4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Cell Transformation, Neoplastic

4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with Cell Transformation, Neoplastic in 72 studies

Research

Studies (72)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.39)	18.7374
1990's	16 (22.22)	18.2507
2000's	17 (23.61)	29.6817
2010's	37 (51.39)	24.3611
2020's	1 (1.39)	2.80

Authors

Authors	Studies
Chan, PKS; Cui, X; Li, J; Sun, G; Zhang, N; Zhao, L; Zhong, R; Zhuang, Z	1
Belinsky, SA; Chen, W; Hutt, J; Kato, K; Kim, KC; Leng, S; Lin, Y; Padilla, MT; Saxton, B; Tessema, M; Xu, X	1
Chang, HL; Chang, HW; Chen, LC; Cheng, TC; Fararjeh, AS; Ho, YS; Huang, CC; Hwang-Verslues, WW; Liu, YR; Tu, SH; Wang, HR; Wu, CH	1
Dallos, M; Dennis, PA; Gills, JJ; Hollander, MC; Kitagawa, H; Kunnumakkara, AB; Memmott, RM; Quinn, BJ	1
Amin, S; Brewer, M; Desai, D; Kopelovich, L; Lightfoot, S; Mohammed, A; Patlolla, JM; Qian, L; Rao, CV; Zhang, Y	1
Hong, KH; Kassie, F; Qian, X; Song, JM; Upadhyayya, P	1
Chen, K; Huang, X; Shen, J; Shen, Y; Wang, Z; Zhang, S	1
Liu, AK; Pluchino, LA; Wang, HC	1
Chen, L; Gao, W; Keohavong, P; Lu, C	1
Bora, HK; Farhan, M; Khan, S; Kumar, S; Maurya, R; Meeran, SM; Shukla, S; Sinha, S	1
Kassie, F; Luo, X; Molla, K; O Sullivan, G; Qian, X; Song, JM; Teferi, F; Upadhyaya, P	1
Imaida, K; Kanie, S; Kishi, S; Nakano, Y; Yamakawa, K; Yokohira, M	1
Khan, S; Kumar, S; Maurya, R; Meeran, SM; Mitra, K; Shukla, S; Singh, K; Sinha, S	1
Han, B; Liu, X; Luo, E; Peng, X; Yang, X; Yu, X	1
Kalscheuer, S; Upadhyaya, P; Zeng, Y; Zhang, X	1
Katayama, H; Kishino, D; Kiura, K; Kuyama, S; Ohashi, K; Okada, T; Sato, K; Takigawa, N; Tanimoto, M	1
Chen, CY; Chen, L; Guo, J; Huppi, P; Nishioka, T; Yamamoto, D	1
Broide, DH; Karin, M; Nishigaki, R; Ogata, H; Takahashi, H	1
Lin, D; Rathore, K; Siriwardhana, N; Song, X; Wang, HC	1
Chen, GG; Hsin, MK; Li, MY; Ma, LT; Mok, TS; Underwood, MJ; Yuan, H	1
Moorehead, RA; Petrik, JJ; Siwicky, MD	1
Song, X; Wang, H	1
Kassie, F; Melkamu, T; Qian, X; Upadhyaya, P	1
Rathore, K; Wang, HC	2
Dennis, PA; Dogan, I; Hobbs, EA; Hollander, MC; Linnoila, RI; Maier, CR	1
Shields, PG	1
Lam, DC; Minna, JD	1
Chikova, A; Grando, SA	1
Barta, P; Dickey, BF; Lotan, R; Men, T; Moghaddam, SJ; Van Pelt, C	1
Avanzo, JL; Dagli, ML; Fukumasu, H; Mennecier, G; Mori, CM; Sanches, DS	1
Bernard, HU; Grando, SA; Kalantari-Dehaghi, M	1
Chen, GG; Hsin, MK; Kong, AW; Li, MY; Ma, LT; Underwood, MJ; Wan, IY; Yuan, H	1
