Page last updated: 2024-11-03

4-aminobenzoic acid and Exocrine Pancreatic Insufficiency

4-aminobenzoic acid has been researched along with Exocrine Pancreatic Insufficiency in 33 studies

para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.
4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.

Exocrine Pancreatic Insufficiency: A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (LIPASE; PROTEASES; and AMYLASE) by the EXOCRINE PANCREAS into the DUODENUM. This condition is often associated with CYSTIC FIBROSIS and with chronic PANCREATITIS.

Research Excerpts

ExcerptRelevanceReference
"The bentiromide test was evaluated using plasma p-aminobenzoic acid as an indirect test of pancreatic insufficiency in young children between 2 months and 4 years of age."7.68The bentiromide test using plasma p-aminobenzoic acid for diagnosing pancreatic insufficiency in young children. The effect of two different doses and a liquid meal. ( Cleghorn, G; Durie, P; Ellis, L; Forstner, G; Koren, G; Laufer, D, 1991)
"The bentiromide test for exocrine pancreatic function was carried out in normal volunteers, patients with cystic fibrosis (CF) without clinical evidence of pancreatic dysfunction, and CF patients with clinically significant exocrine pancreatic insufficiency."7.67Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease. ( Egge, AC; Hubbard, VS; Lester, LA; Wolf, RO, 1984)
"Bentiromide test (BT) has been recently approved in the United States for screening patients with chronic pancreatitis for exocrine insufficiency."7.67Comparison of bentiromide test and rice flour breath hydrogen test in the detection of exocrine pancreatic insufficiency. ( Agarwal, N; GeeVarghese, PJ; Jain, NK; Patel, VP; Pitchumoni, CS, 1986)
"Forty-six subjects (20 chronic pancreatitis, 7 chronic liver disease, 7 recovered from acute pancreatitis, 2 Crohn's disease, and 10 healthy controls) classified by S-C test as having normal pancreatic function (26 subjects), or moderate (10 subjects) and severe (10 cases) pancreatic insufficiency, were given, on different days, 1 g of oral PABA or 348 mg of oral fluorescein dilaurate."7.67Serum PABA and fluorescein in the course of Bz-Ty-PABA and pancreolauryl test as an index of exocrine pancreatic insufficiency. ( Angelini, G; Benini, L; Brocco, G; Cavallini, G; Chech, G; Dalle Molle, L; Micciolo, R; Piubello, W; Riela, A; Vantini, I, 1985)
"The primary objective of this study was to evaluate the accuracy of the bentiromide test in differentiating between dogs with exocrine pancreatic insufficiency (EPI) and those with primary intestinal disease (PID)."7.67Further evaluation of bentiromide in the diagnosis of canine exocrine pancreatic insufficiency. ( Todd, SE; Zimmer, JF, 1985)
"We evaluated the bentiromide test by analyzing para-aminobenzoic acid (PABA) in plasma and urine (a) for the identification of patients with complete pancreatic insufficiency and (b) as an alternative to the secretin-cholecystokinin test."7.67Bentiromide test for assessing pancreatic dysfunction using analysis of para-aminobenzoic acid in plasma and urine. Studies in cystic fibrosis and Shwachman's syndrome. ( Durie, PR; Forstner, GG; Gaskin, KJ; Kopelman, H; Weizman, Z; Wong, S, 1985)
"Forty (40) normal volunteers, 18 adults with cystic fibrosis and four adults with celiac sprue, ingested a liquid test meal along with bentiromide, [13C6]PABA, and xylose (PABAX test)."3.69A noninvasive stable-isotope method to simultaneously assess pancreatic exocrine function and small bowel absorption. ( Deutsch, JC; Kolli, VR; Santhosh-Kumar, CR, 1995)
"The bentiromide test was evaluated using plasma p-aminobenzoic acid as an indirect test of pancreatic insufficiency in young children between 2 months and 4 years of age."3.68The bentiromide test using plasma p-aminobenzoic acid for diagnosing pancreatic insufficiency in young children. The effect of two different doses and a liquid meal. ( Cleghorn, G; Durie, P; Ellis, L; Forstner, G; Koren, G; Laufer, D, 1991)
