4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with Disease Exacerbation in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amin, S; Biddick, L; Desai, D; Lightfoot, S; Patlolla, JM; Qian, L; Rao, CV; Zhang, Y | 1 |
| Chen, SF; Chu, YH; Jao, SW; Lee, TY; Lin, YS; Liu, CL; Liu, TY; Nieh, S; Tseng, YH; Yang, CY | 1 |
| Iyama, S; Kano, J; Kim, Y; Morishita, Y; Noguchi, M; Sakashita, S; Satomi, K; Shiba-Ishii, A; Shiozawa, T | 1 |
| Biddick, L; Kopelovich, L; Kumar, G; Lightfoot, S; Madka, V; Mohammed, A; Patlolla, JM; Qian, L; Rao, CV; Sadeghi, M; Zhang, Y | 1 |
| Chen, X; Duan, W; Huo, X; Jiang, Z; Lei, J; Li, X; Ma, J; Ma, Q; Nan, L; Sheng, L; Wang, Z; Wu, E; Wu, Z; Xu, Q; Zhang, D | 1 |
| Anandharaj, A; Hong, KH; Kassie, F; Kim, JH; Kirtane, AR; Panyam, J; Song, JM; Upadhyaya, P | 1 |
| Hashimoto, N; Imaida, K; Kuno, T; Matsuda, Y; Saoo, K; Suzuki, S; Yamakawa, K; Yokohira, M | 1 |
| Hashimoto, N; Imaida, K; Kuno, T; Saoo, K; Yamakawa, K; Yokohira, M | 1 |
| Chen, GG; Hsin, MK; Kong, AW; Li, MY; Ma, LT; Underwood, MJ; Yip, JH; Yuan, H | 1 |
| Chen, GG; Hsin, MK; Li, MY; Ma, LT; Mok, TS; Underwood, MJ; Yuan, H | 1 |
| Deng, X; Xu, L | 1 |
| Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM | 1 |
| Hao, X; Liao, J; Lu, G; Reuhl, KR; Yang, CS; Yang, G | 1 |
| Chen, X; Kim, S; Liao, J; Seril, DN; Smith, TJ; Wang, ZY; Yang, CS; Yang, G | 1 |
| John, LC | 1 |
15 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Disease Exacerbation
| Article | Year |
|---|---|
β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells.
Topics: Adenocarcinoma; Adenoma; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Carcinogenesis; Cell Line, Tumor; Disease Progression; Escin; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Neoplasm Transplantation; Nicotiana; Nitrosamines; Plant Extracts; Real-Time Polymerase Chain Reaction; Retinal Dehydrogenase; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein | 2013 |
Regulation of tumor progression via the Snail-RKIP signaling pathway by nicotine exposure in head and neck squamous cell carcinoma.
Topics: Aldehyde Dehydrogenase 1 Family; alpha7 Nicotinic Acetylcholine Receptor; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Disease Progression; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Head and Neck Neoplasms; Humans; Hypopharyngeal Neoplasms; Isoenzymes; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Staging; Neoplastic Stem Cells; Nicotine; Nicotinic Agonists; Nitrosamines; Retinal Dehydrogenase; Signal Transduction; Snail Family Transcription Factors; Tongue Neoplasms; Transcription Factors; Up-Regulation | 2015 |
Stratifin accelerates progression of lung adenocarcinoma at an early stage.
Topics: 14-3-3 Proteins; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Disease Progression; Exoribonucleases; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Transgenic; Neoplasm Metastasis; Neoplasm Staging; Nitrosamines; Xenograft Model Antitumor Assays | 2015 |
Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; bcl-X Protein; Carcinogens; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Nicotiana; Nicotine; Nitrosamines; Proliferating Cell Nuclear Antigen; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
β2-adrenogenic signaling regulates NNK-induced pancreatic cancer progression via upregulation of HIF-1α.
Topics: Aged; Animals; Carcinogens; Cell Line, Tumor; Cell Proliferation; Disease Progression; Female; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Middle Aged; Nitrosamines; Pancreatic Neoplasms; Receptors, Adrenergic, beta-2; Signal Transduction; Smoking; Transcriptional Activation; Up-Regulation | 2016 |
Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Assay; Biphenyl Compounds; Bronchi; Carcinogenesis; Cell Cycle; Cell Proliferation; Cell Survival; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Female; Lignans; Lung Neoplasms; Magnolia; Mice; Molecular Docking Simulation; Nitrosamines; Plant Extracts; RNA, Small Interfering | 2016 |
Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Disease Progression; Enzyme Inhibitors; Female; Lung Neoplasms; Methoxsalen; Mice; Neoplasm Staging; Nitrosamines | 2008 |
Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer.
Topics: Animals; Body Weight; Calbindin 2; Cell Proliferation; Disease Progression; Epithelial Cells; Female; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Organ Size; Polymers; Pulmonary Atelectasis; S100 Calcium Binding Protein G; Thoracotomy; Thorax | 2011 |
Roles of peroxisome proliferator-activated receptor-alpha and -gamma in the development of non-small cell lung cancer.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxyeicosatetraenoic Acids; Ligands; Linoleic Acids; Lipid Metabolism; Lung Neoplasms; Male; Mice; Nitrosamines; Pioglitazone; PPAR alpha; PPAR gamma; Precancerous Conditions; Retinoid X Receptor alpha; Signal Transduction; Thiazolidinediones; Transcription, Genetic | 2010 |
15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer.
Topics: Animals; Arachidonate 15-Lipoxygenase; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Disease Models, Animal; Disease Progression; Female; Humans; Hydroxyeicosatetraenoic Acids; Linoleic Acids; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasm Proteins; Nitrosamines; PPAR gamma | 2010 |
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.
Topics: Blotting, Western; Calpain; Carcinogens; Cell Line, Tumor; Cell Movement; Disease Progression; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Silencing; Genetic Vectors; Humans; Immunoprecipitation; Lung Neoplasms; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; Nicotiana; Nitrosamines; Phosphorylation; RNA Interference; RNA, Small Interfering; Signal Transduction | 2004 |
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Caspase 3; Caspases; Cell Growth Processes; Disease Progression; Female; In Situ Nick-End Labeling; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Smoking; Sulfoxides; Thiocyanates | 2005 |
Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine.
Topics: Adenocarcinoma; Adenoma; Analysis of Variance; Animals; Caffeine; Catechin; Cell Proliferation; Disease Progression; Female; Flavonoids; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitrosamines; Phenols; Phosphorylation; Polyphenols; Proliferating Cell Nuclear Antigen; Tea; Time Factors | 2006 |
Characterization of early pulmonary hyperproliferation and tumor progression and their inhibition by black tea in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model with A/J mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; Disease Models, Animal; Disease Progression; Female; Flavonoids; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Phenols; Plant Extracts; Polymers; Polyphenols | 1997 |
Assessment of murine lung tumour development: a comparison of two techniques.
Topics: Animals; Disease Models, Animal; Disease Progression; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Photography | 2001 |