4-amino-5-hexynoic acid has been researched along with Seizures in 7 studies
4-amino-5-hexynoic acid: structure
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "645), a potent irreversible inhibitor of gamma-aminobutyric acid transaminase, was given orally in various dosage schedules to 14 patients with Huntington disease." | 6.65 | Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration. ( Agid, Y; Böhlen, P; Bonnet, AM; Chazot, G; Coquillat, G; Fischer, C; Koch-Weser, J; Schechter, PJ; Tell, G, 1981) |
| "Seven GABAmimetic drugs, namely cetyl gamma-aminobutyric acid (cetyl GABA), 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol, progabide, aminooxyacetic acid, alpha-acetylenic GABA, (-)-nipecotic acid ethyl ester and (+/-)-cis-4-hydroxynipecotic acid methyl ester, were tested for their potency to block "major" (generalized clonic-tonic) seizures in gerbils, induced by blowing at the animals with compressed air." | 3.66 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "645), a potent irreversible inhibitor of gamma-aminobutyric acid transaminase, was given orally in various dosage schedules to 14 patients with Huntington disease." | 2.65 | Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration. ( Agid, Y; Böhlen, P; Bonnet, AM; Chazot, G; Coquillat, G; Fischer, C; Koch-Weser, J; Schechter, PJ; Tell, G, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tell, G | 1 |
| Böhlen, P | 1 |
| Schechter, PJ | 1 |
| Koch-Weser, J | 1 |
| Agid, Y | 1 |
| Bonnet, AM | 1 |
| Coquillat, G | 1 |
| Chazot, G | 1 |
| Fischer, C | 1 |
| Löscher, W | 2 |
| Frey, HH | 1 |
| Reiche, R | 1 |
| Schultz, D | 1 |
| Smiałowski, A | 1 |
| Jobe, PC | 1 |
| Graham, LT | 1 |
| Ray, TB | 1 |
| Mims, ME | 1 |
| Wu, HQ | 1 |
| Schwarcz, R | 1 |
| Myslobodsky, MS | 1 |
| Ackermann, RF | 1 |
| Engel, J | 1 |
1 trial available for 4-amino-5-hexynoic acid and Seizures
| Article | Year |
|---|---|
Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration.
Topics: 4-Aminobutyrate Transaminase; Adult; Aged; Alkynes; Aminocaproates; Brain; Brain Chemistry; Carnosin | 1981 |
6 other studies available for 4-amino-5-hexynoic acid and Seizures
| Article | Year |
|---|---|
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, An | 1983 |
The influence in rabbits and rats of gamma-acetylenic GABA on seizures generated by pentylenetetrazol.
Topics: Alkynes; Aminocaproates; Animals; Electroencephalography; Pentylenetetrazole; Rabbits; Rats; Rats, I | 1980 |
Effects of gamma-acetylenic GABA and gamma-vinyl GABA on electrically-induced spinal cord convulsions and on spinal cord GABA concentration.
Topics: Alkynes; Aminocaproates; Animals; Electroshock; Female; gamma-Aminobutyric Acid; Rats; Seizures; Spi | 1980 |
Focal microinjection of gamma-acetylenic GABA into the rat entorhinal cortex: behavioral and electroencephalographic abnormalities and preferential neuron loss in layer III.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Animals; Electroencephalography; Entorhinal C | 1998 |
Effects of gamma-acetylenic GABA and gamma-vinyl GABA on metrazol-activated, and kindled seizures.
Topics: Alkynes; Aminocaproates; Animals; Arousal; Drug Interactions; Electric Stimulation; Electroencephalo | 1979 |
gamma-Acetylenic GABA antagonizes the decrease in synaptosomal GABA concentrations but not the seizures induced by 3-mercaptopropionic acid in rats.
Topics: 3-Mercaptopropionic Acid; Alkynes; Aminocaproates; Animals; Female; gamma-Aminobutyric Acid; Rats; R | 1986 |