Aging in 54 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Local application of 4-aminopyridine (4-AP) into the CA1 region was used to induce focal motor seizures in different animal age groups representing young, late-middle aged and elderly humans." | 3.80 | Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure. ( Bensalem-Owen, M; Davis, VA; Deel, ME; Gerhardt, GA; Huettl, P; Pomerleau, F; Slevin, J; Stephens, ML; Williamson, A, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (11.11) | 18.7374 |
| 1990's | 23 (42.59) | 18.2507 |
| 2000's | 19 (35.19) | 29.6817 |
| 2010's | 5 (9.26) | 24.3611 |
| 2020's | 1 (1.85) | 2.80 |
| Authors | Studies |
|---|---|
| Holmuhamedov, EL | 1 |
| Chakraborty, P | 1 |
| Oberlin, A | 1 |
| Liu, X | 1 |
| Yousufuddin, M | 1 |
| Shen, WK | 1 |
| Terzic, A | 1 |
| Jahangir, A | 1 |
| Fu, YC | 1 |
| Chen, R | 1 |
| Chen, MY | 1 |
| Chen, Y | 1 |
| Wang, YL | 1 |
| Xu, B | 1 |
| Yang, J | 1 |
| Yin, T | 1 |
| Li, Y | 1 |
| Stephens, ML | 1 |
| Williamson, A | 1 |
| Deel, ME | 1 |
| Bensalem-Owen, M | 1 |
| Davis, VA | 1 |
| Slevin, J | 1 |
| Pomerleau, F | 1 |
| Huettl, P | 1 |
| Gerhardt, GA | 1 |
| Li, GQ | 1 |
| Meredith, FL | 1 |
| Rennie, KJ | 1 |
| Porto, NP | 1 |
| Jucá, DM | 1 |
| Lahlou, S | 1 |
| Coelho-de-Souza, AN | 1 |
| Duarte, GP | 1 |
| Magalhães, PJ | 1 |
| Boido, D | 1 |
| Farisello, P | 1 |
| Cesca, F | 1 |
| Ferrea, E | 1 |
| Valtorta, F | 1 |
| Benfenati, F | 1 |
| Baldelli, P | 1 |
| Verbny, Y | 1 |
| Zhang, CL | 1 |
| Chiu, SY | 1 |
| Schweizer, T | 2 |
| Birthelmer, A | 2 |
| Lazaris, A | 2 |
| Cassel, JC | 2 |
| Jackisch, R | 2 |
| Sharp, PS | 1 |
| Dekkers, J | 1 |
| Dick, JR | 1 |
| Greensmith, L | 1 |
| Knörle, R | 1 |
| Gödtel-Armbrust, U | 1 |
| Förstermann, U | 1 |
| Cogolludo, A | 1 |
| Moreno, L | 1 |
| Lodi, F | 1 |
| Tamargo, J | 1 |
| Perez-Vizcaino, F | 1 |
| Wasicko, MJ | 1 |
| Breitwieser, GE | 1 |
| Kim, I | 1 |
| Carroll, JL | 1 |
| Skov, J | 1 |
| Andreasen, M | 1 |
| Nedergaard, S | 1 |
| Hammack, SE | 1 |
| Mania, I | 1 |
| Rainnie, DG | 1 |
| Tang, ZG | 1 |
| Liang, CZ | 1 |
| Shen, B | 1 |
| Hao, ZY | 1 |
| Zhou, ZX | 1 |
| Fésüs, G | 1 |
| Dubrovska, G | 1 |
| Gorzelniak, K | 1 |
| Kluge, R | 1 |
| Huang, Y | 1 |
| Luft, FC | 1 |
| Gollasch, M | 1 |
| Peterson, C | 3 |
| Gibson, GE | 4 |
| Davis, HP | 1 |
| Idowu, A | 1 |
| Xiong, Z | 1 |
| Sperelakis, N | 1 |
| Noffsinger, A | 1 |
| Fenoglio-Preiser, C | 1 |
| McClellan, AD | 1 |
| McPherson, D | 1 |
| O'Donovan, MJ | 1 |
| Pacioretty, LM | 1 |
| Gilmour, RF | 1 |
| Yokel, RA | 1 |
| Allen, DD | 1 |
| Meyer, JJ | 1 |
| Gross, GJ | 1 |
| Burke, RP | 1 |
| Castle, NA | 1 |
| Sánchez-Prieto, J | 1 |
| Herrero, I | 1 |
| Miras-Portugal, MT | 1 |
| Mora, F | 1 |
| Wahler, GM | 1 |
| Dollinger, SJ | 1 |
| Smith, JM | 1 |
| Flemal, KL | 1 |
| Sánchez-Chapula, J | 1 |
| Elizalde, A | 1 |
| Navarro-Polanco, R | 1 |
| Barajas, H | 1 |
| Mansourati, J | 1 |
| Le Grand, B | 1 |
| Zhang, L | 2 |
| Valiante, TA | 1 |
| Carlen, PL | 2 |
| Konishi, T | 1 |
| Avoli, M | 2 |