"The bentiromide test for exocrine pancreatic function was carried out in normal volunteers, patients with cystic fibrosis (CF) without clinical evidence of pancreatic dysfunction, and CF patients with clinically significant exocrine pancreatic insufficiency."3.67Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease. ( Egge, AC; Hubbard, VS; Lester, LA; Wolf, RO, 1984)
"Bentiromide test (BT) has been recently approved in the United States for screening patients with chronic pancreatitis for exocrine insufficiency."3.67Comparison of bentiromide test and rice flour breath hydrogen test in the detection of exocrine pancreatic insufficiency. ( Agarwal, N; GeeVarghese, PJ; Jain, NK; Patel, VP; Pitchumoni, CS, 1986)
"Forty-six subjects (20 chronic pancreatitis, 7 chronic liver disease, 7 recovered from acute pancreatitis, 2 Crohn's disease, and 10 healthy controls) classified by S-C test as having normal pancreatic function (26 subjects), or moderate (10 subjects) and severe (10 cases) pancreatic insufficiency, were given, on different days, 1 g of oral PABA or 348 mg of oral fluorescein dilaurate."3.67Serum PABA and fluorescein in the course of Bz-Ty-PABA and pancreolauryl test as an index of exocrine pancreatic insufficiency. ( Angelini, G; Benini, L; Brocco, G; Cavallini, G; Chech, G; Dalle Molle, L; Micciolo, R; Piubello, W; Riela, A; Vantini, I, 1985)
"The primary objective of this study was to evaluate the accuracy of the bentiromide test in differentiating between dogs with exocrine pancreatic insufficiency (EPI) and those with primary intestinal disease (PID)."3.67Further evaluation of bentiromide in the diagnosis of canine exocrine pancreatic insufficiency. ( Todd, SE; Zimmer, JF, 1985)
"We evaluated the bentiromide test by analyzing para-aminobenzoic acid (PABA) in plasma and urine (a) for the identification of patients with complete pancreatic insufficiency and (b) as an alternative to the secretin-cholecystokinin test."3.67Bentiromide test for assessing pancreatic dysfunction using analysis of para-aminobenzoic acid in plasma and urine. Studies in cystic fibrosis and Shwachman's syndrome. ( Durie, PR; Forstner, GG; Gaskin, KJ; Kopelman, H; Weizman, Z; Wong, S, 1985)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199028 (84.85)18.7374
1990's4 (12.12)18.2507
2000's1 (3.03)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ishii, Y1
Kohno, T2
Ito, A1
Suzuki, S1
Takayama, T1
Asai, S1
Hubbard, VS1
Wolf, RO1
Lester, LA1
Egge, AC1
Lami, F1
Callegari, C1
Miglioli, M1
Barbara, L1
Bellentani, S1
Grisendi, A1
Rinaldi, M1
Bertolani, P1
Costa, G1
Agostini, M1
Mastella, G1
Balli, F1
Manenti, F1
Tanaka, T1
Ichiba, Y1
Kodama, O1
Ezaki, H1
Toskes, PP1
Imondi, AR1
Cavallini, G2
Piubello, W2
Brocco, G2
Vantini, I2
Angelini, G2
Benini, L2
Chech, G2
Marchiaro, G1
Dobrilla, G1
Bonoldi, C1
Ventrucci, M1
Gullo, L1
Daniele, C1
Priori, P1
Labò, G1
Tanner, AR1
Fisher, D1
Ward, C1
Smith, CL1
Lankisch, PG4
Schreiber, A1
Koop, H2
Ehrhardt-Schmelzer, S1
Caspary, WF1
Fric, P2
Malis, F2
Kasafírek, E2
Slabý, J2
Wolf, C1
Ehrig, C1
Brunner, H1
Batt, RM1
Mann, LC1
Zvárová, J1
Kai, H1
Nose, O1
Harada, T1
Maki, I1
Tajiri, H1
Yabuuchi, H1
Deutsch, JC1
Santhosh-Kumar, CR1
Kolli, VR1
Bruno, MJ1
Borm, JJ1
Hoek, FJ1
Delzenne, B1
Hofmann, AF2
de Goeij, JJ1
van Royen, EA1
van Gulik, TM1
de Wit, LT1
Gouma, DJ1
van Leeuwen, DJ1
Tytgat, GN1
Durie, PR2
Yung-Jato, LY1
Soldin, SJ1
Verjee, Z1
Ellis, L2
Laufer, D1
Cleghorn, G1
Forstner, G1
Koren, G1
Durie, P1
Mundlos, S1
Rhodes, JB1
Puntis, JW1
Berg, JD1
Buckley, BM1
Booth, IW1
McNeish, AS1
Otto, J2
Brauneis, J2
Hilgers, R1
Lembcke, B1
Göke, B1
Patel, VP1
Jain, NK1
Agarwal, N1
GeeVarghese, PJ1
Pitchumoni, CS1
Meyer, B1
Gyr, K1
Micciolo, R1
Riela, A1
Dalle Molle, L1
Zimmer, JF1
Todd, SE1
Weizman, Z1
Forstner, GG1
Gaskin, KJ1
Kopelman, H1
Wong, S1
Gharbo, SA1
Boyer, JA1
Williamson, MJ1
Bornschein, W1
Rageh, W1
Klugmann, HJ1
Schiedewitz, W1
Pohl, A1