Castranova, V; Cavendish, J; Fortney, JE; Gibson, LF; Guo, NL; Luo, D; Qian, Y; Raese, RA; Wan, YW; Xiao, C	1
Choudhary, S; Sood, S; Wang, HC	1
Attia, A; Isom, S; Kock, ND; McBride, JE; Miller, MS; Moore, JE; Munley, MT; Walb, MC	1
Chaible, LM; Cogliati, B; Da Silva, TC; Dagli, ML; Fukumasu, H; Latorre, AO; Mackowiak, II; Mennecier, G; Mori, CM; Nagamine, MK; Sanches, DS; Torres, LN	1
Kido, T; Kimura, S; Paiz, J; Vinson, C; Ward, JM; Yoneda, M	1
Kassie, F; Melkamu, T; Qian, X; Song, JM; Upadhyaya, P	1
Jensen-Taubman, SM; Keefe, KM; Linnoila, RI; Wang, XY; Yang, D	1
Chen, J; Gong, Y; Sun, H; Wang, Q	1
Hu, H; McEntee, M; Mei, J; Plummer, H; Song, P; Wang, HC	1
Calaf, GM; Hei, TK; Zhou, H	1
Belinsky, S; Brognard, J; Dennis, PA; Harris, C; Linnoila, IR; West, KA	1
Linnoila, RI; Mukherjee, AB; Yang, Y; Zhang, Z	1
Chae, C; Cho, MH; Choi, DH; Kang, JK; Kim, GS; Kim, JH; Lee, HJ; Lee, SS; Paik, NW	1
Hecht, SS	2
Cody, D; Hong, WK; Kim, WY; Lee, HY; Moriarty, RM; Oh, SH; Pezzuto, JM; Price, RE; Tran, H; Van Pelt, CS; Woo, JK	1
Mernitz, H; Smith, DE; Wang, XD; Zhu, AX	1
Amin, SG; Das, A; Desai, DH; El-Bayoumy, K; Kleinman, W; Pinto, JT; Richie, JP	1
Askari, MD; Cekanova, M; Schuller, HM; Tsao, MS	1
Akopyan, G; Bonavida, B	1
Abdel-Aziz, HO; Murai, Y; Nomoto, K; Tabuchi, Y; Takano, Y; Takasaki, I; Tsuneyama, K	1
Mernitz, H; Russell, RM; Smith, DE; Wang, XD; Wood, RJ	1
Colacino, JA; Demizu, Y; Huang, P; Liu, J; Pelicano, H; Sasaki, R; Trachootham, D	1
Castonguay, A; Furuya, K; Hecht, SS; Klaunig, JE; Lin, D; Radok, P; Schut, HA; Stoner, GD	1
Chakravarti, A; Eskelson, CD; Mufti, SI; Nachiappan, V; Rajasekharan, R	1
Baskaran, K; Laconi, S; Reddy, MK	1
Beck, S; Crespi, CL; Hosokawa, M; Langenbach, R; Lasley, J; Nesnow, S; Rosenblum, S; Tiano, HF	1
Chulada, PC; Crespi, CL; Gonzalez, FJ; Hosokawa, M; Langenbach, R; Smith, PB; Tiano, HF; Wang, RL	1
Baek, JH; Cherrick, HM; Kim, MS; Park, NH; Shin, KH	1
Gilchrist, EP; Moyer, MP; Murrah, VA	1
Baylin, SB; Belinsky, SA; Issa, JP; Nikula, KJ	1
Ahn, MJ; Dmitrovsky, E; Kiyokawa, H; Langenfeld, J; Lonardo, F; Passalaris, T; Rusch, V	1
Beebe, JS; Dmitrovsky, E; Dragnev, KH; Freemantle, SJ; Knauth, EA; Lonardo, F; Ma, Y; Memoli, N; Sekula, D	1
Caamano, J; Garcia-Palazzo, I; Harris, CC; Iizasa, T; Klein-Szanto, AJ; Metcalf, R; Momiki, S; Welsh, J	1
Gray, TE; Nettesheim, P; Zhu, S	1
Cunningham, ML; Gray, TE; Nettesheim, P; Zhu, SY	1
Castonguay, A; Goldblatt, PJ; Gunning, WT; Stoner, GD	1
Cherrick, HM; Dokko, H; Li, SL; Park, NH	1
Gao, Y	1

