Compounds > 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone
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4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Experimental Neoplasms

4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with Experimental Neoplasms in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199013 (29.55)18.7374
1990's19 (43.18)18.2507
2000's6 (13.64)29.6817
2010's4 (9.09)24.3611
2020's2 (4.55)2.80

Authors

AuthorsStudies
Bai, R; Bode, AM; Chang, X; Dong, Z; Li, X; Liu, K; Ma, W; Ryu, J; Song, Y; Wang, K; Wang, Q; Wang, T; Xia, Q; Zhang, T1
Charoensinphon, N; Han, Y; Qiu, P; Song, M; Sun, Y; Wu, X; Xiao, H; Zheng, J1
Cho, B; Elisia, I; Hay, M; Kowalski, S; Krystal, G; Lam, V; Larsen, M; Wong, J; Yeung, M1
Bakkenist, CJ; Bao, R; Burns, TF; Dacic, S; Devadassan, P; Gaither-Davis, A; Huang, EH; Kumar, V; Stabile, LP; Steinman, RA; Vendetti, FP1
Barra, CN; Cordeiro, YG; Dagli, ML; Fukumasu, H; Rochetti, AL; Sámora, TS; Strefezzi, RF1
Boo, HJ; Hwang, SJ; Jang, HJ; Lee, HJ; Lee, HY; Min, HY; Smith, JK; Yun, HJ1
Katayama, H; Kishino, D; Kiura, K; Kuyama, S; Ohashi, K; Okada, T; Sato, K; Takigawa, N; Tanimoto, M1
Kathman, S; Naufal, Z; Wilson, C1
Chae, C; Cho, MH; Choi, DH; Kang, JK; Kim, GS; Kim, JH; Lee, HJ; Lee, SS; Paik, NW1
Cekanova, M; Schuller, HM1
Alyaqoub, FS; Gunning, WT; Kramer, PM; Liu, Y; Lubet, RA; Nines, R; Pereira, MA; Steele, VE1
Hisamoto, A; Hosokawa, S; Kiura, K; Kondo, E; Mimoto, J; Okada, T; Tabata, M; Takigawa, N; Tanimoto, M1
Amin, S; Hecht, SS; Hoffmann, D; Rivenson, A1
Castonguay, A; Hecht, SS; Hoffmann, D; Rivenson, A1
Chen, CB; Hecht, SS; Hoffmann, D; Ohmori, T1
Chakravarti, A; Eskelson, CD; Mufti, SI; Nachiappan, V; Rajasekharan, R1
Furukawa, F; Ikezaki, S; Imazawa, T; Mitsui, M; Nishikawa, A; Takahashi, M; Yoshimura, H1
Castonguay, A; Jorquera, R; Lu, X; Riechert, A; Schüller, HM1
Abbi, R; Hoffmann, D; Rivenson, A; Wynder, EL1
Anderson, MW; Belinsky, SA; Stefanski, SA1
Akerkar, S; Borukhova, A; Carmella, SG; Hecht, SS; Rigotty, J; Rivenson, A; Trushin, N1
Amin, S; Chang, L; Desai, D1
Foiles, PG; Hecht, SS; Miglietta, LM; Staretz, ME1
Dahle, HK; Hoffmann, D; Koppang, N; Rivenson, A1
Castonguay, A; Rioux, N1
Amin, SG; Chung, FL; Ho, CT; Iatropoulos, MJ; Pittman, B; Reinhardt, JC; Rivenson, A; Wang, M1
Goud, SN; Kaplan, AM1
Hecht, SS1
Gong, Y; Yang, Z; Zhu, M1
Chen, CB; Hecht, SS; Hirota, N; Hoffmann, D; Ornaf, RM; Tso, TC1
Amin, S; Anderson, LM; Hecht, SS; Hoffmann, D; Kovatch, RM; Rice, JM1
Amonkar, AJ; Bhide, SV; Padma, PR1
Chung, FL; Eklind, KI; Hecht, SS; Morse, MA1
Guo, Z; Smith, TJ; Thomas, PE; Yang, CS1
Coccia, JB; Wattenberg, LW1
Amin, S; Djordjevic, MV; Hoffmann, R; Rivenson, A1
Anderson, MW; Belinsky, SA; Devereux, TR; Maronpot, RR; Stoner, GD1
Amin, S; Anderson, LM; Dixon, DE; Dove, LF; Hecht, SS; Hoffmann, D; Kovatch, RM; Rice, JM1
Amin, SG; Chung, FL; Hecht, SS; Morse, MA; Wang, CX1
Belinsky, SA; Boucheron, JA; Charbonneau, M; Deal, FH; Richardson, FC; Short, BG; Swenberg, JA1
Castonguay, A; Hecht, SS; Lin, D; Rivenson, A1
Castonguay, A; Hecht, SS; Rivenson, A; Trushin, N1
Castonguay, A; Foiles, PG; Hecht, SS; Trushin, N1

