4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with Carcinogenesis in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 30 (88.24) | 24.3611 |
| 2020's | 4 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, KH; Im, JS; Jeong, HG; Jin, SW; Kacew, S; Kim, HG; Kim, HS; Kim, KB; Kim, SJ; Kwack, SJ; Lee, BM; Lee, GH; Park, JH | 1 |
| Qu, Z; Song, A; Yang, J; Yu, J; Zhang, L; Zhang, W; Zhuang, C | 1 |
| Bai, R; Bode, AM; Chang, X; Dong, Z; Li, X; Liu, K; Ma, W; Ryu, J; Song, Y; Wang, K; Wang, Q; Wang, T; Xia, Q; Zhang, T | 1 |
| Charoensinphon, N; Han, Y; Qiu, P; Song, M; Sun, Y; Wu, X; Xiao, H; Zheng, J | 1 |
| Chang, HJ; Chang, JY; Chou, ST; Hsiao, JR; Hsu, YM; Kuo, CC; Peng, HY; Shiah, SG; Wu, GH | 1 |
| Lipowicz, PJ; Seeman, JI | 1 |
| Chikara, S; Chittem, K; Christofidou-Solomidou, M; Dyer, N; Mamidi, S; Moorthy, G; Pietrofesa, R; Reindl, KM; Sreedasyam, A; Zuppa, A | 1 |
| Carlson, ES; Hecht, SS; Ma, B; Stepanov, I; Upadhyaya, P; Villalta, PW; Zarth, AT | 1 |
| Chen, LC; Huang, WC; Lee, HW; Lepor, H; Park, SH; Tang, MS; Wang, HT; Weng, MW; Wu, XR | 1 |
| Ahmed, H; Al-Bayedh, SA; Qudsi, M; Rahim, MM; Roos, JF; Samara, A | 1 |
| Ray, DW; Singh, N; Sommer, P; Taylor, KM; Vosloo, D; Wheeler, R | 1 |
| Ashmore, JH; Lazarus, P; Luo, S; Watson, CJW | 1 |
| Hudlikar, RR; Ingle, AD; Kannan, S; Kumar, R; Mahimkar, MB; Maru, GB; Pai, V; Thorat, RA | 1 |
| Ebi, H; Jenkins, BJ; McLeod, L; Rose-John, S; Ruwanpura, S; Saad, MI; Sagi, I; Yu, L | 1 |
| Bhardwaj, U; Dhasmana, A; Gupta, M; Haque, S; Kesari, KK; Kumar, D; Lohani, M; Ruokolainen, J; Somvanshi, P; Uniyal, S | 1 |
| Amin, S; Biddick, L; Desai, D; Lightfoot, S; Patlolla, JM; Qian, L; Rao, CV; Zhang, Y | 1 |
| Imaida, K; Inoue, T; Kishi, S; Kuno, T; Nakano, Y; Ninomiya, F; Yamakawa, K; Yokohira, M | 1 |
| Balbo, S; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B | 1 |
| Jiang, YG; Li, X; Wu, JJ; Xia, Y; Yang, T; Zhao, Y; Zou, F | 1 |
| Hayashi, N; Hiratsuka, A; Ishihara, Y; Kakurai, N; Kuriyama, A; Miyamoto, C; Nishiyama, T; Ogura, K; Ohnuma, T; Yanagita, H | 1 |
| Ding, X; Li, L; Megaraj, V; Wei, Y | 1 |
| Pluchino, LA; Wang, HC | 1 |
| Chen, JX; Jin, H; Li, G; Lin, Y; Liu, A; Lu, G; Tu, S; Wang, H; Yang, CS | 1 |
| Ding, X; Hu, J; Li, L; Liu, Z; Megaraj, V; Sell, S | 1 |
| Chen, C; Ge, GZ; Xu, TR | 1 |
| Cao, B; Feng, M; Liu, S; Mao, J; Zhang, H; Zhang, Q | 1 |
| Carmella, SG; Hecht, SS; Leitzman, P; Murphy, SE; Narayanapillai, SC; Paladino, J; Upadhyaya, P; von Weymarn, LB; Xing, C | 1 |
| Jiang, Y; Li, X; Wu, J; Xu, Y; Yang, C; Yang, Q; Yang, T | 1 |
| Desai, S; Hudlikar, RR; Ingle, AD; Kannan, S; Kumar, R; Mahimkar, MB; Maru, GB; Thorat, RA; Venkadakrishnan, VB | 1 |
| Anandharaj, A; Hong, KH; Kassie, F; Kim, JH; Kirtane, AR; Panyam, J; Song, JM; Upadhyaya, P | 1 |
| Boo, HJ; Hwang, SJ; Jang, HJ; Lee, HJ; Lee, HY; Min, HY; Smith, JK; Yun, HJ | 1 |
| Chae, CH; Cho, CS; Cho, MH; Cho, WY; Davaadamdin, O; Gankhuyag, N; Jiang, HL; Lee, S; Park, C; Singh, B; Yu, KN | 1 |
| Charoensinphon, N; Gao, Z; Li, F; Li, Z; Song, M; Wang, M; Wu, X; Xiao, H; Xu, F; Zheng, J; Zhou, J | 1 |
| Kassie, F; Melkamu, T; O'Sullivan, MG; Qian, X; Upadhyaya, P | 1 |
2 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Carcinogenesis
| Article | Year |
|---|---|
Metformin for lung cancer prevention and improved survival: a novel approach.
Topics: Carcinogenesis; Carcinogens; Diabetes Mellitus, Type 2; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Incidence; Lung; Lung Neoplasms; Metformin; Nicotiana; Nitrosamines; Signal Transduction; Smoke; Survival Analysis; Tobacco Smoking; TOR Serine-Threonine Kinases | 2019 |
Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms.
