4-4-difluoro-4-bora-3a-4a-diaza-s-indacene and Escherichia-coli-Infections

Herein, we report the use of polylactic acid coated with a halogenated BODIPY photosensitizer (PS) as a novel self-sterilizing, low-cost, and eco-friendly material activated with visible light. In this article, polymeric surfaces were 3D-printed and treated with the PS using three simple methodologies: spin coating, aerosolization, and brush dispersion. Our studies showed that the polymeric matrix remains unaffected upon addition of the PS, as observed by dynamic mechanical analysis, Fourier transform infrared, scanning electron microscopy (SEM), and fluorescence microscopy. Furthermore, the photophysical and photodynamic properties of the dye remained intact after being adsorbed on the polymer. This photoactive material can be reused and was successfully inactivating methicillin-resistant

Topics: Anti-Bacterial Agents; Biofilms; Boron Compounds; Escherichia coli; Escherichia coli Infections; Humans; Photosensitizing Agents; Polyesters; Printing, Three-Dimensional; Staphylococcal Infections; Staphylococcus aureus; Sterilization; Surface Properties