Other Studies

33 other studies available for 4-aminobenzoic acid and Exocrine Pancreatic Insufficiency

ArticleYear
Measurement of extra-pancreatic secretory function by 13C-dipeptide breath test.
    Translational research : the journal of laboratory and clinical medicine, 2007, Volume: 149, Issue:6

    Topics: 4-Aminobenzoic Acid; Aged; Breath Tests; Carbon Isotopes; Dipeptides; Exocrine Pancreatic Insufficie

2007
Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease.
    Digestive diseases and sciences, 1984, Volume: 29, Issue:10

    Topics: 4-Aminobenzoic Acid; Adolescent; Adult; Aminobenzoates; Amylases; Child; Cimetidine; Cystic Fibrosis

1984
A single-specimen fecal chymotrypsin test in the diagnosis of pancreatic insufficiency: correlation with secretin-cholecystokinin and NBT-PABA tests.
    The American journal of gastroenterology, 1984, Volume: 79, Issue:9

    Topics: 4-Aminobenzoic Acid; Chymotrypsin; Clinical Enzyme Tests; Drug Stability; Exocrine Pancreatic Insuff

1984
BT-Paba test in the diagnosis of pancreatic exocrine insufficiency in cystic fibrosis: urinary and serum determinations compared.
    European journal of pediatrics, 1984, Volume: 143, Issue:2

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Child; Child, Preschool; Cystic Fibrosis; Exocrine Pancreatic I

1984
Changes of the pancreatic exocrine function in new canine model of pancreaticoduodenectomy by BTPABA test.
    Hiroshima journal of medical sciences, 1984, Volume: 33, Issue:4

    Topics: 4-Aminobenzoic Acid; Animals; Dogs; Duodenum; Exocrine Pancreatic Insufficiency; Female; Male; Pancr

1984
Bentiromide as a test of exocrine pancreatic function in adult patients with pancreatic exocrine insufficiency. Determination of appropriate dose and urinary collection interval.
    Gastroenterology, 1983, Volume: 85, Issue:3

    Topics: 4-Aminobenzoic Acid; Adolescent; Adult; Aged; Aminobenzoates; Chronic Disease; Diarrhea; Exocrine Pa

1983
Optimum dose of bentiromide.
    Digestive diseases and sciences, 1983, Volume: 28, Issue:9

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Exocrine Pancreatic Insufficiency; Humans; para-Aminobenzoates

1983
Reliability of the Bz-Ty-PABA and the pancreolauryl test in the assessment of exocrine pancreatic function.
    Digestion, 1983, Volume: 27, Issue:3

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Ceruletide; Chronic Disease; Exocrine Pancreatic Insufficiency;

1983
Pancreolauryl test for pancreatic exocrine insufficiency.
    The American journal of gastroenterology, 1983, Volume: 78, Issue:12

