Compounds > 4-4-dimethyl-N2-(2-methylphenyl)-1H-1-3-5-triazine-2-6-diamine

4-4-dimethyl-N2-(2-methylphenyl)-1H-1-3-5-triazine-2-6-diamine and Central-Nervous-System-Diseases

4-4-dimethyl-N2-(2-methylphenyl)-1H-1-3-5-triazine-2-6-diamine has been researched along with Central-Nervous-System-Diseases* in 1 studies

Other Studies

1 other study(ies) available for 4-4-dimethyl-N2-(2-methylphenyl)-1H-1-3-5-triazine-2-6-diamine and Central-Nervous-System-Diseases

Article	Year
Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorganic & medicinal chemistry letters, 2009, Oct-01, Volume: 19, Issue:19 Neuronal sodium channels blockers interfere with ion flux and have been used for managing neuropathic pain, epilepsy, and cerebral ischemic disorders. In the current study, four groups of 2,4-diamino-1,3,5-triazine derivatives were synthesized and investigated for their neuronal sodium channels binding activity. 5-Aryl-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamines (4a-4j) were found to have the best neuronal sodium binding activity among the four groups of triazines evaluated. Derivatives 4a-4j blocked the sodium channels with IC50 values ranged from 4.0 to 14.7 microM. The result from this study showed that analogues of 2,4-diamino-1,3,5-triazines could be used as leads for the discovery of neuronal sodium channels blockers for managing central nervous system related disorders. Topics: Animals; Anticonvulsants; Cattle; Central Nervous System Diseases; Sodium Channel Blockers; Sodium Channels; Tetrahydrofolate Dehydrogenase; Triazines	2009

Article

Year

Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers.

Bioorganic & medicinal chemistry letters, 2009, Oct-01, Volume: 19, Issue:19

Neuronal sodium channels blockers interfere with ion flux and have been used for managing neuropathic pain, epilepsy, and cerebral ischemic disorders. In the current study, four groups of 2,4-diamino-1,3,5-triazine derivatives were synthesized and investigated for their neuronal sodium channels binding activity. 5-Aryl-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamines (4a-4j) were found to have the best neuronal sodium binding activity among the four groups of triazines evaluated. Derivatives 4a-4j blocked the sodium channels with IC50 values ranged from 4.0 to 14.7 microM. The result from this study showed that analogues of 2,4-diamino-1,3,5-triazines could be used as leads for the discovery of neuronal sodium channels blockers for managing central nervous system related disorders.

Topics: Animals; Anticonvulsants; Cattle; Central Nervous System Diseases; Sodium Channel Blockers; Sodium Channels; Tetrahydrofolate Dehydrogenase; Triazines

2009