4-4-difluoro-4-bora-3a-4a-diaza-s-indacene and Progeria

4-4-difluoro-4-bora-3a-4a-diaza-s-indacene has been researched along with Progeria* in 2 studies

Other Studies

2 other study(ies) available for 4-4-difluoro-4-bora-3a-4a-diaza-s-indacene and Progeria

Article	Year
Impact of Progerin Expression on Adipogenesis in Hutchinson-Gilford Progeria Skin-Derived Precursor Cells. Cells, 2021, 06-25, Volume: 10, Issue:7 Hutchinson-Gilford progeria syndrome (HGPS) is a segmental premature aging disease caused by a mutation in Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adolescent; Animals; Azetidines; Boron Compounds; Cell Differentiation; Cellular Senescence; Child; Child, Preschool; Cyclin-Dependent Kinase Inhibitor p16; Fatty Acid-Binding Proteins; Female; Fibroblasts; Humans; Interleukin-8; Janus Kinases; Lamin Type A; Male; Mice; PPAR gamma; Progeria; Protein Kinase Inhibitors; Purines; Pyrazoles; Skin; Stem Cells; Sulfonamides	2021
Organization of inner cellular components as reported by a viscosity-sensitive fluorescent Bodipy probe suitable for phasor approach to FLIM. Biophysical chemistry, 2016, Volume: 208 According to the recent developments in imaging strategies and in tailoring fluorescent molecule as probe for monitoring biological systems, we coupled a Bodipy-based molecular rotor (BoMe) with FLIM phasor approach to evaluate the viscosity in different intracellular domains. BoMe rapidly permeates cells, stains cytoplasmic as well as nuclear domains, and its optical properties make it perfectly suited for widely diffused confocal microscopy imaging setups. The capability of BoMe to report on intracellular viscosity was put to the test by using a cellular model of a morbid genetic pathology (Hutchinson-Gilford progeria syndrome, HGPS). Our results show that the nucleoplasm of HGPS cells display reduced viscosity as compared to normal cells. Since BoMe displays significant affinity towards DNA, as demonstrated by an in vitro essay, we hypothesize that genetic features of HGPS, namely the misassembly of lamin A protein within the nuclear lamina, modulates chromatin compaction. This hypothesis nicely agrees with literature data. Topics: Animals; Boron Compounds; Cattle; Cell Line, Tumor; DNA; Fluorescence; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Molecular Structure; Progeria; Viscosity	2016

Article

Year

Impact of Progerin Expression on Adipogenesis in Hutchinson-Gilford Progeria Skin-Derived Precursor Cells.

Cells, 2021, 06-25, Volume: 10, Issue:7

Hutchinson-Gilford progeria syndrome (HGPS) is a segmental premature aging disease caused by a mutation in

Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adolescent; Animals; Azetidines; Boron Compounds; Cell Differentiation; Cellular Senescence; Child; Child, Preschool; Cyclin-Dependent Kinase Inhibitor p16; Fatty Acid-Binding Proteins; Female; Fibroblasts; Humans; Interleukin-8; Janus Kinases; Lamin Type A; Male; Mice; PPAR gamma; Progeria; Protein Kinase Inhibitors; Purines; Pyrazoles; Skin; Stem Cells; Sulfonamides

2021

Organization of inner cellular components as reported by a viscosity-sensitive fluorescent Bodipy probe suitable for phasor approach to FLIM.

Biophysical chemistry, 2016, Volume: 208

According to the recent developments in imaging strategies and in tailoring fluorescent molecule as probe for monitoring biological systems, we coupled a Bodipy-based molecular rotor (BoMe) with FLIM phasor approach to evaluate the viscosity in different intracellular domains. BoMe rapidly permeates cells, stains cytoplasmic as well as nuclear domains, and its optical properties make it perfectly suited for widely diffused confocal microscopy imaging setups. The capability of BoMe to report on intracellular viscosity was put to the test by using a cellular model of a morbid genetic pathology (Hutchinson-Gilford progeria syndrome, HGPS). Our results show that the nucleoplasm of HGPS cells display reduced viscosity as compared to normal cells. Since BoMe displays significant affinity towards DNA, as demonstrated by an in vitro essay, we hypothesize that genetic features of HGPS, namely the misassembly of lamin A protein within the nuclear lamina, modulates chromatin compaction. This hypothesis nicely agrees with literature data.

Topics: Animals; Boron Compounds; Cattle; Cell Line, Tumor; DNA; Fluorescence; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Molecular Structure; Progeria; Viscosity

2016