Page last updated: 2024-11-03

4-aminobenzoic acid and Edema

4-aminobenzoic acid has been researched along with Edema in 8 studies

para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.
4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

Excerpt	Relevance	Reference
"Idiopathic cyclic edema is an aggravating factor for cellulite and is frequently associated with the more advanced stages of the disease."	1.37	Evaluation of the prevalence of concomitant idiopathic cyclic edema and cellulite. ( de Godoy, JM; de Godoy, Mde F, 2011)

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (12.50)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	3 (37.50)	24.3611
2020's	1 (12.50)	2.80

Authors

Authors	Studies
Martinez-Zapata, MJ	2
Vernooij, RW	2
Simancas-Racines, D	1
Uriona Tuma, SM	2
Stein, AT	2
Moreno Carriles, RMM	1
Vargas, E	2
Bonfill Cosp, X	2
Belczak, SQ	1
Sincos, IR	1
Campos, W	1
Beserra, J	1
Nering, G	1
Aun, R	1
Moreno, RM	1
Capellà, D	1
de Godoy, JM	1
de Godoy, Mde F	1
HORN, Z	1
LAZARITS, E	1
ALANT, O	1
Bank, DE	1
Diaz, L	1
Behrman, DA	1
Delaney, J	1
Bizzocco, S	1
Pereira de Godoy, JM	1
Reeve, VE	1
Bosnic, M	1
Domanski, D	1

Clinical Trials (9)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
A 17 Week, Randomised, Double-blind, Placebo Controlled Cross-over Trial to Evaluate the Efficacy of Antistax® Film Coated Tablets (Extr. Vitis Vinifera Siccum), 360 mg/Day p.o. in Improving Microcirculation of the Skin in the Leg of Male and Female Patie[NCT02191163]	Phase 2	71 participants (Actual)	Interventional	2002-04-30	Completed
Randomized, Double-blind Multicenter Clinical Trial Comparing the Efficacy of Calcium Dobesilate With Placebo in the Treatment of Ulcer Secondaries to Chronic Venous Disease[NCT00979836]	Phase 3	230 participants (Anticipated)	Interventional	2008-04-30	Suspended (stopped due to The financial support was withdrawn.)
Evaluation of Efficacy and Safety of the Fixed-dose Combination of Coumarin and Troxerutin (Venalot®) Versus Placebo in the Symptomatic Treatment of Chronic Venous Insufficiency - VENACT[NCT01848210]	Phase 4	829 participants (Actual)	Interventional	2013-05-31	Completed
The Ability of Antistax® to Improve Chronic Venous Insufficiency (CVI) I and II in Male and Female Patients: a Dose Response Study[NCT02191280]	Phase 2	260 participants (Actual)	Interventional	1998-04-30	Completed
A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency[NCT02191254]	Phase 3	245 participants (Actual)	Interventional	2004-04-30	Completed
Assessment of the Efficacy and Safety of Diosmin 600mg on Painful Symptomatology in Patients With Chronic Venous Disease of Lower Limbs: a Multicentric, Randomised, Double-blind, Placebo-controlled Trial in Parallel Groups[NCT01532882]	Phase 3	378 participants (Actual)	Interventional	2012-01-31	Completed
Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease[NCT01654016]	Phase 4	84 participants (Actual)	Interventional	2012-08-31	Completed
Randomized, Double-blind, Placebo-controlled Clinical Trial to Assess the Efficacy of µSmin® Plus (Dietary Supplement) in Chronic Venous Insufficiency Symptoms Relief[NCT04101201]		73 participants (Actual)	Interventional	2019-11-15	Completed
The MUFFIN-PTS Trial: Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome[NCT03833024]	Phase 3	88 participants (Actual)	Interventional	2022-02-04	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change (Reduction) From Baseline in Local Complaint Severity

"Local Complaint Severity will be assessed using the Severity Score of Local Complaints that comprises 8 items: 1=tired legs, 2=heavy legs, 3= feeling of tension, 4=feeling of swelling, 5=aching legs, 6=tingling, 7=itching, 8=burning of soles of the feet.~Each item is classified with a Likert-type scale of 5 levels, where 0=absent, 1=low, 2=medium, 3=high, 4=very high.~A total score is calculated from the sum of the scores of all the 8 items and ranges from 0 (complaints absent) to 32 (very high severity)." (NCT01848210)
Timeframe: Baseline and Week 16