    Topics: 4-Aminobenzoic Acid; Adult; Aged; Evaluation Studies as Topic; Exocrine Pancreatic Insufficiency; Fa

1983
An evaluation of the one-day NBT-PABA/14C-PABA in the assessment of pancreatic exocrine insufficiency.
    Digestion, 1984, Volume: 29, Issue:1

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Evaluation Studies as Topic; Exocrine Pancreatic Insufficiency;

1984
[Pancreolauryl test compared to NBT-PABA test. Screening test for diagnosis of exocrine pancreatic insufficiency?].
    Deutsche medizinische Wochenschrift (1946), 1980, Oct-24, Volume: 105, Issue:43

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Exocrine Pancreatic Insufficiency; Humans; Lauric Acids; Method

1980
[The NBT-PABA test in the diagnosis of exocrine pancreatic insufficiency (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1980, Oct-10, Volume: 105, Issue:41

    Topics: 4-Aminobenzoic Acid; Adolescent; Adult; Aged; Aminobenzoates; Cholecystokinin; Chronic Disease; Exoc

1980
A new method of testing pancreatin therapy in vivo by the use of a peroral chymotrypsin substrate 4-(N-acetyl-L-tyrosyl)aminobenzoic acid.
    Hepato-gastroenterology, 1980, Volume: 27, Issue:3

    Topics: 4-Aminobenzoic Acid; Adult; Aged; Aminobenzoates; Bile; Chymotrypsin; Drug Combinations; Exocrine Pa

1980
[Serum paraaminobenzoic acid following the use of N-benzoyl-L-tyrosyl-paraaminobenzoic acid in the diagnosis of pancreatic insufficiency].
    Schweizerische medizinische Wochenschrift, 1981, Mar-07, Volume: 111, Issue:10

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Chymotrypsin; Exocrine Pancreatic Insufficiency; Humans; Pancre

1981
Specificity of the BT-PABA test for the diagnosis of exocrine pancreatic insufficiency in the dog.
    The Veterinary record, 1981, Apr-04, Volume: 108, Issue:14

    Topics: 4-Aminobenzoic Acid; Absorption; Aminobenzoates; Animals; Chymotrypsin; Dog Diseases; Dogs; Duodenum

1981
[Determination of the external secretory function of the pancreas with a peroral test using the chymotrypsin substrate 4-(N-acetyl-L-tyrosyl) aminobenzoic acid. A methodological study].
    Casopis lekaru ceskych, 1981, Aug-27, Volume: 120, Issue:34

    Topics: 4-Aminobenzoic Acid; Adult; Aged; Aminobenzoates; Exocrine Pancreatic Insufficiency; Female; Humans;

1981
Failure of p-aminobenzoic acid screening test to diagnose pancreatic insufficiency in Shwachman's syndrome.
    Journal of pediatric gastroenterology and nutrition, 1982, Volume: 1, Issue:3

    Topics: 4-Aminobenzoic Acid; Agranulocytosis; Aminobenzoates; Child; Child, Preschool; Chymotrypsin; Exocrin

1982
A noninvasive stable-isotope method to simultaneously assess pancreatic exocrine function and small bowel absorption.
    The American journal of gastroenterology, 1995, Volume: 90, Issue:12

    Topics: 4-Aminobenzoic Acid; Absorption; Adult; Carbon Isotopes; Celiac Disease; Cystic Fibrosis; Diagnosis,

1995
Comparative effects of enteric-coated pancreatin microsphere therapy after conventional and pylorus-preserving pancreatoduodenectomy.
    The British journal of surgery, 1997, Volume: 84, Issue:7

    Topics: 4-Aminobenzoic Acid; Aged; Breath Tests; Cholesterol Esters; Exocrine Pancreatic Insufficiency; Fema

1997
Bentiromide test using liquid-chromatographic measurement of p-aminobenzoic acid and its metabolites for diagnosing pancreatic insufficiency in childhood.
    The Journal of pediatrics, 1992, Volume: 121, Issue:3

    Topics: 4-Aminobenzoic Acid; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cystic Fibrosis;

