4-aminobenzoic acid has been researched along with Disease Models, Animal in 33 studies
para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.
4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pulmonary hypertension is characterized by increased vascular resistances, that could lead to right heart failure and death." | 5.37 | Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension. ( Beretta, L; Fumagalli, F; Latini, R; Masson, S; Santaniello, A; Scorza, R; Zambelli, V, 2011) |
| "5-Hydroxytryptophan has the opposite effect exacerbating the behavioural response to the aversive situation." | 2.38 | The pharmacology of the 5-HT4 receptor. ( Costall, B; Naylor, RJ, 1993) |
| "An orally bioavailable small molecule inhibitor of plasminogen activator inhibitor‑1 (PAI‑1) is currently being clinically assessed as a novel antithrombotic agent." | 1.56 | Novel oral plasminogen activator inhibitor‑1 inhibitor TM5275 attenuates hepatic fibrosis under metabolic syndrome via suppression of activated hepatic stellate cells in rats. ( Aihara, Y; Asada, K; Douhara, A; Kaji, K; Kawaratani, H; Kitade, M; Miyata, T; Moriya, K; Namisaki, T; Nishimura, N; Noguchi, R; Takaya, H; Yoshiji, H, 2020) |
| "Genetic hearing loss is a common health problem with no effective therapy currently available." | 1.56 | Aldh inhibitor restores auditory function in a mouse model of human deafness. ( Chen, H; Chen, X; Fan, C; Gao, X; Gong, S; He, WQ; Ma, DB; Qian, XY; Sun, J; Tao, T; Wan, G; Wang, F; Wang, P; Wang, Y; Zhang, L; Zhao, W; Zhou, H; Zhu, GJ; Zhu, MS; Zuo, J, 2020) |
| "Stroke is a life-threatening neurological disease with limited therapeutic options." | 1.51 | Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF-κB activation. ( Cao, Y; Dai, Z; Li, Q; Wang, L, 2019) |
| "To investigate whether the glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab (GA101) combined with the selective MDM2 antagonist idasanutlin (RG7388) offers superior efficacy to monotherapy in treating B-lymphoid malignancies in preclinical models." | 1.43 | Antitumour activity of the glycoengineered type II anti-CD20 antibody obinutuzumab (GA101) in combination with the MDM2-selective antagonist idasanutlin (RG7388). ( Bacac, M; Dangl, M; Friess, T; Herter, S; Herting, F; Klein, C; Muth, G; Sulcova, J; Umana, P, 2016) |
| "Diabetic nephropathy is the leading cause of end-stage renal disease worldwide, but no effective therapeutic strategy is available." | 1.43 | Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model. ( Ha, H; Jeong, BY; Lee, HB; Lee, JH; Miyata, T; Park, JH; Uddin, MJ, 2016) |
| "Pulmonary hypertension is characterized by increased vascular resistances, that could lead to right heart failure and death." | 1.37 | Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension. ( Beretta, L; Fumagalli, F; Latini, R; Masson, S; Santaniello, A; Scorza, R; Zambelli, V, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.06) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 3 (9.09) | 29.6817 |
| 2010's | 19 (57.58) | 24.3611 |
