4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with Lung Neoplasms in 392 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (4.85) | 18.7374 |
| 1990's | 105 (26.79) | 18.2507 |
| 2000's | 132 (33.67) | 29.6817 |
| 2010's | 123 (31.38) | 24.3611 |
| 2020's | 13 (3.32) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, KH; Im, JS; Jeong, HG; Jin, SW; Kacew, S; Kim, HG; Kim, HS; Kim, KB; Kim, SJ; Kwack, SJ; Lee, BM; Lee, GH; Park, JH | 1 |
| Qu, Z; Song, A; Yang, J; Yu, J; Zhang, L; Zhang, W; Zhuang, C | 1 |
| Gao, W; Marshall, K; Twum, Y | 1 |
| Asad, M; Jain, SK; Katare, DP; Mani, RJ; Wajid, S | 1 |
| Bai, R; Bode, AM; Chang, X; Dong, Z; Li, X; Liu, K; Ma, W; Ryu, J; Song, Y; Wang, K; Wang, Q; Wang, T; Xia, Q; Zhang, T | 1 |
| Li, J; Shi, L; Wang, H; Wang, Y; Yang, H | 1 |
| Rothenberger, NJ; Stabile, LP | 1 |
| Hashimoto, N; Imaida, K; Matsuda, Y; Nakano-Narusawa, Y; Yamakawa, K; Yokohira, M | 1 |
| Cho, B; Elisia, I; Hay, M; Kowalski, S; Krystal, G; Lam, V; Larsen, M; Wong, J; Yeung, M | 1 |
| Alam, N; Iqbal, S; Islam, M; Najnin, H; Zaidi, R | 1 |
| Bakkenist, CJ; Bao, R; Burns, TF; Dacic, S; Devadassan, P; Gaither-Davis, A; Huang, EH; Kumar, V; Stabile, LP; Steinman, RA; Vendetti, FP | 1 |
| Balbo, S; Flavin, M; Floeder, AC; Hecht, SS; Ho, YY; O'Sullivan, MG; Oram, MK; Peterson, LA; Seabloom, D; Smith, WE; Stornetta, A; Upadhyaya, P; Vevang, KR; Wiedmann, TS; Zhang, L | 1 |
| Hou, R; Ma, X; Qu, Z; Yu, J; Zhang, L; Zhang, W; Zhuang, C | 1 |
| Arimoto-Kobayashi, S; Daimaru, K; Fujii, N; Hida, R; Kiura, K; Kubo, T; Miyake, N; Nakashima, H; Saiki, Y; Sasaki, K | 1 |
| Hirata, N; Kanda, Y; Sekino, Y; Yamada, S | 1 |
| Belinsky, SA; Chen, W; Hutt, J; Kato, K; Kim, KC; Leng, S; Lin, Y; Padilla, MT; Saxton, B; Tessema, M; Xu, X | 1 |
| Davies, G; Ehli, E; Ezzeddine, D; Fowler, J; Fujimoto, J; Fukuoka, J; Jakubek, Y; Kadara, H; Kapere Ochieng, J; Lang, W; Liu, Y; McDowell, T; Nunomura-Nakamura, S; Petersen, J; Scheet, P; Wistuba, II | 1 |
| Maser, E; Neumann, KT; Stapelfeld, C | 1 |
| Hecht, SS; Leitzman, P; Narayanapillai, SC; O'Sullivan, MG; Puppala, M; Sun, H; Upadhyaya, P; Xing, C | 1 |
| Jang, CY; Jang, YL; Park, JE | 1 |
| Chikara, S; Chittem, K; Christofidou-Solomidou, M; Dyer, N; Mamidi, S; Moorthy, G; Pietrofesa, R; Reindl, KM; Sreedasyam, A; Zuppa, A | 1 |
| Balbo, S; Hecht, SS; Johnson, CS; Kovi, RC; O'Sullivan, MG | 1 |
| Ahmed, H; Al-Bayedh, SA; Qudsi, M; Rahim, MM; Roos, JF; Samara, A | 1 |
| Ray, DW; Singh, N; Sommer, P; Taylor, KM; Vosloo, D; Wheeler, R | 1 |
| Ashmore, JH; Lazarus, P; Luo, S; Watson, CJW | 1 |
| Barzegari, A; Mirdar, S; Ranayi, M | 1 |
| Hudlikar, RR; Ingle, AD; Kannan, S; Kumar, R; Mahimkar, MB; Maru, GB; Pai, V; Thorat, RA | 1 |
| Cho, B; Dyer, RA; Elisia, I; Hay, M; Hofs, E; Krystal, G; Lam, V; Li, MY; Lum, J | 1 |
| Ebi, H; Jenkins, BJ; McLeod, L; Rose-John, S; Ruwanpura, S; Saad, MI; Sagi, I; Yu, L | 1 |
| Balbo, S; Kassie, F; Qian, X; Upadhyaya, P; Villalta, PW | 1 |
| Harada, A; Jogie-Brahim, S; Oh, Y | 1 |
| El-Zein, R; Lloyd, SM; Lopez, M | 1 |
| Bhatnagar, S; Chaudhary, N; Jain, SK; Katare, DP; Malik, S | 1 |
| Aubé, J; Blake, LC; Neul, D; Roy, A; Schoenen, FJ; Scott, EE | 1 |
| Dallos, M; Dennis, PA; Gills, JJ; Hollander, MC; Kitagawa, H; Kunnumakkara, AB; Memmott, RM; Quinn, BJ | 1 |
| Ahluwalia, JS; Carmella, SG; Hecht, SS; Luo, X; Ming, X; Thomas, JL | 1 |
| Ding, X; Liu, Z; Megaraj, V; Xie, F; Yang, W; Zhou, X | 1 |
| Amin, S; Biddick, L; Desai, D; Lightfoot, S; Patlolla, JM; Qian, L; Rao, CV; Zhang, Y | 1 |
| Amin, S; Brewer, M; Desai, D; Kopelovich, L; Lightfoot, S; Mohammed, A; Patlolla, JM; Qian, L; Rao, CV; Zhang, Y | 1 |
| Imaida, K; Inoue, T; Kishi, S; Kuno, T; Nakano, Y; Ninomiya, F; Yamakawa, K; Yokohira, M | 1 |
| Hong, KH; Kassie, F; Qian, X; Song, JM; Upadhyayya, P | 1 |
| Gao, YT; Hecht, SS; Sebero, E; Stepanov, I; Wang, R; Yuan, JM | 1 |
| Imaida, K; Kinouch, S; Kishi, S; Nakano, Y; Ninomiya, F; Saoo, K; Tanizawa, J; Yamakawa, K; Yokohira, M | 1 |
| Aizawa, K; Hu, KQ; Liu, C; Smith, DE; Veeramachaneni, S; Wang, XD | 1 |
| Balbo, S; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B | 1 |
| Alvord, WG; Bode, C; Kinjo, T; Klinman, DM | 1 |
| Butler, LM; Hecht, SS; Stepanov, I; Yuan, JM | 1 |
| Harada, D; Hotta, K; Ichihara, E; Kiura, K; Ochi, N; Tabata, M; Takigawa, N; Tanimoto, M; Yasugi, M | 1 |
| Jiang, YG; Li, X; Wu, JJ; Xia, Y; Yang, T; Zhao, Y; Zou, F | 1 |
| Falk, W; Frese, S; Frese-Schaper, M; Keil, A; Schmid, RA; Steiner, SK; Yagita, H | 1 |
| Chang, CY; Chang, LW; Chen, RJ; Foo, NP; Ho, YS; Lin, P; Siao, SH; Wang, YJ; Wu, CH | 1 |
| Brooks, GD; Jenkins, BJ; McLeod, L; Miller, A; Ruwanpura, S | 1 |
| Chang, CY; Chang, LW; Chen, RJ; Hsu, CH; Lin, P; Siao, SH; Wang, YJ; Wu, CH | 1 |
| Angstadt, AY; Berg, A; Gallagher, CJ; Hull, A; Lazarus, P; Modesto, JL; Muscat, JE | 1 |
| Balbo, S; Grill, AE; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Peterson, LA; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B | 1 |
| Ding, X; Li, L; Megaraj, V; Wei, Y | 1 |
| Balbo, S; Hecht, SS; James-Yi, SA; Johnson, CS; Khariwala, SS; Kovi, RC; Le, CT; O'Sullivan, MG; Upadhyaya, P; Wang, M | 1 |
| Balbo, S; Kassie, F; Kirtane, AR; Panyam, J; Qian, X; Song, JM; Teferi, F; Upadhyaya, P | 1 |
| Chen, JX; Jin, H; Li, G; Lin, Y; Liu, A; Lu, G; Tu, S; Wang, H; Yang, CS | 1 |
| Carmella, SG; Hecht, SS; Le Marchand, L; Ming, X; Park, SL; Stram, DO; Vielguth, E | 1 |
| Cheng, G; Li, J; Li, W; Zhao, Y; Zheng, M; Zhou, J | 1 |
| Chen, JX; Deng, Y; Wang, H; Yang, CS; Yang, MQ; Zhou, H | 1 |
| Chen, L; Gao, W; Keohavong, P; Lu, C | 1 |
| Ding, X; Hu, J; Li, L; Liu, Z; Megaraj, V; Sell, S | 1 |
| Barra, CN; Cordeiro, YG; Dagli, ML; Fukumasu, H; Rochetti, AL; Sámora, TS; Strefezzi, RF | 1 |
| Bora, HK; Farhan, M; Khan, S; Kumar, S; Maurya, R; Meeran, SM; Shukla, S; Sinha, S | 1 |
| Kassie, F; Luo, X; Molla, K; O Sullivan, G; Qian, X; Song, JM; Teferi, F; Upadhyaya, P | 1 |
| Chen, C; Ge, GZ; Xu, TR | 1 |
| Li, L; Liu, Y; Lv, Y; Wu, K; Yang, X; Ye, H; Zheng, X | 1 |
| Iyama, S; Kano, J; Kim, Y; Morishita, Y; Noguchi, M; Sakashita, S; Satomi, K; Shiba-Ishii, A; Shiozawa, T | 1 |
| Biddick, L; Kopelovich, L; Kumar, G; Lightfoot, S; Madka, V; Mohammed, A; Patlolla, JM; Qian, L; Rao, CV; Sadeghi, M; Zhang, Y | 1 |
| Hecht, SS; Kotandeniya, D; Ma, B; Stepanov, I; Upadhyaya, P; Villalta, PW; Zarth, AT | 1 |
| Chen, GG; Du, J; Huang, R; Li, MY; Liu, Y; Long, X; Mok, TS; Ng, CS; Underwood, MJ; Wan, IY; Wu, B; Wu, J; Yang, S | 1 |
| Carmella, SG; Hecht, SS; Stepanov, I | 1 |
| Carmella, SG; Hecht, SS; Leitzman, P; Murphy, SE; Narayanapillai, SC; Paladino, J; Upadhyaya, P; von Weymarn, LB; Xing, C | 1 |
| Imaida, K; Kanie, S; Kishi, S; Nakano, Y; Yamakawa, K; Yokohira, M | 1 |
| Khan, S; Kumar, S; Maurya, R; Meeran, SM; Mitra, K; Shukla, S; Singh, K; Sinha, S | 1 |
| Jiang, Y; Li, X; Wu, J; Xu, Y; Yang, C; Yang, Q; Yang, T | 1 |
| Desai, S; Hudlikar, RR; Ingle, AD; Kannan, S; Kumar, R; Mahimkar, MB; Maru, GB; Thorat, RA; Venkadakrishnan, VB | 1 |
| Anandharaj, A; Hong, KH; Kassie, F; Kim, JH; Kirtane, AR; Panyam, J; Song, JM; Upadhyaya, P | 1 |
| Boo, HJ; Hwang, SJ; Jang, HJ; Lee, HJ; Lee, HY; Min, HY; Smith, JK; Yun, HJ | 1 |
| Chae, CH; Cho, CS; Cho, MH; Cho, WY; Davaadamdin, O; Gankhuyag, N; Jiang, HL; Lee, S; Park, C; Singh, B; Yu, KN | 1 |
| Charoensinphon, N; Gao, Z; Li, F; Li, Z; Song, M; Wang, M; Wu, X; Xiao, H; Xu, F; Zheng, J; Zhou, J | 1 |
| Adams-Haduch, J; Carmella, SG; Hecht, SS; Jin, A; Koh, WP; Kuriger-Laber, J; Murphy, SE; Nelson, HH; Wang, R; Yuan, JM | 1 |
| Chen, GG; Hsin, MK; Li, MY; Mok, TS; Underwood, MJ; Wu, Y; Yip, J | 1 |
| Carmella, SG; Feuer, R; Hatsukami, DK; Hecht, SS; Jensen, J; Stepanov, I; Upadhyaya, P | 1 |
| Hosokawa, K; Imaida, K; Kuno, T; Matsuda, Y; Saoo, K; Takeuchi, H; Yamakawa, K; Yokohira, M | 1 |
| Anver, MR; Balogh, AR; Dennis, PA; Han, W; Hollander, MC; Linnoila, RI; Liwanag, J | 1 |
| Linnoila, RI; Naizhen, X; Poulsen, HS; Poulsen, TT | 1 |
| Kalscheuer, S; Upadhyaya, P; Zeng, Y; Zhang, X | 1 |
| Hashimoto, N; Imaida, K; Kuno, T; Matsuda, Y; Saoo, K; Suzuki, S; Yamakawa, K; Yokohira, M | 1 |
| Carmella, SG; Derby, KS; Hatsukami, D; Hecht, SS; Le Marchand, L; Murphy, SE; Tiirikainen, M; Wang, H | 1 |
| Hung, WC; Hung, YH | 1 |
| Huang, W; Jin, G; Jin, L; Liu, G; Lu, D; Qian, J; Shen, H; Wang, H; Wei, Q | 1 |
| Anderson, KE; Benoit, AR; Caporaso, NE; Carmella, SG; Church, TR; Geisser, MS; Hecht, SS; Le, CT; Zhang, Y | 1 |
| Hanson, TE; Hecht, SS; Johnson, TE; Kassie, F; Negia, M; O'Sullivan, MG; Ruvolo, PP; Upadhyaya, P; Xing, C | 1 |
| Hecht, SS; Kassie, F; Matise, I; Negia, M; Upadhyaya, P | 1 |
| Hara, A; Hirata, A; Iwasaki, T; Kobayashi, H; Limtrakul, PN; Mori, H; Phutthaphadoong, S; Taguchi, A; Tomita, H; Yamada, Y | 1 |
| Katayama, H; Kishino, D; Kiura, K; Kuyama, S; Ohashi, K; Okada, T; Sato, K; Takigawa, N; Tanimoto, M | 1 |
| Al-Wadei, HAN; Schuller, HM | 1 |
| Al-Wadei, HA; Schuller, HM | 1 |
| Hecht, SS; Lindgren, BR; Upadhyaya, P | 1 |
| Abe, M; Endo, Y; Igarashi, M; Miyajima, N; Nakae, D; Sugano, S; Sugaya, K; Watanabe, M; Yoshida, M | 1 |
| Chen, GG; Hsin, MK; Li, MY; Mok, TS; Underwood, MJ; Yip, J | 1 |
| Blake, DC; Freeman, WM; Herzog, CR; Mikse, OR | 1 |
| Spindel, ER | 1 |
| Kathman, S; Naufal, Z; Wilson, C | 1 |
| Austin, DF; Djordjevic, MV; Pankow, JF; Stellman, SD; Toccalino, PL; Watanabe, KH | 1 |
| Aliaga, C; Bortner, JD; Das, A; El-Bayoumy, K; Freeman, WM; Phelps, DS; Somiari, R; Umstead, TM | 1 |
| Caberto, C; Carmella, S; Cuthrell, K; Derby, KS; Hecht, SS; Le Marchand, L; Murphy, SE | 1 |
| Blake, DC; Grigoryeva, LS; Gundermann, EL; Herzog, CR; Mikse, OR | 1 |
| Lian, F; Mernitz, H; Meydani, SN; Smith, DE; Wang, XD | 1 |
| Bitterman, PB; Fan, D; Hecht, SS; Kim, YY; Larsson, O; Peterson, MS; Polunovsky, VA; Underwood, JM; Von Weymarn, L | 1 |
| Al-Wadei, HA; Al-Wadei, MH; Masi, T; Schuller, HM | 1 |
| De Buck, SS; Ensch, C; Muller, CP; Schellenberger, MT | 1 |
| Hashimoto, N; Imaida, K; Kuno, T; Saoo, K; Yamakawa, K; Yokohira, M | 1 |
| Baldi, A; Beleford, D; Boccellino, M; Liu, Z; Maguire, J; Molina, J; Quagliuolo, L; Rattan, R; Shridhar, V; Staub, J | 1 |
| Chen, GG; Hsin, MK; Kong, AW; Li, MY; Ma, LT; Underwood, MJ; Yip, JH; Yuan, H | 1 |
| Li, C; Naren, AP; Schuetz, JD | 1 |
| Chen, CY; Hsieh, YS; Hsu, HS; Lee, CF; Lin, P; Lin, RK; Tang, YA; Wang, YC | 1 |
| Chen, YK; Lee, MJ; Li, GX; Liu, A; Loy, S; Lu, G; Picinich, SC; Xiao, H; Yang, CS | 1 |
| Broide, DH; Karin, M; Nishigaki, R; Ogata, H; Takahashi, H | 1 |
| Halling, ML; Perez, DS; Pritchett, JR; Silva, JM; Smith, DI; Tang, H | 1 |
| Chen, GG; Hsin, MK; Li, MY; Ma, LT; Mok, TS; Underwood, MJ; Yuan, H | 1 |
| Moorehead, RA; Petrik, JJ; Siwicky, MD | 1 |
| Hashimoto, N; Imaida, K; Kuno, T; Yokohira, M | 1 |
| Appaiah, H; Cheng, L; Crooks, P; Klaunig, J; Kusumanchi, P; Matthews, W; Nakshatri, H; Neelakantan, S; Peat, T; Shanmugam, R; Sweeney, CJ | 1 |
| Fujimoto, J; Kadara, H; Lotan, D; Lotan, R; Men, T; van Pelt, C | 1 |
| Dennis, PA; Fox, SD; Kawabata, S; Maier, CR; Memmott, RM; Mercado, JR | 1 |
| Chen, GG; Hsin, MK; Huang, RY; Li, MY; Ma, LT; Mok, TS; Underwood, MJ; Warner, TD | 1 |
| Chen, GG; Deng, YF; Gong, X; Hsin, MK; Kong, AW; Leung, J; Li, MY; Liang, NC; Lv, Y; Mok, TS; Underwood, MJ; Wu, K | 1 |
| Bhat, SH; Blair, IA; Gelhaus, SL; Mesaros, C; Vachani, A | 1 |
| Chang, H; Chang, LW; Kuo, YC; Lin, P; Siao, SH; Wang, CK; Wang, YJ | 1 |
| Dagne, A; Kassie, F; Luo, X; Melkamu, T; Qian, X; Schutten, MM; Upadhyaya, P | 1 |
| Chen, L; Li, W; Luo, Z; Zhao, Y; Zhou, J | 1 |
| Asomaning, K; Carmella, SG; Chen, F; Christiani, DC; Hecht, SS; Lin, X; Su, L; Ter-Minassian, M; Zhao, Y | 1 |
| Dennis, PA; Ding, X; Hollander, MC; Maier, CR; Patterson, AD; Zhou, X | 1 |
| Hecht, SS; Hermanson, D; Johnson, TE; Kassie, F; Lu, J; O'Sullivan, MG; Upadhyaya, P; Wang, L; Xing, C | 1 |
| Kassie, F; Melkamu, T; Qian, X; Upadhyaya, P | 1 |
| DI, YP; Jin, J; Kahkonen, B; Keohavong, P; Kinchington, E; Liu, X; Siegfried, JM; Yin, J | 1 |
| Kassie, F; Modiano, JF; Murphy, SE; Schutten, MM; von Weymarn, LB | 1 |
| Dennis, PA; Dogan, I; Hobbs, EA; Hollander, MC; Linnoila, RI; Maier, CR | 1 |
| Carmella, SG; Chen, M; Davis, AB; Gao, YT; Han, S; Hecht, SS; Moy, KA; Murphy, SE; Nelson, HH; Tao, L; Wang, R; Yu, MC; Yuan, JM; Zhong, Y | 1 |
| Shields, PG | 1 |
| Lam, DC; Minna, JD | 1 |
| Casto, BC; Knobloch, TJ; Lubet, RA; Pereira, MA; Steele, VE; Warner, BM; Weghorst, CM | 1 |
| Curran, WJ; Deng, X; Khuri, FR; Owonikoko, TK; Shen, J; Sun, SY; Xu, L | 1 |
| Barta, P; Dickey, BF; Lotan, R; Men, T; Moghaddam, SJ; Van Pelt, C | 1 |
| Avanzo, JL; Dagli, ML; Fukumasu, H; Mennecier, G; Mori, CM; Sanches, DS | 1 |
| Bernard, HU; Grando, SA; Kalantari-Dehaghi, M | 1 |
| Chen, GG; Hsin, MK; Kong, AW; Li, MY; Ma, LT; Underwood, MJ; Wan, IY; Yuan, H | 1 |
| Castranova, V; Cavendish, J; Fortney, JE; Gibson, LF; Guo, NL; Luo, D; Qian, Y; Raese, RA; Wan, YW; Xiao, C | 1 |
| Cunningham, DE; Dacic, S; Keohavong, P; Land, SR; Rothstein, ME; Siegfried, JM; Stabile, LP | 1 |
| Cao, Q; Peterson, LA; Upadhyaya, P; Urban, AM | 1 |
| Andersen, B; Edwards, R; Galitovskiy, V; Gordon, W; Grando, SA | 1 |
| Attia, A; Isom, S; Kock, ND; McBride, JE; Miller, MS; Moore, JE; Munley, MT; Walb, MC | 1 |
| Chaible, LM; Cogliati, B; Da Silva, TC; Dagli, ML; Fukumasu, H; Latorre, AO; Mackowiak, II; Mennecier, G; Mori, CM; Nagamine, MK; Sanches, DS; Torres, LN | 1 |
| Kido, T; Kimura, S; Paiz, J; Vinson, C; Ward, JM; Yoneda, M | 1 |
| Kassie, F; Melkamu, T; Qian, X; Song, JM; Upadhyaya, P | 1 |
| Jensen-Taubman, SM; Keefe, KM; Linnoila, RI; Wang, XY; Yang, D | 1 |
| Bhatnagar, S; Chaudhary, N; Jain, SK; Katare, DP | 1 |