Reviews

2 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Cell Transformation, Neoplastic

Article	Year
Understanding tobacco smoke carcinogen NNK and lung tumorigenesis. International journal of oncology, 2006, Volume: 29, Issue:4 Topics: Carcinogens; Cell Transformation, Neoplastic; Humans; Lung Neoplasms; Nitrosamines; Smoking	2006
Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. Critical reviews in toxicology, 1996, Volume: 26, Issue:2 Topics: Animals; Animals, Laboratory; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; DNA Adducts; Genes, p53; Genes, ras; Humans; Lung Neoplasms; Mice; Mutation; Nicotiana; Nitrosamines; Oncogenes; Plants, Toxic; Protein Binding; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Smoking	1996

Article

Year

Understanding tobacco smoke carcinogen NNK and lung tumorigenesis.

International journal of oncology, 2006, Volume: 29, Issue:4

Topics: Carcinogens; Cell Transformation, Neoplastic; Humans; Lung Neoplasms; Nitrosamines; Smoking

2006

Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen.

Critical reviews in toxicology, 1996, Volume: 26, Issue:2

Topics: Animals; Animals, Laboratory; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; DNA Adducts; Genes, p53; Genes, ras; Humans; Lung Neoplasms; Mice; Mutation; Nicotiana; Nitrosamines; Oncogenes; Plants, Toxic; Protein Binding; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Smoking

1996

Other Studies

70 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Cell Transformation, Neoplastic