Reviews

2 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Experimental Neoplasms

ArticleYear
Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism.
    The Journal of nutrition, 1999, Volume: 129, Issue:3

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Isothiocyanates; Lung Neoplasms; Neoplasms, Experimental; Nitrosamines; Vegetables

1999
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 1985, Volume: 37

    Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Carcinogens; Chemical Phenomena; Chemistry; Cricetinae; Female; Humans; Male; Mesocricetus; Mice; Mice, Inbred C57BL; Mutagenicity Tests; Neoplasms, Experimental; Nicotiana; Nitrosamines; Plants, Toxic; Pregnancy; Rats; Rats, Inbred F344; Salmonella typhimurium; Tissue Distribution

1985

Other Studies

42 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Experimental Neoplasms

ArticleYear
Fluvastatin Inhibits HMG-CoA Reductase and Prevents Non-Small Cell Lung Carcinogenesis.
    Cancer prevention research (Philadelphia, Pa.), 2019, Volume: 12, Issue:12

    Topics: Acyl Coenzyme A; Adult; Aged; Animals; Apoptosis; Carcinogenesis; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Fluvastatin; Gene Knockdown Techniques; HEK293 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Lung Neoplasms; Male; Mevalonic Acid; Mice; Middle Aged; Neoplasms, Experimental; Nitrosamines; RNA, Small Interfering; Xenograft Model Antitumor Assays

2019
Inhibitory effects of nobiletin and its major metabolites on lung tumorigenesis.
    Food & function, 2019, Nov-01, Volume: 10, Issue:11

    Topics: Animals; Antioxidants; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Female; Flavones; Humans; Mice; Neoplasms, Experimental; Nitrosamines

2019
Low carbohydrate diets containing soy protein and fish oil slow the growth of established NNK-induced lung tumors.
    Carcinogenesis, 2020, 08-12, Volume: 41, Issue:8

    Topics: Amylose; Animals; Apoptosis; Carcinogens; Caspase 3; Cytokines; Diet, Carbohydrate-Restricted; DNA Nucleotidylexotransferase; Fatty Acid Synthases; Fatty Acids; Female; Fish Oils; Glycolysis; In Situ Nick-End Labeling; Ki-67 Antigen; Liver; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosamines; Oxidation-Reduction; Soybean Proteins; Tumor Necrosis Factor-alpha

2020
Syngeneic tobacco carcinogen-induced mouse lung adenocarcinoma model exhibits PD-L1 expression and high tumor mutational burden.
    JCI insight, 2021, 02-08, Volume: 6, Issue:3

    Topics: Adenocarcinoma of Lung; Animals; B7-H1 Antigen; Carcinogens; Cell Line, Tumor; Female; Humans; Lung Neoplasms; Male; Mice; Mutation; Neoplasms, Experimental; Nicotiana; Nitrosamines; Smoke; Tumor Microenvironment

