4-aminopiperidine has been researched along with Mycoses* in 1 studies
1 other study(ies) available for 4-aminopiperidine and Mycoses
| Article | Year |
|---|---|
Synthesis, Biological Evaluation, and Structure-Activity Relationships of 4-Aminopiperidines as Novel Antifungal Agents Targeting Ergosterol Biosynthesis.
The aliphatic heterocycles piperidine and morpholine are core structures of well-known antifungals such as fenpropidin and fenpropimorph, commonly used as agrofungicides, and the related morpholine amorolfine is approved for the treatment of dermal mycoses in humans. Inspired by these lead structures, we describe here the synthesis and biological evaluation of 4-aminopiperidines as a novel chemotype of antifungals with remarkable antifungal activity. A library of more than 30 4-aminopiperidines was synthesized, starting from Topics: Antifungal Agents; Aspergillus; Biosynthetic Pathways; Candida; Drug Discovery; Ergosterol; Fungi; Humans; Mucorales; Mycoses; Piperidines; Structure-Activity Relationship | 2021 |