1992
The bentiromide test using plasma p-aminobenzoic acid for diagnosing pancreatic insufficiency in young children. The effect of two different doses and a liquid meal.
    Gastroenterology, 1991, Volume: 101, Issue:1

    Topics: 4-Aminobenzoic Acid; Analysis of Variance; Diet; Exocrine Pancreatic Insufficiency; Female; Humans;

1991
The cholesteryl octanoate breath test: a new procedure for detection of pancreatic insufficiency in the rat.
    Pediatric research, 1987, Volume: 22, Issue:3

    Topics: 4-Aminobenzoic Acid; Animals; Breath Tests; Carbon Dioxide; Cholesterol Esters; Dietary Fats; Exocri

1987
Simplified oral pancreatic function test.
    Archives of disease in childhood, 1988, Volume: 63, Issue:7

    Topics: 4-Aminobenzoic Acid; Adolescent; Aminosalicylic Acid; Aminosalicylic Acids; Child; Child, Preschool;

1988
Detection of pancreatic steatorrhea by oral pancreatic function tests.
    Digestive diseases and sciences, 1988, Volume: 33, Issue:10

    Topics: 4-Aminobenzoic Acid; Adult; Aged; Celiac Disease; Dietary Fats; Exocrine Pancreatic Insufficiency; F

1988
Pancreolauryl and NBT-PABA tests. Are serum tests more practicable alternatives to urine tests in the diagnosis of exocrine pancreatic insufficiency?
    Gastroenterology, 1986, Volume: 90, Issue:2

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Cholecystokinin; Exocrine Pancreatic Insufficiency; Feces; Fluo

1986
Comparison of bentiromide test and rice flour breath hydrogen test in the detection of exocrine pancreatic insufficiency.
    Pancreas, 1986, Volume: 1, Issue:2

    Topics: 4-Aminobenzoic Acid; Adult; Alcoholism; Aminobenzoates; Breath Tests; Exocrine Pancreatic Insufficie

1986
[Significance of the oral NBT-PABA test for the diagnosis of chronic pancreatitis].
    Leber, Magen, Darm, 1987, Volume: 17, Issue:5

    Topics: 4-Aminobenzoic Acid; Administration, Oral; Aminobenzoates; Chronic Disease; Exocrine Pancreatic Insu

1987
Serum PABA and fluorescein in the course of Bz-Ty-PABA and pancreolauryl test as an index of exocrine pancreatic insufficiency.
    Digestive diseases and sciences, 1985, Volume: 30, Issue:7

    Topics: 4-Aminobenzoic Acid; Adult; Aminobenzoates; Ceruletide; Chymotrypsin; Exocrine Pancreatic Insufficie

1985
Further evaluation of bentiromide in the diagnosis of canine exocrine pancreatic insufficiency.
    The Cornell veterinarian, 1985, Volume: 75, Issue:3

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Animals; Biopsy; Diagnosis, Differential; Dog Diseases; Dogs; E

1985
Bentiromide test for assessing pancreatic dysfunction using analysis of para-aminobenzoic acid in plasma and urine. Studies in cystic fibrosis and Shwachman's syndrome.
    Gastroenterology, 1985, Volume: 89, Issue:3

    Topics: 4-Aminobenzoic Acid; Adolescent; Adult; Aminobenzoates; Celiac Disease; Cystic Fibrosis; Evaluation

1985
Colorimetric plasma assay for the bentiromide test (BT-PABA) for exocrine pancreatic insufficiency.
    Analytical biochemistry, 1985, Volume: 148, Issue:1

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Colorimetry; Exocrine Pancreatic Insufficiency; Humans; para-Am

1985
[Improvement in the specificity of the PABA test (PFT) by combined PABA peptide/D-xylose administration and serum kinetic measurement?].
    Zeitschrift fur Gastroenterologie, 1985, Volume: 23, Issue:5

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Chronic Disease; Exocrine Pancreatic Insufficiency; Female; Hum

1985
[Modified ALTAB test in the diagnosis of exocrine pancreatic insufficiency].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1985, Volume: 45, Issue:6

    Topics: 4-Aminobenzoic Acid; Aminobenzoates; Chronic Disease; Exocrine Pancreatic Insufficiency; Humans; Pan

1985