| Huang, J; Jiang, Y; Li, X; Li, Y; Liu, R; Wu, J; Yang, C; Yang, Q; Yang, T | 1 |
| Kassie, F; Melkamu, T; O'Sullivan, MG; Qian, X; Upadhyaya, P | 1 |
| Endo, T; Hagiwara, K; Kumagai, H; Matsuyama, C; Miyahara, M; Pokorny, J; Sakurai, H; Satoh, H; Shin, SJ; Yamaki, T; Yano, T | 1 |
| Bedard, LL; Massey, TE; Petsikas, D; Reid, KR; Smith, GB | 1 |
| Rom, WN; Tchou-Wong, KM | 1 |
| Devereux, TR; Herzog, CR; Pittman, B; You, M | 1 |
| Belinsky, S; Brognard, J; Clark, AS; Dennis, PA; Harris, C; Linnoila, IR; Swain, SM; West, KA; Yang, X | 1 |
| Bartels, T; Ehrhardt, A; Halter, R; Klocke, R; Paul, D | 1 |
| Alejandra Hossen, M; Iba, Y; Kamei, C; Kayasuga, R; Kirino, Y; Nishiga, M; Okihara, K; Sugimoto, H; Sugimoto, Y; Yamada, H | 1 |
| Hecht, SS; Jalas, JR; Kenney, PM; McIntee, EJ; Peterson, LA; Upadhyaya, P | 1 |
| Belinsky, SA; Tesfaigzi, Y; Wright, PS | 1 |
| Ikeda, M; Imaida, K; Kamataki, T; Maeta, H; Miyazaki, M; Saoo, K; Takeuchi, H; Yamazaki, H; Yokohira, M | 1 |
| Hao, B; He, F; Lin, D; Miao, X; Tan, W; Wang, H; Zhou, G | 1 |
| Amin, S; Das, A; Desai, D; El-Bayoumy, K; Pittman, B | 1 |
| Djordjevic, MV; Leischow, SJ | 1 |
| Carmella, SG; Hatsukami, DK; Hecht, SS; Jensen, J; Kramarczuk, I; Le, C; Li, YS; Losey, L; Murphy, SE; Puumala, SS; Roe, MR; Zimmerman, CL | 1 |
| Hecht, SS | 10 |
| Maser, E | 2 |
| Belinsky, S; Brognard, J; Dennis, PA; Harris, C; Linnoila, IR; West, KA | 1 |
| Linnoila, RI; Mukherjee, AB; Yang, Y; Zhang, Z | 1 |
| Belinsky, SA; Devereux, TR; Hutt, JA; Pulling, LC; Vuillemenot, BR | 1 |
| Chae, CH; Cho, MH; Choi, DH; Kang, JK; Kim, JH; Lee, HJ; Lee, KH; Lee, SS; Paik, NW; Yeon, SC | 1 |
| Arakawa, K; Carmella, SG; Hecht, SS; Kenney, PM; Low, SH; Yu, MC | 1 |
| Jia, D; Liao, J; Meng, X; Park, ES; Seril, DN; Sun, Y; Yang, CS; Yang, GY | 1 |
| Espiritu, I; Ly, M; Uyeminami, D; Witschi, H | 2 |
| Deng, X; Flagg, T; Gao, F; Jin, Z | 1 |
| Chae, C; Cho, MH; Choi, DH; Kang, JK; Kim, GS; Kim, JH; Lee, HJ; Lee, SS; Paik, NW | 1 |
| Deng, X; Xu, L | 1 |
| Deng, X; Jin, Z; Xin, M | 1 |
| Brognard, J; Castillo, SS; Dennis, PA; Gills, JJ; Granville, CA; Sayyah, J; Tsurutani, J; Zhang, C | 1 |
| Fujieda, M; Imaida, K; Kamataki, T; Matsuda, Y; Miyazaki, M; Saoo, K; Takeuchi, H; Yamakawa, K; Yokohira, M; Zeng, Y | 1 |
| Albanese, C; Chang, MC; Chen, CH; Chen, LC; Chen, RJ; Chu, JS; Ho, YS; Jeng, JH; Lai, YC; Lee, CH; Lee, WS; Liang, YC; Lin, JK; Lin, SY; Pestell, RG; Tseng, H; Tso, WL; Wang, YJ; Wu, CH | 1 |
| Kim, Y; Liu, C; Liu, XS; Russell, RM; Smith, DE; Wang, XD | 1 |
| Carmella, SG; Hatsukami, DK; Hecht, SS; Lemmonds, C; Murphy, S; Tulunay, OE; Zhang, Y | 1 |
| Becker, JM; Bernert, H; Cekanova, M; Majidi, M; Masi, T; Schuller, HM; Walker, K | 1 |
| Cekanova, M; Schuller, HM | 1 |
| Aebischer, CP; Bachmann, H; Buchwald Hunziker, P; Geatrix, B; Goralczyk, R; Lenz, B; Riss, G; Wertz, K | 1 |
| Funae, Y; Imaida, K; Kamataki, T; Masumura, K; Miyazaki, M; Nohmi, T; Saoo, K; Takeuchi, H; Yamazaki, H; Yokohira, M | 1 |
| Calin, GA; Croce, CM; Gnarra, JR; Huebner, K; Kaou, M; Mancini, R; Pekarsky, Y; Sevignani, C; Valtieri, M; Vecchione, A; Zanesi, N | 1 |
| Howard, EF; Kanehira, T; Nakano, Y; Takagi, T; Tamura, M; Tani, T | 1 |
| Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM | 1 |
| Cody, D; Hong, WK; Kim, WY; Lee, HY; Moriarty, RM; Oh, SH; Pezzuto, JM; Price, RE; Tran, H; Van Pelt, CS; Woo, JK | 1 |
| Alyaqoub, FS; Gunning, WT; Kramer, PM; Liu, Y; Lubet, RA; Nines, R; Pereira, MA; Steele, VE | 1 |
| Chongviriyaphan, N; Kim, Y; Liu, C; Russell, RM; Wang, XD | 1 |
| Mernitz, H; Smith, DE; Wang, XD; Zhu, AX | 1 |
| El-Sayed, WM; Franklin, MR; Li, L; Roberts, JC; Szakacs, JG; Xie, Y | 1 |
| Duca, G; Hecht, SS; Mardari, I; Stepanov, I | 1 |
| Amin, S; Desai, D; Herzog, CR | 1 |
| Dacic, S; Land, SR; Lyker, JS; Siegfried, JM; Stabile, LP; Zamboni, BA | 1 |
| Hosokawa, K; Imaida, K; Matsuda, Y; Saoo, K; Takeuchi, H; Yamakawa, K; Yokohira, M; Zeng, Y | 1 |
| Amin, SG; Das, A; Desai, DH; El-Bayoumy, K; Kleinman, W; Pinto, JT; Richie, JP | 1 |
| Cekanova, M; Laag, E; Majidi, M; Masi, T; Schuller, HM; Takahashi, T | 1 |
| El-Zein, RA; Etzel, CJ; Franklin, JD; Lopez, MS; Schabath, MB; Spitz, MR | 1 |
| Razani-Boroujerdi, S; Sopori, ML | 1 |
| Aebischer, CP; Bachmann, H; Buchwald Hunziker, P; Goralczyk, R; Greatrix, B; Lenz, B; Riss, G; Wertz, K | 1 |
| Hayata, I; Ikeda, M; Masumura, K; Nenoi, M; Nohmi, T; Sakamoto, Y; Sakuma, K; Wang, B | 1 |
| Akopyan, G; Bonavida, B | 1 |
| Chung, YC; Jeong, HG; Lee, KJ; Shin, DW | 1 |
| Abdel-Aziz, HO; Murai, Y; Nomoto, K; Tabuchi, Y; Takano, Y; Takasaki, I; Tsuneyama, K | 1 |
| Kamataki, T | 1 |
| Hao, X; Liao, J; Lu, G; Reuhl, KR; Yang, CS; Yang, G | 1 |
| Mernitz, H; Russell, RM; Smith, DE; Wang, XD; Wood, RJ | 1 |
| Choi, SW; Chongviriyaphan, N; Kim, Y; Lian, F; Russell, RM; Wang, XD; Yeum, KJ | 1 |
| Chang, SI; El-Bayoumy, K; Pittman, B; Prokopczyk, B; Sinha, I; Stanley, B; Trushin, N | 1 |
| Hecht, SS; Kassie, F; Lao, Y; Villalta, PW; Yu, N | 1 |
| Guo, Z; Qiao, Y; Shi, Q; Spitz, MR; Wang, L; Wei, Q | 1 |
| Dennis, PA; Fox, SD; Granville, CA; Hollander, MC; Issaq, HJ; Linnoila, RI; Robertson, M; Tsurutani, J; Veenstra, TD; Warfel, N | 1 |
| Ernst, H; Lian, F; Russell, RM; Smith, DE; Wang, XD | 1 |
| Chen, HL; Lai, BT; Liu, MQ; Xia, D; Yang, F; Ye, B; Zhang, YX | 1 |
| Hisamoto, A; Hosokawa, S; Kiura, K; Kondo, E; Mimoto, J; Okada, T; Tabata, M; Takigawa, N; Tanimoto, M | 1 |
| Anderson, LB; Hecht, SS; Kassie, F; Lahti, D; Scherber, R; Upadhyaya, P; Yu, N | 1 |
| Al-Wadei, HA; Majidi, M; Schuller, HM; Takahashi, T | 1 |
| Behr, M; Ding, X; Fang, C; Kaminsky, LS; Turesky, RJ; Weng, Y | 1 |
| Caporaso, N; Hatsukami, DK; Hecht, SS; Joseph, AM; Lubin, JH | 1 |
| Chen, GG; Lee, TW; Li, M; Mok, TS; Xu, H; Yim, AP; Yip, JH | 1 |
| Anderson, LB; Hecht, SS; Higgins, L; Kassie, F; Matise, I; Negia, M; Pan, Y; Upadhyaya, P; Wang, M | 1 |
| Abdel-Aziz, HO; Hiraga, K; Hsu, DK; Kato, I; Liu, FT; Murai, Y; Nomoto, K; Tabuchi, Y; Takahashi, H; Takano, Y; Takasaki, I; Tsuneyama, K; Zheng, HC | 1 |
| Imaida, K; Kitahashi, T; Oghiso, Y; Sugimura, T; Takahashi, M; Takasuka, N; Tsutsumi, M; Wakabayashi, K; Yamada, Y; Yokohira, M | 1 |
| Al-Wadei, HA; Majidi, M; Schuller, HM | 1 |
| Coulter, J; Gabrielson, E; Kuhajda, FP; Orita, H; Tully, E | 1 |
| El-Zein, RA; Etzel, CJ; Fenech, M; Lopez, MS; Spitz, MR | 1 |
| Adams, JD; Hecht, SS; Hoffmann, D; Numoto, S | 1 |
| Amin, S; Hecht, SS; Hoffmann, D; Rivenson, A | 1 |
| Castonguay, A; Hecht, SS; Hoffmann, D; Rivenson, A | 1 |
| Chen, CB; Hecht, SS; Hoffmann, D; Ohmori, T | 1 |
| Kresty, LA; Morse, MA; Toburen, AL | 1 |
| Anderson, MW; Crist, KA; Kelloff, GJ; Lubet, RA; Matzinger, SA; Pereira, MA; Steele, VE; Stoner, GD; You, M | 1 |
| Graham, SA; Linnoila, RI; Oreffo, VI; Sunday, ME; Willett, CG; Witschi, H | 1 |
| Gradia, S; Hecht, SS; Peterson, LA; Ronai, ZA | 1 |
| Castonguay, A; Gunning, WT; Matzinger, SA; You, M | 1 |
| Hoffmann, D; Wynder, EL | 1 |
| Hecht, SS; Isaacs, S; Trushin, N | 1 |
| Chen, WF; Ho, CT; Hong, JY; Shi, ST; Smith, TJ; Wang, ZY; Yang, CS | 1 |
| Carmella, SG; Foiles, PG; Hecht, SS; Murphy, SE; Peterson, LA | 2 |
| Furukawa, F; Kleihues, P; Ohgaki, H; Takahashi, M | 1 |
| Amin, S; Anderson, LM; Beebe, LE; Kim, YE; Kovatch, RM; Riggs, CW | 1 |
| Anderson, MW; Castonguay, A; Chen, B; Liu, L; Maronpot, RR; You, M | 1 |
| Alworth, WL; Hecht, SS; Young-Sciame, R | 1 |
| Amin, S; Desai, D; Djordjevic, MV; Hoffmann, D; Rivenson, A; Zang, E | 1 |
| Abbi, R; Hoffmann, D; Rivenson, A; Wynder, EL | 1 |
| Akerkar, S; Brunnemann, KD; Carmella, SG; Hecht, SS; Hoffmann, D; Murphy, SE | 1 |
| Anderson, MW; Belinsky, SA; Stefanski, SA | 1 |
| Lin, HW; Oreffo, VI; Padmanabhan, R; Witschi, H | 1 |
| Chung, FL; Eklind, KI; Morse, MA; Xu, Y | 1 |
| Castonguay, A | 1 |
| Fuchs, SY; Ronai, Z | 1 |
| Inai, K; Kawano, R; Takeshima, Y | 1 |
| Barr, EB; Belinsky, SA; Finch, GL; Lechner, JF; Nikula, KJ; Stoner, GD | 1 |
| Amin, S; Cox, JE; Desai, D; el-Bayoumy, K; Hoffmann, D; Prokopczyk, B; Upadhyaya, P | 1 |
| Amin, S; Chung, FL; Desai, D; Jiao, D; Kim, S; Smith, TJ; Yang, CS | 1 |
| Choi, CI; Chung, FL; Jiao, D; Kelloff, G; Pittman, B; Rigotty, J; Rivenson, A; Steele, V; Zang, E | 1 |
| Baylin, SB; Belinsky, SA; Issa, JP; Nikula, KJ | 1 |
| Akerkar, SA; Borukhova, A; Carmella, SG; Chung, FL; Hecht, SS; Richie, JP; Skowronski, L | 1 |
| Hecht, SS; Hoffmann, D; Rivenson, A | 1 |
| Akerkar, S; Borukhova, A; Carmella, SG; Hecht, SS; Rigotty, J; Rivenson, A; Trushin, N | 1 |
| Akerkar, S; Amin, S; Borukhova, A; Carmella, SG; Desai, D; Hecht, SS; Rigotty, J; Rivenson, A; Trushin, N | 1 |
| Amin, S; Chang, L; Desai, D | 1 |
| Foiles, PG; Hecht, SS; Miglietta, LM; Staretz, ME | 1 |
| Cesen, KT; Hawk, MA; Ruch, RJ; Siglin, JC; Stoner, GD | 1 |
| Akerkar, SA; Borukhova, A; Carmella, SG; Hecht, SS | 1 |
| Castonguay, A; Rioux, N | 5 |
| Morse, MA; Stoner, GD | 1 |
| Chen, X; Kim, S; Liao, J; Seril, DN; Smith, TJ; Wang, ZY; Yang, CS; Yang, G | 1 |
| Castonguay, A; Duperron, C | 1 |
| Amin, S; Desai, DH; El-Bayoumy, K; Kurtzke, C; Prokopczyk, B; Upadhyaya, P | 1 |
| Akerkar, SA; Carmella, SG; Hecht, SS; Muscat, JE; Richie, JP; Scott, DG | 1 |
| Espiritu, I; Jones, AD; Maronpot, RR; Pinkerton, KE; Witschi, H | 1 |
| Amin, S; Chung, FL; Desai, D; Jiao, D; Pittman, B; Smith, TJ; Yang, CS | 1 |
| Gram, TE | 1 |
| Bondoc, F; Ding, W; Kim, S; Liao, J; Liu, Z; Seril, DN; Yang, CS; Yang, GY | 1 |
| Dahl, AR; Gerde, P; Lewis, JL; Muggenburg, BA; Pyon, KH; Stephens, T | 1 |
| Foth, H; Hirsch-Ernst, KI; Richter, E; Schrader, E | 1 |
| Ichikawa, T; Kishimoto, M; Otani, S; Yajima, S; Yano, T; Yano, Y | 1 |
| Crist, KA; Gao, F; Kelloff, GJ; Lantry, LE; Lubet, RA; Wang, Y; You, M; Zhang, Z | 1 |
| Chung, FL; Conaway, CC; Jiao, D; Smith, TJ; Yang, CS; Yu, MC | 1 |
| Kim, S; Liao, J; Seril, DN; Smith, TJ; Yang, GY | 1 |
| Ahnen, DJ; Castonguay, A; Dwyer-Nield, LD; Koski, KM; Malkinson, AM; Pamukcu, R; Piazza, GA; Rice, PL; Rioux, N; Thompson, H | 1 |
| Anderson, MW; Belinsky, SA; Johansson, E; Jones-Bolin, SE; Palmisano, WA; Wiest, JS | 1 |
| Horikawa, S; Ichikawa, T; Kishimoto, M; Nakamura, T; Yajima, S; Yano, T | 1 |
| Amin, SG; Chung, FL; Ho, CT; Iatropoulos, MJ; Pittman, B; Reinhardt, JC; Rivenson, A; Wang, M | 1 |
| Baylin, SB; Belinsky, SA; Gabrielson, E; Herman, JG; Michels, R; Nikula, KJ; Palmisano, WA; Saccomanno, G | 1 |
| Jarrard, JA; Lee, H; Linnoila, RI; Steinberg, SM; Szabo, E; Witschi, H | 1 |
| Goud, SN; Kaplan, AM | 1 |
| Carmella, SG; Chen, M; Dor Koch, JF; Hatsukami, DK; Hecht, SS; Jensen, JA; Miller, AT; Murphy, SE; Zimmerman, CL | 1 |
| Gerson, SL; Liu, L; Qin, X | 1 |
| Crist, KA; Kelloff, GJ; Lantry, LE; Lubet, RA; Wang, Y; You, M; Zhang, Z | 1 |
| Orloff, M; Schuller, HM | 1 |
| Kawabata, K; Matsunaga, K; Mori, H; Nishikawa, A; Sugie, S; Tanakamaru, Y; Yamada, Y | 1 |
| Amin, S; El-Bayoumy, K; Hoffmann, D; Iatropoulos, M; Wynder, EL | 1 |
| Chung, FL | 1 |
| Agarwal, S; Hecht, SS; Kenney, PM; Rao, AV; Trushin, N; Upadhyaya, P; Wang, M | 1 |
| Castonguay, A; Donnelly, PJ; Massey, TE; Petsikas, D; Reid, KR; Smith, GB | 1 |
| Plummer, H; Schuller, HM; Tithof, PK; Williams, M | 1 |
| Crist, KA; Hamilton, AD; Lantry, LE; Lubet, RA; Ohkanda, J; Sebti, SM; Wang, Y; Yao, R; You, M; Zhang, Z | 1 |
| Plummer, HK; Schuller, HM; Sheppard, BJ; Williams, M | 1 |
| Anderson, MW; Kelloff, GJ; Lantry, LE; Liu, Q; Lubet, RA; Wang, Y; Wiseman, RW; You, M; Zhang, Z | 1 |
| Hecht, SS; Kenney, PM; Trushin, N; Upadhyaya, P; Wang, M | 1 |
| Ichikawa, T; Kishimoto, M; Kumagai, H; Otani, S; Sakurai, H; Virgona, N; Yajima, S; Yano, T; Yano, Y | 1 |
| Belinsky, SA; March, TH; Wardlaw, SA | 1 |
| Carlton, PS; Kresty, LA; Stoner, GD | 1 |
| Amin, S; Desai, D; El-Bayoumy, K; Fiala, ES; Prokopczyk, B; Rosa, JG; Sohn, OS | 1 |
| Porter, B; Riechert, A; Schuller, HM | 1 |
| Castonguay, A; Rioux, N; Yao, R; You, M | 1 |
| Boyle, P; Gray, N | 1 |
| Chhabra, SK; Hong, JY; Smith, TJ; Yang, CS | 1 |
| Atalla, A; Finckh, C; Maser, E; Nagel, G; Stinner, B | 1 |
| Hecht, SS; Kenney, PM; Upadhyaya, P; Wang, M | 1 |
| Crankshaw, DL; Donaldson, EE; Kenney, PJ; Peterson, LA; Thomson, NM | 1 |
| John, LC | 1 |
| Chobanyan, NS; Nersesyan, AK | 1 |
| Castonguay, A; Cloutier, JF; Drouin, R; O'Connor, TR; Weinfeld, M | 1 |
| Azuma, Y; Kohno, H; Ogawa, H; Sumida, T; Taima, M; Tanaka, T | 1 |
| Hirose, M; Imai, T; Mitsumori, K; Takizawa, T; Tamura, T; Ueda, M; Yasuhara, K | 1 |
| Jull, BA; Plummer, HK; Schuller, HM | 1 |
| Beebe, JS; Dmitrovsky, E; Dragnev, KH; Freemantle, SJ; Knauth, EA; Lonardo, F; Ma, Y; Memoli, N; Sekula, D | 1 |
| Akiyama, T; Kainuma, M; Kumagai, H; Nagamine, I; Sakurai, H; Satoh, H; Yamada, K; Yano, T | 1 |
| Chen, CB; Hecht, SS; Hirota, N; Hoffmann, D; Ornaf, RM; Tso, TC | 1 |
| Schüller, HM | 2 |
| Caamano, J; Garcia-Palazzo, I; Harris, CC; Iizasa, T; Klein-Szanto, AJ; Metcalf, R; Momiki, S; Welsh, J | 1 |
| Boukharta, M; Castonguay, A; Jalbert, G | 1 |
| Castonguay, A; Jalbert, G | 1 |
| Brunnemann, KD; Cheng, SC; Hoffmann, D; Rivenson, A; Saa, V | 1 |
| Amin, SG; Chung, FL; Eklind, KI; Morse, MA | 1 |
| Bouchard, L; Castonguay, A; Nicole, P; Pepin, P | 1 |
| Conney, AH; Hong, JY; Huang, MT; Reuhl, KR; Wang, ZY; Yang, CS | 1 |
| Chung, FL; Eklind, KI; Morse, MA | 1 |
| Hong, JY; Pan, J; Shi, S; Smith, TJ; Wang, ZY; Yang, CS; Zhou, S | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; Foley, JF; Maronpot, RR | 1 |
| Amin, SG; Chung, FL; Han, C; Ho, CT; Xu, Y | 1 |
| Castonguay, A; Goldblatt, PJ; Gunning, WT; Stoner, GD | 1 |
| Amin, S; Anderson, LM; Hecht, SS; Hoffmann, D; Kovatch, RM; Rice, JM | 1 |
| Hecht, SS; Hoffmann, D | 1 |
| Hecht, SS; Peterson, LA | 1 |
| Hoffmann, D; Prokopczyk, B; Rivenson, A | 1 |
