4-aminobenzamidine has been researched along with Hemophilia B in 3 studies
4-aminobenzamidine: a urokinase inhibitor; inhibits acrosin; structure given in first source
Hemophilia B: A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient with severe haemophilia B with a glycine-to-valine missense mutation at residue 190 (c25, chymotrypsin numbering) in factor IX (FIX; FIX-G190V or FIX-FuChou) had <1% of normal FIX clotting activity and 36% of normal FIX antigen levels (cross-reacting material- reduced, CRMr)." | 1.37 | Characterisation of factor IX with a glycine-to-valine missense mutation at residue 190 in a patient with severe haemophilia B. ( Hamaguchi, N; Kao, CY; Kao, JT; Lin, CN; Lin, SW; Shen, MC; Yang, SJ; Yang, YL, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kao, CY | 1 |
| Lin, CN | 2 |
| Yang, YL | 1 |
| Hamaguchi, N | 2 |
| Yang, SJ | 1 |
| Shen, MC | 2 |
| Kao, JT | 1 |
| Lin, SW | 2 |
| Smith, KJ | 1 |
| Nishimura, H | 1 |
| Takeya, H | 1 |
| Miyata, T | 1 |
| Suehiro, K | 1 |
| Okamura, T | 1 |
| Niho, Y | 1 |
| Iwanaga, S | 1 |
3 other studies available for 4-aminobenzamidine and Hemophilia B
| Article | Year |
|---|---|
Characterisation of factor IX with a glycine-to-valine missense mutation at residue 190 in a patient with severe haemophilia B.
Topics: Animals; Benzamidines; Factor IX; Gene Transfer Techniques; Glycine; HEK293 Cells; Hemophilia B; Hum | 2011 |
Characterization of a factor IX variant with a glycine207 to glutamic acid mutation.
Topics: Benzamidines; Binding Sites; Calcium; Codon; Computer Simulation; Electrophoresis, Polyacrylamide Ge | 1994 |
Factor IX Fukuoka. Substitution of ASN92 by His in the second epidermal growth factor-like domain results in defective interaction with factors VIIa/X.
Topics: Adult; Asparagine; Benzamidines; Blood Coagulation Factors; Epidermal Growth Factor; Esterases; Fact | 1993 |