2021
Expression of NR1I3 in mouse lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2015, Volume: 48, Issue:3

    Topics: Animals; Constitutive Androstane Receptor; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger

2015
Smoking-associated lung cancer prevention by blockade of the beta-adrenergic receptor-mediated insulin-like growth factor receptor activation.
    Oncotarget, 2016, Oct-25, Volume: 7, Issue:43

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Insulin-Like Growth Factor II; Lung Neoplasms; Mice; Neoplasms, Experimental; NF-kappa B; Nitrosamines; Phosphorylation; Receptor, IGF Type 1; Receptors, Adrenergic, beta; Receptors, Somatomedin; Signal Transduction; Smoking; STAT3 Transcription Factor; Tumor Burden

2016
Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice.
    Lung cancer (Amsterdam, Netherlands), 2009, Volume: 65, Issue:3

    Topics: Animals; Antineoplastic Agents; Carcinogens, Environmental; Cell Growth Processes; Cell Line, Tumor; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gefitinib; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosamines; Pulmonary Fibrosis; Quinazolines; Smoking; Tumor Burden

2009
Bayesian derivation of an oral cancer slope factor distribution for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
    Regulatory toxicology and pharmacology : RTP, 2009, Volume: 55, Issue:1

    Topics: Animals; Bayes Theorem; Carcinogenicity Tests; Carcinogens; Decision Support Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Environmental Exposure; Female; Humans; Lung Neoplasms; Male; Mice; Models, Biological; Monte Carlo Method; Mouth Neoplasms; Neoplasms, Experimental; Nitrosamines; Pancreatic Neoplasms; Rats; Risk Assessment; United States; United States Environmental Protection Agency

2009
Inhibitory effects of 7-hydroxy-3-methoxy-cadalene on 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice.
    Cancer letters, 2004, Sep-30, Volume: 213, Issue:2

    Topics: Administration, Oral; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Polycyclic Sesquiterpenes; Sesquiterpenes; Ulmaceae

2004
NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways.
    Lung cancer (Amsterdam, Netherlands), 2005, Volume: 49, Issue:1

    Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cricetinae; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; ErbB Receptors; Gene Expression Profiling; Immunohistochemistry; Lung Neoplasms; Male; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Protein Serine-Threonine Kinases; Receptors, Adrenergic, beta-2; Signal Transduction

2005
Prevention of mouse lung tumors by targretin.
    International journal of cancer, 2006, May-01, Volume: 118, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Bexarotene; Chemoprevention; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Tetrahydronaphthalenes; Urethane

2006
Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice.
    Lung cancer (Amsterdam, Netherlands), 2007, Volume: 58, Issue:1

    Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cisplatin; Codon; Female; Genes, ras; Lung Neoplasms; Mice; Neoplasms, Experimental; Neoplasms, Second Primary; Nitrosamines; Point Mutation

2007
Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats.
    Journal of cancer research and clinical oncology, 1984, Volume: 108, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Male; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344

1984
Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in Syrian golden hamsters.
    Cancer research, 1981, Volume: 41, Issue:6

    Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cricetinae; Feces; Female; Injections, Subcutaneous; Lung Neoplasms; Male; Mesocricetus; Nasal Cavity; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Plants, Toxic; Pyridines

1981
Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
    Cancer research, 1980, Volume: 40, Issue:2

    Topics: Animals; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Nasal Cavity; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Plants, Toxic; Pyridines; Rats; Rats, Inbred F344

1980
Lipid peroxidation and ethanol-related tumor promotion in Fischer-344 rats treated with tobacco-specific nitrosamines.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1994, Volume: 29, Issue:5

    Topics: Alcoholism; Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Esophagus; Glutathione; Lipid Metabolism; Lipid Peroxidation; Liver; Lung; Male; Malondialdehyde; Neoplasms, Experimental; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Vitamin E

1994
Effects of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on N-nitrosobis(2-oxopropyl)amine (BOP)-initiated carcinogenesis in hamsters.
    Cancer letters, 1994, Oct-28, Volume: 86, Issue:1

    Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Cricetinae; Disease Models, Animal; Drug Synergism; Female; Mesocricetus; Neoplasms, Experimental; Nitrosamines

1994
Transplacental carcinogenicity of low doses of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone administered subcutaneously or intratracheally to hamsters.
    Journal of cancer research and clinical oncology, 1994, Volume: 120, Issue:4

    Topics: Animals; Carcinogens; Cricetinae; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Injections, Subcutaneous; Male; Maternal-Fetal Exchange; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Pregnancy; Prenatal Exposure Delayed Effects; Trachea

1994
A study of tobacco carcinogenesis: effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
    Cancer research, 1993, Jun-15, Volume: 53, Issue:12

    Topics: Adenoma, Islet Cell; Animals; Body Weight; Carcinogenicity Tests; Corn Oil; Drinking; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; Pancreatic Neoplasms; Rats; Rats, Inbred F344

1993
The A/J mouse lung as a model for developing new chemointervention strategies.
    Cancer research, 1993, Jan-15, Volume: 53, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinogens; Disease Models, Animal; Female; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines

1993
Complete inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Volume: 5, Issue:8

    Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; DNA Adducts; Isothiocyanates; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344

1996
Synthesis and bioassay of 4-ipomeanol analogs as potential chemopreventive agents against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced tumorigenicity in A/J mice.
    Cancer letters, 1996, Nov-29, Volume: 108, Issue:2

    Topics: Animals; Antineoplastic Agents; Carcinogens; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines; Terpenes

1996
Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate.
    Cancer research, 1997, Jan-15, Volume: 57, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Isothiocyanates; Lung; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344

1997
A study of tobacco carcinogenesis, LIII: carcinogenicity of N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mink (Mustela vison).
    Cancer letters, 1997, Jan-01, Volume: 111, Issue:1-2

    Topics: Age Factors; Animals; Body Weight; Carcinogens; Female; Lethal Dose 50; Male; Mink; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms

1997
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
    Carcinogenesis, 1998, Volume: 19, Issue:8

    Topics: Animals; Anticarcinogenic Agents; Arachidonic Acid; Aspirin; Body Weight; Carcinogens; Drug Screening Assays, Antitumor; Female; Hydroxyurea; Indoles; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines

1998
Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituent.
    Cancer research, 1998, Sep-15, Volume: 58, Issue:18

    Topics: Animals; Anticarcinogenic Agents; Body Weight; Caffeine; Carcinogens; Drug Screening Assays, Antitumor; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; Rats; Rats, Inbred F344; Survival Rate; Tea

1998
Inhibition of natural killer cell activity in mice treated with tobacco specific carcinogen NNK.
    Journal of toxicology and environmental health. Part A, 1999, Jan-22, Volume: 56, Issue:2

    Topics: Animals; Carcinogens; Cortisone; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Female; Immunologic Factors; Interleukin-12; Killer Cells, Natural; Lung Neoplasms; Lymphocyte Subsets; Melanoma; Mice; Neoplasms, Experimental; Nitrosamines; Poly I-C; Tumor Cells, Cultured

1999
[Protective effect of tea on immune function in mice].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 1998, Volume: 32, Issue:5

    Topics: Adjuvants, Immunologic; Animals; Carcinogens; Female; Flavonoids; Killer Cells, Natural; Macrophages; Mice; Neoplasms, Experimental; Nitrosamines; Phagocytosis; Phenols; Plant Extracts; Polymers; Polyphenols; Tea

1998
Tobacco-specific nitrosamines: formation from nicotine in vitro and during tobacco curing and carcinogenicity in strain A mice.
    Journal of the National Cancer Institute, 1978, Volume: 60, Issue:4

    Topics: Adenoma; Animals; Female; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Pyridines

1978
Tumorigenicity of the tobacco-specific carcinogen 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in infant mice.
    Cancer letters, 1991, Jul-04, Volume: 58, Issue:3