| Coccia, JB; Wattenberg, LW | 1 |
| Amin, SG; Choi, CI; Chung, FL; Desai, DH; Eklind, KI; Hecht, SS; Jordan, KG; Morse, MA | 1 |
| Becker, KL; Correa, E; Joshi, PA; Nylen, E; Schuller, HM; Witschi, HP | 1 |
| Chung, FL; Hecht, SS; Morse, MA | 1 |
| Amin, SG; Chung, FL; LaGreca, SD; Morse, MA | 1 |
| Anderson, MW; Belinsky, SA; Foley, JF; Maronpot, RR; White, CM | 1 |
| Choi, CI; Hecht, SS; Jordan, KG; Trushin, N | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; Maronpot, RR; Stoner, GD | 1 |
| Amin, S; Anderson, LM; Dixon, DE; Dove, LF; Hecht, SS; Hoffmann, D; Kovatch, RM; Rice, JM | 1 |
| Amin, SG; Chung, FL; Eklind, KI; Hecht, SS; Morse, MA | 1 |
| Amin, S; Choi, CI; Chung, FL; Hecht, SS; Jordan, KG; Morse, MA; Stoner, GD | 1 |
| Amin, SG; Chung, FL; Conran, PB; Hecht, SS; Mandal, S; Morse, MA; Stoner, GD; Wang, CX | 1 |
| Amin, SG; Chung, FL; Hecht, SS; Morse, MA; Wang, CX | 1 |
| Amin, S; Hecht, SS; Hoffmann, D; Prokopczyk, B; Rivenson, A | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; Swenberg, JA; White, CM | 1 |
| Castonguay, A; Hecht, SS; Lin, D; Rivenson, A | 1 |
| Castonguay, A; Hecht, SS; Rivenson, A; Trushin, N | 1 |
| Hecht, SS; Hoffmann, D; Lavoie, EJ | 1 |
| Adams, JD; Brunnemann, KD; Haley, NJ; Hoffmann, D; Melikian, A | 1 |
| Castonguay, A; d'Argy, R; Sperber, G; Tjälve, H; Trushin, N | 1 |
22 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Lung Neoplasms
| Article | Year |
|---|---|
Metformin for lung cancer prevention and improved survival: a novel approach.
Topics: Carcinogenesis; Carcinogens; Diabetes Mellitus, Type 2; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Incidence; Lung; Lung Neoplasms; Metformin; Nicotiana; Nitrosamines; Signal Transduction; Smoke; Survival Analysis; Tobacco Smoking; TOR Serine-Threonine Kinases | 2019 |
Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer.
Topics: Biomarkers; Carcinogens; Cotinine; Glucuronides; Humans; Lung Neoplasms; Mass Spectrometry; Multivariate Analysis; Nicotiana; Nicotine; Nitrosamines; Phenanthrenes; Polycyclic Aromatic Hydrocarbons; Prospective Studies; Pyridines; Risk; Risk Assessment; Smoke | 2014 |
Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms.
Topics: Animals; Carcinogenesis; Carcinogens; Lung Neoplasms; Models, Animal; Nitrosamines | 2015 |
Lysyl oxidase, a critical intra- and extra-cellular target in the lung for cigarette smoke pathogenesis.
Topics: Cadmium; Carcinogens; Down-Regulation; Emphysema; Humans; Lung Neoplasms; Nicotiana; Nitrosamines; Protein-Lysine 6-Oxidase; Proto-Oncogene Mas; Pulmonary Disease, Chronic Obstructive; Smoke; Smoking | 2011 |
Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke.
Topics: Air Pollutants; Benzene; Biomarkers, Tumor; Carcinogens; Environmental Exposure; Female; Humans; Hydrocarbons, Aromatic; Lung Neoplasms; Male; Nitrosamines; Pyridines; Risk Factors; Tobacco Smoke Pollution | 2004 |
Understanding tobacco smoke carcinogen NNK and lung tumorigenesis.
Topics: Carcinogens; Cell Transformation, Neoplastic; Humans; Lung Neoplasms; Nitrosamines; Smoking | 2006 |
[How I was enticed into molecular toxicology].
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Gene Deletion; Humans; Lung Neoplasms; Mixed Function Oxygenases; Molecular Biology; Nitrosamines; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk; Smoking; Thiazolidines; Toxicology | 2006 |
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis by compounds derived from cruciferous vegetables and green tea.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catechin; DNA; DNA Damage; Indoles; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Rats; Rats, Inbred F344; Tea; Thiocyanates; Vegetables | 1993 |
Chemoprevention by isothiocyanates.
Topics: Animals; Anticarcinogenic Agents; Biotransformation; Carcinogens; Humans; Inactivation, Metabolic; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Rats | 1995 |
Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen.
Topics: Animals; Animals, Laboratory; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; DNA Adducts; Genes, p53; Genes, ras; Humans; Lung Neoplasms; Mice; Mutation; Nicotiana; Nitrosamines; Oncogenes; Plants, Toxic; Protein Binding; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Smoking | 1996 |
The biological significance of tobacco-specific N-nitrosamines: smoking and adenocarcinoma of the lung.
Topics: Adenocarcinoma; Animals; Black People; Carcinogenicity Tests; Carcinogens; Cricetinae; Female; Humans; Lung Neoplasms; Male; Mice; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Smoking; Tars; United States; White People | 1996 |
Chemoprevention of lung cancer by isothiocyanates.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Isothiocyanates; Lung Neoplasms; Nitrosamines | 1996 |
Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Humans; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Rats | 1997 |
Chemically reactive intermediates and pulmonary xenobiotic toxicity.
Topics: Animals; Anti-Infective Agents, Urinary; Antibiotics, Antineoplastic; Antineoplastic Agents; Antioxidants; Benzo(a)pyrene; Biotransformation; Bleomycin; Butylated Hydroxytoluene; Carcinogens; Cytochrome P-450 Enzyme System; Dichloroethylenes; DNA Adducts; Herbicides; Hyperoxia; Lung; Lung Neoplasms; Naphthalenes; Nitrofurantoin; Nitrosamines; Paraquat; Skatole; Terpenes; Xenobiotics | 1997 |
Tobacco and cancer: approaches using carcinogen biomarkers and chemoprevention.
Topics: Adult; Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; Chemoprevention; Humans; Isothiocyanates; Lung Neoplasms; Male; Neoplasms; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Risk Factors; Smoke; Smoking; Smoking Cessation; Smoking Prevention; Substance-Related Disorders | 1997 |
Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.
Topics: Animals; Carcinogens; DNA Adducts; DNA Damage; Genes, p53; Genes, ras; Hemoglobins; Humans; Lung Neoplasms; Mutation; Nitrosamines | 1998 |
Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Isothiocyanates; Lung Neoplasms; Neoplasms, Experimental; Nitrosamines; Vegetables | 1999 |
The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black Tea.
Topics: Adenoma; Animals; Carcinogens; Disease Models, Animal; Lung Neoplasms; Nitrosamines; Phytotherapy; Plant Extracts; Rats; Rats, Inbred F344; Tea | 1999 |
Tobacco smoke carcinogens and lung cancer.
Topics: Animals; Carcinogens; DNA; Free Radicals; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Mutation; Nitrosamines; Oncogenes; Polycyclic Aromatic Hydrocarbons; Smoking; Tobacco Smoke Pollution | 1999 |
Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic.
Topics: Allyl Compounds; Animals; Anticarcinogenic Agents; Carcinogens; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Garlic; Glutathione Transferase; Incidence; Liver; Lung Neoplasms; Nitrosamines; Plants, Medicinal; Rodentia; Sulfides; Sulfones; Sulfoxides | 2001 |
Nitrosamine-induced lung carcinogenesis and Ca2+/calmodulin antagonists.
Topics: Animals; Calcium; Calmodulin; Carcinogens; Diethylnitrosamine; Lung; Lung Neoplasms; Neoplasms, Nerve Tissue; Neurosecretory Systems; Nitrosamines; Receptors, Nicotinic | 1992 |
DNA and hemoglobin adducts as markers of metabolic activation of tobacco-specific carcinogens.
Topics: Animals; Biotransformation; Butanones; Carcinogens; DNA, Neoplasm; Hemoglobins; Humans; Lung Neoplasms; Nitrosamines; Pyridines; Risk Factors | 1992 |
1 trial(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Lung Neoplasms
| Article | Year |
|---|---|
Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen.
Topics: Adult; Aged; Alkaloids; Biomarkers, Tumor; Carcinogens; Cotinine; Female; Glucuronates; Humans; Lung Neoplasms; Male; Middle Aged; Nitrosamines; Pyridines; Research Design; Smoking; Smoking Cessation; Treatment Outcome | 2004 |
369 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Lung Neoplasms
| Article | Year |
|---|---|
Effects of tobacco compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the expression of epigenetically regulated genes in lung carcinogenesis.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; DNA Methylation; Epigenesis, Genetic; Epigenome; Gene Expression; Lung; Lung Neoplasms; Mice; Nitrosamines; Tobacco Smoking | 2021 |
Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.
Topics: Allyl Compounds; Animals; Benzothiazoles; Blotting, Western; Carcinogenesis; Comet Assay; Female; Flow Cytometry; Lung Neoplasms; Male; Membrane Potential, Mitochondrial; Mice; Nitrosamines; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Sulfides | 2021 |
Proteome derangement in malignant epithelial cells and its stroma following exposure to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Cadherins; Carcinogens; Epithelial Cells; Humans; Lung Neoplasms; Mice; Nitrosamines; Proteome; Tumor Microenvironment | 2023 |
Differential Expression of TOM34, AL1A1, PADI2 and KLRBA in NNK Induced Lung Cancer in Wistar Rats and their Implications.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Male; Mitochondrial Membrane Transport Proteins; Nitrosamines; Protein-Arginine Deiminase Type 2; Proteomics; Rats; Rats, Wistar; Receptors, Immunologic; Retinal Dehydrogenase | 2019 |
Fluvastatin Inhibits HMG-CoA Reductase and Prevents Non-Small Cell Lung Carcinogenesis.
Topics: Acyl Coenzyme A; Adult; Aged; Animals; Apoptosis; Carcinogenesis; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Fluvastatin; Gene Knockdown Techniques; HEK293 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Lung Neoplasms; Male; Mevalonic Acid; Mice; Middle Aged; Neoplasms, Experimental; Nitrosamines; RNA, Small Interfering; Xenograft Model Antitumor Assays | 2019 |
Involvement of twist in NNK exposure-promoted lung cancer cell migration and invasion.
Topics: Antigens, CD; Cadherins; Carcinogens; Cell Line, Tumor; Cell Movement; Humans; Lung Neoplasms; Nitrosamines; Nuclear Proteins; Twist-Related Protein 1 | 2020 |
Induction of Lung Tumors and Mutational Analysis in FVB/N Mice Treated with the Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone.
Topics: Animals; Carcinogens; Disease Models, Animal; DNA; DNA Mutational Analysis; Immunohistochemistry; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Nicotiana; Nitrosamines; Workflow | 2020 |
Lung proliferative lesion-promoting effects of left pulmonary ligation in A/J female mice.
Topics: Animals; Carcinogens; Disease Models, Animal; Female; Ligation; Lung; Lung Neoplasms; Mice; Nitrosamines | 2020 |
Low carbohydrate diets containing soy protein and fish oil slow the growth of established NNK-induced lung tumors.
Topics: Amylose; Animals; Apoptosis; Carcinogens; Caspase 3; Cytokines; Diet, Carbohydrate-Restricted; DNA Nucleotidylexotransferase; Fatty Acid Synthases; Fatty Acids; Female; Fish Oils; Glycolysis; In Situ Nick-End Labeling; Ki-67 Antigen; Liver; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosamines; Oxidation-Reduction; Soybean Proteins; Tumor Necrosis Factor-alpha | 2020 |
Development of a Lung Cancer Model in Wistar Rat and In Silico Screening of its Biomarkers.
Topics: Adenocarcinoma of Lung; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Computer Simulation; Disease Models, Animal; Drug Design; ErbB Receptors; Lung Neoplasms; Male; Molecular Docking Simulation; Molecular Targeted Therapy; Nitrosamines; Rats; Rats, Wistar | 2021 |
Syngeneic tobacco carcinogen-induced mouse lung adenocarcinoma model exhibits PD-L1 expression and high tumor mutational burden.
Topics: Adenocarcinoma of Lung; Animals; B7-H1 Antigen; Carcinogens; Cell Line, Tumor; Female; Humans; Lung Neoplasms; Male; Mice; Mutation; Neoplasms, Experimental; Nicotiana; Nitrosamines; Smoke; Tumor Microenvironment | 2021 |
Coexposure to Inhaled Aldehydes or Carbon Dioxide Enhances the Carcinogenic Properties of the Tobacco-Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone in the A/J Mouse Lung.
Topics: Administration, Inhalation; Aldehydes; Animals; Carbon Dioxide; Carcinogens; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Mice; Molecular Structure; Nicotiana; Nitrosamines | 2021 |
Exposure to a mixture of cigarette smoke carcinogens disturbs gut microbiota and influences metabolic homeostasis in A/J mice.
Topics: Adenocarcinoma of Lung; Animals; Bacteria; Benzo(a)pyrene; Carcinogens; Dysbiosis; Feces; Female; Gastrointestinal Microbiome; Lung; Lung Neoplasms; Metabolome; Metabolomics; Mice, Inbred Strains; Nitrosamines | 2021 |
Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung
Topics: A549 Cells; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Benzoquinones; Carcinogens; DNA Repair; Female; Humans; Lung Neoplasms; Mice; Nitrosamines; Phosphorylation; Vitis | 2021 |
Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells.
Topics: A549 Cells; Aldehyde Dehydrogenase; Carcinogens; Humans; Lung Neoplasms; Nicotiana; Nitrosamines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Wnt Signaling Pathway | 2017 |
Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Epiregulin; ErbB Receptors; Feedback, Physiological; Female; Fibroblasts; Humans; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Knockout; Mucin-1; Nitrosamines; Smoking | 2017 |
Development of Kras mutant lung adenocarcinoma in mice with knockout of the airway lineage-specific gene Gprc5a.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Carcinogens; Cell Lineage; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Mice; Mice, Knockout; Mutation; Nitrosamines; Proto-Oncogene Proteins p21(ras); Receptors, G-Protein-Coupled | 2017 |
Different inhibitory potential of sex hormones on NNK detoxification in vitro: A possible explanation for gender-specific lung cancer risk.