Intervention	score on a scale (Mean)
Coumarin + Troxerutin	10.83
Placebo	10.45

Mean Change (Reduction) From Baseline in Volume of Reference Leg at Week 16

Change in the partial volume of legs will be measured using a water plethysmometer. The volume of water (at 34 ± 0.2 °C) displaced after limb immersion is collected in an empty plastic Beaker which has been previously weighed (scale tare). The equilibrium/stability will be estimated using the absolute difference between measures of volume obtained at the Week 16 visit and Baseline to determine the reduction in edema. (NCT01848210)
Timeframe: Baseline and Week 16

Intervention	milliliters (mL) (Mean)
Coumarin + Troxerutin	1.13
Placebo	5.78

Number of Participants With Adverse Events (AEs)

Adverse events are any unwanted medical occurrences in an individual taking part in a clinical study who is receiving a pharmaceutical product. The adverse event does not have necessarily a causal relationship with the treatment. In this definition, any adverse or unwanted signals and symptoms, or findings that appear from the start or that deteriorate during the clinical study are also included, i.e. any intercurrent diseases (recently diagnosed concomitant diseases or symptoms), accidents and clinically relevant changes in clinical laboratory values. (NCT01848210)
Timeframe: Baseline to Week 16

Intervention	participants (Number)
Coumarin + Troxerutin	131
Placebo	120

Overall Assessment by the Investigator

The investigator recorded their impression of the overall clinical picture at the end of the treatment period (Week 16), taking into account the clinical picture compared with the Baseline visit. Data is reported for the percentage of participants in each of the following assessment categories: worsening, unchanged, discreet improvement or accentuated improvement. (NCT01848210)
Timeframe: Baseline and Week 16

Intervention	percentage of participants (Number)
	Worsening	Unchanged	Discreet improvement	Accentuated improvement
Coumarin + Troxerutin	0.6	11.2	25.3	62.9
Placebo	0.8	14.3	24.4	60.4

Reviews

2 reviews available for 4-aminobenzoic acid and Edema

Article	Year
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2020, 11-03, Volume: 11 Topics: 4-Aminobenzoic Acid; Angioedemas, Hereditary; Calcium Dobesilate; Centella; Chronic Disease; Diosmin	2020
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2016, Apr-06, Volume: 4 Topics: 4-Aminobenzoic Acid; Calcium Dobesilate; Centella; Chronic Disease; Diosmin; Edema; Hematologic Agen	2016
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2016, Apr-06, Volume: 4 Topics: 4-Aminobenzoic Acid; Calcium Dobesilate; Centella; Chronic Disease; Diosmin; Edema; Hematologic Agen	2016
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2016, Apr-06, Volume: 4 Topics: 4-Aminobenzoic Acid; Calcium Dobesilate; Centella; Chronic Disease; Diosmin; Edema; Hematologic Agen	2016
Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews, 2016, Apr-06, Volume: 4 Topics: 4-Aminobenzoic Acid; Calcium Dobesilate; Centella; Chronic Disease; Diosmin; Edema; Hematologic Agen	2016

Trials

2 trials available for 4-aminobenzoic acid and Edema

Article	Year
Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial. Phlebology, 2014, Volume: 29, Issue:7 Topics: Biomechanical Phenomena; Brazil; Cardiovascular Agents; Chronic Disease; Coumarins; Diosmin; Double-	2014
Aminaphtone in idiopathic cyclic oedema syndrome. Phlebology, 2008, Volume: 23, Issue:3 Topics: 4-Aminobenzoic Acid; Adult; Body Weight; Capillary Permeability; Circadian Rhythm; Edema; Extracellu	2008

Other Studies

4 other studies available for 4-aminobenzoic acid and Edema

Article	Year
Evaluation of the prevalence of concomitant idiopathic cyclic edema and cellulite. International journal of medical sciences, 2011, Volume: 8, Issue:6 Topics: 4-Aminobenzoic Acid; Adipose Tissue; Adolescent; Adult; Cross-Sectional Studies; Edema; Female; Hemo	2011
[Treatment of postthrombotic edema with panthesin and hydergine]. Die Medizinische Welt, 1961, Mar-04, Volume: 9 Topics: Cardiovascular Agents; Edema; Ergoloid Mesylates; Ergot Alkaloids; Leucine; para-Aminobenzoates; Thr	1961
Tongue entrapment in an aluminum juice can. Pediatric emergency care, 2004, Volume: 20, Issue:4 Topics: 4-Aminobenzoic Acid; Airway Obstruction; Anesthetics, Local; Benzalkonium Compounds; Benzocaine; Cet	2004
Interaction of UVB-absorbing sunscreen ingredients with cutaneous molecules may alter photoimmune protection. Photochemistry and photobiology, 2001, Volume: 74, Issue:6 Topics: 4-Aminobenzoic Acid; Animals; Cinnamates; Dermatitis, Contact; Edema; Erythema; Female; Mice; Mice,	2001