| 2020's | 7 (21.21) | 2.80 |
| Authors | Studies |
|---|---|
| Kuru Bektaşoğlu, P | 1 |
| Koyuncuoğlu, T | 1 |
| Akbulut, S | 1 |
| Akakın, D | 1 |
| Eyüboğlu, İP | 1 |
| Erzik, C | 1 |
| Yüksel, M | 1 |
| Kurtel, H | 1 |
| Liu, W | 2 |
| Shen, J | 1 |
| Li, Y | 2 |
| Wu, J | 1 |
| Luo, X | 1 |
| Yu, Y | 1 |
| Zhang, Y | 2 |
| Gu, L | 1 |
| Zhang, X | 1 |
| Jiang, C | 1 |
| Li, J | 1 |
| Niu, X | 1 |
| Xu, H | 1 |
| Li, Q | 3 |
| Meng, L | 1 |
| He, M | 1 |
| Zhang, J | 1 |
| Zhang, Z | 2 |
| Flores, J | 2 |
| Noël, A | 2 |
| Foveau, B | 2 |
| Beauchet, O | 1 |
| LeBlanc, AC | 2 |
| Noguchi, R | 1 |
| Kaji, K | 1 |
| Namisaki, T | 1 |
| Moriya, K | 1 |
| Kawaratani, H | 1 |
| Kitade, M | 1 |
| Takaya, H | 1 |
| Aihara, Y | 1 |
| Douhara, A | 1 |
| Asada, K | 1 |
| Nishimura, N | 1 |
| Miyata, T | 5 |
| Yoshiji, H | 1 |
| Zhu, GJ | 1 |
| Gong, S | 1 |
| Ma, DB | 1 |
| Tao, T | 1 |
| He, WQ | 1 |
| Zhang, L | 1 |
| Wang, F | 1 |
| Qian, XY | 1 |
| Zhou, H | 1 |
| Fan, C | 1 |
| Wang, P | 1 |
| Chen, X | 1 |
| Zhao, W | 1 |
| Sun, J | 1 |
| Chen, H | 1 |
| Wang, Y | 2 |
| Gao, X | 2 |
| Zuo, J | 1 |
| Zhu, MS | 1 |
| Wan, G | 1 |
| Vernooij, L | 1 |
| Bate-Eya, LT | 1 |
| Alles, LK | 1 |
| Lee, JY | 1 |
| Koopmans, B | 1 |
| Jonus, HC | 1 |
| Schubert, NA | 1 |
| Schild, L | 1 |
| Lelieveld, D | 1 |
| Egan, DA | 1 |
| Kerstjens, M | 1 |
| Stam, RW | 1 |
| Koster, J | 1 |
| Goldsmith, KC | 1 |
| Molenaar, JJ | 1 |
| Dolman, MEM | 1 |
| Galanopoulou, AS | 1 |
| Mowrey, WB | 1 |
| Shandra, O | 1 |
| Moshé, SL | 1 |
| Herting, F | 2 |
| Friess, T | 2 |
| Umaña, P | 2 |
| Middleton, S | 1 |
| Klein, C | 2 |
| Kuboniwa, M | 1 |
| Houser, JR | 1 |
| Hendrickson, EL | 1 |
| Wang, Q | 1 |
| Alghamdi, SA | 1 |
| Sakanaka, A | 1 |
| Miller, DP | 1 |
| Hutcherson, JA | 1 |
| Wang, T | 1 |
| Beck, DAC | 1 |
| Whiteley, M | 1 |
| Amano, A | 1 |
| Wang, H | 1 |
| Marcotte, EM | 1 |
| Hackett, M | 1 |
| Lamont, RJ | 1 |
| Chen, L | 1 |
| Esfandiari, A | 1 |
| Reaves, W | 1 |
| Vu, A | 1 |
| Hogarty, MD | 1 |
| Lunec, J | 1 |
| Tweddle, DA | 1 |
| Do Carmo, H | 1 |
| Arjun, S | 1 |
| Petrucci, O | 1 |
| Yellon, DM | 1 |
| Davidson, SM | 1 |
| Akhter, H | 1 |
| Huang, WT | 1 |
| van Groen, T | 1 |
| Kuo, HC | 1 |
| Liu, RM | 1 |
| Lynham, J | 1 |
| Lecrux, C | 1 |
| Dai, Z | 1 |
| Cao, Y | 1 |
| Wang, L | 1 |
| Noe, FM | 1 |
| Polascheck, N | 1 |
| Frigerio, F | 1 |
| Bankstahl, M | 1 |
| Ravizza, T | 4 |
| Marchini, S | 2 |
| Beltrame, L | 2 |
| Banderó, CR | 1 |
| Löscher, W | 1 |
| Vezzani, A | 4 |
| Dan, T | 2 |
| Ichimura, A | 1 |
| Pelisch, N | 1 |
| Miyata, K | 1 |
| Akahori, K | 1 |
| Liu, L | 1 |
| Liu, YZ | 1 |
| Shen, XL | 1 |
| Wu, TY | 1 |
| Zhang, T | 1 |
| Wang, W | 1 |
| Wang, YX | 1 |
| Jiang, CL | 1 |
| Chi, Y | 1 |
| Jasmin, JF | 1 |
| Seki, Y | 1 |
| Lisanti, MP | 1 |
| Charron, MJ | 1 |
| Lefer, DJ | 1 |
| Schuster, VL | 1 |
| Herter, S | 1 |
| Muth, G | 1 |
| Bacac, M | 1 |
| Sulcova, J | 1 |
| Dangl, M | 1 |
| Jeong, BY | 1 |
| Uddin, MJ | 1 |
| Park, JH | 1 |
| Lee, JH | 1 |
| Lee, HB | 1 |
| Ha, H | 1 |