Topics: Carcinogens; Female; Gonadal Steroid Hormones; Humans; Liver; Lung Neoplasms; Male; Nicotiana; Nitrosamines; Pyridines; Sex Factors; Smoking; Tumor Cells, Cultured | 2017 |
Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Female; Guanine; Lung; Lung Neoplasms; Mice; Nitrosamines; Pyrones; Structure-Activity Relationship | 2017 |
The tobacco carcinogen NNK disturbs mitotic chromosome alignment by interrupting p53 targeting to the centrosome.
Topics: A549 Cells; Carcinogens; Cell Line, Tumor; Centrosome; Chromosomes, Human; HeLa Cells; Humans; Lung Neoplasms; Mitosis; Nicotiana; Nitrosamines; Risk Factors; Tumor Suppressor Protein p53 | 2017 |
Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cytochrome P-450 CYP1A1; Cytokines; Flax; Glucuronosyltransferase; Glutathione Transferase; High-Throughput Nucleotide Sequencing; Inflammation Mediators; Lung; Lung Neoplasms; Male; Metabolic Detoxication, Phase II; Mice; Mice, Inbred A; Nitrosamines; Plant Extracts; Seeds | 2018 |
Metastasis to the F344 Rat Pancreas from Lung Cancer Induced by 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)- 1-butanol, Constituents of Tobacco Products.
Topics: Animals; Carcinogens; Carcinoma; Lung Neoplasms; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Rats; Rats, Inbred F344; Stereoisomerism | 2018 |
The tobacco carcinogen NNK drives accumulation of DNMT1 at the GR promoter thereby reducing GR expression in untransformed lung fibroblasts.
Topics: Carcinogenesis; Carcinogens; Cell Line; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Mifepristone; Nitrosamines; Promoter Regions, Genetic; Protein Binding; Receptors, Glucocorticoid; Small Cell Lung Carcinoma; Tobacco Smoking | 2018 |
Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung.
Topics: 17-Hydroxysteroid Dehydrogenases; Carcinogenesis; Carcinogens; Cytosol; Enzyme Assays; Gene Knockdown Techniques; HEK293 Cells; Humans; Lung; Lung Neoplasms; Microsomes; Nicotiana; Nitrosamines; Oxidation-Reduction; Recombinant Proteins; RNA, Small Interfering; Smoking; Stereoisomerism | 2018 |
Modulation of Vascular Endothelial Growth Factor and Annexin A2 in Response to 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone -Induced Inflammation via Swimming Training.
Topics: Animals; Annexin A2; Carcinogens; Humans; Immunohistochemistry; Lung; Lung Neoplasms; Nitrosamines; Physical Conditioning, Animal; Pneumonia; Rats; Rats, Wistar; Swimming; Tobacco Smoking; Vascular Endothelial Growth Factor A | 2018 |
Dose-Related Modulatory Effects of Polymeric Black Tea Polyphenols (PBPs) on Initiation and Promotion Events in B(a)P and NNK-Induced Lung Carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Camellia sinensis; Carcinogenesis; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2 Inhibitors; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Plant Extracts; Polyphenols; Tea | 2019 |
The effect of diet and exercise on tobacco carcinogen-induced lung cancer.
Topics: Animals; Bronchoalveolar Lavage Fluid; Carcinogens; Diet; Dietary Carbohydrates; Female; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Physical Conditioning, Animal; Soybean Proteins | 2019 |
The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis.
Topics: ADAM17 Protein; Adenocarcinoma of Lung; Animals; Carcinogenesis; Carcinogens; Humans; Lung Neoplasms; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Nitrosamines; Phosphorylation; Signal Transduction; Tobacco Smoke Pollution | 2020 |
DNA adducts in aldehyde dehydrogenase-positive lung stem cells of A/J mice treated with the tobacco specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Topics: Aldehyde Dehydrogenase; Animals; Carcinogens; DNA Adducts; Female; Lung; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Stem Cells | 2013 |
Tobacco specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone suppresses a newly identified anti-tumor IGFBP-3/IGFBP-3R system in lung cancer cells.
Topics: Carcinogens; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor Binding Protein 3; Lung Neoplasms; Nicotiana; Nitrosamines; Receptors, Cell Surface; Smoking | 2013 |
Cytokinesis-blocked micronucleus cytome assay and spectral karyotyping as methods for identifying chromosome damage in a lung cancer case-control population.
Topics: Aged; Case-Control Studies; Chromosome Aberrations; Cytokinesis; DNA Damage; Female; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Lung Neoplasms; Male; Micronucleus Tests; Middle Aged; Nitrosamines | 2013 |
Proteomic analysis of differentially expressed proteins in lung cancer in Wistar rats using NNK as an inducer.
Topics: Animals; Blotting, Western; Carcinogens; Chromatography, Liquid; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Male; Mass Spectrometry; Nitrosamines; Peroxiredoxin VI; Protein Array Analysis; Proteomics; Rats; Rats, Wistar; Up-Regulation | 2013 |
Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users.
Topics: Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Carcinogens; Chemoprevention; Cytochrome P-450 CYP2A6; Humans; Liver; Lung; Lung Neoplasms; Male; Mice; Microsomes; Morpholines; Nicotiana; Nitrosamines; Rats; Smoking | 2013 |
Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling.
Topics: AMP-Activated Protein Kinases; Animals; Carcinogens; Cell Transformation, Neoplastic; Energy Metabolism; Enzyme-Linked Immunosorbent Assay; Female; Hypoglycemic Agents; Insulin-Like Growth Factor I; Lung Neoplasms; Male; Metformin; Mice; Mice, Inbred A; Mice, Knockout; Nitrosamines; Phosphorylation; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tissue Distribution | 2013 |
Thirdhand tobacco smoke: a tobacco-specific lung carcinogen on surfaces in smokers' homes.
Topics: Adult; Carcinogens; Child; Chromatography, Liquid; Female; Humans; Lung Neoplasms; Male; Nitrosamines; Smoking; Tandem Mass Spectrometry; Tobacco Smoke Pollution | 2014 |
Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; DNA Adducts; Guanine; Humans; Lung Neoplasms; Mice, Transgenic; Microsomes; Nicotiana; Nitrosamines; Pyridines | 2014 |
β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells.
Topics: Adenocarcinoma; Adenoma; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Carcinogenesis; Cell Line, Tumor; Disease Progression; Escin; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Neoplasm Transplantation; Nicotiana; Nitrosamines; Plant Extracts; Real-Time Polymerase Chain Reaction; Retinal Dehydrogenase; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein | 2013 |
Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Transformation, Neoplastic; Chemoprevention; Cyclin-Dependent Kinase Inhibitor p21; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Pyrimidines; Random Allocation; Tumor Suppressor Protein p53 | 2013 |
Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenesis; Estradiol; Female; Humans; Hyperplasia; Lung; Lung Neoplasms; Male; Mice; Neoplasms, Hormone-Dependent; Nitrosamines; Orchiectomy; Ovariectomy; Sex Characteristics; Testosterone | 2013 |
Dimethylaminoparthenolide, a water soluble parthenolide, suppresses lung tumorigenesis through down-regulating the STAT3 signaling pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bronchi; Cell Line; Cell Transformation, Neoplastic; Down-Regulation; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred Strains; Myeloid Cell Leukemia Sequence 1 Protein; Nitrosamines; Sesquiterpenes; Solubility; STAT3 Transcription Factor | 2014 |
Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites.
Topics: Animals; Asian People; Case-Control Studies; China; Cohort Studies; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Molecular Structure; Multivariate Analysis; Nicotiana; Nicotine; Nitrosamines; Phenanthrenes; Rats; Risk Factors; Smoking | 2014 |
Napsin A is possibly useful marker to predict the tumorigenic potential of lung bronchiolo-alveolar hyperplasia in F344 rats.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenoma; Animals; Aspartic Acid Endopeptidases; Biomarkers, Tumor; Bronchioles; Hyperplasia; Immunohistochemistry; Lung; Lung Neoplasms; Nitrosamines; Prognosis; Pulmonary Alveoli; Rats; Rats, Inbred F344 | 2014 |
Development of ferret as a human lung cancer model by injecting 4-(Nmethyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Topics: Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Animals; Carcinogens; Cells, Cultured; Disease Models, Animal; Epithelial Cells; Ferrets; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Metaplasia; Neoplasms, Squamous Cell; Nitrosamines | 2013 |
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice.
Topics: Adenoma; Animal Feed; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; DNA Adducts; DNA Damage; Female; Guanine; Kava; Lung; Lung Neoplasms; Mice; Nitrosamines | 2014 |
Suppressive oligodeoxynucleotides reduce lung cancer susceptibility in mice with silicosis.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Disease Models, Animal; Disease Susceptibility; Female; Gene Expression; Humans; Interleukin-1beta; Lung Neoplasms; Mice; Nitrosamines; Oligodeoxyribonucleotides; Pneumonia; RNA, Messenger; Silicon Dioxide; Silicosis | 2014 |
Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Humans; Lung Neoplasms; Nitrosamines; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); Quinazolines | 2014 |
4-(Methylnitrosamino)-1-(3-pyridyl) -1-butanone induces circulating microRNA deregulation in early lung carcinogenesis.
Topics: Adenocarcinoma; Animals; Carcinogenesis; Cell Line, Tumor; Gene Expression Regulation; Humans; Lung; Lung Neoplasms; Male; MicroRNAs; Nitrosamines; Rats; Rats, Inbred F344 | 2014 |
Influence of natural killer cells and perforin‑mediated cytolysis on the development of chemically induced lung cancer in A/J mice.
Topics: Adenocarcinoma; Animals; Apoptosis; Carcinogens; Cytotoxicity, Immunologic; Female; Forkhead Transcription Factors; Killer Cells, Natural; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Pore Forming Cytotoxic Proteins; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2014 |
The regulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumor promotion by estradiol in female A/J mice.
Topics: Animals; Carcinogens; Estradiol; Female; Inflammation; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Polychlorinated Dibenzodioxins; Signal Transduction | 2014 |
Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis.
Topics: Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Proliferation; Cytokine Receptor gp130; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Lung Neoplasms; Male; MAP Kinase Signaling System; Mice; Nitrosamines | 2015 |
TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways.
Topics: Animals; Apoptosis; Carcinogens, Environmental; Cell Line; Cell Proliferation; Cocarcinogenesis; Drug Synergism; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Signaling System; Mice; Nitrosamines; Polychlorinated Dibenzodioxins; Staurosporine | 2014 |
NNK reduction pathway gene polymorphisms and risk of lung cancer.
Topics: Aged; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Male; Middle Aged; Nitrosamines; Polymorphism, Single Nucleotide | 2015 |
Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.
Topics: Animals; Carcinogens; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Female; Guanine; Kava; Liver; Lung Neoplasms; Mice; Mice, Inbred Strains; Nicotiana; Nitrosamines; Pyrones; Structure-Activity Relationship | 2014 |
Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse.
Topics: Animals; Carcinogenesis; Carcinogens; Cytochrome P-450 Enzyme System; DNA Adducts; Lung Neoplasms; Mice; Microsomes, Liver; Multigene Family; Nicotiana; Nitrosamines | 2014 |
Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.
Topics: Adenocarcinoma; Adenoma; Animals; Apoptosis; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; Humans; Lung Neoplasms; Male; Nitrosamines; Pancreatic Neoplasms; Prohibitins; Pyridines; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2014 |
Intranasal delivery of liposomal indole-3-carbinol improves its pulmonary bioavailability.
Topics: Administration, Intranasal; Administration, Oral; Animals; Anticarcinogenic Agents; Biological Availability; Carcinogens; Cytochrome P-450 CYP1A1; Drug Delivery Systems; Female; Gene Expression Regulation, Enzymologic; Indoles; Liposomes; Lung; Lung Neoplasms; Mice; Nitrosamines; Tissue Distribution | 2014 |
NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Bronchi; Carcinogenesis; Carcinogens; Catechin; Dietary Supplements; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Lung; Lung Neoplasms; Mice, Inbred A; Neoplasm Proteins; Nitrosamines; Promoter Regions, Genetic; Respiratory Mucosa | 2015 |
Variation in levels of the lung carcinogen NNAL and its glucuronides in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer.
Topics: Aged; Cohort Studies; Female; Glucuronides; Humans; Lung Neoplasms; Male; Middle Aged; Nitrosamines; Prospective Studies; Smoking | 2015 |
NNK, a tobacco-specific carcinogen, inhibits the expression of lysyl oxidase, a tumor suppressor.
Topics: Acetylation; Animals; Antineoplastic Agents; Carcinogens; Cell Line; CpG Islands; DNA Methylation; Enzyme Inhibitors; Histones; Lung Neoplasms; Nitrosamines; Protein-Lysine 6-Oxidase; Rats; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Proteins | 2014 |
Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer.
Topics: Animals; Anticarcinogenic Agents; Camellia sinensis; Carcinogens; Catechin; Cell Cycle Proteins; Female; Gene Expression Regulation; Lung Neoplasms; Mice; MicroRNAs; Mitogen-Activated Protein Kinases; NF-kappa B; Nitrosamines; Polyphenols; Proto-Oncogene Proteins c-akt | 2014 |
Overexpression of CRM1: A Characteristic Feature in a Transformed Phenotype of Lung Carcinogenesis and a Molecular Target for Lung Cancer Adjuvant Therapy.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Exportin 1 Protein; Fatty Acids, Unsaturated; Female; Gene Expression; Gene Silencing; Humans; Inhibitor of Apoptosis Proteins; Karyopherins; Lung; Lung Neoplasms; Male; Mice; Mice, Nude; Middle Aged; Nitrosamines; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Smoking; Survivin; Transfection; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2015 |
Suppression of pulmonary CYP2A13 expression by carcinogen-induced lung tumorigenesis in a CYP2A13-humanized mouse model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogenesis; Carcinogens; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Female; Inflammation; Interferon-gamma; Interleukin-6; Lung; Lung Neoplasms; Mice; Nitrosamines; RNA, Messenger; Steroid Hydroxylases; Tumor Necrosis Factor-alpha | 2015 |
Expression of NR1I3 in mouse lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone.
Topics: Animals; Constitutive Androstane Receptor; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger | 2015 |
Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis.
Topics: Animals; Apoptosis; Blotting, Southwestern; Blotting, Western; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Histone Deacetylases; Humans; Immunoenzyme Techniques; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triterpenes; Tumor Cells, Cultured | 2015 |
Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators.
Topics: Animals; Anticarcinogenic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Cyclin D1; Cyclin-Dependent Kinases; Cyclooxygenase 2; Drug Combinations; Female; Humans; I-kappa B Proteins; Indoles; Inflammation; Interleukin-6; Lipopolysaccharides; Lung; Lung Neoplasms; Mice; Mice, Inbred A; NF-KappaB Inhibitor alpha; Nitrosamines; Proto-Oncogene Proteins c-akt; Random Allocation; Retinoblastoma Protein; Silybin; Silymarin; Smoke; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2015 |
Inhibitory effect of 5F on development of lung cancer in A/J mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzo(a)pyrene; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Lung Neoplasms; Mice; Nitrosamines; Proto-Oncogene Proteins c-bcl-2; Time Factors; Transcription Factor RelA | 2015 |
Stratifin accelerates progression of lung adenocarcinoma at an early stage.
Topics: 14-3-3 Proteins; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Disease Progression; Exoribonucleases; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Transgenic; Neoplasm Metastasis; Neoplasm Staging; Nitrosamines; Xenograft Model Antitumor Assays | 2015 |
Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; bcl-X Protein; Carcinogens; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Nicotiana; Nicotine; Nitrosamines; Proliferating Cell Nuclear Antigen; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; DNA; DNA Adducts; Lung; Lung Neoplasms; Male; Nicotiana; Nitrosamines; Phosphates; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
Tumorigenesis of smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is related to its ability to stimulate thromboxane synthase and enhance stemness of non-small cell lung cancer stem cells.
Topics: beta Catenin; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Neoplastic Stem Cells; Nitrosamines; Thromboxane-A Synthase | 2016 |
Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines.
Topics: Activation, Metabolic; Animals; Biomarkers, Tumor; Carcinogens; Humans; Lung Neoplasms; Mouth Neoplasms; Nitrosamines; Rats; Smoking; Tobacco Products | 2016 |
Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.
Topics: Animals; Carcinogenesis; Chemoprevention; Diet; DNA Adducts; DNA Damage; Female; Inactivation, Metabolic; Lung; Lung Neoplasms; Mice; Microsomes, Liver; Nitrosamines; Pyrones | 2016 |
Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenoma; Animals; Cell Transformation, Neoplastic; Enzyme Activation; Female; Lung Neoplasms; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Signaling System; Mice, Inbred A; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nitrosamines; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins p21(ras) | 2016 |
Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis.
Topics: A549 Cells; Animals; beta Catenin; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Human Umbilical Vein Endothelial Cells; Humans; Immunoprecipitation; Lung Neoplasms; Mice; Microscopy, Fluorescence; Neovascularization, Physiologic; Nitrosamines; RNA Interference; RNA, Small Interfering; Transforming Growth Factor beta1; Triterpenes; Wnt Signaling Pathway; Wnt3 Protein; Wnt3A Protein | 2016 |
Identification of a long non-coding RNA NR_026689 associated with lung carcinogenesis induced by NNK.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Nitrosamines; Rats; RNA, Long Noncoding; Tumor Cells, Cultured | 2016 |
Polymeric black tea polyphenols (PBPs) inhibit benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung carcinogenesis potentially through down-regulation of p38 and Akt phosphorylation in A/J mice.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Proliferation; Humans; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polyphenols; Proto-Oncogene Proteins c-akt; Tea | 2017 |
Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Assay; Biphenyl Compounds; Bronchi; Carcinogenesis; Cell Cycle; Cell Proliferation; Cell Survival; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Female; Lignans; Lung Neoplasms; Magnolia; Mice; Molecular Docking Simulation; Nitrosamines; Plant Extracts; RNA, Small Interfering | 2016 |
Smoking-associated lung cancer prevention by blockade of the beta-adrenergic receptor-mediated insulin-like growth factor receptor activation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Insulin-Like Growth Factor II; Lung Neoplasms; Mice; Neoplasms, Experimental; NF-kappa B; Nitrosamines; Phosphorylation; Receptor, IGF Type 1; Receptors, Adrenergic, beta; Receptors, Somatomedin; Signal Transduction; Smoking; STAT3 Transcription Factor; Tumor Burden | 2016 |
Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice.
Topics: Administration, Inhalation; Aerosols; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogenesis; Carcinogens; Female; Glycerol; In Situ Nick-End Labeling; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Spermine | 2017 |
Dietary 5-demethylnobiletin inhibits cigarette carcinogen NNK-induced lung tumorigenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinogenesis; Carcinogens; Citrus; Female; Flavones; Humans; Lung; Lung Neoplasms; Mice; Nitrosamines; Tobacco Products | 2017 |
CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study.
Topics: Asian People; Biomarkers; Carcinogens; Case-Control Studies; Cytochrome P-450 CYP2A6; Female; Genotype; Humans; Lung Neoplasms; Male; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Polymorphism, Genetic; Prospective Studies; Risk; Singapore; Smoke; Smoking | 2017 |
Haem oxygenase-1 plays a central role in NNK-mediated lung carcinogenesis.
Topics: Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; bcl-Associated Death Protein; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Heme Oxygenase-1; Humans; Inhibitor of Apoptosis Proteins; Lung; Lung Neoplasms; MAP Kinase Signaling System; NF-kappa B; Nitrosamines; Proto-Oncogene Proteins c-bcl-2; Smoking; Ubiquitin-Protein Ligases | 2008 |
Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers.
Topics: Adult; Biotransformation; Carcinogens; Female; Humans; Incidence; Lung Neoplasms; Male; Middle Aged; Nicotiana; Nitrosamines; Risk Factors; Smoking; United States; Young Adult | 2008 |
Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Hyperplasia; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Time Factors | 2008 |
Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice.
