Compounds > 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone
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4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Disease Models, Animal

4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with Disease Models, Animal in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (18.60)18.2507
2000's14 (32.56)29.6817
2010's16 (37.21)24.3611
2020's5 (11.63)2.80

Authors

AuthorsStudies
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV1
Rothenberger, NJ; Stabile, LP1
Hashimoto, N; Imaida, K; Matsuda, Y; Nakano-Narusawa, Y; Yamakawa, K; Yokohira, M1
Alam, N; Iqbal, S; Islam, M; Najnin, H; Zaidi, R1
Balbo, S; Flavin, M; Floeder, AC; Hecht, SS; Ho, YY; O'Sullivan, MG; Oram, MK; Peterson, LA; Seabloom, D; Smith, WE; Stornetta, A; Upadhyaya, P; Vevang, KR; Wiedmann, TS; Zhang, L1
Galli, SJ; Mukai, K; Tsai, M; Yu, M1
Aizawa, K; Hu, KQ; Liu, C; Smith, DE; Veeramachaneni, S; Wang, XD1
Alvord, WG; Bode, C; Kinjo, T; Klinman, DM1
Balbo, S; de la Monte, SM; Deochand, C; Hecht, S; Nunez, K; Ramirez, T; Silbermann, E; Tong, M; Yalcin, EB; Yu, R; Zabala, V1
Barra, CN; Cordeiro, YG; Dagli, ML; Fukumasu, H; Rochetti, AL; Sámora, TS; Strefezzi, RF1
Fritz, V; Fujioka, N; Hecht, SS; Kassie, F; Upadhyaya, P1
Hosokawa, K; Imaida, K; Kuno, T; Matsuda, Y; Saoo, K; Takeuchi, H; Yamakawa, K; Yokohira, M1
Kathman, S; Naufal, Z; Wilson, C1
Blake, DC; Grigoryeva, LS; Gundermann, EL; Herzog, CR; Mikse, OR1
Chen, GG; Hsin, MK; Li, MY; Ma, LT; Mok, TS; Underwood, MJ; Yuan, H1
Hashimoto, N; Imaida, K; Kuno, T; Yokohira, M1
Chen, GG; Deng, YF; Gong, X; Hsin, MK; Kong, AW; Leung, J; Li, MY; Liang, NC; Lv, Y; Mok, TS; Underwood, MJ; Wu, K1
Dennis, PA; Dogan, I; Hobbs, EA; Hollander, MC; Linnoila, RI; Maier, CR1
Shields, PG1
Lam, DC; Minna, JD1
Barta, P; Dickey, BF; Lotan, R; Men, T; Moghaddam, SJ; Van Pelt, C1
Chaible, LM; Cogliati, B; Da Silva, TC; Dagli, ML; Fukumasu, H; Latorre, AO; Mackowiak, II; Mennecier, G; Mori, CM; Nagamine, MK; Sanches, DS; Torres, LN1
Bhatnagar, S; Chaudhary, N; Jain, SK; Katare, DP1
Kassie, F; Melkamu, T; O'Sullivan, MG; Qian, X; Upadhyaya, P1
Rom, WN; Tchou-Wong, KM1
Espiritu, I; Ly, M; Uyeminami, D; Witschi, H1
Kim, Y; Liu, C; Liu, XS; Russell, RM; Smith, DE; Wang, XD1
Cekanova, M; Schuller, HM1
Aebischer, CP; Bachmann, H; Buchwald Hunziker, P; Geatrix, B; Goralczyk, R; Lenz, B; Riss, G; Wertz, K1
Mernitz, H; Smith, DE; Wang, XD; Zhu, AX1
Aebischer, CP; Bachmann, H; Buchwald Hunziker, P; Goralczyk, R; Greatrix, B; Lenz, B; Riss, G; Wertz, K1
Mernitz, H; Russell, RM; Smith, DE; Wang, XD; Wood, RJ1
Choi, SW; Chongviriyaphan, N; Kim, Y; Lian, F; Russell, RM; Wang, XD; Yeum, KJ1
Chen, HL; Lai, BT; Liu, MQ; Xia, D; Yang, F; Ye, B; Zhang, YX1
Richards, RJ1
Furukawa, F; Ikezaki, S; Imazawa, T; Mitsui, M; Nishikawa, A; Takahashi, M; Yoshimura, H1
Graham, SA; Patidar, K; Sunday, ME; Willett, CG1
Anderson, MW; Belinsky, SA; Stefanski, SA1
Chen, X; Kim, S; Liao, J; Seril, DN; Smith, TJ; Wang, ZY; Yang, CS; Yang, G1
Amin, S; Desai, DH; El-Bayoumy, K; Kurtzke, C; Prokopczyk, B; Upadhyaya, P1
Chung, FL1
Chen, J; Ge, G; Gong, Y; Han, C; Yang, Z; Zhu, M1
John, LC1