Article	Year
Synergistic Effect between Human Papillomavirus 18 and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone on Malignant Transformation of Immortalized SHEE Cells. Chemical research in toxicology, 2020, 02-17, Volume: 33, Issue:2 Topics: Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Human papillomavirus 18; Humans; Molecular Structure; Nitrosamines	2020
Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop. Carcinogenesis, 2017, 06-01, Volume: 38, Issue:6 Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Epiregulin; ErbB Receptors; Feedback, Physiological; Female; Fibroblasts; Humans; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Knockout; Mucin-1; Nitrosamines; Smoking	2017
Long-term exposure to extremely low-dose of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induce non-malignant breast epithelial cell transformation through activation of the a9-nicotinic acetylcholine receptor-mediated signaling pathw Environmental toxicology, 2019, Volume: 34, Issue:1 Topics: Acetylcholine; Breast Neoplasms; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells; Female; Humans; Mammary Glands, Human; Nicotine; Nitrosamines; Receptors, Nicotinic; Signal Transduction; Time Factors; Toxicity Tests, Chronic	2019
Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling. Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:8 Topics: AMP-Activated Protein Kinases; Animals; Carcinogens; Cell Transformation, Neoplastic; Energy Metabolism; Enzyme-Linked Immunosorbent Assay; Female; Hypoglycemic Agents; Insulin-Like Growth Factor I; Lung Neoplasms; Male; Metformin; Mice; Mice, Inbred A; Mice, Knockout; Nitrosamines; Phosphorylation; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tissue Distribution	2013
Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:9 Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Transformation, Neoplastic; Chemoprevention; Cyclin-Dependent Kinase Inhibitor p21; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Pyrimidines; Random Allocation; Tumor Suppressor Protein p53	2013
Dimethylaminoparthenolide, a water soluble parthenolide, suppresses lung tumorigenesis through down-regulating the STAT3 signaling pathway. Current cancer drug targets, 2014, Volume: 14, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Bronchi; Cell Line; Cell Transformation, Neoplastic; Down-Regulation; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred Strains; Myeloid Cell Leukemia Sequence 1 Protein; Nitrosamines; Sesquiterpenes; Solubility; STAT3 Transcription Factor	2014
Involvement of p53 mutation and mismatch repair proteins dysregulation in NNK-induced malignant transformation of human bronchial epithelial cells. BioMed research international, 2014, Volume: 2014 Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Apoptosis; Bronchi; Cell Proliferation; Cell Transformation, Neoplastic; DNA Mismatch Repair; DNA Repair Enzymes; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; Neoplasms; Nicotiana; Nitrosamines; Nuclear Proteins; Tumor Suppressor Protein p53	2014
Reactive oxygen species-mediated breast cell carcinogenesis enhanced by multiple carcinogens and intervened by dietary ergosterol and mimosine. Free radical biology & medicine, 2015, Volume: 80 Topics: Aldehyde Dehydrogenase; Benzopyrenes; Carcinogens; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; DNA Damage; Ergosterol; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mammary Glands, Human; MAP Kinase Signaling System; Mimosine; Nitrosamines; Oxidation-Reduction; Reactive Oxygen Species	2015
Overexpression of CRM1: A Characteristic Feature in a Transformed Phenotype of Lung Carcinogenesis and a Molecular Target for Lung Cancer Adjuvant Therapy. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2015, Volume: 10, Issue:5 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Exportin 1 Protein; Fatty Acids, Unsaturated; Female; Gene Expression; Gene Silencing; Humans; Inhibitor of Apoptosis Proteins; Karyopherins; Lung; Lung Neoplasms; Male; Mice; Mice, Nude; Middle Aged; Nitrosamines; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Smoking; Survivin; Transfection; Tumor Stem Cell Assay; Tumor Suppressor Protein p53	2015
Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis. Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:6 Topics: Animals; Apoptosis; Blotting, Southwestern; Blotting, Western; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Histone Deacetylases; Humans; Immunoenzyme Techniques; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triterpenes; Tumor Cells, Cultured	2015
Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators. Carcinogenesis, 2015, Volume: 36, Issue:6 Topics: Animals; Anticarcinogenic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Cyclin D1; Cyclin-Dependent Kinases; Cyclooxygenase 2; Drug Combinations; Female; Humans; I-kappa B Proteins; Indoles; Inflammation; Interleukin-6; Lipopolysaccharides; Lung; Lung Neoplasms; Mice; Mice, Inbred A; NF-KappaB Inhibitor alpha; Nitrosamines; Proto-Oncogene Proteins c-akt; Random Allocation; Retinoblastoma Protein; Silybin; Silymarin; Smoke; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha	2015
Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice. Cancer medicine, 2016, Volume: 5, Issue:5 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenoma; Animals; Cell Transformation, Neoplastic; Enzyme Activation; Female; Lung Neoplasms; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Signaling System; Mice, Inbred A; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nitrosamines; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins p21(ras)	2016
Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis. Scientific reports, 2016, Feb-24, Volume: 6 Topics: A549 Cells; Animals; beta Catenin; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Human Umbilical Vein Endothelial Cells; Humans; Immunoprecipitation; Lung Neoplasms; Mice; Microscopy, Fluorescence; Neovascularization, Physiologic; Nitrosamines; RNA Interference; RNA, Small Interfering; Transforming Growth Factor beta1; Triterpenes; Wnt Signaling Pathway; Wnt3 Protein; Wnt3A Protein	2016
Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway. BMC cancer, 2016, 07-07, Volume: 16 Topics: Animals; Anthocyanins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; Glucosides; Humans; Mice; Nitrosamines; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; RNA, Long Noncoding; Signal Transduction; Xenograft Model Antitumor Assays	2016
Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis, 2008, Volume: 29, Issue:12 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Gene Expression; Gene Expression Profiling; Lung Neoplasms; Male; MicroRNAs; Nicotiana; Nitrosamines; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Steroid Hydroxylases	2008
Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice. Lung cancer (Amsterdam, Netherlands), 2009, Volume: 65, Issue:3 Topics: Animals; Antineoplastic Agents; Carcinogens, Environmental; Cell Growth Processes; Cell Line, Tumor; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gefitinib; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosamines; Pulmonary Fibrosis; Quinazolines; Smoking; Tumor Burden	2009
Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation. Journal of cellular biochemistry, 2010, Jan-01, Volume: 109, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cisplatin; DNA Fragmentation; Humans; Immunoblotting; Mice; Nicotine; Nicotinic Agonists; Nitrosamines; Rats; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Up-Regulation	2010
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer cell, 2010, Jan-19, Volume: 17, Issue:1 Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Enzyme-Linked Immunosorbent Assay; Genes, ras; I-kappa B Kinase; Immunohistochemistry; Inflammation; Lung Neoplasms; Male; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 8; Nitrosamines; Reverse Transcriptase Polymerase Chain Reaction; Tobacco Smoke Pollution	2010
Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene. Molecular carcinogenesis, 2010, Volume: 49, Issue:5 Topics: Base Sequence; Benzo(a)pyrene; Blotting, Western; Breast Neoplasms; Carcinogens; Cell Adhesion; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Primers; Female; Humans; Nitrosamines; Proanthocyanidins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Seeds; Vitis	2010
15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. Thorax, 2010, Volume: 65, Issue:4 Topics: Animals; Arachidonate 15-Lipoxygenase; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Disease Models, Animal; Disease Progression; Female; Humans; Hydroxyeicosatetraenoic Acids; Linoleic Acids; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasm Proteins; Nitrosamines; PPAR gamma	2010
The function of IGF-IR in NNK-mediated lung tumorigenesis. Lung cancer (Amsterdam, Netherlands), 2011, Volume: 71, Issue:1 Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Humans; Immunohistochemistry; Lung Neoplasms; Male; Mice; Mice, Transgenic; Nitrosamines; Receptor, IGF Type 1; Signal Transduction; Up-Regulation	2011
[Biological change of normal human breast epithelial cells induced by B( a )P and NNK]. Wei sheng yan jiu = Journal of hygiene research, 2011, Volume: 40, Issue:3 Topics: Benzo(a)pyrene; Breast; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Drug Synergism; Epithelial Cells; Female; Humans; Nitrosamines	2011
Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis. Cancer letters, 2011, Dec-01, Volume: 311, Issue:1 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anticarcinogenic Agents; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Female; Humans; Indoles; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptor Protein-Tyrosine Kinases	2011
Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens. Molecular carcinogenesis, 2012, Volume: 51, Issue:3 Topics: Benzo(a)pyrene; Breast; Breast Neoplasms; Carcinogens, Environmental; Catechin; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Female; Gene Expression Regulation; Histones; Humans; Nitrosamines; Phosphorylation; Plant Extracts; Reactive Oxygen Species; Tea	2012
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer. Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11 Topics: Adenocarcinoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Drinking Water; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)	2011
Long-term nicotine replacement therapy: cancer risk in context. Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11 Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)	2011
How do we safely get people to stop smoking? Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11 Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)	2011
Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation. PloS one, 2011, Volume: 6, Issue:11 Topics: Alternative Splicing; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression; Genetic Variation; Humans; Male; Mice; Mice, SCID; Molecular Sequence Data; Neoplasm Transplantation; Nitrosamines; Polymorphism, Genetic; Protein Isoforms; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Sequence Deletion; Sequence Homology, Amino Acid; Transplantation, Heterologous; Tumor Burden	2011
Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation. Molecular cancer, 2012, Jan-12, Volume: 11 Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Haemophilus Infections; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Lung Neoplasms; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Nitrosamines; Pulmonary Disease, Chronic Obstructive; Receptors, G-Protein-Coupled	2012
Higher susceptibility of spontaneous and NNK-induced lung neoplasms in connexin 43 deficient CD1 × AJ F1 mice: paradoxical expression of connexin 43 during lung carcinogenesis. Molecular carcinogenesis, 2013, Volume: 52, Issue:7 Topics: Animals; beta Catenin; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Connexin 43; Disease Susceptibility; Female; Immunoenzyme Techniques; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrosamines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2013
Reciprocal effects of NNK and SLURP-1 on oncogene expression in target epithelial cells. Life sciences, 2012, Nov-27, Volume: 91, Issue:21-22 Topics: Antigens, Ly; Bronchi; Carcinogens; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mouth; Mouth Neoplasms; Nitrosamines; Urokinase-Type Plasminogen Activator	2012
Pioglitazone prevents smoking carcinogen-induced lung tumor development in mice. Current cancer drug targets, 2012, Volume: 12, Issue:6 Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Hydroxyeicosatetraenoic Acids; Hyperplasia; Ligands; Linoleic Acids; Lung Neoplasms; Mice; Nitrosamines; Pioglitazone; PPAR gamma; Pulmonary Alveoli; Smoking; Thiazolidinediones; Time Factors; Transcription, Genetic	2012
A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis. International journal of oncology, 2012, Volume: 41, Issue:4 Topics: Aged; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Nitrosamines; Prognosis; Retinoblastoma Protein; Signal Transduction; Smoking; Tumor Suppressor Protein p53	2012
Dipyridamole intervention of breast cell carcinogenesis. Molecular carcinogenesis, 2014, Volume: 53, Issue:3 Topics: Apoptosis; Benzo(a)pyrene; Blotting, Western; Breast; Breast Neoplasms; Carcinogens; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Dipyridamole; DNA Damage; Female; Humans; Imidazoles; MAP Kinase Signaling System; Nitrosamines; Reactive Oxygen Species; Vasodilator Agents	2014
Chemoprevention by N-acetylcysteine of low-dose CT-induced murine lung tumorigenesis. Carcinogenesis, 2013, Volume: 34, Issue:2 Topics: Acetylcysteine; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Free Radical Scavengers; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neoplasms, Radiation-Induced; Nitrosamines; Tomography, X-Ray Computed	2013
Chronic exposure of lung alveolar epithelial type II cells to tobacco-specific carcinogen NNK results in malignant transformation: a new in vitro lung carcinogenesis model. Molecular carcinogenesis, 2014, Volume: 53, Issue:5 Topics: Animals; Blotting, Western; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Epithelial-Mesenchymal Transition; Female; Fluorescent Antibody Technique, Indirect; Immunoenzyme Techniques; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Nicotiana; Nitrosamines; Pulmonary Alveoli; Wound Healing	2014
Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse. Molecular cancer, 2012, Dec-12, Volume: 11 Topics: Adenoma; Animals; Biomarkers, Tumor; Carcinoma; CCAAT-Enhancer-Binding Proteins; Cell Transformation, Neoplastic; In Situ Nick-End Labeling; Incidence; Ki-67 Antigen; Lung Neoplasms; Male; Mice; Mice, Transgenic; Nitrosamines; Pulmonary Alveoli	2012
Chemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice. Carcinogenesis, 2013, Volume: 34, Issue:4 Topics: Administration, Intranasal; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Humans; Indoles; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Phosphatidylinositol 3-Kinase; Random Allocation	2013
Achaete-scute complex homolog-1 promotes DNA repair in the lung carcinogenesis through matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase. PloS one, 2012, Volume: 7, Issue:12 Topics: Adenoma; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Transformation, Neoplastic; Cisplatin; DNA Damage; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Enzyme Induction; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Lung Neoplasms; Matrix Metalloproteinase 7; Mice; Mice, Transgenic; Nitrosamines; Promoter Regions, Genetic; Protein Binding; RNA, Small Interfering; Small Cell Lung Carcinoma; Tumor Suppressor Proteins; Up-Regulation	2012
Mesenchymal and stem-like cell properties targeted in suppression of chronically-induced breast cell carcinogenesis. Cancer letters, 2013, Jun-01, Volume: 333, Issue:1 Topics: Benzo(a)pyrene; Breast Neoplasms; Catechin; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Female; Grape Seed Extract; Humans; Nitrosamines; Proanthocyanidins; Stem Cells; Tea	2013
[Alterations of p16 gene in transformed BEP2D cells induced by NNK]. Wei sheng yan jiu = Journal of hygiene research, 1999, May-30, Volume: 28, Issue:3 Topics: Animals; Bronchi; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Gene Deletion; Genes, p16; Humans; Mice; Mice, Nude; Mutation; Nitrosamines	1999
Transformation of non-cancerous human breast epithelial cell line MCF10A by the tobacco-specific carcinogen NNK. Breast cancer research and treatment, 2003, Volume: 79, Issue:1 Topics: Animals; Breast; Carcinogenicity Tests; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Epithelial Cells; Estradiol; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Nitrosamines; Toxicity Tests, Chronic	2003