Topics: Alleles; Animals; Dose-Response Relationship, Drug; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, ras; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nitrosamines; Phenotype; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Species Specificity | 2008 |
Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cyclin-Dependent Kinase Inhibitor p27; Epithelial Cells; Hyperplasia; Lung; Lung Neoplasms; Male; Mice; Naphthalenes; Neurosecretory Systems; Nitrosamines; RNA, Messenger; Ubiquitin Thiolesterase | 2008 |
Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Gene Expression; Gene Expression Profiling; Lung Neoplasms; Male; MicroRNAs; Nicotiana; Nitrosamines; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Steroid Hydroxylases | 2008 |
Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Disease Progression; Enzyme Inhibitors; Female; Lung Neoplasms; Methoxsalen; Mice; Neoplasm Staging; Nitrosamines | 2008 |
Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine.
Topics: Adult; Aged; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nerve Tissue Proteins; Nicotine; Nitrosamines; Polymorphism, Single Nucleotide; Pyridines; Receptors, Nicotinic; Smoking | 2008 |
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) enhances invasiveness of lung cancer cells by up-regulating contactin-1 via the alpha7 nicotinic acetylcholine receptor/ERK signaling pathway.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Cell Adhesion Molecules, Neuronal; Contactin 1; Contactins; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Profiling; Humans; Lung Neoplasms; Neoplasm Invasiveness; Nitrosamines; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Up-Regulation | 2009 |
Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export.
Topics: 3' Untranslated Regions; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinogens; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Nitrosamines; Polymorphism, Single Nucleotide; Smoking | 2009 |
A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers.
Topics: Aged; Biomarkers, Tumor; Case-Control Studies; Chi-Square Distribution; Female; Glucuronates; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Nicotiana; Nitrosamines; Prospective Studies; Pyridines; Risk Factors | 2009 |
Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice.
Topics: Adenoma; Algorithms; Animals; Antineoplastic Agents; Apoptosis; Benzo(a)pyrene; Body Weight; Cell Proliferation; Chemoprevention; Drug Evaluation, Preclinical; Eating; Female; Kava; Lung Neoplasms; Mice; Neoplasms, Multiple Primary; Nitrosamines; Plant Extracts | 2008 |
Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Blotting, Western; Carcinogens; Cell Proliferation; Chromatography, High Pressure Liquid; Diet; Dose-Response Relationship, Drug; Female; Immunoblotting; Immunohistochemistry; Indoles; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Smoke | 2008 |
Chemopreventive effects of fermented brown rice and rice bran against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice.
Topics: Animals; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Aspergillus oryzae; Carcinogens; Chemoprevention; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Dietary Fiber; Female; Fermentation; Gene Expression; Immunohistochemistry; Lung Neoplasms; Mice; Nitrosamines; Oryza; Phytotherapy; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice.
Topics: Animals; Antineoplastic Agents; Carcinogens, Environmental; Cell Growth Processes; Cell Line, Tumor; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gefitinib; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosamines; Pulmonary Fibrosis; Quinazolines; Smoking; Tumor Burden | 2009 |
beta-Carotene promotes the development of NNK-induced small airway-derived lung adenocarcinoma.
Topics: Adenocarcinoma; Animals; beta Carotene; Biological Assay; Blotting, Western; Cricetinae; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Lung Neoplasms; Male; Mesocricetus; Models, Animal; Nitrosamines; Phosphorylation; Random Allocation; Retinoids; Signal Transduction; Time Factors | 2009 |
Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas.
Topics: Adenocarcinoma; Animals; Blotting, Western; Carcinoma, Pancreatic Ductal; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Epinephrine; Female; gamma-Aminobutyric Acid; Lung Neoplasms; Male; Mesocricetus; Models, Animal; Neurotransmitter Agents; Nitrosamines; Norepinephrine; Pancreatic Neoplasms; Pregnancy; Receptors, Nicotinic; Signal Transduction; Smoking | 2009 |
Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Guanine; Liver; Lung; Lung Neoplasms; Nicotiana; Nitrosamines; Prohibitins; Rats; Rats, Inbred F344 | 2009 |
Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice.
Topics: Adenocarcinoma; Adenoma; Administration, Oral; Animals; Antioxidants; Carcinogens; DNA Glycosylases; Drug Antagonism; Female; Genes, erbB-1; Genes, ras; Humans; Infusions, Subcutaneous; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nitrosamines; Precancerous Conditions; Sex Factors | 2009 |
PPARgamma activation extinguishes smoking carcinogen by inhibiting NNK-mediated proliferation.
Topics: Carcinogens; Cell Line, Tumor; Cell Proliferation; Chromans; Cyclin-Dependent Kinase Inhibitor p21; Heme Oxygenase-1; Humans; Lung; Lung Neoplasms; NF-kappa B; Nitrosamines; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Smoking; Thiazolidinediones; Transcription, Genetic; Troglitazone | 2010 |
FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK).
Topics: Adenocarcinoma; Apoptosis; Carcinogens; Cell Line, Tumor; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Nicotine; Nitrosamines; Transcription, Genetic; Tumor Suppressor Proteins | 2010 |
Is nicotine the estrogen of lung cancer?
Topics: alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Nicotine; Nitrosamines; Prognosis; Receptors, Nicotinic; Risk Factors; Tobacco Smoke Pollution | 2009 |
Bayesian derivation of an oral cancer slope factor distribution for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Topics: Animals; Bayes Theorem; Carcinogenicity Tests; Carcinogens; Decision Support Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Environmental Exposure; Female; Humans; Lung Neoplasms; Male; Mice; Models, Biological; Monte Carlo Method; Mouth Neoplasms; Neoplasms, Experimental; Nitrosamines; Pancreatic Neoplasms; Rats; Risk Assessment; United States; United States Environmental Protection Agency | 2009 |
Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data.
Topics: Benzo(a)pyrene; Carcinogens; Dose-Response Relationship, Drug; Female; Humans; Inhalation Exposure; Lung Neoplasms; Male; Monte Carlo Method; Nitrosamines; Risk Assessment; Smoke; Smoking; United States | 2009 |
Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis.
Topics: 14-3-3 Proteins; Adenocarcinoma; Animals; Annexin A5; Carcinogens; Cluster Analysis; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Female; Histocytochemistry; Immunoblotting; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Organoselenium Compounds; Protein Interaction Mapping; Protein Isoforms; Proteomics; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2009 |
Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer.
Topics: Aged; Asian; Carcinogens; Cross-Sectional Studies; Ethnicity; Female; Follow-Up Studies; Glucuronates; Hawaii; Humans; Inactivation, Metabolic; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Prognosis; Pyridines; Risk Factors; Smoking; Survival Rate; White People | 2009 |
FoxO3a gene is a target of deletion in mouse lung adenocarcinoma.
Topics: Adenocarcinoma; Aflatoxin B1; Animals; Carcinogens; Disease Models, Animal; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Deletion; Loss of Heterozygosity; Lung Neoplasms; Mice; Nitrosamines; Polymerase Chain Reaction; Smoking; Urethane | 2009 |
Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Cycle Proteins; Cyclooxygenase 2; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fish Oils; Gene Expression Regulation; Isoenzymes; Lipoxygenase; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Plant Oils; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Burden | 2009 |
Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinogens; Carrier Proteins; Cell Cycle Proteins; Cell Proliferation; Cytochrome P-450 Enzyme System; DNA Adducts; Eukaryotic Initiation Factors; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Knockout; Microarray Analysis; Microsomes; Neovascularization, Pathologic; Nitrosamines; Phosphoproteins; Protein Biosynthesis; Ribosomes | 2009 |
Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulates nicotinic receptors in small airway epithelial cells.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Carcinogens; Drug Synergism; Epithelial Cells; Estrogens; Female; gamma-Aminobutyric Acid; Humans; Lung Neoplasms; Nitrosamines; Norepinephrine; Receptor Cross-Talk; Receptors, Nicotinic; Signal Transduction; Small Cell Lung Carcinoma; Smoking; Up-Regulation | 2010 |
Effects of antibodies induced by a conjugate vaccine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone absorptive transport, metabolism, and proliferation of human lung cells.
Topics: Antibodies, Monoclonal; Biological Transport; Cell Line, Tumor; Cell Proliferation; Humans; Lung; Lung Neoplasms; Nitrosamines; Vaccines | 2010 |
Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer.
Topics: Animals; Body Weight; Calbindin 2; Cell Proliferation; Disease Progression; Epithelial Cells; Female; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Organ Size; Polymers; Pulmonary Atelectasis; S100 Calcium Binding Protein G; Thoracotomy; Thorax | 2011 |
Methylation induced gene silencing of HtrA3 in smoking-related lung cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Large Cell; Carcinoma, Squamous Cell; Cell Line, Tumor; Cells, Cultured; Cisplatin; DNA Methylation; Drug Resistance, Neoplasm; Etoposide; Gene Silencing; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Nitrosamines; Serine Endopeptidases; Smoking | 2010 |
Roles of peroxisome proliferator-activated receptor-alpha and -gamma in the development of non-small cell lung cancer.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxyeicosatetraenoic Acids; Ligands; Linoleic Acids; Lipid Metabolism; Lung Neoplasms; Male; Mice; Nitrosamines; Pioglitazone; PPAR alpha; PPAR gamma; Precancerous Conditions; Retinoid X Receptor alpha; Signal Transduction; Thiazolidinediones; Transcription, Genetic | 2010 |
Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer.
Topics: Animals; Carcinogens; Cell Line; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; Dogs; Epithelial Cells; Humans; Lung; Lung Neoplasms; Microscopy, Fluorescence; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Nicotiana; Nitrosamines | 2010 |
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
Topics: Animals; Carcinogens; Cell Line; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Mice; Nitrosamines; Phosphorylation; Prognosis; Smoking | 2010 |
A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Apoptosis; Benzo(a)pyrene; Cell Line, Tumor; Cell Proliferation; Deoxyguanosine; Dinoprostone; Female; gamma-Tocopherol; Histones; Leukotriene B4; Lung Neoplasms; Mice; Neovascularization, Pathologic; Nitrosamines; Tyrosine; Xenograft Model Antitumor Assays | 2010 |
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Enzyme-Linked Immunosorbent Assay; Genes, ras; I-kappa B Kinase; Immunohistochemistry; Inflammation; Lung Neoplasms; Male; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 8; Nitrosamines; Reverse Transcriptase Polymerase Chain Reaction; Tobacco Smoke Pollution | 2010 |
Identification of long stress-induced non-coding transcripts that have altered expression in cancer.
Topics: Base Sequence; Breast Neoplasms; Carcinogens; Cell Line; Cell Line, Tumor; Epithelial Cells; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Lung Neoplasms; Molecular Sequence Data; Neoplasms; Nitrosamines; RNA, Untranslated; Stress, Physiological; Transcription, Genetic | 2010 |
15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer.
Topics: Animals; Arachidonate 15-Lipoxygenase; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Disease Models, Animal; Disease Progression; Female; Humans; Hydroxyeicosatetraenoic Acids; Linoleic Acids; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasm Proteins; Nitrosamines; PPAR gamma | 2010 |
The function of IGF-IR in NNK-mediated lung tumorigenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Humans; Immunohistochemistry; Lung Neoplasms; Male; Mice; Mice, Transgenic; Nitrosamines; Receptor, IGF Type 1; Signal Transduction; Up-Regulation | 2011 |
Risk analysis of environmental chemicals on lung carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cattle; Disease Models, Animal; Female; Humans; Lactoferrin; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred ICR; Nitrosamines; Risk Assessment | 2010 |
A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species.
Topics: Animals; Base Sequence; Carcinogens; Cell Cycle; Cell Division; DNA Primers; Electrophoretic Mobility Shift Assay; Flow Cytometry; Lung Neoplasms; Male; Mice; Mice, Nude; NF-kappa B; Nicotiana; Nitrosamines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sesquiterpenes; Urinary Bladder Neoplasms | 2011 |
Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.
Topics: Adenocarcinoma; Animals; Blotting, Western; Carcinogens; Cyclin D1; Flap Endonucleases; Genomics; Humans; Immunohistochemistry; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Knockout; Nitrosamines; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Receptors, G-Protein-Coupled; Ubiquitin-Conjugating Enzymes | 2010 |
Metformin prevents tobacco carcinogen--induced lung tumorigenesis.
Topics: Adenylate Kinase; Administration, Oral; Animals; Antineoplastic Agents; Carcinogens; Carcinoma; Drug Evaluation, Preclinical; Female; Hypoglycemic Agents; Injections, Intraperitoneal; Lung Neoplasms; Metformin; Mice; Nicotiana; Nitrosamines; Signal Transduction; TOR Serine-Threonine Kinases | 2010 |
4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinogens; Cell Growth Processes; Cell Survival; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Unsaturated; Humans; Hydrazines; Lung Neoplasms; Nitrosamines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, Thromboxane A2, Prostaglandin H2; Smoking; Thromboxane A2; Thromboxane-A Synthase; Tumor Cells, Cultured | 2011 |
Anticancer efficacy of 5F in NNK-induced lung cancer development of A/J mice and human lung cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Nucleus; Cell Proliferation; Cell Survival; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Down-Regulation; Drug Screening Assays, Antitumor; Extracellular Signal-Regulated MAP Kinases; Humans; Lung Neoplasms; Mice; Mitochondria; Nitrosamines; Protein Transport; Proto-Oncogene Proteins c-akt; Time Factors; Treatment Outcome; Up-Regulation | 2010 |
A new liquid chromatography/mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine.
Topics: Biomarkers, Tumor; Case-Control Studies; Chromatography, Liquid; Creatinine; DNA Adducts; Drug Stability; Humans; Isotope Labeling; Lung Neoplasms; Mass Spectrometry; Nitrosamines; Phenotype; Pyridines; Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Smoking | 2011 |
Synergism between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumor incidence in mice.
Topics: Animals; Carcinogens; Female; Genes, p16; Immunohistochemistry; Incidence; Lung Neoplasms; Male; Mice; Nitrosamines; Polychlorinated Dibenzodioxins; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Indoles; Lung Neoplasms; Mice; Nitrosamines; Proto-Oncogene Proteins c-akt; Silybin; Silymarin | 2011 |
Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adult; Aged; Case-Control Studies; Creatinine; Female; Humans; Individuality; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Oxidoreductases; Polymorphism, Single Nucleotide; Pyridines; Smoking; Tobacco Smoke Pollution | 2012 |
A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Female; Immunoblotting; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Knockout; Microsomes, Liver; Nicotiana; Nitrosamines; Polymerase Chain Reaction; Polymorphism, Genetic; Proto-Oncogene Proteins c-akt; Steroid Hydroxylases | 2011 |
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Carcinogens; Cell Death; Cell Proliferation; Chalcone; Dose-Response Relationship, Drug; Female; Kava; Liver; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Phytotherapy; Plant Extracts | 2011 |
Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anticarcinogenic Agents; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Female; Humans; Indoles; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptor Protein-Tyrosine Kinases | 2011 |
K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation.
Topics: Animals; Base Sequence; Bronchoalveolar Lavage Fluid; DNA Primers; Genes, ras; Lipopolysaccharides; Lung; Lung Neoplasms; Mice; Mutation; Nitrosamines; Pneumonia; Polymerase Chain Reaction | 2011 |
Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Adenoma; Animals; Carcinogens; Cells, Cultured; Drinking Water; Female; Guanine; Humans; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nicotine; Nitrosamines | 2011 |
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
Topics: Adenocarcinoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Drinking Water; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras) | 2011 |
Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers.
Topics: Aged; China; Cotinine; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Phenanthrenes; Prospective Studies; Pyridines; Smoke; Smoking | 2011 |
Long-term nicotine replacement therapy: cancer risk in context.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras) | 2011 |
How do we safely get people to stop smoking?
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras) | 2011 |
Chemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin.
Topics: Animals; Atorvastatin; Colonic Neoplasms; Dimethylhydrazines; Female; Heptanoic Acids; Histone Deacetylase Inhibitors; Hydroxamic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung Neoplasms; Mice; Nitrosamines; Pyrroles; RNA, Messenger; Urethane; Vorinostat | 2012 |
NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Blotting, Western; Bungarotoxins; Carcinogens; Cell Adhesion; Cell Movement; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Humans; Isoenzymes; Lung Neoplasms; Neoplasm Invasiveness; Nitrosamines; Protein Kinase C; Proto-Oncogene Proteins pp60(c-src); Receptors, Nicotinic; RNA, Small Interfering; Tumor Cells, Cultured; Wound Healing | 2012 |
Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation.
Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Haemophilus Infections; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Lung Neoplasms; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Nitrosamines; Pulmonary Disease, Chronic Obstructive; Receptors, G-Protein-Coupled | 2012 |
Higher susceptibility of spontaneous and NNK-induced lung neoplasms in connexin 43 deficient CD1 × AJ F1 mice: paradoxical expression of connexin 43 during lung carcinogenesis.
Topics: Animals; beta Catenin; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Connexin 43; Disease Susceptibility; Female; Immunoenzyme Techniques; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrosamines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2013 |
Reciprocal effects of NNK and SLURP-1 on oncogene expression in target epithelial cells.
Topics: Antigens, Ly; Bronchi; Carcinogens; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mouth; Mouth Neoplasms; Nitrosamines; Urokinase-Type Plasminogen Activator | 2012 |
Pioglitazone prevents smoking carcinogen-induced lung tumor development in mice.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Hydroxyeicosatetraenoic Acids; Hyperplasia; Ligands; Linoleic Acids; Lung Neoplasms; Mice; Nitrosamines; Pioglitazone; PPAR gamma; Pulmonary Alveoli; Smoking; Thiazolidinediones; Time Factors; Transcription, Genetic | 2012 |
A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis.
Topics: Aged; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Nitrosamines; Prognosis; Retinoblastoma Protein; Signal Transduction; Smoking; Tumor Suppressor Protein p53 | 2012 |
Prevention of tobacco carcinogen-induced lung cancer in female mice using antiestrogens.
Topics: Anastrozole; Animals; Aromatase Inhibitors; Carcinogens; Cell Proliferation; Estradiol; Estrogen Receptor Modulators; Female; Fulvestrant; Immunoenzyme Techniques; Lung Neoplasms; Mice; Mice, Inbred BALB C; Nicotiana; Nitriles; Nitrosamines; Receptors, Estrogen; Triazoles | 2012 |
Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice.
Topics: Animals; Carcinogens; Deoxyguanosine; DNA Adducts; Enzyme Inhibitors; Female; Guanine; Lung; Lung Neoplasms; Mice; Mutagens; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines | 2012 |
The tobacco carcinogen nitrosamine induces a differential gene expression response in tumour susceptible A/J and resistant C3H mouse lungs.
Topics: Animals; Carcinogens; Genetic Predisposition to Disease; Immunity, Innate; Lung Neoplasms; Mice; Mice, Inbred C3H; Nitrosamines | 2013 |
Chemoprevention by N-acetylcysteine of low-dose CT-induced murine lung tumorigenesis.
Topics: Acetylcysteine; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Free Radical Scavengers; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neoplasms, Radiation-Induced; Nitrosamines; Tomography, X-Ray Computed | 2013 |
Chronic exposure of lung alveolar epithelial type II cells to tobacco-specific carcinogen NNK results in malignant transformation: a new in vitro lung carcinogenesis model.
Topics: Animals; Blotting, Western; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Epithelial-Mesenchymal Transition; Female; Fluorescent Antibody Technique, Indirect; Immunoenzyme Techniques; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Nicotiana; Nitrosamines; Pulmonary Alveoli; Wound Healing | 2014 |
Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse.
Topics: Adenoma; Animals; Biomarkers, Tumor; Carcinoma; CCAAT-Enhancer-Binding Proteins; Cell Transformation, Neoplastic; In Situ Nick-End Labeling; Incidence; Ki-67 Antigen; Lung Neoplasms; Male; Mice; Mice, Transgenic; Nitrosamines; Pulmonary Alveoli | 2012 |
Chemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice.