| Louvel, J | 1 |
| Kurcewicz, I | 1 |
| Pumain, R | 1 |
| Barbarosie, M | 1 |
| Fiset, C | 1 |
| Clark, RB | 1 |
| Shimoni, Y | 1 |
| Giles, WR | 1 |
| Hibino, H | 1 |
| Horio, Y | 1 |
| Inanobe, A | 1 |
| Doi, K | 1 |
| Ito, M | 1 |
| Yamada, M | 1 |
| Gotow, T | 1 |
| Uchiyama, Y | 1 |
| Kawamura, M | 1 |
| Kubo, T | 1 |
| Kurachi, Y | 1 |
| van LUNTEREN, E | 1 |
| Moyer, M | 1 |
| Strata, F | 1 |
| Reiff, DF | 1 |
| Guenther, E | 1 |
| Wang, L | 1 |
| Swirp, S | 1 |
| Duff, H | 1 |
| Yang, Q | 1 |
| Kaji, R | 1 |
| Hirota, N | 1 |
| Kojima, Y | 1 |
| Takagi, T | 1 |
| Kohara, N | 1 |
| Kimura, J | 1 |
| Shibasaki, H | 1 |
| Bostock, H | 1 |
| Aomine, M | 1 |
| Yamato, T | 1 |
| Cornfield, DN | 1 |
| Saqueton, CB | 1 |
| Porter, VA | 1 |
| Herron, J | 1 |
| Resnik, E | 1 |
| Haddad, IY | 1 |
| Reeve, HL | 1 |
| Gomez, JP | 1 |
| Ghisdal, P | 1 |
| Morel, N | 1 |
| Wu, N | 1 |
| Hsiao, CF | 1 |
| Chandler, SH | 1 |
| Wu, LJ | 1 |
| Lu, Y | 1 |
| Xu, TL | 1 |
| Lohr, C | 1 |
| Oland, LA | 1 |
| Tolbert, LP | 1 |
| Farries, MA | 1 |
| Perkel, DJ | 1 |
| Gibbs, LM | 1 |
| Kendig, JJ | 1 |
| Okamoto, M | 1 |
| Walewski, JL | 1 |
| Artusio, JF | 1 |
| Riker, WF | 1 |
| Psarropoulou, C | 1 |
| Beck, H | 1 |
| Ficker, E | 1 |
| Heinemann, U | 1 |
| Spigelman, I | 1 |
| Osborne, NN | 1 |
| Broyden, NJ | 1 |
| Barnett, NL | 1 |
| Morris, NJ | 1 |
| Bowe, CM | 1 |
| Kocsis, JD | 1 |
| Waxman, SG | 1 |
| Hildebrand, C | 1 |
| Escande, D | 1 |
| Loisance, D | 1 |
| Planche, C | 1 |
| Coraboeuf, E | 1 |
| Nicholls, DG | 1 |
54 other studies available for 4-aminopyridine and Aging
| Article | Year |
|---|---|
Aging-associated susceptibility to stress-induced ventricular arrhythmogenesis is attenuated by tetrodotoxin.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Arrhythmias, Cardiac; Isoproterenol; Male; Myocy | 2022 |
[Age-related changes in transient outward potassium current of rat ventricular myocyte].
Topics: 4-Aminopyridine; Aging; Animals; Cells, Cultured; Heart Ventricles; Isoproterenol; Myocytes, Cardiac | 2013 |
Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure.
Topics: 4-Aminopyridine; Aging; Animals; Behavior, Animal; CA1 Region, Hippocampal; Glutamic Acid; Hippocamp | 2014 |
Development of K(+) and Na(+) conductances in rodent postnatal semicircular canal type I hair cells.
Topics: 4-Aminopyridine; Aging; Animals; Data Interpretation, Statistical; Electrophysiology; Gerbillinae; H | 2010 |
Effects of K+channels inhibitors on the cholinergic relaxation of the isolated aorta of adult offspring rats exposed to maternal diabetes.
Topics: 4-Aminopyridine; Acetylcholine; Aging; Animals; Aorta; Blood Glucose; Body Weight; Diabetes Mellitus | 2010 |
Cortico-hippocampal hyperexcitability in synapsin I/II/III knockout mice: age-dependency and response to the antiepileptic drug levetiracetam.
Topics: 4-Aminopyridine; Aging; Analysis of Variance; Animals; Anticonvulsants; Cerebral Cortex; Disease Mod | 2010 |
Coupling of calcium homeostasis to axonal sodium in axons of mouse optic nerve.