Malignant transformation of human bronchial epithelial cells with the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. International journal of cancer, 2003, Oct-10, Volume: 106, Issue:6 Topics: Animals; beta Catenin; Biomarkers, Tumor; Bronchi; Carcinogens; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Cytoskeletal Proteins; Epithelial Cells; Fluorescent Antibody Technique, Indirect; Humans; Male; Mice; Mice, Nude; Microscopy, Confocal; Nicotiana; Nitrosamines; Papillomaviridae; Proliferating Cell Nuclear Antigen; Trans-Activators; Tumor Virus Infections	2003
Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo. Chest, 2004, Volume: 125, Issue:5 Suppl Topics: Animals; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Activation; ErbB Receptors; Humans; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt	2004
Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke. The Journal of biological chemistry, 2004, Jul-09, Volume: 279, Issue:28 Topics: Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Susceptibility; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Fas Ligand Protein; Humans; Lung; Lung Neoplasms; MAP Kinase Signaling System; Membrane Glycoproteins; Mice; Mice, Knockout; Nitrosamines; Smoking; Tobacco Smoke Pollution; Uteroglobin	2004
Inhibitory effects of 7-hydroxy-3-methoxy-cadalene on 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice. Cancer letters, 2004, Sep-30, Volume: 213, Issue:2 Topics: Administration, Oral; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Polycyclic Sesquiterpenes; Sesquiterpenes; Ulmaceae	2004
Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens. Journal of the National Cancer Institute, 2005, Nov-16, Volume: 97, Issue:22 Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Smoking; Tobacco Smoke Pollution	2005
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. Journal of the National Cancer Institute, 2005, Nov-16, Volume: 97, Issue:22 Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Bronchial Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Smoking; Tobacco Smoke Pollution	2005
9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2. Cancer letters, 2006, Nov-28, Volume: 244, Issue:1 Topics: Alitretinoin; Animals; Antineoplastic Agents; Carcinogens; Celecoxib; Cell Transformation, Neoplastic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dietary Supplements; Disease Models, Animal; Lung; Lung Neoplasms; Male; Membrane Proteins; Mice; Mice, Inbred A; Nitrosamines; Pyrazoles; Receptors, Retinoic Acid; Sulfonamides; Tretinoin	2006
The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung. Chemico-biological interactions, 2006, Jun-10, Volume: 161, Issue:2 Topics: Animal Feed; Animals; Antioxidants; Ascorbic Acid; Cell Transformation, Neoplastic; Cysteine; Disulfides; Female; Glutathione; Lung Neoplasms; Mice; Molecular Structure; Nitrosamines; Organoselenium Compounds; Selenium; Sulfhydryl Compounds; Time Factors; Yeasts	2006
Ethanol and the tobacco-specific carcinogen, NNK, contribute to signaling in immortalized human pancreatic duct epithelial cells. Pancreas, 2006, Volume: 33, Issue:1 Topics: Carcinogens; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cocarcinogenesis; CREB-Binding Protein; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Epithelial Cells; Ethanol; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitrosamines; Pancreatic Ducts; Phosphorylation; Signal Transduction	2006
High-density oligonucleotide microarrays and functional network analysis reveal extended lung carcinogenesis pathway maps and multiple interacting genes in NNK [4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone] induced CD1 mouse lung tumor. Journal of cancer research and clinical oncology, 2007, Volume: 133, Issue:2 Topics: Animals; Carcinogens; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Gene Expression Profiling; Gene Regulatory Networks; Lung Neoplasms; Mice; Mice, Inbred Strains; Models, Animal; Models, Biological; Nitrosamines; Oligonucleotide Array Sequence Analysis; Signal Transduction	2007
Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity. International journal of cancer, 2007, Apr-01, Volume: 120, Issue:7 Topics: Adenoma; Alitretinoin; Animals; Antineoplastic Agents; Calcitriol; Carcinogens; Cell Transformation, Neoplastic; Dietary Supplements; Disease Models, Animal; Drug Therapy, Combination; Lung Neoplasms; Male; Mice; Mice, Inbred A; Nitrosamines; Retinoid X Receptors; Steroid Hydroxylases; Tretinoin; Vitamin D3 24-Hydroxylase; Vitamins	2007
Alterations of cellular redox state during NNK-induced malignant transformation and resistance to radiation. Antioxidants & redox signaling, 2008, Volume: 10, Issue:5 Topics: Antioxidants; Bronchi; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Epithelial Cells; Glutathione; Humans; Nitrosamines; Oxidation-Reduction; Radiation Tolerance; Radiation, Ionizing; Reactive Oxygen Species; RNA, Small Interfering; Superoxide Dismutase; Thioredoxins	2008
Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues. Cancer research, 1983, Volume: 43, Issue:3 Topics: Animals; Autoradiography; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Lung; Male; Mice; Nitrosamines	1983
Lipid peroxidation and ethanol-related tumor promotion in Fischer-344 rats treated with tobacco-specific nitrosamines. Alcohol and alcoholism (Oxford, Oxfordshire), 1994, Volume: 29, Issue:5 Topics: Alcoholism; Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Esophagus; Glutathione; Lipid Metabolism; Lipid Peroxidation; Liver; Lung; Male; Malondialdehyde; Neoplasms, Experimental; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Vitamin E	1994