| Bassil, F | 1 |
| Fernagut, PO | 1 |
| Bezard, E | 1 |
| Pruvost, A | 1 |
| Leste-Lasserre, T | 1 |
| Hoang, QQ | 1 |
| Ringe, D | 1 |
| Petsko, GA | 1 |
| Meissner, WG | 1 |
| Iori, V | 1 |
| Iyer, AM | 1 |
| Paracchini, L | 1 |
| Cerovic, M | 1 |
| Hill, C | 1 |
| Ferrari, M | 1 |
| Zucchetti, M | 1 |
| Molteni, M | 1 |
| Rossetti, C | 1 |
| Brambilla, R | 1 |
| Steve White, H | 1 |
| D'Incalci, M | 1 |
| Aronica, E | 1 |
| Noé, F | 1 |
| Zardoni, D | 1 |
| Vaghi, V | 1 |
| Sifringer, M | 1 |
| Izuhara, Y | 1 |
| Yamaoka, N | 1 |
| Kodama, H | 1 |
| Takizawa, S | 1 |
| Hirayama, N | 1 |
| Meguro, K | 1 |
| van Ypersele de Strihou, C | 1 |
| Zambelli, V | 1 |
| Santaniello, A | 1 |
| Fumagalli, F | 1 |
| Masson, S | 1 |
| Scorza, R | 1 |
| Beretta, L | 1 |
| Latini, R | 1 |
| Akin, D | 1 |
| Maroso, M | 1 |
| Carcak, N | 1 |
| Eryigit, T | 1 |
| Vanzulli, I | 1 |
| Aker, RG | 1 |
| Onat, FY | 1 |
| Akada, Y | 1 |
| Mori, R | 1 |
| Matsuura, K | 1 |
| Suzuki, K | 1 |
| Kato, K | 1 |
| Kamiya, M | 1 |
| Naba, H | 1 |
| Kurokawa, M | 1 |
| Ogihara, T | 1 |
| Kato, Y | 1 |
| Yamasaki, F | 1 |
| Yamamoto, I | 1 |
| Shen, ZJ | 1 |
| Ding, GQ | 1 |
| Pan, CW | 1 |
| Zheng, RM | 1 |
| Niedner, W | 1 |
| Laube, R | 1 |
| Schmidt, D | 1 |
| Hofmann, KD | 1 |
| Hinske, G | 1 |
| Costall, B | 1 |
| Naylor, RJ | 1 |
| Lankisch, PG | 1 |
| Koop, H | 1 |
| Winckler, K | 1 |
| Köstering, H | 1 |
| Yamaguchi, Y | 1 |
| Yamada, K | 1 |
| Kitagawa, S | 1 |
| Kunitomo, M | 1 |
2 reviews available for 4-aminobenzoic acid and Disease Models, Animal
| Article | Year |
|---|---|
Plasminogen activator inhibitor-1 (PAI-1) molecule: new physiological roles and clinical applications.
Topics: Aging; Animals; Blood Coagulation; Clinical Trials as Topic; Disease Models, Animal; Drug Discovery; | 2014 |
The pharmacology of the 5-HT4 receptor.
Topics: 4-Aminobenzoic Acid; 5-Hydroxytryptophan; Animals; Anxiety; Arousal; Brain; Diazepam; Disease Models | 1993 |
31 other studies available for 4-aminobenzoic acid and Disease Models, Animal
| Article | Year |
|---|---|
Neuroprotective Effect of Plasminogen Activator Inhibitor-1 Antagonist in the Rat Model of Mild Traumatic Brain Injury.
Topics: Animals; Behavior, Animal; Brain; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Infl | 2021 |
Pyroptosis inhibition improves the symptom of acute myocardial infarction.
Topics: Animals; Autophagy-Related Proteins; Biomarkers; Dipeptides; Disease Models, Animal; Gene Expression | 2021 |
VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Dipeptides; Disease Models, Animal; Disease Progression | 2020 |
Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Cognitive Dysfunction; C | 2020 |
Novel oral plasminogen activator inhibitor‑1 inhibitor TM5275 attenuates hepatic fibrosis under metabolic syndrome via suppression of activated hepatic stellate cells in rats.
Topics: Administration, Oral; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Fibrinol | 2020 |
Aldh inhibitor restores auditory function in a mouse model of human deafness.