Reviews

2 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Disease Models, Animal

ArticleYear
Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg.
    Molecular nutrition & food research, 2016, Volume: 60, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biomarkers; Brassicaceae; Carcinogens; Cell Line, Tumor; Diet; Disease Models, Animal; Epigenesis, Genetic; Glucosinolates; Humans; Indoles; Lung; Neoplasms; Nitrosamines; Vegetables

2016
The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black Tea.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1999, Volume: 220, Issue:4

    Topics: Adenoma; Animals; Carcinogens; Disease Models, Animal; Lung Neoplasms; Nitrosamines; Phytotherapy; Plant Extracts; Rats; Rats, Inbred F344; Tea

1999

Other Studies

41 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

2020
Induction of Lung Tumors and Mutational Analysis in FVB/N Mice Treated with the Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone.
    Methods in molecular biology (Clifton, N.J.), 2020, Volume: 2102

    Topics: Animals; Carcinogens; Disease Models, Animal; DNA; DNA Mutational Analysis; Immunohistochemistry; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Nicotiana; Nitrosamines; Workflow

2020
Lung proliferative lesion-promoting effects of left pulmonary ligation in A/J female mice.
    Pathology international, 2020, Volume: 70, Issue:6

    Topics: Animals; Carcinogens; Disease Models, Animal; Female; Ligation; Lung; Lung Neoplasms; Mice; Nitrosamines

2020
Development of a Lung Cancer Model in Wistar Rat and In Silico Screening of its Biomarkers.
    Current computer-aided drug design, 2021, Volume: 17, Issue:3

    Topics: Adenocarcinoma of Lung; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Computer Simulation; Disease Models, Animal; Drug Design; ErbB Receptors; Lung Neoplasms; Male; Molecular Docking Simulation; Molecular Targeted Therapy; Nitrosamines; Rats; Rats, Wistar

2021
Coexposure to Inhaled Aldehydes or Carbon Dioxide Enhances the Carcinogenic Properties of the Tobacco-Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone in the A/J Mouse Lung.
    Chemical research in toxicology, 2021, 03-15, Volume: 34, Issue:3

    Topics: Administration, Inhalation; Aldehydes; Animals; Carbon Dioxide; Carcinogens; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Mice; Molecular Structure; Nicotiana; Nitrosamines

2021
Thirdhand smoke component can exacerbate a mouse asthma model through mast cells.
    The Journal of allergy and clinical immunology, 2018, Volume: 142, Issue:5

    Topics: Administration, Intranasal; Allergens; alpha7 Nicotinic Acetylcholine Receptor; Animals; Asthma; Cockroaches; Cytokines; Disease Models, Animal; Female; Lung; Mast Cells; Mice, Inbred C57BL; Mice, Transgenic; Nitrosamines; Ovalbumin; Skin; Smoke; Tobacco Smoke Pollution

2018
Development of ferret as a human lung cancer model by injecting 4-(Nmethyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
    Lung cancer (Amsterdam, Netherlands), 2013, Volume: 82, Issue:3

