4-aminobenzoic acid has been researched along with Melanoma in 3 studies
para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.
4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "GSK2830371, a WIP1 inhibitor, at doses with no growth-inhibitory activity alone, potentiated the growth-inhibitory and cytotoxic activity of MDM2 inhibitors by increasing phosphorylation, acetylation and stabilisation of p53 in cutaneous melanoma cells in a functional p53-dependent manner." | 3.88 | Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma. ( Aptullahoglu, E; Esfandiari, A; Ho, YH; Lovat, P; Lunec, J; Mahdi, AK; Wang, N; Wu, CE, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vilgelm, AE | 1 |
| Cobb, P | 1 |
| Malikayil, K | 1 |
| Flaherty, D | 1 |
| Andrew Johnson, C | 1 |
| Raman, D | 1 |
| Saleh, N | 1 |
| Higgins, B | 1 |
| Vara, BA | 1 |
| Johnston, JN | 1 |
| Johnson, DB | 1 |
| Kelley, MC | 1 |
| Chen, SC | 1 |
| Ayers, GD | 1 |
| Richmond, A | 1 |
| Wu, CE | 1 |
| Esfandiari, A | 1 |
| Ho, YH | 1 |
| Wang, N | 1 |
| Mahdi, AK | 1 |
| Aptullahoglu, E | 1 |
| Lovat, P | 1 |
| Lunec, J | 1 |
| Krause, M | 1 |
| Klit, A | 1 |
| Blomberg Jensen, M | 1 |
| Søeborg, T | 1 |
| Frederiksen, H | 1 |
| Schlumpf, M | 1 |
| Lichtensteiger, W | 1 |
| Skakkebaek, NE | 1 |
| Drzewiecki, KT | 1 |
1 review available for 4-aminobenzoic acid and Melanoma
| Article | Year |
|---|---|
Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters.
Topics: 4-Aminobenzoic Acid; Animals; Benzyl Compounds; Camphor; Cinnamates; Endocrine Disruptors; Humans; H | 2012 |
2 other studies available for 4-aminobenzoic acid and Melanoma
| Article | Year |
|---|---|
MDM2 Antagonists Counteract Drug-Induced DNA Damage.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azepines; Cell Line, Tumor; Cyclin-Dependen | 2017 |
Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma.
Topics: Aminopyridines; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dipeptides; Drug Sy | 2018 |