Transformation of hamster pancreatic duct cells by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in vitro. Carcinogenesis, 1994, Volume: 15, Issue:11 Topics: Animals; Base Sequence; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Genes, ras; Mesocricetus; Mice; Molecular Sequence Data; Mutation; Nitrosamines; Pancreatic Ducts; Pancreatic Neoplasms	1994
N-nitrosodiethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced morphological transformation of C3H/10T1/2CL8 cells expressing human cytochrome P450 2A6. Mutation research, 1994, Volume: 324, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens, Environmental; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Fibroblasts; Mice; Mice, Inbred C3H; Mixed Function Oxygenases; Nitrosamines; Transfection	1994
Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Carcinogenesis, 1993, Volume: 14, Issue:7 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blotting, Southern; Blotting, Western; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cloning, Molecular; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Genetic Vectors; Humans; Mice; Mice, Inbred C3H; Mixed Function Oxygenases; Nitrosamines; Retroviridae	1993
HPV-16, tobacco-specific N-nitrosamine, and N-methyl-N'-nitro-N-nitrosoguanidine in oral carcinogenesis. Cancer research, 1993, Oct-15, Volume: 53, Issue:20 Topics: Base Sequence; Carcinogens; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; DNA Primers; ErbB Receptors; Exons; Genes, myc; Genes, p53; Genes, ras; Humans; Keratinocytes; Male; Methylnitronitrosoguanidine; Molecular Sequence Data; Mouth Neoplasms; Mutagenesis; Nicotiana; Nitrosamines; Oligonucleotides, Antisense; Papillomaviridae; Plants, Toxic; Polymerase Chain Reaction; Transforming Growth Factor alpha	1993
Morphologic and growth effects of tobacco-associated chemical carcinogens and smokeless tobacco extracts on human oral epithelial cells in culture. Oral surgery, oral medicine, and oral pathology, 1993, Volume: 75, Issue:3 Topics: Analysis of Variance; Carcinogens; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Humans; Immunophenotyping; Mouth Mucosa; Nitrosamines; Plants, Toxic; Tobacco, Smokeless	1993
Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proceedings of the National Academy of Sciences of the United States of America, 1996, Apr-30, Volume: 93, Issue:9 Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Modification Methylases; DNA-Cytosine Methylases; Gene Expression; Hyperplasia; Lung; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Mice, Inbred C3H; Nitrosamines; Species Specificity	1996
Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation. Oncogene, 1996, Nov-07, Volume: 13, Issue:9 Topics: Adenoviridae; Animals; Bronchi; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cyclins; Down-Regulation; Drug Evaluation; Enzyme Activation; Epithelial Cells; Humans; Mice; Models, Biological; Nitrosamines; Protein Serine-Threonine Kinases; Rabbits; Simian virus 40; Smoke; Transfection; Tretinoin	1996
Evidence for the epidermal growth factor receptor as a target for lung cancer prevention. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:1 Topics: Antineoplastic Agents; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Cyclin D1; DNA Primers; ErbB Receptors; Gene Expression Regulation; Humans; Lung Neoplasms; Mitosis; Nitrosamines; Phosphotyrosine; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tretinoin	2002
A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells. Proceedings of the National Academy of Sciences of the United States of America, 1992, Aug-01, Volume: 89, Issue:15 Topics: Animals; Biomarkers, Tumor; Bronchi; Carcinogens; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Chemotaxis; Epithelium; ErbB Receptors; Gelatinases; Humans; Isoenzymes; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Invasiveness; Nitrosamines; Pepsin A; Rats; Smoke; Smoking; Tetradecanoylphorbol Acetate; Trachea; Transforming Growth Factor alpha; Transplantation, Heterologous	1992
The effect of sodium selenite on cell proliferation and transformation of primary rat tracheal epithelial cells. Carcinogenesis, 1992, Volume: 13, Issue:10 Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Epithelium; Nitrosamines; Rats; Selenium; Sodium Selenite; Trachea	1992
Cytotoxicity, genotoxicity and transforming activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rat tracheal epithelial cells. Mutation research, 1991, Volume: 261, Issue:4 Topics: Animals; Biotransformation; Carcinogenicity Tests; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Colony-Forming Units Assay; Epithelium; Liver; Micronucleus Tests; Mutagenicity Tests; Mutagens; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Salmonella typhimurium; Smoke; Trachea	1991
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens. Toxicologic pathology, 1991, Volume: 19, Issue:2 Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylhydrazines; Lung Neoplasms; Methylcholanthrene; Methylnitrosourea; Mice; Mice, Inbred A; Microscopy, Electron; Nitrosamines	1991
Synergism of herpes simplex virus and tobacco-specific N'-nitrosamines in cell transformation. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1991, Volume: 49, Issue:3 Topics: Animals; Carcinogens; Cell Count; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cocarcinogenesis; Nicotiana; Nitrosamines; Plants, Toxic; Simplexvirus; Ultraviolet Rays; Vero Cells	1991
[In vitro transformation induced by carcinogens in rat tracheal epithelial cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1990, Volume: 12, Issue:5 Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Epithelial Cells; Methylnitronitrosoguanidine; Nitrosamines; Rats; Trachea	1990