    Topics: Animals; Animals, Newborn; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrosamines

1991
Antimutagenic and anticarcinogenic effects of betel leaf extract against the tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK).
    IARC scientific publications, 1991, Issue:105

    Topics: Animals; Antineoplastic Agents; Areca; Carcinogens; Liver; Male; Mice; Mutagens; Neoplasms, Experimental; Nitrosamines; Plant Extracts; Plants, Medicinal; Vitamin A

1991
Inhibition of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) tumorigenesis with aromatic isothiocyanates.
    IARC scientific publications, 1991, Issue:105

    Topics: Animals; Carcinogens; DNA; Guanine; Isothiocyanates; Mice; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiocyanates

1991
Metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone as measured by DNA alkylation in vitro and its inhibition by isothiocyanates.
    Cancer research, 1991, Sep-15, Volume: 51, Issue:18

    Topics: Alkylation; Animals; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme System; DNA; Female; Glutathione; Isoenzymes; Isothiocyanates; Lung; Male; Mice; Microsomes; Nasal Cavity; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred Strains; Thiocyanates

1991
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils.
    Carcinogenesis, 1991, Volume: 12, Issue:1

    Topics: Adenoma; Animals; Carcinogens; Citrus; Cyclohexenes; Female; Limonene; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Plant Oils; Stomach Neoplasms; Terpenes

1991
A study of tobacco carcinogenesis XLIV. Bioassay in A/J mice of some N-nitrosamines.
    Cancer letters, 1989, Sep-15, Volume: 47, Issue:1-2

    Topics: Animals; Carcinogens; Female; Mice; Neoplasms, Experimental; Nicotiana; Nitrosamines; Plants, Toxic

1989
Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines.
    Cancer research, 1989, Oct-01, Volume: 49, Issue:19

    Topics: Adenocarcinoma; Animals; Blotting, Southern; Codon; Dimethylnitrosamine; DNA Mutational Analysis; Female; Gene Expression Regulation; Genes, ras; Lung Neoplasms; Mice; Mice, Inbred Strains; Mutation; Neoplasms, Experimental; Nitrosamines; Transfection

1989
Evaluation of the transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.
    Cancer research, 1989, Jul-15, Volume: 49, Issue:14

    Topics: Animals; Carcinogens; Female; Fetus; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasms, Experimental; Nicotiana; Nitrosamines; Placenta; Plants, Toxic; Pregnancy

1989
Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats.
    Carcinogenesis, 1988, Volume: 9, Issue:10

    Topics: Animals; Carcinogens; Diet; DNA; Glucosinolates; Indoles; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Methyltransferases; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Rats; Rats, Inbred F344; Thioglycosides

1988
High- to low-dose extrapolation: critical determinants involved in the dose response of carcinogenic substances.
    Environmental health perspectives, 1987, Volume: 76

    Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Damage; Dose-Response Relationship, Drug; Female; Formaldehyde; Gasoline; Male; Mice; Neoplasms, Experimental; Nitrosamines; Rats; Risk

1987
Effects of alpha-deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
    Carcinogenesis, 1987, Volume: 8, Issue:2

    Topics: Animals; Biotransformation; Deuterium; DNA Damage; Hydroxylation; Liver Neoplasms; Lung Neoplasms; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; Rats; Rats, Inbred F344; Structure-Activity Relationship

1987
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.
    Cancer research, 1986, Volume: 46, Issue:2

    Topics: Animals; Dimethylnitrosamine; DNA, Neoplasm; Guanine; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats

1986
Study of DNA methylation by tobacco-specific N-nitrosamines.
    Environmental health perspectives, 1985, Volume: 62

    Topics: Animals; Antibodies; Carcinogens; Cells, Cultured; Deoxyguanosine; Deoxyribonucleosides; DNA; Enzyme-Linked Immunosorbent Assay; Methylation; Mucous Membrane; Nasal Mucosa; Neoplasms, Experimental; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Smoking

1985