4-aminopyridine has been researched along with Ache in 13 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "A Phase I trial of 4-aminopyridine (4-AP) was carried out in 39 dogs referred to the veterinary teaching hospital with naturally occurring traumatic paraplegia or paraparesis." | 5.07 | The effects of 4-aminopyridine on neurological deficits in chronic cases of traumatic spinal cord injury in dogs: a phase I clinical trial. ( Bauer, MS; Blight, AR; Toombs, JP; Widmer, WR, 1991) |
| " The accompanying mechanical allodynia may be reduced by the intrathecal administration of adenosine." | 3.77 | Adenosine triphosphate-sensitive potassium channel blockers attenuate the antiallodynic effect of R-PIA in neuropathic rats. ( Hahm, KD; Jeong, SM; Kim, YK; Lee, C; Leem, JG; Park, PH; Shin, JW; Song, JG, 2011) |
| "Cancer pain is one of the most severe types of chronic pain, and the most common cancer pain is bone cancer pain." | 1.38 | Targeting A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model. ( Duan, KZ; Mei, YA; Xu, Q; Zhang, XM; Zhang, YQ; Zhao, ZQ, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, JG | 1 |
| Hahm, KD | 1 |
| Kim, YK | 1 |
| Leem, JG | 1 |
| Lee, C | 1 |
| Jeong, SM | 1 |
| Park, PH | 1 |
| Shin, JW | 1 |
| Duan, KZ | 1 |
| Xu, Q | 1 |
| Zhang, XM | 1 |
| Zhao, ZQ | 1 |
| Mei, YA | 1 |
| Zhang, YQ | 1 |
| Yang, K | 1 |
| Fujita, T | 1 |
| Kumamoto, E | 1 |
| Ortiz, MI | 2 |
| Castañeda-Hernández, G | 2 |
| Granados-Soto, V | 2 |
| Mert, T | 1 |
| Gunes, Y | 1 |
| Gunay, I | 1 |
| Ocaña, M | 1 |
| Del Pozo, E | 1 |
| Barrios, M | 1 |
| Baeyens, JM | 1 |
| Morisset, V | 1 |
| Nagy, F | 1 |
| Donovan, WH | 1 |
| Halter, JA | 1 |
| Graves, DE | 1 |
| Blight, AR | 2 |
| Calvillo, O | 1 |
| McCann, MT | 1 |
| Sherwood, AM | 1 |
| Castillo, T | 1 |
| Parsons, KC | 1 |
| Strayer, JR | 1 |
| Soares, AC | 1 |
| Duarte, ID | 1 |
| Torres-López, JE | 1 |
| Rosas, R | 1 |
| Vidal-Cantú, GC | 1 |
| Kajander, KC | 1 |
| Wakisaka, S | 1 |
| Bennett, GJ | 1 |
| Toombs, JP | 1 |
| Bauer, MS | 1 |
| Widmer, WR | 1 |
| Baklavadzhian, OG | 1 |
| Darbinian, AG | 1 |
| Taturian, IKh | 1 |
| Ipekchian, NM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Quality of Life, Efficacy and Safety of High Doses of 4-aminopyridine in Patients With Clinically Complete Chronic Spinal Cord Injury: Multicenter, Randomized, Double Blind, Placebo Controlled Clinical Trial[NCT03899584] | Phase 3 | 150 participants (Actual) | Interventional | 2019-07-17 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for 4-aminopyridine and Ache
| Article | Year |
|---|---|
Intravenous infusion of 4-AP in chronic spinal cord injured subjects.
Topics: 4-Aminopyridine; Adult; Aged; Chronic Disease; Cross-Over Studies; Double-Blind Method; Electromyogr | 2000 |
The effects of 4-aminopyridine on neurological deficits in chronic cases of traumatic spinal cord injury in dogs: a phase I clinical trial.
Topics: 4-Aminopyridine; Animals; Dog Diseases; Dogs; Drug Evaluation; Muscles; Pain; Paraplegia; Propriocep | 1991 |
11 other studies available for 4-aminopyridine and Ache
| Article | Year |
|---|---|
Adenosine triphosphate-sensitive potassium channel blockers attenuate the antiallodynic effect of R-PIA in neuropathic rats.
Topics: 4-Aminopyridine; Adenosine; Adenosine Triphosphate; Animals; Glyburide; Humans; Hyperalgesia; Inject | 2011 |
Targeting A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model.
Topics: 4-Aminopyridine; Activating Transcription Factor 3; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2012 |
Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons.
Topics: 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Colforsin; GABA Antagon | 2004 |
Pharmacological evidence for the activation of Ca2+-activated K+ channels by meloxicam in the formalin test.
Topics: 4-Aminopyridine; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Apamin; Behavior, Animal; | 2005 |
Role of 4-aminopyridine-sensitive potassium channels in peripheral antinociception.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Female; Lidocaine; Pain; Potassium Channel Blockers; P | 2007 |
Subgroups among mu-opioid receptor agonists distinguished by ATP-sensitive K+ channel-acting drugs.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Baclofen; Benzopyrans; Cromakalim; Female; Mice; N | 1995 |
Nociceptive integration in the rat spinal cord: role of non-linear membrane properties of deep dorsal horn neurons.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cell Membrane; Cycloleucine; Electric Stimulation; Elec | 1998 |
Dibutyryl-cyclic GMP induces peripheral antinociception via activation of ATP-sensitive K(+) channels in the rat PGE2-induced hyperalgesic paw.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Analgesics; Animals; Apamin; Cesium; Charybdotoxin; Dibutyr | 2001 |
Pharmacological evidence for the activation of K(+) channels by diclofenac.
Topics: 4-Aminopyridine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; A | 2002 |
Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat.
Topics: 4-Aminopyridine; Animals; Electrophysiology; Gallamine Triethiodide; Ganglia, Spinal; Male; Neurons; | 1992 |
[Neuronal and neurochemical mechanisms of hypothalamic inhibition of the pain reflex].
Topics: 4-Aminopyridine; Analgesics; Animals; Cats; Hypothalamus; Naloxone; Pain; Periaqueductal Gray; Refle | 1987 |