    Topics: Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Animals; Carcinogens; Cells, Cultured; Disease Models, Animal; Epithelial Cells; Ferrets; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Metaplasia; Neoplasms, Squamous Cell; Nitrosamines

2013
Suppressive oligodeoxynucleotides reduce lung cancer susceptibility in mice with silicosis.
    Carcinogenesis, 2014, Volume: 35, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Disease Models, Animal; Disease Susceptibility; Female; Gene Expression; Humans; Interleukin-1beta; Lung Neoplasms; Mice; Nitrosamines; Oligodeoxyribonucleotides; Pneumonia; RNA, Messenger; Silicon Dioxide; Silicosis

2014
Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease.
    Alcohol and alcoholism (Oxford, Oxfordshire), 2015, Volume: 50, Issue:2

    Topics: Alcoholism; Animals; Binge Drinking; Carcinogens; Central Nervous System Depressants; Disease Models, Animal; Endoplasmic Reticulum; Ethanol; Fatty Liver, Alcoholic; Hepatocytes; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Liver; Liver Diseases, Alcoholic; Mitochondria, Liver; Necrosis; Nitrosamines; Rats; Rats, Long-Evans; Receptor, IGF Type 1; Receptor, Insulin; Signal Transduction

2015
Expression of NR1I3 in mouse lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2015, Volume: 48, Issue:3

    Topics: Animals; Constitutive Androstane Receptor; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger

2015
Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2008, Volume: 60, Issue:6

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Hyperplasia; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Time Factors

2008
Bayesian derivation of an oral cancer slope factor distribution for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
    Regulatory toxicology and pharmacology : RTP, 2009, Volume: 55, Issue:1

    Topics: Animals; Bayes Theorem; Carcinogenicity Tests; Carcinogens; Decision Support Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Environmental Exposure; Female; Humans; Lung Neoplasms; Male; Mice; Models, Biological; Monte Carlo Method; Mouth Neoplasms; Neoplasms, Experimental; Nitrosamines; Pancreatic Neoplasms; Rats; Risk Assessment; United States; United States Environmental Protection Agency

2009
FoxO3a gene is a target of deletion in mouse lung adenocarcinoma.
    Oncology reports, 2009, Volume: 22, Issue:4

    Topics: Adenocarcinoma; Aflatoxin B1; Animals; Carcinogens; Disease Models, Animal; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Deletion; Loss of Heterozygosity; Lung Neoplasms; Mice; Nitrosamines; Polymerase Chain Reaction; Smoking; Urethane

2009
15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer.
    Thorax, 2010, Volume: 65, Issue:4

    Topics: Animals; Arachidonate 15-Lipoxygenase; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Disease Models, Animal; Disease Progression; Female; Humans; Hydroxyeicosatetraenoic Acids; Linoleic Acids; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasm Proteins; Nitrosamines; PPAR gamma

2010
Risk analysis of environmental chemicals on lung carcinogenesis.
    Asian Pacific journal of cancer prevention : APJCP, 2010, Volume: 11, Issue:1

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cattle; Disease Models, Animal; Female; Humans; Lactoferrin; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred ICR; Nitrosamines; Risk Assessment

2010
Anticancer efficacy of 5F in NNK-induced lung cancer development of A/J mice and human lung cancer cells.
    Journal of molecular medicine (Berlin, Germany), 2010, Volume: 88, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Nucleus; Cell Proliferation; Cell Survival; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Down-Regulation; Drug Screening Assays, Antitumor; Extracellular Signal-Regulated MAP Kinases; Humans; Lung Neoplasms; Mice; Mitochondria; Nitrosamines; Protein Transport; Proto-Oncogene Proteins c-akt; Time Factors; Treatment Outcome; Up-Regulation

2010
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11

    Topics: Adenocarcinoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Drinking Water; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)

2011
Long-term nicotine replacement therapy: cancer risk in context.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)

2011
How do we safely get people to stop smoking?
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)

2011
Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation.
    Molecular cancer, 2012, Jan-12, Volume: 11

    Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Haemophilus Infections; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Lung Neoplasms; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Nitrosamines; Pulmonary Disease, Chronic Obstructive; Receptors, G-Protein-Coupled

2012
Chronic exposure of lung alveolar epithelial type II cells to tobacco-specific carcinogen NNK results in malignant transformation: a new in vitro lung carcinogenesis model.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:5

    Topics: Animals; Blotting, Western; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Epithelial-Mesenchymal Transition; Female; Fluorescent Antibody Technique, Indirect; Immunoenzyme Techniques; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Nicotiana; Nitrosamines; Pulmonary Alveoli; Wound Healing

2014
A non-surgical method for induction of lung cancer in Wistar rats using a combination of NNK and high dietary fats.
    Protoplasma, 2013, Volume: 250, Issue:4

    Topics: Animals; Carcinogens; Dietary Fats; Disease Models, Animal; Lung Neoplasms; Male; Nitrosamines; Oxidative Stress; Rats; Rats, Wistar

2013
Lipopolysaccharide enhances mouse lung tumorigenesis: a model for inflammation-driven lung cancer.
    Veterinary pathology, 2013, Volume: 50, Issue:5

    Topics: Administration, Intranasal; Animals; Blotting, Western; Carcinogenesis; Disease Models, Animal; Immunohistochemistry; Linear Models; Lipopolysaccharides; Lung Neoplasms; Mice; Nitrosamines

2013
Lung-specific expression of mutant p53 as mouse model for lung cancer.
    Methods in molecular medicine, 2003, Volume: 74

    Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Genes, p53; Humans; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Transgenic; Mutation; Nitrosamines; Proliferating Cell Nuclear Antigen; Promoter Regions, Genetic; Proteins; Uteroglobin

2003
The chemopreventive effects of orally administered dexamethasone in Strain A/J mice following cessation of smoke exposure.
    Inhalation toxicology, 2005, Volume: 17, Issue:2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carcinogens; Chemoprevention; Dexamethasone; Disease Models, Animal; Lung Neoplasms; Male; Mice; Nitrosamines; Smoking; Tobacco Smoke Pollution

2005
Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer.
    Cancer letters, 2006, Mar-28, Volume: 234, Issue:2

    Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Ferrets; Humans; Immunohistochemistry; Lung Neoplasms; Male; Nitrosamines; Precancerous Conditions; Smoking

2006
NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways.
    Lung cancer (Amsterdam, Netherlands), 2005, Volume: 49, Issue:1

    Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cricetinae; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; ErbB Receptors; Gene Expression Profiling; Immunohistochemistry; Lung Neoplasms; Male; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Protein Serine-Threonine Kinases; Receptors, Adrenergic, beta-2; Signal Transduction

2005
Beta-carotene interaction with NNK in the AJ-mouse model: effects on cell proliferation, tumor formation and retinoic acid responsive genes.
    Biochimica et biophysica acta, 2005, May-30, Volume: 1740, Issue:2

    Topics: Adenoma; Animals; beta Carotene; Bronchi; Carcinogens; Cytochrome P-450 Enzyme System; Disease Models, Animal; Down-Regulation; Drug Interactions; Epithelial Cells; Gene Expression Regulation; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Protein Isoforms; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase

2005
9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2.
    Cancer letters, 2006, Nov-28, Volume: 244, Issue:1

    Topics: Alitretinoin; Animals; Antineoplastic Agents; Carcinogens; Celecoxib; Cell Transformation, Neoplastic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dietary Supplements; Disease Models, Animal; Lung; Lung Neoplasms; Male; Membrane Proteins; Mice; Mice, Inbred A; Nitrosamines; Pyrazoles; Receptors, Retinoic Acid; Sulfonamides; Tretinoin

2006
beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model.
    Nutrition and cancer, 2006, Volume: 54, Issue:2

    Topics: Adenoma; Animals; beta Carotene; Carcinogens; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Protein Isoforms; Random Allocation; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smoking; Vitamins

