4-aminobenzoic acid has been researched along with Methemoglobinemia in 11 studies
para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.
4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methemoglobinemia (MetHb) after exposure to benzocaine (BZC) has been reported for more than 50 years, however the pathophysiologic mechanism has not been previously established." | 3.80 | Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. ( Casavant, MJ; Gerona, RR; Ho, RY; Russell, JL; Spiller, HA, 2014) |
| "A 2-month-old infant developed severe methemoglobinemia following topical pharyngeal application of a common benzocaine containing agent ( Cetacaine )." | 3.67 | Infantile methemoglobinemia induced by a topical anesthetic, Cetacaine. ( Seibert, JJ; Seibert, RW, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spiller, HA | 1 |
| Russell, JL | 1 |
| Casavant, MJ | 1 |
| Ho, RY | 1 |
| Gerona, RR | 1 |
| Raymond, P | 1 |
| Byrne, MF | 1 |
| Mitchell, RM | 1 |
| Gerke, H | 1 |
| Goller, S | 1 |
| Stiffler, HL | 1 |
| Golioto, M | 1 |
| Branch, MS | 1 |
| Jowell, PS | 1 |
| Baillie, J | 1 |
| Lunenfeld, E | 1 |
| Kane, GC | 1 |
| Basra, SK | 1 |
| Vives, MJ | 1 |
| Reilly, MC | 1 |
| Reiter, MF | 1 |
| Kushins, LG | 1 |
| Seibert, RW | 1 |
| Seibert, JJ | 1 |
| Sandza, JG | 1 |
| Roberts, RW | 1 |
| Shaw, RC | 1 |
| Connors, JP | 1 |
| Vessely, MB | 1 |
| Zitsch, RP | 1 |
| Khan, NA | 1 |
| Kruse, JA | 1 |
| Gregory, PJ | 1 |
| Matsuda, K | 1 |
| Ferraro, L | 1 |
| Zeichner, S | 1 |
| Greenblott, G | 1 |
| Groeger, JS | 1 |
2 reviews available for 4-aminobenzoic acid and Methemoglobinemia
| Article | Year |
|---|---|
Topical anesthetic-induced methemoglobinemia: a case report and review of the literature.
Topics: 4-Aminobenzoic Acid; Administration, Topical; Anesthetics, Local; Benzalkonium Compounds; Benzocaine | 1993 |
Methemoglobinemia induced by topical anesthesia: a case report and review.
Topics: 4-Aminobenzoic Acid; Aged; Anesthesia, Local; Anesthetics, Local; Benzalkonium Compounds; Benzocaine | 1999 |
9 other studies available for 4-aminobenzoic acid and Methemoglobinemia
| Article | Year |
|---|---|
Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure.
Topics: 4-Aminobenzoic Acid; Acetaminophen; Administration, Topical; Benzocaine; Bupivacaine; Child; Cyanosi | 2014 |
Bye-bye benzocaine?
Topics: 4-Aminobenzoic Acid; Anesthetics, Local; Benzalkonium Compounds; Benzocaine; Cetrimonium Compounds; | 2003 |
The need for caution with topical anesthesia during endoscopic procedures, as liberal use may result in methemoglobinemia.
Topics: 4-Aminobenzoic Acid; Administration, Topical; Aged; Anesthetics, Local; Benzalkonium Compounds; Benz | 2004 |
Methemoglobinemia: sudden dyspnea and oxyhemoglobin desaturation after esophagoduodenoscopy.
Topics: 4-Aminobenzoic Acid; Administration, Topical; Anesthetics, Local; Benzalkonium Compounds; Benzocaine | 2004 |
Methemoglobinemia after fiberoptic intubation in a patient with an unstable cervical fracture: a case report.
Topics: 4-Aminobenzoic Acid; Adult; Anesthetics, Local; Benzalkonium Compounds; Benzocaine; Cetrimonium Comp | 2006 |
Infantile methemoglobinemia induced by a topical anesthetic, Cetacaine.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Anesthetics, Local; Benzalkonium Compounds; Benzocaine; Cetrimo | 1984 |
Symptomatic methemoglobinemia with a commonly used topical anesthetic, cetacaine.
Topics: 4-Aminobenzoic Acid; Adult; Aminobenzoates; Anesthetics, Local; Benzalkonium Compounds; Benzocaine; | 1980 |
Cetacaine spray-induced methemoglobinemia after transesophageal echocardiography.
Topics: 4-Aminobenzoic Acid; Aged; Aged, 80 and over; Anesthetics, Local; Benzalkonium Compounds; Benzocaine | 2000 |
Cetacaine-induced acute methemoglobinemia.
Topics: 4-Aminobenzoic Acid; Acute Disease; Aged; Aminobenzoates; Benzalkonium Compounds; Benzocaine; Cetrim | 1988 |