4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol has been researched along with Seizures in 4 studies
4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol: inhibitor of GABA uptake systems; RN given refers to parent cpd
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") to mice, had only a marginal protective effect against seizures induced 1 hr later by 3-mercaptopropionic acid (MPA)." | 3.67 | Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor. ( Hjeds, H; Krogsgaard-Larsen, P; Sarhan, S; Schousboe, A; Seiler, N, 1985) |
| "THPO was also effective in preventing seizures induced in epileptic chicks by intermittent photic stimulation." | 1.27 | Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO. ( Johnson, DD; Krogsgaard-Larsen, P; Schousboe, A; Wood, JD, 1983) |
| "Sound-induced seizures are suppressed by the i." | 1.27 | Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration. ( Croucher, MJ; Krogsgaard-Larsen, P; Meldrum, BS, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schousboe, A | 3 |
| Madsen, KK | 1 |
| Wood, JD | 1 |
| Johnson, DD | 1 |
| Krogsgaard-Larsen, P | 3 |
| Croucher, MJ | 1 |
| Meldrum, BS | 1 |
| Seiler, N | 1 |
| Sarhan, S | 1 |
| Hjeds, H | 1 |
1 review available for 4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol and Seizures
| Article | Year |
|---|---|
Delineation of the Role of Astroglial GABA Transporters in Seizure Control.
Topics: Animals; Anticonvulsants; Astrocytes; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitor | 2017 |
3 other studies available for 4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol and Seizures
| Article | Year |
|---|---|
Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO.
Topics: 4-Aminobutyrate Transaminase; Animals; Animals, Newborn; Anticonvulsants; Chickens; Cyclohexanecarbo | 1983 |
Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Body Temperature; Female; GABA Antagonists; gamma-Am | 1983 |
Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Drug Synergism; gamma-Aminobuty | 1985 |