4-4-difluoro-4-bora-3a-4a-diaza-s-indacene and Keratitis

Hypoxia, a common characteristic of bacterial infections, is known to be closely associated with the emergence of multidrug-resistant bacteria, which hastens the need to develop advanced microbicides and antibacterial techniques. Photodynamic therapy is a promising strategy to reduce bacterial antibiotic resistance and employs photosensitizers, excitation light sources, and sufficient oxygen to generate toxic reactive oxygen species (ROS). The inherent limitation of PDT is that the generation of ROS is restricted by the hypoxic microenvironment in infection sites. Here, an oxygen self-supplying nanotherapeutic is developed to enhance antibacterial activity against multidrug-resistant bacteria on the basis of fluorinated boron dipyrromethene (BODIPY)-based glycomimetics. The nanotherapeutic not only could capture the bacteria efficiently but also was able to act as an oxygen carrier to relieve the hypoxic microenvironment of bacterial infections, thus achieving enhanced PDT efficacy. In a

Topics: Animals; Anti-Bacterial Agents; Biofilms; Boron Compounds; Cornea; Drug Resistance, Multiple, Bacterial; Eye Infections, Bacterial; Hypoxia; Keratitis; Light; Mice; Nanoparticles; NIH 3T3 Cells; Oxygen; Photosensitizing Agents; Polymethacrylic Acids; Pseudomonas aeruginosa; Pseudomonas Infections; Rats