2006
Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity.
    International journal of cancer, 2007, Apr-01, Volume: 120, Issue:7

    Topics: Adenoma; Alitretinoin; Animals; Antineoplastic Agents; Calcitriol; Carcinogens; Cell Transformation, Neoplastic; Dietary Supplements; Disease Models, Animal; Drug Therapy, Combination; Lung Neoplasms; Male; Mice; Mice, Inbred A; Nitrosamines; Retinoid X Receptors; Steroid Hydroxylases; Tretinoin; Vitamin D3 24-Hydroxylase; Vitamins

2007
The effects of combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer.
    International journal of cancer, 2007, May-01, Volume: 120, Issue:9

    Topics: Animals; Antioxidants; Ascorbic Acid; beta Carotene; Disease Models, Animal; DNA Breaks, Single-Stranded; Ferrets; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Liver; Lung; Lung Neoplasms; Male; Nitrosamines; Smoke; Vitamin E

2007
Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate.
    BMC cancer, 2007, May-29, Volume: 7

    Topics: Animals; Anticarcinogenic Agents; Aspirin; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Female; Immunohistochemistry; Isothiocyanates; Lung Neoplasms; Nicotiana; Nitrosamines; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar

2007
Networks controlling pneumocyte proliferation. Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia.
    Human & experimental toxicology, 1994, Volume: 13, Issue:12

    Topics: Animals; Carcinogens; Cell Differentiation; Cell Division; Cricetinae; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, Tumor Suppressor; Hyperplasia; Lung; Neurosecretory Systems; Nitrosamines

1994
Effects of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on N-nitrosobis(2-oxopropyl)amine (BOP)-initiated carcinogenesis in hamsters.
    Cancer letters, 1994, Oct-28, Volume: 86, Issue:1

    Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Cricetinae; Disease Models, Animal; Drug Synergism; Female; Mesocricetus; Neoplasms, Experimental; Nitrosamines

1994
Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia.
    Laboratory investigation; a journal of technical methods and pathology, 1994, Volume: 70, Issue:6

    Topics: Animals; Base Sequence; Carcinogens; Cell Differentiation; Cell Division; Cricetinae; Diethylnitrosamine; Disease Models, Animal; DNA Primers; Female; Gene Expression Regulation; Genes, myc; Genes, p53; Genes, ras; Genes, Retinoblastoma; Genes, Tumor Suppressor; Hyperplasia; Lung; Mesocricetus; Molecular Sequence Data; Neurosecretory Systems; Nitrosamines; Oligonucleotide Probes; Oncogenes; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogenes; Transcription, Genetic

1994
The A/J mouse lung as a model for developing new chemointervention strategies.
    Cancer research, 1993, Jan-15, Volume: 53, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinogens; Disease Models, Animal; Female; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines

1993
Characterization of early pulmonary hyperproliferation and tumor progression and their inhibition by black tea in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model with A/J mice.
    Cancer research, 1997, May-15, Volume: 57, Issue:10

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; Disease Models, Animal; Disease Progression; Female; Flavonoids; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Phenols; Plant Extracts; Polymers; Polyphenols

1997
Effects of 1,4-phenylenebis(methylene)selenocyanate and selenomethionine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mouse lung.
    Carcinogenesis, 1997, Volume: 18, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Female; Lung Neoplasms; Mice; Nitrosamines; Organoselenium Compounds; Selenomethionine; Smoking

1997
Green tea and its major components ameliorate immune dysfunction in mice bearing Lewis lung carcinoma and treated with the carcinogen NNK.
    Nutrition and cancer, 1999, Volume: 35, Issue:1

    Topics: Animals; Carcinogens; Carcinoma, Lewis Lung; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Models, Animal; Female; Immunity, Cellular; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Nitrosamines; Tea; Thymus Gland

1999
Assessment of murine lung tumour development: a comparison of two techniques.
    British journal of biomedical science, 2001, Volume: 58, Issue:3

    Topics: Animals; Disease Models, Animal; Disease Progression; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Photography

2001