Topics: 4-Aminopyridine; Action Potentials; Adenosine; Aging; Animals; Animals, Newborn; Axons; Calcium; Car | 2002 |
3,4-DAP-evoked transmitter release in hippocampal slices of aged rats with impaired memory.
Topics: 4-Aminopyridine; Acetylcholine; Aging; Amifampridine; Animals; Female; Hippocampus; Maze Learning; M | 2003 |
Manipulating transmitter release at the neuromuscular junction of neonatal rats alters the expression of ChAT and GAP-43 in motoneurons.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Blotting, Western; Cell Survival; Choline O-Acety | 2003 |
Cognitive deficits in aged rats correlate with levels of L-arginine, not with nNOS expression or 3,4-DAP-evoked transmitter release in the frontoparietal cortex.
Topics: 4-Aminopyridine; Acetylcholine; Aging; Amifampridine; Animals; Arginine; Cerebral Cortex; Cognition | 2005 |
Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Aging; Amides; | 2005 |
Postnatal development of carotid body glomus cell response to hypoxia.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Calcium; Carotid Body; Electric Capacitance; Elec | 2006 |
Postnatal development of a new type of epileptiform activity in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; | 2006 |
Differential expression of intrinsic membrane currents in defined cell types of the anterolateral bed nucleus of the stria terminalis.
Topics: 4-Aminopyridine; Aging; Animals; Benzylamines; Dose-Response Relationship, Radiation; Electric Stimu | 2007 |
[Changes in potassium channel currents of prostate epithelial cell of old rats and significance thereof].
Topics: 4-Aminopyridine; Aging; Animals; Cells, Cultured; Epithelial Cells; Male; Membrane Potentials; Patch | 2007 |
Adiponectin is a novel humoral vasodilator.
Topics: 4-Aminopyridine; Adiponectin; Adipose Tissue; Aging; Animals; Aorta; Gene Expression; In Vitro Techn | 2007 |
Aging and 3,4-diaminopyridine alter synaptosomal calcium uptake.
Topics: 4-Aminopyridine; Aging; Aminopyridines; Animals; Biological Transport, Active; Brain; Calcium; Kinet | 1983 |
Improvement of 8-arm maze performance in aged Fischer 344 rats with 3,4-diaminopyridine.
Topics: 4-Aminopyridine; Aging; Amifampridine; Aminopyridines; Animals; Male; Memory, Short-Term; Rats | 1983 |
Amelioration of age-related neurochemical and behavioral deficits by 3,4-diaminopyridine.
Topics: 4-Aminopyridine; Acetylcholine; Aging; Amifampridine; Aminopyridines; Animals; Behavior, Animal; Mal | 1983 |
Potassium currents in rat colonic smooth muscle cells and changes during development and aging.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Calcium; Colon; Electrophysiology; Ion Channel Ga | 1995 |
Combined retrograde labeling and calcium imaging in spinal cord and brainstem neurons of the lamprey.
Topics: 4-Aminopyridine; Aging; Animals; Axonal Transport; Brain Stem; Cadmium; Calcium; Calcium Channel Blo | 1994 |
Developmental changes of action potential configuration and I(to) in canine epicardium.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Cells, Cultured; Dogs; Fetus; Heart; Patch-Clamp | 1995 |
Studies of aluminum neurobehavioral toxicity in the intact mammal.
Topics: 4-Aminopyridine; Acetylcholine; Aging; Aluminum; Alzheimer Disease; Animals; Blinking; Blood-Brain B | 1994 |
Characterisation of transient outward current in young human atrial myocytes.
Topics: 4-Aminopyridine; Action Potentials; Adolescent; Aging; Cells, Cultured; Child; Child, Preschool; Fem | 1995 |
Unchanged exocytotic release of glutamic acid in cortex and neostriatum of the rat during aging.
Topics: 4-Aminopyridine; Aging; Animals; Basal Ganglia; Cerebral Cortex; Corpus Striatum; Exocytosis; Glutam | 1994 |
Time course of postnatal changes in rat heart action potential and in transient outward current is different.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Animals, Newborn; Electric Conductivity; Heart; | 1994 |
Differences in outward currents between neonatal and adult rabbit ventricular cells.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Animals, Newborn; Electrophysiology; Heart; Hear | 1994 |
Transient outward current in young and adult diseased human atria.
Topics: 4-Aminopyridine; Adult; Aged; Aging; Atrial Function; Child; Child, Preschool; Electric Conductivity | 1993 |
Contribution of the low-threshold T-type calcium current in generating the post-spike depolarizing afterpotential in dentate granule neurons of immature rats.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels; Cultu | 1993 |
Developmental and activity-dependent changes in K+ currents in satellite glial cells in mouse superior cervical ganglion.