Topics: Administration, Intranasal; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Humans; Indoles; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Phosphatidylinositol 3-Kinase; Random Allocation | 2013 |
Achaete-scute complex homolog-1 promotes DNA repair in the lung carcinogenesis through matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase.
Topics: Adenoma; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Transformation, Neoplastic; Cisplatin; DNA Damage; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Enzyme Induction; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Lung Neoplasms; Matrix Metalloproteinase 7; Mice; Mice, Transgenic; Nitrosamines; Promoter Regions, Genetic; Protein Binding; RNA, Small Interfering; Small Cell Lung Carcinoma; Tumor Suppressor Proteins; Up-Regulation | 2012 |
A non-surgical method for induction of lung cancer in Wistar rats using a combination of NNK and high dietary fats.
Topics: Animals; Carcinogens; Dietary Fats; Disease Models, Animal; Lung Neoplasms; Male; Nitrosamines; Oxidative Stress; Rats; Rats, Wistar | 2013 |
Alteration of serum miR-206 and miR-133b is associated with lung carcinogenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Lung Neoplasms; Male; MicroRNAs; Nitrosamines; Rats; Rats, Inbred F344; Up-Regulation | 2013 |
Lipopolysaccharide enhances mouse lung tumorigenesis: a model for inflammation-driven lung cancer.
Topics: Administration, Intranasal; Animals; Blotting, Western; Carcinogenesis; Disease Models, Animal; Immunohistochemistry; Linear Models; Lipopolysaccharides; Lung Neoplasms; Mice; Nitrosamines | 2013 |
High oleic acid oil suppresses lung tumorigenesis in mice through the modulation of extracellular signal-regulated kinase cascade.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Dinoprostone; Enzyme Inhibitors; Immunoblotting; Lung Neoplasms; MAP Kinase Signaling System; Mice; Mice, Inbred A; Mitogen-Activated Protein Kinases; Nitrosamines; Oleic Acid; Plant Oils; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-raf | 2002 |
Investigation of the role of lipoxygenase in bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung.
Topics: Aged; Biotransformation; Carcinogens; Cytosol; Female; Hemoglobins; Humans; Hydroxylation; Lipoxygenase; Lung; Lung Neoplasms; Male; Middle Aged; Nitrosamines; Smoking | 2002 |
Lung-specific expression of mutant p53 as mouse model for lung cancer.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Genes, p53; Humans; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Transgenic; Mutation; Nitrosamines; Proliferating Cell Nuclear Antigen; Promoter Regions, Genetic; Proteins; Uteroglobin | 2003 |
Carcinogenic induction directs the selection of allelic losses in mouse lung tumorigenesis.
Topics: Adenocarcinoma; Animals; Carcinogens; Loss of Heterozygosity; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Inbred C3H; Nitrosamines; Urethane | 2002 |
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Bronchi; Carcinogens; Carrier Proteins; Cell Cycle Proteins; Cell Death; Cell Survival; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Forkhead Box Protein O1; Forkhead Transcription Factors; Glycogen Synthase Kinase 3; Humans; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Nicotiana; Nicotine; Nitrosamines; Phenotype; Phosphoproteins; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; Time Factors; Transcription Factors; Ultraviolet Rays | 2003 |
Increased susceptibility to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in transgenic mice overexpressing c-myc and epidermal growth factor in alveolar type II cells.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Carcinogens; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Hyperplasia; Intercellular Signaling Peptides and Proteins; Lung; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Peptides; Proto-Oncogene Proteins c-myc; Pulmonary Surfactant-Associated Protein C; Pulmonary Surfactants | 2003 |
Inhibitory effects of propolis granular A P C on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Carcinogens; Female; Lung Neoplasms; Mice; Nitrosamines; Nucleic Acid Synthesis Inhibitors; Phenylpropionates; Propolis; Time Factors | 2003 |
Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Deuterium; DNA; DNA Adducts; Dose-Response Relationship, Drug; Female; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Microsomes; Mixed Function Oxygenases; Molecular Structure; Nitrosamines; Stereoisomerism; Structure-Activity Relationship | 2003 |
SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle.
Topics: Adenocarcinoma; Animals; Beryllium; Carcinogens; CHO Cells; Cornified Envelope Proline-Rich Proteins; Cricetinae; Humans; Lung; Lung Neoplasms; Membrane Proteins; Mice; Mice, Inbred Strains; Mice, Nude; Nitrosamines; Ploidies; Proteins; Rats; Rats, Inbred F344; Resting Phase, Cell Cycle; Transfection | 2003 |
Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
Topics: Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Female; Lung Neoplasms; Methoxsalen; Mice; Mice, Inbred A; Mixed Function Oxygenases; Nitrosamines | 2003 |
Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
Topics: Adenocarcinoma; Alleles; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Carcinoma, Squamous Cell; Case-Control Studies; Cytochrome P-450 CYP2A6; Female; Gene Deletion; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Male; Middle Aged; Mixed Function Oxygenases; Nitrosamines; Polymorphism, Genetic; Smoking | 2003 |
Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; DNA Methylation; Female; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Organoselenium Compounds; Saccharomyces cerevisiae; Selenium | 2003 |
Smoking reduction and tobacco-related cancers: the more things change, the more they stay the same.
Topics: Biomarkers, Tumor; Carcinogens; Global Health; Humans; International Agencies; Lung Neoplasms; Neoplasms; Nicotine; Nicotinic Agonists; Nitrosamines; Risk Factors; Smoking; Smoking Cessation; Tobacco Smoke Pollution; Tobacco Use Disorder; United States | 2004 |
Significance of reductases in the detoxification of the tobacco-specific carcinogen NNK.
Topics: Alcohol Oxidoreductases; Anti-Inflammatory Agents; Carcinogens; Glycyrrhetinic Acid; Humans; Inactivation, Metabolic; Lung Neoplasms; Nitrosamines | 2004 |
Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo.
Topics: Animals; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Activation; ErbB Receptors; Humans; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt | 2004 |
Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke.
Topics: Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Susceptibility; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Fas Ligand Protein; Humans; Lung; Lung Neoplasms; MAP Kinase Signaling System; Membrane Glycoproteins; Mice; Mice, Knockout; Nitrosamines; Smoking; Tobacco Smoke Pollution; Uteroglobin | 2004 |
Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens.
Topics: Animals; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Line, Tumor; CpG Islands; Death-Associated Protein Kinases; DNA Methylation; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Hyperplasia; Lung; Lung Neoplasms; Methylene Chloride; Mice; Mice, Inbred A; Nitrosamines; Promoter Regions, Genetic; Smoking; Urethane | 2004 |
Antioxidative effects of 7-hydroxy-3-methoxy-cadalene extracted from Zelkova serrata on 4-(methylinitros amino)-1-(3-pyridyl)-1-butanone-induced oxidative stress in A/J mice.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Female; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Oxidative Stress; Phytotherapy; Plant Extracts; Specific Pathogen-Free Organisms; Ulmaceae | 2004 |
Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese.
Topics: Aged; Anticarcinogenic Agents; Carcinogens; China; Female; Glucosinolates; Glucuronides; Humans; Indoles; Lung Neoplasms; Male; Middle Aged; Nicotiana; Nitrosamines; Prospective Studies; Singapore; Smoking; Surveys and Questionnaires; Vegetables | 2004 |
Inhibition of lung carcinogenesis and effects on angiogenesis and apoptosis in A/J mice by oral administration of green tea.
Topics: Adenoma; Administration, Oral; Animals; Apoptosis; Carcinogens; Dose-Response Relationship, Drug; Female; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Inbred A; Neovascularization, Pathologic; Nitrosamines; Random Allocation; Tea; Vascular Endothelial Growth Factor A; von Willebrand Factor | 2004 |
The effects of dietary myoinositol on lung tumor development in tobacco smoke-exposed mice.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Diet; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Inositol; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nicotiana; Nitrosamines; Smoke | 2004 |
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Antineoplastic Agents; Apoptosis; Bungarotoxins; Carcinogens; Carcinoma, Small Cell; Cell Division; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cisplatin; Enzyme Inhibitors; Flavonoids; Humans; Lung Neoplasms; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitrosamines; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Receptors, Nicotinic; RNA, Small Interfering; Signal Transduction; Staurosporine | 2004 |
Inhibitory effects of 7-hydroxy-3-methoxy-cadalene on 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice.
Topics: Administration, Oral; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Polycyclic Sesquiterpenes; Sesquiterpenes; Ulmaceae | 2004 |
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.
Topics: Blotting, Western; Calpain; Carcinogens; Cell Line, Tumor; Cell Movement; Disease Progression; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Silencing; Genetic Vectors; Humans; Immunoprecipitation; Lung Neoplasms; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; Nicotiana; Nitrosamines; Phosphorylation; RNA Interference; RNA, Small Interfering; Signal Transduction | 2004 |
Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase.
Topics: bcl-Associated Death Protein; Carrier Proteins; Humans; Isoenzymes; Lung Neoplasms; Nitrosamines; Phosphorylation; Protein Kinase C; Tumor Cells, Cultured | 2005 |
The chemopreventive effects of orally administered dexamethasone in Strain A/J mice following cessation of smoke exposure.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carcinogens; Chemoprevention; Dexamethasone; Disease Models, Animal; Lung Neoplasms; Male; Mice; Nitrosamines; Smoking; Tobacco Smoke Pollution | 2005 |
Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.
Topics: Carcinogens; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Proliferation; Cell Survival; Ganglionic Stimulants; Humans; Lung; Lung Neoplasms; NF-kappa B; Nicotine; Nitrosamines; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Smoking; Tumor Cells, Cultured | 2005 |
Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice.
Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Dose-Response Relationship, Drug; Female; Gene Expression; Humans; Lung Neoplasms; Methoxsalen; Mice; Mixed Function Oxygenases; Nitrosamines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Steroid Hydroxylases | 2006 |
Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation.
Topics: Bronchi; Carcinogens; Cell Proliferation; Cells, Cultured; Cyclin D1; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitrosamines; Phosphorylation; Receptors, Nicotinic; Retinoblastoma Protein; Up-Regulation | 2005 |
Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Ferrets; Humans; Immunohistochemistry; Lung Neoplasms; Male; Nitrosamines; Precancerous Conditions; Smoking | 2006 |
Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers.
Topics: Adolescent; Adult; Air Pollutants, Occupational; Biomarkers; Carcinogens; Cotinine; Creatinine; Female; Glucuronates; Humans; Interviews as Topic; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Pyridines; Restaurants; Tobacco Smoke Pollution; Workforce | 2005 |
Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta 2-adrenergic receptor single-nucleotide polymorphisms.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Carcinogens; Cricetinae; Lung Neoplasms; Mesocricetus; Molecular Sequence Data; Nitrosamines; Polymorphism, Single Nucleotide; Receptors, Adrenergic, beta-2 | 2005 |
NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cricetinae; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; ErbB Receptors; Gene Expression Profiling; Immunohistochemistry; Lung Neoplasms; Male; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Protein Serine-Threonine Kinases; Receptors, Adrenergic, beta-2; Signal Transduction | 2005 |
Beta-carotene interaction with NNK in the AJ-mouse model: effects on cell proliferation, tumor formation and retinoic acid responsive genes.
Topics: Adenoma; Animals; beta Carotene; Bronchi; Carcinogens; Cytochrome P-450 Enzyme System; Disease Models, Animal; Down-Regulation; Drug Interactions; Epithelial Cells; Gene Expression Regulation; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Protein Isoforms; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase | 2005 |
Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
Topics: Adenoma; Animals; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Carcinogens; Chemoprevention; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Escherichia coli Proteins; Female; Humans; Lung Neoplasms; Methoxsalen; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microsomes; Mixed Function Oxygenases; Mutation; Nitrosamines; Pentosyltransferases; Proteins; Salmonella typhimurium; Steroid Hydroxylases | 2005 |
Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency.
Topics: Acid Anhydride Hydrolases; Alleles; Animals; Carcinogens; Cocarcinogenesis; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Predisposition to Disease; Haploidy; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Nitrosamines; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein | 2005 |
Angiotensin II type 2 receptor gene deficiency attenuates susceptibility to tobacco-specific nitrosamine-induced lung tumorigenesis: involvement of transforming growth factor-beta-dependent cell growth attenuation.
Topics: Angiotensin II Type 2 Receptor Blockers; Animals; Carcinogens; Cell Growth Processes; Cocarcinogenesis; Female; Fibroblasts; Genetic Predisposition to Disease; Humans; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Proteins; Receptor, Angiotensin, Type 2 | 2005 |
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Caspase 3; Caspases; Cell Growth Processes; Disease Progression; Female; In Situ Nick-End Labeling; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Smoking; Sulfoxides; Thiocyanates | 2005 |
Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Smoking; Tobacco Smoke Pollution | 2005 |
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Bronchial Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Smoking; Tobacco Smoke Pollution | 2005 |
Prevention of mouse lung tumors by targretin.
Topics: Animals; Anticarcinogenic Agents; Bexarotene; Chemoprevention; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Tetrahydronaphthalenes; Urethane | 2006 |
Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; bcl-2-Associated X Protein; beta Carotene; Blotting, Western; Carcinogens; Chromatography, High Pressure Liquid; Dietary Supplements; Enzyme Activation; Ferrets; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Lung; Lung Neoplasms; Mitogen-Activated Protein Kinases; Nitrosamines; Proliferating Cell Nuclear Antigen; Tobacco Smoke Pollution; Tretinoin; Tumor Suppressor Protein p53 | 2006 |
9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2.
Topics: Alitretinoin; Animals; Antineoplastic Agents; Carcinogens; Celecoxib; Cell Transformation, Neoplastic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dietary Supplements; Disease Models, Animal; Lung; Lung Neoplasms; Male; Membrane Proteins; Mice; Mice, Inbred A; Nitrosamines; Pyrazoles; Receptors, Retinoic Acid; Sulfonamides; Tretinoin | 2006 |
Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK) induced lung tumors in the A/J mouse.
Topics: Animals; Body Weight; Carcinogens; Female; Glutathione Peroxidase; Liver; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Organ Size; Prodrugs; Selenium; Selenocysteine | 2005 |
Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan children.
Topics: Adenocarcinoma; Biomarkers; Carcinogens; Child; Child, Preschool; Cotinine; Environmental Exposure; Female; Humans; Lung Neoplasms; Male; Moldova; Nitrosamines; Rural Population; Tobacco Smoke Pollution; Urban Population | 2006 |
Array CGH analysis reveals chromosomal aberrations in mouse lung adenocarcinomas induced by the human lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Adenocarcinoma; Animals; Carcinogens; Cell Line, Tumor; Chromosome Aberrations; DNA; Gene Dosage; Humans; Karyotyping; Lung Neoplasms; Mice; Nitrosamines; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis | 2006 |
Transgenic mice overexpressing hepatocyte growth factor in the airways show increased susceptibility to lung cancer.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Carcinogens; Disease Susceptibility; Epithelium; Female; Hepatocyte Growth Factor; Humans; Lung; Lung Neoplasms; Male; Mice; Mice, Transgenic; Nitrosamines; Respiratory Mucosa | 2006 |
Post-initiation chemopreventive effects of dietary bovine lactoferrin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice.
Topics: Adenoma; Animals; Body Weight; Caspase 3; Cattle; Dietary Supplements; Female; Hyperplasia; Lactoferrin; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Organ Size; Proliferating Cell Nuclear Antigen | 2007 |
The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung.
Topics: Animal Feed; Animals; Antioxidants; Ascorbic Acid; Cell Transformation, Neoplastic; Cysteine; Disulfides; Female; Glutathione; Lung Neoplasms; Mice; Molecular Structure; Nitrosamines; Organoselenium Compounds; Selenium; Sulfhydryl Compounds; Time Factors; Yeasts | 2006 |
NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells.
Topics: Activating Transcription Factor 1; Adenocarcinoma; Cell Line; Cyclic AMP Response Element-Binding Protein; DNA; DNA-Binding Proteins; Enzyme Activation; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Lung; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nitrosamines; Nuclear Proteins; Phosphorylation; Receptors, Adrenergic, beta-1; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors | 2006 |
Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk.
Topics: Carcinogens; Case-Control Studies; Cytokinesis; DNA Repair; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Middle Aged; Nitrosamines | 2006 |
Early manifestations of NNK-induced lung cancer: role of lung immunity in tumor susceptibility.
Topics: ADP-ribosyl Cyclase 1; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; CD3 Complex; Cell Proliferation; Cyclooxygenase 2; Disease Susceptibility; Erythrocytes; Immunization; Lung; Lung Neoplasms; Lymph Nodes; Mice; Nitrosamines; Receptors, Nicotinic; Species Specificity; Spleen; T-Lymphocytes | 2007 |
beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model.
Topics: Adenoma; Animals; beta Carotene; Carcinogens; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Protein Isoforms; Random Allocation; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smoking; Vitamins | 2006 |
Combined genotoxic effects of radiation and a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice.
Topics: Animals; Base Sequence; Cocarcinogenesis; DNA Primers; Dose-Response Relationship, Radiation; Escherichia coli Proteins; Female; Gamma Rays; Lung; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagens; Nicotiana; Nitrosamines; Pentosyltransferases | 2007 |
Chemopreventive effect of saponins derived from roots of Platycodon grandiflorum on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Lung Neoplasms; Mice; Nitrosamines; Plant Extracts; Platycodon; Proliferating Cell Nuclear Antigen; Saponins | 2006 |
High-density oligonucleotide microarrays and functional network analysis reveal extended lung carcinogenesis pathway maps and multiple interacting genes in NNK [4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone] induced CD1 mouse lung tumor.
Topics: Animals; Carcinogens; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Gene Expression Profiling; Gene Regulatory Networks; Lung Neoplasms; Mice; Mice, Inbred Strains; Models, Animal; Models, Biological; Nitrosamines; Oligonucleotide Array Sequence Analysis; Signal Transduction | 2007 |
Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine.
Topics: Adenocarcinoma; Adenoma; Analysis of Variance; Animals; Caffeine; Catechin; Cell Proliferation; Disease Progression; Female; Flavonoids; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitrosamines; Phenols; Phosphorylation; Polyphenols; Proliferating Cell Nuclear Antigen; Tea; Time Factors | 2006 |
Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity.
Topics: Adenoma; Alitretinoin; Animals; Antineoplastic Agents; Calcitriol; Carcinogens; Cell Transformation, Neoplastic; Dietary Supplements; Disease Models, Animal; Drug Therapy, Combination; Lung Neoplasms; Male; Mice; Mice, Inbred A; Nitrosamines; Retinoid X Receptors; Steroid Hydroxylases; Tretinoin; Vitamin D3 24-Hydroxylase; Vitamins | 2007 |
The effects of combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer.
Topics: Animals; Antioxidants; Ascorbic Acid; beta Carotene; Disease Models, Animal; DNA Breaks, Single-Stranded; Ferrets; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Liver; Lung; Lung Neoplasms; Male; Nitrosamines; Smoke; Vitamin E | 2007 |
4-(Methylnitrosamino)-I-(3-pyridyl)-1-butanone enhances the expression of apolipoprotein A-I and Clara cell 17-kDa protein in the lung proteomes of rats fed a corn oil diet but not a fish oil diet.
Topics: Analysis of Variance; Animals; Apolipoprotein A-I; Biomarkers; Blotting, Western; Chromatography, Liquid; Corn Oil; Diet; Fish Oils; Lung Neoplasms; Nitrosamines; Pilot Projects; Proteome; Rats; Rats, Inbred F344; Uteroglobin | 2007 |
Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; DNA Adducts; Dose-Response Relationship, Drug; Lung Neoplasms; Male; Molecular Structure; Nitrosamines; Organ Specificity; Pyridines; Rats; Rats, Inbred F344; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Time Factors | 2007 |
A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adult; Aged; Alkylating Agents; Alkylation; Biological Assay; Carcinogens; Case-Control Studies; Cells, Cultured; DNA Damage; DNA Repair; Female; Humans; In Vitro Techniques; Lung Neoplasms; Lymphocyte Activation; Lymphocytes; Male; Middle Aged; Nitrosamines; Phytohemagglutinins; Pilot Projects; Plasmids; Risk Factors; Sulfuric Acid Esters | 2007 |
Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.