Topics: Aldehyde Dehydrogenase; Animals; Benzaldehydes; Disease Models, Animal; Enzyme Inhibitors; Hair Cell | 2020 |
High-Throughput Screening Identifies Idasanutlin as a Resensitizing Drug for Venetoclax-Resistant Neuroblastoma Cells.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; High-Throughput Screening Assays; Humans; Mice; N | 2021 |
Preclinical Screening for Treatments for Infantile Spasms in the Multiple Hit Rat Model of Infantile Spasms: An Update.
Topics: Animals; Anticonvulsants; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Doxo | 2017 |
Chemotherapy-free, triple combination of obinutuzumab, venetoclax and idasanutlin: antitumor activity in xenograft models of non-Hodgkin lymphoma.
Topics: Animals; Antibodies, Monoclonal, Humanized; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, | 2018 |
Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial infection.
Topics: 4-Aminobenzoic Acid; Adhesins, Bacterial; Animals; Bacterial Adhesion; Bacteroidaceae Infections; Bi | 2017 |
Characterisation of the p53 pathway in cell lines established from TH-MYCN transgenic mouse tumours.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Humans; Imidazoles; Indoles; Mice; Mice, Transgen | 2018 |
The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway.
Topics: Animals; Caspase 1; Caspase Inhibitors; Cytoprotection; Dipeptides; Disease Models, Animal; Isolated | 2018 |
A Small Molecule Inhibitor of Plasminogen Activator Inhibitor-1 Reduces Brain Amyloid-β Load and Improves Memory in an Animal Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Line, | 2018 |
Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Caspase 1; Caspase Inhibitors; Cognition; | 2018 |
Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF-κB activation.
Topics: Animals; Caspase 1; Caspase Inhibitors; Dipeptides; Disease Models, Animal; Infarction, Middle Cereb | 2019 |
Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.
Topics: Animals; Cell Death; Cerebral Cortex; Dipeptides; Disease Models, Animal; Electric Stimulation; Epil | 2013 |
NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrier Proteins; Caspase 1 | 2015 |
Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hypertension; Mice; Organic Anion Transporters; par | 2015 |
Antitumour activity of the glycoengineered type II anti-CD20 antibody obinutuzumab (GA101) in combination with the MDM2-selective antagonist idasanutlin (RG7388).
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibody-Dependent Cell Cytotoxi | 2016 |
Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, A | 2016 |
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.
Topics: alpha-Synuclein; Animals; Caspase 1; Clinical Trials as Topic; Corpus Striatum; Dipeptides; Disease | 2016 |
Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Carbamazepine; Cyanobacteria; Dip | 2017 |
Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production.
Topics: 4-Aminobenzoic Acid; Animals; Anticonvulsants; Astrocytes; Caspase 1; Caspase Inhibitors; Dipeptides | 2008 |
A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates.
Topics: 4-Aminobenzoic Acid; Animals; Disease Models, Animal; Drug Design; Female; Fibrinolytic Agents; Hemo | 2010 |
Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: 4-Aminobenzoic Acid; Animals; Body Weight; Cardiomegaly; Disease Models, Animal; Endothelin-1; Hemod | 2011 |
IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence.
Topics: 4-Aminobenzoic Acid; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Brain | 2011 |
Pharmacological profiles of the novel analgesic M58996 in rat models of persistent and neuropathic pain.
Topics: 4-Aminobenzoic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Biogenic Monoamine | 2006 |
Study on enhancement of fibronectin-mediated bacillus Calmette-Guérin attachment to urinary bladder wall in rabbits.
Topics: 4-Aminobenzoic Acid; Administration, Intravesical; Aminocaproic Acid; Animals; Antifibrinolytic Agen | 2007 |
[Asphyxial shock and disseminated intravascular coagulation (DIC) in animal experiments. 3. Secondary fibrinolysis (author's transl)].
Topics: 4-Aminobenzoic Acid; Animals; Asphyxia; Disease Models, Animal; Disseminated Intravascular Coagulati | 1980 |
[Therapy of acute experimental pancreatitis with the antifibrinolytic drug PAMBA (author's transl)].
Topics: Acute Disease; Animals; Benzoates; Disease Models, Animal; Dogs; Humans; Injections, Intramuscular; | 1977 |
Atherosclerosis mouse model induced by a high-cholesterol diet supplemented with beta-aminopropionitrile: effects of various anti-atherosclerotic agents on the biochemical parameters.
Topics: 4-Aminobenzoic Acid; Aminopropionitrile; Animals; Aorta; Arteriosclerosis; Body Weight; Cholesterol; | 1990 |