Page last updated: 2024-11-03

4-aminobenzoic acid and Melanoma

4-aminobenzoic acid has been researched along with Melanoma in 3 studies

para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.
4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"GSK2830371, a WIP1 inhibitor, at doses with no growth-inhibitory activity alone, potentiated the growth-inhibitory and cytotoxic activity of MDM2 inhibitors by increasing phosphorylation, acetylation and stabilisation of p53 in cutaneous melanoma cells in a functional p53-dependent manner."3.88Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma. ( Aptullahoglu, E; Esfandiari, A; Ho, YH; Lovat, P; Lunec, J; Mahdi, AK; Wang, N; Wu, CE, 2018)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vilgelm, AE1
Cobb, P1
Malikayil, K1
Flaherty, D1
Andrew Johnson, C1
Raman, D1
Saleh, N1
Higgins, B1
Vara, BA1
Johnston, JN1
Johnson, DB1
Kelley, MC1
Chen, SC1
Ayers, GD1
Richmond, A1
Wu, CE1
Esfandiari, A1
Ho, YH1
Wang, N1
Mahdi, AK1
Aptullahoglu, E1
Lovat, P1
Lunec, J1
Krause, M1
Klit, A1
Blomberg Jensen, M1
Søeborg, T1
Frederiksen, H1
Schlumpf, M1
Lichtensteiger, W1
Skakkebaek, NE1
Drzewiecki, KT1

Reviews

1 review available for 4-aminobenzoic acid and Melanoma

ArticleYear
Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters.
    International journal of andrology, 2012, Volume: 35, Issue:3

    Topics: 4-Aminobenzoic Acid; Animals; Benzyl Compounds; Camphor; Cinnamates; Endocrine Disruptors; Humans; H

2012

Other Studies

2 other studies available for 4-aminobenzoic acid and Melanoma

ArticleYear
MDM2 Antagonists Counteract Drug-Induced DNA Damage.
    EBioMedicine, 2017, Volume: 24

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azepines; Cell Line, Tumor; Cyclin-Dependen

2017
Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma.
    British journal of cancer, 2018, 02-20, Volume: 118, Issue:4

    Topics: Aminopyridines; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dipeptides; Drug Sy

2018