Compounds > 4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid

4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid and Leukemia--Myelogenous--Chronic--BCR-ABL-Positive

4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid has been researched along with Leukemia--Myelogenous--Chronic--BCR-ABL-Positive* in 2 studies

Other Studies

2 other study(ies) available for 4-acetamido-4--isothiocyanatostilbene-2-2--disulfonic-acid and Leukemia--Myelogenous--Chronic--BCR-ABL-Positive

Article	Year
Chronic myelogenous leukemia: alterations in red cell membrane band 3 and increased IgG binding. Indian journal of biochemistry & biophysics, 1990, Volume: 27, Issue:6 Chronic myelogenous leukemia (CML) is a hematologic malignancy arising from an abnormal hemopoietic stem cell. Our earlier studies have identified defects in spectrin tetramer formation and organization of cytoskeletal proteins (Basu et al., Biochim. Biophys. Acta 1988, 121-126); and decreased ankyrin binding to ankyrin-depleted vesicles in CML patients. These may lead to clustering of band 3 and increased binding of autologous IgG. This has now been explored by studying the binding of 125I-protein A to normal and CML erythrocytes. There is increased binding of 125I-protein A in CML erythrocytes compared to normal erythrocytes. Since binding of autologous IgG is responsible for removal of erythrocytes from the circulation, the above findings suggest that CML erythrocytes are likely to be prematurely removed from the circulation, accounting for anemia. Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anion Exchange Protein 1, Erythrocyte; Ankyrins; Blood Proteins; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Humans; Immunoglobulin G; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Staphylococcal Protein A; Sulfates	1990
Abnormalities in erythrocyte membrane band 3 in chronic myelogenous leukemia. Biochimica et biophysica acta, 1989, Oct-02, Volume: 985, Issue:1 The anion transport activities of erythrocytes from patients with chronic myelogenous leukemia (CML) and normal donors were comparable. In CML erythrocytes, significant reduction in the number of ankyrin-binding sites, present in the cytoplasmic domain of band 3, may lead to partial loss of cytoskeletal anchorage to the bilayer and account for their increased Con-A agglutinability and heat-sensitivity (Basu, J., Kundu, M., Rakshit, M.M. and Chakrabarti, P. (1988) Biochim. Biophys. Acta 945, 121-126). Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anion Exchange Protein 1, Erythrocyte; Ankyrins; Blood Proteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Receptors, Concanavalin A; Sulfates	1989

Article

Year

Chronic myelogenous leukemia: alterations in red cell membrane band 3 and increased IgG binding.

Indian journal of biochemistry & biophysics, 1990, Volume: 27, Issue:6

Chronic myelogenous leukemia (CML) is a hematologic malignancy arising from an abnormal hemopoietic stem cell. Our earlier studies have identified defects in spectrin tetramer formation and organization of cytoskeletal proteins (Basu et al., Biochim. Biophys. Acta 1988, 121-126); and decreased ankyrin binding to ankyrin-depleted vesicles in CML patients. These may lead to clustering of band 3 and increased binding of autologous IgG. This has now been explored by studying the binding of 125I-protein A to normal and CML erythrocytes. There is increased binding of 125I-protein A in CML erythrocytes compared to normal erythrocytes. Since binding of autologous IgG is responsible for removal of erythrocytes from the circulation, the above findings suggest that CML erythrocytes are likely to be prematurely removed from the circulation, accounting for anemia.

Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anion Exchange Protein 1, Erythrocyte; Ankyrins; Blood Proteins; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Humans; Immunoglobulin G; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Staphylococcal Protein A; Sulfates

1990

Abnormalities in erythrocyte membrane band 3 in chronic myelogenous leukemia.

Biochimica et biophysica acta, 1989, Oct-02, Volume: 985, Issue:1

The anion transport activities of erythrocytes from patients with chronic myelogenous leukemia (CML) and normal donors were comparable. In CML erythrocytes, significant reduction in the number of ankyrin-binding sites, present in the cytoplasmic domain of band 3, may lead to partial loss of cytoskeletal anchorage to the bilayer and account for their increased Con-A agglutinability and heat-sensitivity (Basu, J., Kundu, M., Rakshit, M.M. and Chakrabarti, P. (1988) Biochim. Biophys. Acta 945, 121-126).

Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anion Exchange Protein 1, Erythrocyte; Ankyrins; Blood Proteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Receptors, Concanavalin A; Sulfates

1989