4--7-8-trihydroxyisoflavone and Leukemia--Myeloid--Acute

4--7-8-trihydroxyisoflavone has been researched along with Leukemia--Myeloid--Acute* in 1 studies

Other Studies

1 other study(ies) available for 4--7-8-trihydroxyisoflavone and Leukemia--Myeloid--Acute

Article	Year
8-Hydroxydaidzein Induces Apoptosis and Inhibits AML-Associated Gene Expression in U-937 Cells: Potential Phytochemical for AML Treatment. Biomolecules, 2023, Oct-26, Volume: 13, Issue:11 8-hydroxydaidzein (8-OHD) is a compound derived from daidzein, known for its anti-inflammatory and anti-proliferative properties in K562 human chronic myeloid leukemia (CML) cells. However, its effects on acute myeloid leukemia (AML) cells have not been fully understood.. To investigate its potential anti-AML mechanism, we employed an integrated in vitro-in silico approach.. Our findings demonstrate that 8-OHD suppresses the expression of CDK6 and CCND2 proteins and induces cell apoptosis in U-937 cells by activating Caspase-7 and cleaving PARP-1. Microarray analysis revealed that 8-OHD downregulates differentially expressed genes (DEGs) associated with rRNA processing and ribosome biogenesis pathways. Moreover, AML-target genes, including. Overall, this study provides insights into the therapeutic applications of 8-OHD in treating AML and elucidates its underlying mechanisms of action. Topics: Apoptosis; Cell Line, Tumor; Cytarabine; Gene Expression; Humans; Leukemia, Myeloid, Acute; Molecular Docking Simulation	2023

Article

Year

8-Hydroxydaidzein Induces Apoptosis and Inhibits AML-Associated Gene Expression in U-937 Cells: Potential Phytochemical for AML Treatment.

Biomolecules, 2023, Oct-26, Volume: 13, Issue:11

8-hydroxydaidzein (8-OHD) is a compound derived from daidzein, known for its anti-inflammatory and anti-proliferative properties in K562 human chronic myeloid leukemia (CML) cells. However, its effects on acute myeloid leukemia (AML) cells have not been fully understood.. To investigate its potential anti-AML mechanism, we employed an integrated in vitro-in silico approach.. Our findings demonstrate that 8-OHD suppresses the expression of CDK6 and CCND2 proteins and induces cell apoptosis in U-937 cells by activating Caspase-7 and cleaving PARP-1. Microarray analysis revealed that 8-OHD downregulates differentially expressed genes (DEGs) associated with rRNA processing and ribosome biogenesis pathways. Moreover, AML-target genes, including. Overall, this study provides insights into the therapeutic applications of 8-OHD in treating AML and elucidates its underlying mechanisms of action.

Topics: Apoptosis; Cell Line, Tumor; Cytarabine; Gene Expression; Humans; Leukemia, Myeloid, Acute; Molecular Docking Simulation

2023