Topics: Animals; Antibiotics, Antineoplastic; Carcinogens; Female; Immunohistochemistry; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Phenotype; Protein Kinases; Sirolimus; TOR Serine-Threonine Kinases | 2007 |
Apo-10'-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo.
Topics: Animals; Anticarcinogenic Agents; Carotenoids; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Epithelial Cells; Fatty Acids, Unsaturated; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lycopene; Male; Mice; Nitrosamines; Promoter Regions, Genetic; Receptors, Retinoic Acid; Transcriptional Activation | 2007 |
Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Female; Immunohistochemistry; Isothiocyanates; Lung Neoplasms; Nicotiana; Nitrosamines; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar | 2007 |
Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cisplatin; Codon; Female; Genes, ras; Lung Neoplasms; Mice; Neoplasms, Experimental; Neoplasms, Second Primary; Nitrosamines; Point Mutation | 2007 |
Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels.
Topics: Amino Acid Sequence; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Chromatography, Ion Exchange; Chromatography, Liquid; Gene Expression Regulation, Neoplastic; Indoles; Lung Neoplasms; Mass Spectrometry; Mice; Molecular Sequence Data; Nitrosamines | 2007 |
Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells.
Topics: Adenocarcinoma; Carcinogens; Epithelial Cells; Estrogen Receptor beta; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Nicotine; Nitrosamines; Receptors, Adrenergic, beta-1; Smoking; Trachea | 2007 |
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
Topics: Animals; Carcinogens; Doxycycline; Female; Guanine; Inbreeding; Liver; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Transgenic; NADPH-Ferrihemoprotein Reductase; Nitrosamines; Pyridines | 2007 |
The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics.
Topics: Adult; Age Factors; Biomarkers; Carcinogens; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitrosamines; Sex Factors; Smoking | 2007 |
Increased inducible nitric oxide synthase in lung carcinoma of smokers.
Topics: Adult; Aged; Aged, 80 and over; Caspase 3; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrosamines; S-Nitroso-N-Acetylpenicillamine; Smoking; Staurosporine | 2008 |
Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.
Topics: Amino Acid Sequence; Animals; Benzo(a)pyrene; Blotting, Western; Carcinogens; Chromatography, Liquid; Lung Neoplasms; Mice; Molecular Sequence Data; Neoplasm Proteins; Nitrosamines; Tandem Mass Spectrometry | 2008 |
Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study.
Topics: Adenocarcinoma; Animals; Carcinogens; Galectin 3; Gene Expression; Genetic Predisposition to Disease; Lung Neoplasms; Mice; Mice, Knockout; Nitrosamines; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2008 |
Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors.
Topics: Animals; Base Sequence; Carcinogens; Exons; Female; Genes, erbB-1; Genes, ras; Lung Neoplasms; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Neoplasms, Radiation-Induced; Nitrosamines; Rats; Urethane; X-Rays | 2008 |
Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma.
Topics: Adenocarcinoma; Animals; Cell Line; Cell Line, Tumor; Cricetinae; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; gamma-Aminobutyric Acid; Humans; Immunohistochemistry; Lung Neoplasms; Nitrosamines; Phosphorylation; Receptors, Adrenergic, beta-1; Receptors, GABA-B; Smoking | 2008 |
Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors.
Topics: Animals; Anticarcinogenic Agents; Enzyme Inhibitors; Fatty Acid Synthases; Female; Humans; Lung Neoplasms; Mice; Nitrosamines; Proto-Oncogene Proteins c-akt; Urethane | 2008 |
Cytokinesis-blocked micronucleus cytome assay biomarkers identify lung cancer cases amongst smokers.
Topics: Apoptosis; Biomarkers, Tumor; Case-Control Studies; Chi-Square Distribution; Chromosome Aberrations; Cytokinesis; DNA Damage; Female; Genetic Predisposition to Disease; Humans; Logistic Models; Lung Neoplasms; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Middle Aged; Nitrosamines; Risk Factors; Smoking; Surveys and Questionnaires | 2008 |
Induction of respiratory tract tumors in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation.
Topics: Animals; Cricetinae; Female; Lung Neoplasms; Male; Mesocricetus; Nasal Mucosa; Nitrosamines; Nose Neoplasms; Respiratory Tract Neoplasms; Smoking; Tracheal Neoplasms | 1983 |
Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Male; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344 | 1984 |
Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in Syrian golden hamsters.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cricetinae; Feces; Female; Injections, Subcutaneous; Lung Neoplasms; Male; Mesocricetus; Nasal Cavity; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Plants, Toxic; Pyridines | 1981 |
Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Nasal Cavity; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Plants, Toxic; Pyridines; Rats; Rats, Inbred F344 | 1980 |
Inhibition of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by dietary benzaldehydes.
Topics: Animals; Benzaldehydes; Carcinogens; Diet; Lung Neoplasms; Mice; Mice, Inbred BALB C; Microsomes; Nitrosamines | 1995 |
K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Base Sequence; Carcinogens; Codon; Crosses, Genetic; DNA Primers; Female; Genes, p53; Genes, ras; Isothiocyanates; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred Strains; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Nitrosamines; Point Mutation; Polymerase Chain Reaction; Species Specificity | 1995 |
Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia.
Topics: Animals; Carcinogens; Cricetinae; Histocytochemistry; Hyperplasia; Immunoenzyme Techniques; Lung Neoplasms; Male; Mesocricetus; Neurosecretory Systems; Nitrosamines; Oxygen | 1995 |
G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents.
Topics: Adenine; Animals; Base Sequence; Carcinogens; Codon; Dimethylnitrosamine; DNA, Neoplasm; Female; Genes, ras; Guanine; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nitrosamines; Point Mutation; Polymorphism, Restriction Fragment Length; Pyridines; Thymine | 1993 |
Ki-ras mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-initiated and butylated hydroxytoluene-promoted lung tumors in A/J mice.
Topics: Adenoma; Animals; Base Sequence; Butylated Hydroxytoluene; Carcinogens; Female; Genes, ras; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Sequence Data; Mutation; Nitrosamines; Papilloma; Polymerase Chain Reaction; Stomach Neoplasms | 1994 |
Smoking and lung cancer: scientific challenges and opportunities.
Topics: Adenocarcinoma; Black or African American; Black People; Carcinoma, Squamous Cell; Disease Susceptibility; Female; Humans; Incidence; Japan; Lung Neoplasms; Male; Nitrosamines; Risk Factors; Sex Factors; Smoking; Tobacco Smoke Pollution; United Kingdom; United States; White People | 1994 |
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents.
Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Stomach Neoplasms | 1994 |
Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice.
Topics: Animals; Beverages; Carcinogens; Catechin; DNA; Female; Flavonoids; Lung; Lung Neoplasms; Methylation; Mice; Microsomes; Nitrosamines; Pyridines; Tea | 1994 |
Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans.
Topics: Animals; Biomarkers; Carcinogens; DNA; DNA Damage; Hemoglobins; Humans; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Smoking; Tobacco, Smokeless | 1993 |
K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine.
Topics: Adenocarcinoma; Animals; Base Sequence; Carcinoma, Squamous Cell; DNA, Single-Stranded; Genes, ras; Lung Neoplasms; Male; Molecular Sequence Data; Nitrosamines; Point Mutation; Rats | 1993 |
Comparison of transplacental and neonatal initiation of mouse lung and liver tumors by N-nitrosodimethylamine (NDMA) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and promotability by a polychlorinated biphenyls mixture (Aroclor 1254).
Topics: Animals; Animals, Newborn; Aroclors; Carcinogens; Chlorodiphenyl (54% Chlorine); Cocarcinogenesis; Dimethylnitrosamine; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Maternal-Fetal Exchange; Mice; Nitrosamines; Pregnancy; Time Factors | 1993 |
Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors.
Topics: Animals; Base Sequence; Diethylnitrosamine; DNA, Neoplasm; DNA, Single-Stranded; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genes, p53; Genes, ras; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Nitrosamines; Polymerase Chain Reaction | 1993 |
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone mouse lung tumorigenesis by arylalkynes, mechanism-based inactivators of cytochrome P450.
Topics: Alkynes; Animals; Anticarcinogenic Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Female; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Naphthalenes; Nitrosamines; Thiocyanates | 1993 |
A study of tobacco carcinogenesis. LI. Relative potencies of tobacco-specific N-nitrosamines as inducers of lung tumours in A/J mice.
Topics: Adenoma; Animals; Female; Lung Neoplasms; Mice; N-Nitrosopyrrolidine; Nicotiana; Nitrosamines; Nitroso Compounds; Plants, Toxic; Smoke; Structure-Activity Relationship | 1993 |
A study of tobacco carcinogenesis: effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
Topics: Adenoma, Islet Cell; Animals; Body Weight; Carcinogenicity Tests; Corn Oil; Drinking; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; Pancreatic Neoplasms; Rats; Rats, Inbred F344 | 1993 |
A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke.
Topics: Adult; Carcinogens; Cotinine; Humans; Lung Neoplasms; Male; Middle Aged; Nitrosamines; Tobacco Smoke Pollution | 1993 |
The A/J mouse lung as a model for developing new chemointervention strategies.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinogens; Disease Models, Animal; Female; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines | 1993 |
K-ras and p53 point mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors.
Topics: Animals; Base Sequence; Carcinogens; Cricetinae; Genes, p53; Genes, ras; Lung Neoplasms; Male; Mesocricetus; Molecular Sequence Data; Nitrosamines; Point Mutation | 1993 |
Pulmonary carcinogenesis and its prevention by dietary polyphenolic compounds.
Topics: Adenoma; Animals; Carcinogens; Diet; Dose-Response Relationship, Drug; Ellagic Acid; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Plants, Toxic; Smoke; Smoking; Tissue Distribution | 1993 |
Elevated binding to URE/PEBP2 during the late stages of NNK and benzo[a]pyrene-induced carcinogenesis in A/J mice.
Topics: Animals; Base Sequence; Benzo(a)pyrene; Carcinogens; DNA-Binding Proteins; Female; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Sequence Data; Nitrosamines; Protein Binding; Tissue Distribution; Transcription Factor AP-1; Transcription Factor AP-2; Transcription Factors | 1996 |
Effects of K-ras gene mutations in the development of lung lesions induced by 4-(N-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
Topics: Animals; Base Sequence; Bromodeoxyuridine; Carcinogens; Cell Division; Female; Genes, ras; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Sequence Data; Nitrosamines; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Sensitivity and Specificity | 1996 |
Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse.
Topics: Analysis of Variance; Animals; Body Weight; Carboxyhemoglobin; Carcinogens; Female; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Organ Size; Reference Values; Smoke; Smoking; Survival Analysis | 1996 |
Effects of dietary 1,4-phenylenebis(methylene)selenocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation in lung and liver of A/J mice and F344 rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Carcinogens; Diet; DNA Adducts; Female; Liver; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Organoselenium Compounds; Rats; Rats, Inbred F344 | 1996 |
The essential role of the functional group in alkyl isothiocyanates for inhibition of tobacco nitrosamine-induced lung tumorigenesis.
Topics: Adenoma; Animals; Carcinogens; Female; Isothiocyanates; Lung; Lung Neoplasms; Mice; Microsomes; Nicotiana; Nitrosamines; Oxidation-Reduction; Plants, Toxic; Structure-Activity Relationship | 1996 |
Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats.
Topics: Acetylcysteine; Analysis of Variance; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Chi-Square Distribution; Diet; Free Radical Scavengers; Incidence; Isothiocyanates; Leukemia, Experimental; Leydig Cell Tumor; Lung Neoplasms; Lymphoma; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Survival Rate; Testicular Neoplasms | 1996 |
Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Modification Methylases; DNA-Cytosine Methylases; Gene Expression; Hyperplasia; Lung; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Mice, Inbred C3H; Nitrosamines; Species Specificity | 1996 |
Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers.
Topics: Adult; Anticarcinogenic Agents; Carcinogens; Female; Follow-Up Studies; Glucuronates; Humans; Isothiocyanates; Lung Neoplasms; Male; Nitrosamines; Prognosis; Smoking; Vegetables | 1995 |
Complete inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; DNA Adducts; Isothiocyanates; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344 | 1996 |
Inhibitory effects of 6-phenylhexyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation and lung tumorigenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Biotransformation; Carcinogens; Drinking Behavior; Feeding Behavior; Glucuronates; Hemoglobins; Isothiocyanates; Lung Neoplasms; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344 | 1996 |
Synthesis and bioassay of 4-ipomeanol analogs as potential chemopreventive agents against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced tumorigenicity in A/J mice.
Topics: Animals; Antineoplastic Agents; Carcinogens; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines; Terpenes | 1996 |
Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Isothiocyanates; Lung; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344 | 1997 |
Inhibition of lung tumor cell growth in vitro and mouse lung tumor formation by lovastatin.
Topics: Animals; Antineoplastic Agents; Carcinogens; Cell Division; Drug Screening Assays, Antitumor; Humans; Lovastatin; Lung Neoplasms; Male; Mice; Mice, Inbred A; Nitrosamines; Tumor Cells, Cultured | 1996 |
Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.
Topics: Anticarcinogenic Agents; Biomarkers; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Cotinine; Creatinine; Enzyme Inhibitors; Glucuronates; Humans; Inactivation, Metabolic; Isothiocyanates; Lung Neoplasms; Mass Spectrometry; Nicotine; Nitrosamines; Proteus mirabilis; Pyridines | 1997 |
Inhibition of lung tumourigenesis by sulindac: comparison of two experimental protocols.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carcinogens; Cyclooxygenase Inhibitors; Diet; Dinoprostone; Disease Susceptibility; Drug Administration Schedule; Female; Hemolytic Plaque Technique; Immunosuppressive Agents; Lung Neoplasms; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Plants, Toxic; Smoke; Stomach Neoplasms; Sulindac | 1997 |
Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Dimethylnitrosamine; DNA Methylation; Dose-Response Relationship, Drug; Ellagic Acid; Esophageal Neoplasms; Female; Guanine; Isothiocyanates; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Rats; Rats, Inbred F344 | 1997 |
Characterization of early pulmonary hyperproliferation and tumor progression and their inhibition by black tea in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model with A/J mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; Disease Models, Animal; Disease Progression; Female; Flavonoids; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Phenols; Plant Extracts; Polymers; Polyphenols | 1997 |
Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J mice.
Topics: Adenoma; Animals; Aspirin; Cells, Cultured; Cytochrome P-450 CYP1A2; Enzyme Activation; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Prodrugs; Sulindac | 1997 |
Effects of 1,4-phenylenebis(methylene)selenocyanate and selenomethionine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mouse lung.
Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Female; Lung Neoplasms; Mice; Nitrosamines; Organoselenium Compounds; Selenomethionine; Smoking | 1997 |
Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in black and white smokers.
Topics: Adult; Analysis of Variance; Animals; Biomarkers; Black People; Carcinogens; Cotinine; Creatinine; Female; Glucuronates; Humans; Incidence; Lung Neoplasms; Male; Menthol; Middle Aged; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Smoking; White People | 1997 |
The carcinogenic potential of the gas phase of environmental tobacco smoke.
Topics: Animals; Benzo(a)pyrene; Carcinogens, Environmental; Female; Lung; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Plants, Toxic; Smoke | 1997 |
Chemopreventive activity of thiol conjugates of isothiocyanates for lung tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Female; Isothiocyanates; Lung; Lung Neoplasms; Mice; Nitrosamines; Sulfhydryl Compounds | 1997 |
Black tea constituents, theaflavins, inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice.
Topics: Animals; Antineoplastic Agents; Biflavonoids; Body Weight; Bromodeoxyuridine; Carcinogens; Catechin; Cell Division; Chemoprevention; Female; Hyperplasia; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Tea; Vitamin A; Vitamin E | 1997 |
A relevant dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is extensively metabolized and rapidly absorbed in the canine tracheal mucosa.
Topics: Absorption; Administration, Inhalation; Animals; Biotransformation; Carcinogens; Dogs; Epithelium; Female; Lung Neoplasms; Mucous Membrane; Nitrosamines; Trachea | 1998 |
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in isolated rat lung and liver.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; Liver; Lung; Lung Neoplasms; Male; Metabolic Clearance Rate; Nitrosamines; Perfusion; Rats; Rats, Inbred F344 | 1998 |
The inhibitory effect of vitamin E on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in mice based on the regulation of polyamine metabolism.
Topics: Animals; Arylamine N-Acetyltransferase; Carcinogens; Enzyme Activation; Female; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasm Proteins; Nitrosamines; Ornithine Decarboxylase; Polyamines; Proliferating Cell Nuclear Antigen; Vitamin E | 1998 |
Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung.
Topics: Animals; Anticarcinogenic Agents; Biological Assay; Carcinogens; Genes, ras; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Models, Biological; Monoterpenes; Nitrosamines; Terpenes | 1997 |
Chemopreventive potential of thiol conjugates of isothiocyanates for lung cancer and a urinary biomarker of dietary isothiocyanates.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; Cohort Studies; Cytochrome P-450 Enzyme Inhibitors; Diet; Humans; Isoenzymes; Isothiocyanates; Lung Neoplasms; Mice; Microsomes, Liver; Nitrosamines; Rats; Sulfhydryl Compounds; Vegetables | 1997 |
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squalene.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; Dietary Fats, Unsaturated; Female; Lung Neoplasms; Mice; Nitrosamines; Olive Oil; Plant Oils; Squalene | 1998 |
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone).
Topics: Animals; Antineoplastic Agents; Carcinogens; Drug Screening Assays, Antitumor; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Sulindac | 1998 |
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
Topics: Animals; Anticarcinogenic Agents; Arachidonic Acid; Aspirin; Body Weight; Carcinogens; Drug Screening Assays, Antitumor; Female; Hydroxyurea; Indoles; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines | 1998 |
Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression.
Topics: 3T3 Cells; Animals; Base Sequence; Carcinogens; Gene Expression; Genes, ras; Genes, Reporter; Introns; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Inbred C3H; Mice, Nude; Molecular Sequence Data; Nitrosamines; Polymorphism, Genetic; Promoter Regions, Genetic; ras Proteins; Sp1 Transcription Factor; Species Specificity | 1998 |
The inhibitory effect of vitamin E on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA injury and the fixation of the DNA injury in mouse lungs.
Topics: Animals; Carcinogens; DNA Damage; DNA, Neoplasm; Female; Genes, ras; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Point Mutation; Polymerase Chain Reaction; Rabbits; Specific Pathogen-Free Organisms; Vitamin E | 1998 |
Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituent.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Caffeine; Carcinogens; Drug Screening Assays, Antitumor; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; Rats; Rats, Inbred F344; Survival Rate; Tea | 1998 |
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis.
Topics: Adenoma; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma in Situ; Carcinoma, Squamous Cell; DNA Methylation; DNA, Neoplasm; Genes, p16; Humans; Hyperplasia; Lung Neoplasms; Metaplasia; Nitrosamines; Precancerous Conditions; Rats; Rats, Inbred F344; Sputum | 1998 |
Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Biotransformation; Carcinogens; Cell Division; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Stability; Female; Hydroxylation; Isoenzymes; Lung Neoplasms; Membrane Proteins; Mice; Mice, Inbred A; Nitrobenzenes; Nitrosamines; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 1998 |
MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Differentiation; Cell Lineage; Cricetinae; Down-Regulation; Female; Histone Deacetylase Inhibitors; Humans; Immunohistochemistry; Lung; Lung Neoplasms; Male; Mesocricetus; Middle Aged; Mucin-1; Nitrosamines; Oligopeptides; Peptide Fragments; Pulmonary Alveoli; RNA, Messenger | 1998 |
Inhibition of natural killer cell activity in mice treated with tobacco specific carcinogen NNK.
