4-aminophenol has been researched along with Kidney Diseases in 13 studies
4-aminophenol: RN given refers to parent cpd
4-aminophenol : An amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have recently reported that a glutathione conjugate of PAP, 4-amino-3-S-glutathionylphenol, is more toxic to the kidney than the parent compound itself." | 1.29 | Effect of ascorbic acid, acivicin and probenecid on the nephrotoxicity of 4-aminophenol in the Fischer 344 rat. ( Foster, JR; Fowler, LM; Lock, EA, 1993) |
| " These studies indicate that glutathione conjugation of PAP generates a metabolite that is more toxic to the kidney than the parent compound." | 1.28 | Nephrotoxicity of 4-aminophenol glutathione conjugate. ( Foster, JR; Fowler, LM; Lock, EA; Moore, RB, 1991) |
| " These data suggest that the nephrotoxicity of PAP may be due in part to the formation of a proximate toxic metabolite in the liver which is excreted in the bile, subsequently reabsorbed and transported via the systemic circulation to the kidney where the toxic effects occur." | 1.28 | Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat. ( Bonner, FW; Eason, CT; Gartland, KP; Nicholson, JK, 1990) |
| " Dosing PAP (25-100 mg/kg) to male F344 rats resulted in a dose-related proximal nephropathy with consequent elevations in urinary enzymes, glucose, and urine total protein as shown by conventional methodology." | 1.28 | Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F344 rat. ( Bonner, FW; Gartland, KP; Nicholson, JK; Timbrell, JA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, A | 1 |
| Trajkovic, D | 1 |
| Illanes, O | 1 |
| Ramiro-Ibáñez, F | 1 |
| Peyrou, M | 1 |
| Hanna, PE | 1 |
| Cribb, AE | 1 |
| Newton, JF | 2 |
| Yoshimoto, M | 1 |
| Bernstein, J | 1 |
| Rush, GF | 1 |
| Hook, JB | 2 |
| Kuo, CH | 1 |
| Gemborys, MW | 1 |
| Mudge, GH | 2 |
| Carpenter, HM | 1 |
| Lock, EA | 3 |
| Cross, TJ | 1 |
| Schnellmann, RG | 1 |
| Fowler, LM | 2 |
| Foster, JR | 2 |
| Robertson, DG | 1 |
| Reily, MD | 1 |
| Sigler, RE | 1 |
| Wells, DF | 1 |
| Paterson, DA | 1 |
| Braden, TK | 1 |
| Moore, RB | 1 |
| Hegedus, ZL | 1 |
| Nayak, U | 1 |
| Emeigh Hart, SG | 1 |
| Beierschmitt, WP | 1 |
| Bartolone, JB | 1 |
| Wyand, DS | 1 |
| Khairallah, EA | 1 |
| Cohen, SD | 1 |
| Gartland, KP | 2 |
| Eason, CT | 1 |
| Bonner, FW | 2 |
| Nicholson, JK | 2 |
| Timbrell, JA | 1 |
13 other studies available for 4-aminophenol and Kidney Diseases
| Article | Year |
|---|---|
Clinicopathological and tissue indicators of para-aminophenol nephrotoxicity in sprague-dawley rats.
Topics: Aminophenols; Animals; Biomarkers; Body Weight; Caspase 3; Cell Adhesion Molecules; Clusterin; Dose- | 2007 |
Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys.
Topics: Aminophenols; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Basic-Leucine Zipper | 2007 |
Acetaminophen nephrotoxicity in the rat. II. Strain differences in nephrotoxicity and metabolism of p-aminophenol, a metabolite of acetaminophen.
Topics: Acetaminophen; Aminophenols; Animals; Drug Resistance; In Vitro Techniques; Kidney Cortex; Kidney Di | 1983 |
Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the fischer 344 rat.
Topics: Acetaminophen; Alanine Transaminase; Aminophenols; Animals; Blood Urea Nitrogen; Isomerism; Kidney D | 1982 |
Acetaminophen nephrotoxicity: studies on renal acetylation and deacetylation.
Topics: Acetaminophen; Acetylation; Acetyltransferases; Aminophenols; Animals; In Vitro Techniques; Kidney; | 1981 |
Studies on the mechanism of 4-aminophenol-induced toxicity to renal proximal tubules.
Topics: Adenosine Triphosphate; Aminophenols; Animals; Ascorbic Acid; Cell Death; Energy Metabolism; Female; | 1993 |
Effect of ascorbic acid, acivicin and probenecid on the nephrotoxicity of 4-aminophenol in the Fischer 344 rat.
Topics: Aminophenols; Animals; Antimetabolites; Ascorbic Acid; Isoxazoles; Kidney; Kidney Diseases; Kidney F | 1993 |
Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants.
Topics: 1-Naphthylisothiocyanate; Aminophenols; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2000 |
Nephrotoxicity of 4-aminophenol glutathione conjugate.
Topics: Acetaminophen; Aminophenols; Animals; Glutathione; Kidney; Kidney Diseases; Liver; Male; Rats; Rats, | 1991 |
Para-aminophenol and structurally related compounds as intermediates in lipofuscin formation and in renal and other tissue toxicities.
Topics: Adult; Aminophenols; Humans; Kidney Diseases; Kinetics; Lipofuscin; Male; Melanins; Spectrophotometr | 1991 |
Evidence against deacetylation and for cytochrome P450-mediated activation in acetaminophen-induced nephrotoxicity in the CD-1 mouse.
Topics: Acetaminophen; Acetylation; Aminophenols; Animals; Blood Urea Nitrogen; Cytochrome P-450 Enzyme Inhi | 1991 |
Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat.
Topics: Aminophenols; Animals; Antimetabolites; Biliary Tract; Buthionine Sulfoximine; Catheterization; Glut | 1990 |
Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F344 rat.
Topics: Amino Acids; Aminophenols; Animals; Citrates; Glycosuria; Kidney; Kidney Diseases; Lactates; Magneti | 1989 |