Topics: 4-Aminopyridine; Aging; Animals; Barium; Cells, Cultured; Ion Channel Gating; Membrane Potentials; M | 1996 |
Extracellular free potassium and calcium during synchronous activity induced by 4-aminopyridine in the juvenile rat hippocampus.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Analgesics; Animals; Calcium; Electrop | 1996 |
Shal-type channels contribute to the Ca2+-independent transient outward K+ current in rat ventricle.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Base Sequence; Cells, Cultured; Heart; Heart Vent | 1997 |
An ATP-dependent inwardly rectifying potassium channel, KAB-2 (Kir4. 1), in cochlear stria vascularis of inner ear: its specific subcellular localization and correlation with the formation of endocochlear potential.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Barium; Cochlear Duct; Deafness; DNA Primers; En | 1997 |
Electrophysiologic and inotropic effects of K+-channel blockade in aged diaphragm.
Topics: 4-Aminopyridine; Action Potentials; Adenosine Triphosphate; Aging; Amifampridine; Analysis of Varian | 1998 |
Intrinsic oscillations in CA3 hippocampal pyramids: physiological relevance to theta rhythm generation.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Calcium; Calcium Channels; Carbachol; Cesium; Hip | 1998 |
Developmental changes in voltage-activated potassium currents of rat retinal ganglion cells.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Calcium; Electric Conductivity; Electrophysiology | 1999 |
Age-dependent response of the electrocardiogram to K(+) channel blockers in mice.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cation Transport Proteins | 2000 |
Effect of maturation on nerve excitability in an experimental model of threshold electrotonus.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Cesium; Chlorides; Electric Stimulation; Electro | 2000 |
Electrophysiological properties of ventricular muscle obtained from spontaneously diabetic mice.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Blood Glucose; Calcium Channel Blockers; Calcium | 2000 |
Voltage-gated K(+)-channel activity in ovine pulmonary vasculature is developmentally regulated.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Cells, Cultured; Delayed Rectifier Potassium Chan | 2000 |
Changes of the potassium currents in rat aortic smooth muscle cells during postnatal development.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Membrane resonance and subthreshold membrane oscillations in mesencephalic V neurons: participants in burst generation.
Topics: 4-Aminopyridine; Aging; Animals; Biological Clocks; Cell Membrane; In Vitro Techniques; Membrane Pot | 2001 |
A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons.
Topics: 4-Aminopyridine; Aging; Animals; Cell Culture Techniques; Cell Membrane; Cell Separation; Cell Size; | 2001 |
Olfactory receptor axons influence the development of glial potassium currents in the antennal lobe of the moth Manduca sexta.
Topics: 4-Aminopyridine; Aging; Animals; Axons; Cell Communication; Ganglia, Invertebrate; Isoquinolines; Ma | 2001 |
A telencephalic nucleus essential for song learning contains neurons with physiological characteristics of both striatum and globus pallidus.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Canaries; Cesium; Chlorides; Choline O-Acetyltra | 2002 |
Substance P and NMDA receptor-mediated slow potentials in neonatal rat spinal cord: age-related changes.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Aging; Analgesics; Animals; Animals, Newborn; Electric | 1992 |
Neuromuscular pharmacology in rat neonates: development of responsiveness to prototypic blocking and reversal drugs.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Cholinesterase Inhibitors; Curare; Dose-Response | 1992 |
CPP, an NMDA-receptor antagonist, blocks 4-aminopyridine-induced spreading depression episodes but not epileptiform activity in immature rat hippocampal slices.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Anticonvuls | 1992 |
Properties of two voltage-activated potassium currents in acutely isolated juvenile rat dentate gyrus granule cells.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Barium; Cadmium; Electrophysiology; Hippocampus; | 1992 |
Patch-clamp study of postnatal development of CA1 neurons in rat hippocampal slices: membrane excitability and K+ currents.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Electrophysiology; Hippocampus; In Vitro Techniq | 1992 |
Protein kinase C (alpha and beta) immunoreactivity in rabbit and rat retina: effect of phorbol esters and transmitter agonists on immunoreactivity and the translocation of the enzyme from cytosolic to membrane compartments.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Aging; Alkaloids; Animals; Antibodie | 1991 |
Physiological properties of regenerated rat sciatic nerve following lesions at different postnatal ages.
Topics: 4-Aminopyridine; Aging; Aminopyridines; Animals; Ion Channels; Myelin Sheath; Nerve Regeneration; Pe | 1987 |
Age-related changes of action potential plateau shape in isolated human atrial fibers.
Topics: 4-Aminopyridine; Action Potentials; Adult; Aged; Aging; Aminopyridines; Atrial Function; Caffeine; H | 1985 |
Subsynaptosomal distribution of calcium during aging and 3,4-diaminopyridine treatment.
Topics: 4-Aminopyridine; Aging; Amifampridine; Aminopyridines; Animals; Brain; Calcium; Digitonin; In Vitro | 1985 |