Topics: Animals; Carcinogens; Cortisone; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Female; Immunologic Factors; Interleukin-12; Killer Cells, Natural; Lung Neoplasms; Lymphocyte Subsets; Melanoma; Mice; Neoplasms, Experimental; Nitrosamines; Poly I-C; Tumor Cells, Cultured | 1999 |
Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation.
Topics: Adult; Animals; Carcinogens; Cotinine; Female; Glucuronates; Humans; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Rats; Rats, Inbred F344; Smoking Cessation | 1999 |
Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.
Topics: Adenoma; Alkyl and Aryl Transferases; Animals; Carcinogens; Crosses, Genetic; DNA Repair; DNA, Neoplasm; Humans; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Transgenic; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Transgenes | 1999 |
5-Aza-2'-deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced primary mouse lung tumor model.
Topics: Animals; Anticarcinogenic Agents; Azacitidine; Carcinogens; Decitabine; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C3H; Nitrosamines | 1999 |
Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells.
Topics: Adenocarcinoma; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Carcinogens; Carcinoma, Small Cell; Cell Division; Humans; Kinetics; Ligands; Lung Neoplasms; Nicotiana; Nitrosamines; Plants, Toxic; Pyridines; Receptors, Nicotinic; Tumor Cells, Cultured | 1998 |
Effects of protocatechuic acid, S-methylmethanethiosulfonate or 5-hydroxy-4-(2-phenyl-(E)ethenyl)-2(5H)-furanone(KYN-54) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary carcinogenesis in mice.
Topics: 4-Butyrolactone; Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Drug Screening Assays, Antitumor; Female; Hydroxybenzoates; Lung Neoplasms; Methyl Methanesulfonate; Mice; Mice, Inbred A; Nitrosamines; Retinoids | 1999 |
Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet.
Topics: Animals; Aspirin; Carcinogens; Cyclooxygenase 2; Dietary Fats; Immunohistochemistry; Isoenzymes; Lung Neoplasms; Male; Nitrosamines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 1999 |
The protective role of 11 beta-hydroxysteroid dehydrogenase/carbonyl reductase against tobacco-smoke related lung cancer.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Animals; Glucocorticoids; Glycyrrhetinic Acid; Hydroxysteroid Dehydrogenases; Kinetics; Lung; Lung Neoplasms; Mice; Nitrosamines; Oxidation-Reduction; Rats; Smoking | 1999 |
Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Butylated Hydroxyanisole; Carotenoids; Curcumin; Female; Inositol; Lung Neoplasms; Lycopene; Mice; Mice, Inbred A; Nitrosamines; Resveratrol; Stilbenes; Umbelliferones | 1999 |
Biotransformation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in freshly isolated human lung cells.
Topics: Aged; Biotransformation; Carcinogens; Female; Humans; Hydroxylation; Inactivation, Metabolic; Lung; Lung Neoplasms; Macrophages, Alveolar; Male; Middle Aged; Nitrosamines; Oxidation-Reduction; Proadifen; Pulmonary Alveoli | 1999 |
The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid.
Topics: Adenocarcinoma; Adrenergic beta-Agonists; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carcinogens; CHO Cells; Cricetinae; DNA Replication; DNA, Neoplasm; Humans; Indoles; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Nitrosamines; Radioligand Assay; Receptors, Adrenergic, beta; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tumor Cells, Cultured | 1999 |
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Adenoma; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Carcinogens; Enzyme Inhibitors; Genes, ras; Lung Neoplasms; Methionine; Mice; Mutation; Nitrosamines | 2000 |
Induction of COX expression by a tobacco carcinogen: implication in lung cancer chemoprevention.
Topics: Animals; Anticarcinogenic Agents; Biotransformation; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Female; Humans; Isoenzymes; Lung Neoplasms; Membrane Proteins; Mice; Nitrosamines; Prostaglandin-Endoperoxide Synthases; Tumor Cells, Cultured | 1999 |
Activation of voltage-operated Ca2+-channels in human small cell lung carcinoma by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Calcium Channels; Carcinogens; Carcinoma, Small Cell; Humans; Lung Neoplasms; Nicotine; Nitrosamines; Tumor Cells, Cultured | 2000 |
A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin.
Topics: Alleles; Animals; Anticarcinogenic Agents; Dexamethasone; Doxorubicin; Genes, p53; Germ-Line Mutation; Humans; Inositol; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Transgenic; Nitrosamines; Paclitaxel; Proto-Oncogene Mas; Tea | 2000 |
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Diet; Dose-Response Relationship, Drug; Drug Therapy, Combination; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines | 2000 |
The effect of 6-methylthiohexyl isothiocyanate isolated from Wasabia japonica (wasabi) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-buatnone-induced lung tumorigenesis in mice.
Topics: Animals; Body Weight; Carcinogens; Female; Guanine; Immunoblotting; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Ornithine Decarboxylase; Plant Extracts; Proliferating Cell Nuclear Antigen; Spices | 2000 |
Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogens; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Susceptibility; Humans; Isoenzymes; Lung Neoplasms; Membrane Proteins; Mice; Mice, Inbred A; Mice, Inbred C3H; Mice, Nude; Neoplasm Transplantation; Nitrosamines; Precancerous Conditions; Proline; Prostaglandin-Endoperoxide Synthases; Pulmonary Alveoli; Pyrazoles; RNA, Messenger; Sulfonamides; Thiocarbamates; Transcription, Genetic; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[a]pyrene-induced lung tumorigenesis in strain A/J mice.
Topics: Adenoma; Animals; Antineoplastic Agents; Benzo(a)pyrene; Biological Assay; Carcinogens; Diet; Freeze Drying; Fruit; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines | 2000 |
Chemoprevention of lung tumorigenesis induced by a mixture of benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; Drug Administration Schedule; Female; Glutathione Transferase; Inactivation, Metabolic; Isoenzymes; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Organoselenium Compounds; Stomach Neoplasms | 2000 |
Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters.
Topics: Adenocarcinoma; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carcinogens; Cricetinae; Drug Synergism; Epinephrine; Lung Neoplasms; Male; Mesocricetus; Nitrosamines; Propranolol; Receptors, Adrenergic, beta; Theophylline | 2000 |
Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis.
Topics: Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Chemoprevention; Cyclooxygenase 1; Cyclooxygenase 2; DNA, Neoplasm; Enzyme Inhibitors; Female; Genes, ras; Immunoenzyme Techniques; Isoenzymes; Lung Neoplasms; Membrane Proteins; Mice; Mice, Inbred A; Mutation; Nitrobenzenes; Nitrosamines; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Sulfonamides | 2000 |
Tobacco industry must not dump its high nitrosamine tobacco on poor countries.
Topics: Adenocarcinoma; Carcinogens; Developing Countries; Humans; Lung Neoplasms; Nitrosamines; Smoking; Tobacco Industry; United States | 2001 |
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone modulation of cytokine release in U937 human macrophages.
Topics: Alkylation; Carcinogens; Chemokine CCL2; Cytokines; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-10; Interleukin-12; Interleukin-2; Interleukin-6; Lung; Lung Neoplasms; Lymphoma; Macrophages; Molecular Structure; Nitrosamines; Tumor Necrosis Factor-alpha; U937 Cells | 2001 |
Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2; Base Sequence; Biotransformation; Carcinogens; Cytosol; DNA Primers; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression; Humans; Hydroxysteroid Dehydrogenases; Inactivation, Metabolic; Lung; Lung Neoplasms; Microsomes; Nicotiana; Nitrosamines; Oxidation-Reduction; Plants, Toxic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smoking | 2001 |
Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Diet; Dose-Response Relationship, Drug; Eating; Female; Inositol; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines | 2001 |
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Dimethylnitrosamine; DNA Methylation; DNA Repair; Drug Synergism; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Pyridines | 2001 |
Assessment of murine lung tumour development: a comparison of two techniques.
Topics: Animals; Disease Models, Animal; Disease Progression; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Photography | 2001 |
Re: metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke.
Topics: Adult; Age Factors; Alcohol Drinking; Biotransformation; Carcinogens; Confounding Factors, Epidemiologic; Cytochrome P-450 CYP2D6; Ethnicity; Female; Humans; Lung; Lung Neoplasms; Menstrual Cycle; Middle Aged; Nicotiana; Nitrosamines; Postmenopause; Premenopause; Risk; Tobacco Smoke Pollution; White People | 2001 |
Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA.
Topics: Alkylation; Base Sequence; Carcinogens; DNA Adducts; DNA Damage; DNA Methylation; DNA Mutational Analysis; DNA, Single-Stranded; Escherichia coli; Exons; Genes, p53; Genes, ras; Genome, Human; Humans; Lung Neoplasms; Molecular Sequence Data; Mutagenesis; Nitrosamines; Nucleotides; Phosphodiesterase I; Phosphoric Diester Hydrolases; Phosphorylation; Polymerase Chain Reaction; Smoking; Substrate Specificity | 2001 |
Inhibitory effect of mandarin juice rich in beta-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in mice.
Topics: Animals; Anticarcinogenic Agents; beta Carotene; Beverages; Carcinogens; Citrus; Cryptoxanthins; Hesperidin; Immunoenzyme Techniques; Incidence; Injections, Intraperitoneal; Lung Neoplasms; Male; Mice; Mice, Inbred A; Nitrosamines; Nucleolus Organizer Region; Proliferating Cell Nuclear Antigen; Xanthophylls | 2001 |
Inhibitory effects of cinnamaldehyde on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung carcinogenesis in rasH2 mice.
Topics: Animals; Carcinogens; Female; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Nitrosamines; ras Proteins | 2002 |
Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells.
Topics: Animals; Bungarotoxins; Carcinogens; Carcinoma, Small Cell; Cricetinae; Enzyme Activation; Humans; Imipramine; Lung; Lung Neoplasms; Mitogen-Activated Protein Kinases; Neurosecretory Systems; Nitrosamines; Phosphorylation; Polymerase Chain Reaction; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-raf; Receptors, Nicotinic; Serotonin; Tumor Cells, Cultured | 2001 |
Evidence for the epidermal growth factor receptor as a target for lung cancer prevention.
Topics: Antineoplastic Agents; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Cyclin D1; DNA Primers; ErbB Receptors; Gene Expression Regulation; Humans; Lung Neoplasms; Mitosis; Nitrosamines; Phosphotyrosine; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tretinoin | 2002 |
Effect of acerola cherry extract on cell proliferation and activation of ras signal pathway at the promotion stage of lung tumorigenesis in mice.
Topics: Animals; Carcinogens; Cell Division; Densitometry; Electrophoresis; Female; Immunoblotting; Lung Neoplasms; Malpighiaceae; Mice; Nitrosamines; Phytotherapy; Plant Extracts; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins p21(ras) | 2002 |
Tobacco-specific nitrosamines: formation from nicotine in vitro and during tobacco curing and carcinogenicity in strain A mice.
Topics: Adenoma; Animals; Female; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Pyridines | 1978 |
A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells.
Topics: Animals; Biomarkers, Tumor; Bronchi; Carcinogens; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Chemotaxis; Epithelium; ErbB Receptors; Gelatinases; Humans; Isoenzymes; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Invasiveness; Nitrosamines; Pepsin A; Rats; Smoke; Smoking; Tetradecanoylphorbol Acetate; Trachea; Transforming Growth Factor alpha; Transplantation, Heterologous | 1992 |
Biodistribution of ellagic acid and dose-related inhibition of lung tumorigenesis in A/J mice.
Topics: Animals; Carcinogens; Cyclodextrins; Dose-Response Relationship, Drug; Drug Carriers; Ellagic Acid; Female; Liver; Lung; Lung Neoplasms; Mice; Nitrosamines; Tissue Distribution | 1992 |
Effects of NSAIDs on NNK-induced pulmonary and gastric tumorigenesis in A/J mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carcinogens; Drug Interactions; Female; Ibuprofen; Lung Neoplasms; Mice; Mice, Inbred A; Naproxen; Nitrosamines; Piroxicam; Stomach Neoplasms; Sulindac; Time Factors | 1992 |
A study of tobacco carcinogenesis. XLVII. Bioassays of vinylpyridines for genotoxicity and for tumorigenicity in A/J mice.
Topics: Animals; Biotransformation; Carcinogens; DNA Repair; Female; Liver; Lung Neoplasms; Mice; Mice, Inbred A; Microsomes, Liver; Mutagenicity Tests; Mutagens; Nasal Mucosa; Nitrosamines; Pyridines; Rats; Salmonella typhimurium; Smoking; Styrene; Styrenes; Tobacco Smoke Pollution; Vinyl Compounds | 1992 |
Effect of frequency of isothiocyanate administration on inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenoma formation in A/J mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Drug Administration Schedule; Female; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Thiocyanates | 1992 |
Effects of sulindac and oltipraz on the tumorigenicity of 4-(methylnitrosamino)1-(3-pyridyl)-1-butanone in A/J mouse lung.
Topics: Adenoma; Animals; Carcinogens; Drug Screening Assays, Antitumor; Female; Intestinal Absorption; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Oxidation-Reduction; Pyrazines; Schistosomicides; Sulindac; Thiones; Thiophenes | 1992 |
Inhibition of N-nitrosodiethylamine- and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mice by green tea and black tea.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Reference Values; Stomach Neoplasms; Tea | 1992 |
New potential chemopreventive agents for lung carcinogenesis of tobacco-specific nitrosamine.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Humans; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Structure; Nitrosamines; Rats; Rats, Inbred F344; Thiocyanates | 1992 |
Inhibitory effects of diallyl sulfide on the metabolism and tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung.
Topics: Allyl Compounds; Animals; Carcinogens; Female; Garlic; Lung; Lung Neoplasms; Mice; Microsomes, Liver; Nitrosamines; Plants, Medicinal; Sulfides | 1992 |
Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Female; Hyperplasia; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Microscopy, Electron; Nitrosamines; Pulmonary Alveoli; Time Factors | 1992 |
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Caffeine; Carcinogens; Catechin; Deoxyguanosine; DNA; Female; Guanine; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Tea | 1992 |
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylhydrazines; Lung Neoplasms; Methylcholanthrene; Methylnitrosourea; Mice; Mice, Inbred A; Microscopy, Electron; Nitrosamines | 1991 |
Tumorigenicity of the tobacco-specific carcinogen 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in infant mice.
Topics: Animals; Animals, Newborn; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrosamines | 1991 |
N-nitroso compounds and tobacco-induced cancers in man.
Topics: Carcinogens; Esophageal Neoplasms; Humans; Lung Neoplasms; Mouth Neoplasms; Nitrosamines; Pancreatic Neoplasms; Smoking | 1991 |
O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; Female; Guanine; Hydroxylation; Lung Neoplasms; Methylation; Mice; Nitrosamines | 1991 |
A study of betel quid carcinogenesis. IX. Comparative carcinogenicity of 3-(methylnitrosamino)propionitrile and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone upon local application to mouse skin and rat oral mucosa.
Topics: Administration, Topical; Animals; Areca; Body Weight; Carcinogens; Esophageal Neoplasms; Female; Humans; Infant, Newborn; Lung Neoplasms; Male; Mice; Mouth Neoplasms; Nitrosamines; Nose Neoplasms; Plants, Medicinal; Rats; Rats, Inbred F344; Skin Neoplasms | 1991 |
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils.
Topics: Adenoma; Animals; Carcinogens; Citrus; Cyclohexenes; Female; Limonene; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Plant Oils; Stomach Neoplasms; Terpenes | 1991 |
Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice.
Topics: Animals; Corn Oil; Female; Lung Neoplasms; Mice; Nitrosamines; Structure-Activity Relationship; Thiocyanates | 1991 |
Pathobiology of lung tumors induced in hamsters by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the modulating effect of hyperoxia.
Topics: Adenoma; Air; Animals; Bombesin; Carcinogens; Cricetinae; Lung Neoplasms; Male; Mesocricetus; Microscopy, Electron; Neurosecretory Systems; Nitrosamines; Oxygen | 1990 |
Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate.
Topics: Animals; DNA; Isothiocyanates; Liver Neoplasms, Experimental; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nitrosamines; Nose Neoplasms; Organ Specificity; Rats; Rats, Inbred F344; Thiocyanates | 1990 |
Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice.
Topics: Adenoma; Animals; Carcinogens; DNA; Female; In Vitro Techniques; Indoles; Liver; Lung; Lung Neoplasms; Methylation; Mice; Nitrosamines | 1990 |
Dose-response relationship between O6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Cell Line; DNA; Dose-Response Relationship, Drug; Guanine; Hyperplasia; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Metaplasia; Methylation; Microscopy, Electron; Nitrosamines; Nose Neoplasms; Olfactory Mucosa; Rats; Rats, Inbred F344 | 1990 |
Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice.
Topics: Adenoma; Animals; Carcinogens; Deuterium; DNA; Female; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Structure-Activity Relationship | 1990 |
Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines.
Topics: Adenocarcinoma; Carcinogens; Cell Division; Diethylnitrosamine; Hexamethonium; Hexamethonium Compounds; Humans; Lung Neoplasms; Nicotine; Nitrosamines; Receptors, Nicotinic; Tumor Cells, Cultured | 1989 |
Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines.
Topics: Adenocarcinoma; Animals; Blotting, Southern; Codon; Dimethylnitrosamine; DNA Mutational Analysis; Female; Gene Expression Regulation; Genes, ras; Lung Neoplasms; Mice; Mice, Inbred Strains; Mutation; Neoplasms, Experimental; Nitrosamines; Transfection | 1989 |
Evaluation of the transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.
Topics: Animals; Carcinogens; Female; Fetus; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasms, Experimental; Nicotiana; Nitrosamines; Placenta; Plants, Toxic; Pregnancy | 1989 |
Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates.
Topics: Adenoma; Animals; Carcinogens; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Structure-Activity Relationship; Thiocyanates | 1989 |
Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet.
Topics: Adenoma; Animals; Carcinogens; Diet; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Reference Values | 1989 |
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate.
Topics: Alkylation; Animals; Biological Assay; Diet; DNA; Isothiocyanates; Liver Neoplasms; Lung Neoplasms; Methylation; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Thiocyanates | 1989 |
Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats.
Topics: Animals; Carcinogens; Diet; DNA; Glucosinolates; Indoles; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Methyltransferases; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Rats; Rats, Inbred F344; Thioglycosides | 1988 |
Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines.
Topics: Animals; Areca; Carcinogens; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Nicotiana; Nitrosamines; Nitroso Compounds; Nose Neoplasms; Pancreatic Neoplasms; Plants, Medicinal; Plants, Toxic; Rats; Rats, Inbred F344 | 1988 |
Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Alkylation; Animals; DNA; Dose-Response Relationship, Drug; Guanine; Lung; Lung Neoplasms; Methyltransferases; Nicotiana; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Plants, Toxic; Rats; Rats, Inbred F344 | 1987 |
Effects of alpha-deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
Topics: Animals; Biotransformation; Deuterium; DNA Damage; Hydroxylation; Liver Neoplasms; Lung Neoplasms; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1987 |
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.
Topics: Animals; Dimethylnitrosamine; DNA, Neoplasm; Guanine; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats | 1986 |
Nicotine: a precursor for carcinogens.
Topics: Animals; Biotransformation; Carcinogens; Cotinine; Humans; Lung Neoplasms; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Smoking | 1985 |
New aspects of tobacco carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Catechols; Humans; Lung Neoplasms; Nicotiana; Nitrosamines; Plants, Toxic; Smoking; Tobacco Smoke Pollution; Tritium | 1985 |
Metabolism and tissue distribution of tobacco-specific N-nitrosamines in the marmoset monkey (Callithrix jacchus).
Topics: Animals; Autoradiography; Callithrix; Carbon Radioisotopes; Carcinogens; Computers; Densitometry; DNA; Lung Neoplasms; Male; Methylation; Nitrosamines; Species Specificity; Tissue Distribution | 1985 |