Topics: Animals; Carcinogenesis; Carcinogens; Lung Neoplasms; Models, Animal; Nitrosamines | 2015 |
32 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Carcinogenesis
| Article | Year |
|---|---|
Effects of tobacco compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the expression of epigenetically regulated genes in lung carcinogenesis.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; DNA Methylation; Epigenesis, Genetic; Epigenome; Gene Expression; Lung; Lung Neoplasms; Mice; Nitrosamines; Tobacco Smoking | 2021 |
Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.
Topics: Allyl Compounds; Animals; Benzothiazoles; Blotting, Western; Carcinogenesis; Comet Assay; Female; Flow Cytometry; Lung Neoplasms; Male; Membrane Potential, Mitochondrial; Mice; Nitrosamines; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Sulfides | 2021 |
Fluvastatin Inhibits HMG-CoA Reductase and Prevents Non-Small Cell Lung Carcinogenesis.
Topics: Acyl Coenzyme A; Adult; Aged; Animals; Apoptosis; Carcinogenesis; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Fluvastatin; Gene Knockdown Techniques; HEK293 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Lung Neoplasms; Male; Mevalonic Acid; Mice; Middle Aged; Neoplasms, Experimental; Nitrosamines; RNA, Small Interfering; Xenograft Model Antitumor Assays | 2019 |
Inhibitory effects of nobiletin and its major metabolites on lung tumorigenesis.
Topics: Animals; Antioxidants; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Female; Flavones; Humans; Mice; Neoplasms, Experimental; Nitrosamines | 2019 |
MiR-30a and miR-379 modulate retinoic acid pathway by targeting DNA methyltransferase 3B in oral cancer.
Topics: Alcohol Oxidoreductases; Aldehyde Dehydrogenase 1 Family; Arecoline; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Metabolic Networks and Pathways; MicroRNAs; Mitochondrial Proteins; Mouth Neoplasms; Nitrosamines; Retinal Dehydrogenase; Tretinoin | 2020 |
A Model To Estimate the Sources of Tobacco-Specific Nitrosamines in Cigarette Smoke.
Topics: Carcinogenesis; Gases; Humans; Models, Chemical; Nicotiana; Nicotine; Nitrosamines; Smoking; Temperature | 2017 |
Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cytochrome P-450 CYP1A1; Cytokines; Flax; Glucuronosyltransferase; Glutathione Transferase; High-Throughput Nucleotide Sequencing; Inflammation Mediators; Lung; Lung Neoplasms; Male; Metabolic Detoxication, Phase II; Mice; Mice, Inbred A; Nitrosamines; Plant Extracts; Seeds | 2018 |
Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Carcinogenesis; Carcinogens; DNA Adducts; Liver; Lung; Nicotiana; Nitrosamines; Rats | 2018 |
E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells.
Topics: Animals; Carcinogenesis; Cell Line; DNA Damage; DNA Repair; Electronic Nicotine Delivery Systems; Heart; Humans; Lung; Male; Mice; Mutation; Nicotine; Nitrosamines; Smoke; Urinary Bladder | 2018 |
The tobacco carcinogen NNK drives accumulation of DNMT1 at the GR promoter thereby reducing GR expression in untransformed lung fibroblasts.
Topics: Carcinogenesis; Carcinogens; Cell Line; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Mifepristone; Nitrosamines; Promoter Regions, Genetic; Protein Binding; Receptors, Glucocorticoid; Small Cell Lung Carcinoma; Tobacco Smoking | 2018 |
Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung.
Topics: 17-Hydroxysteroid Dehydrogenases; Carcinogenesis; Carcinogens; Cytosol; Enzyme Assays; Gene Knockdown Techniques; HEK293 Cells; Humans; Lung; Lung Neoplasms; Microsomes; Nicotiana; Nitrosamines; Oxidation-Reduction; Recombinant Proteins; RNA, Small Interfering; Smoking; Stereoisomerism | 2018 |
Dose-Related Modulatory Effects of Polymeric Black Tea Polyphenols (PBPs) on Initiation and Promotion Events in B(a)P and NNK-Induced Lung Carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Camellia sinensis; Carcinogenesis; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2 Inhibitors; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Plant Extracts; Polyphenols; Tea | 2019 |
The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis.
Topics: ADAM17 Protein; Adenocarcinoma of Lung; Animals; Carcinogenesis; Carcinogens; Humans; Lung Neoplasms; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Nitrosamines; Phosphorylation; Signal Transduction; Tobacco Smoke Pollution | 2020 |
Investigation of Precise Molecular Mechanistic Action of Tobacco-Associated Carcinogen `NNK´ Induced Carcinogenesis: A System Biology Approach.
Topics: Carcinogenesis; Carcinogens; Gene Ontology; Humans; Molecular Docking Simulation; Nitrosamines; Protein Binding; Protein Interaction Maps; Proteome; Systems Biology | 2019 |
β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells.
Topics: Adenocarcinoma; Adenoma; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Carcinogenesis; Cell Line, Tumor; Disease Progression; Escin; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Neoplasm Transplantation; Nicotiana; Nitrosamines; Plant Extracts; Real-Time Polymerase Chain Reaction; Retinal Dehydrogenase; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein | 2013 |
Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenesis; Estradiol; Female; Humans; Hyperplasia; Lung; Lung Neoplasms; Male; Mice; Neoplasms, Hormone-Dependent; Nitrosamines; Orchiectomy; Ovariectomy; Sex Characteristics; Testosterone | 2013 |
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice.
Topics: Adenoma; Animal Feed; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; DNA Adducts; DNA Damage; Female; Guanine; Kava; Lung; Lung Neoplasms; Mice; Nitrosamines | 2014 |
4-(Methylnitrosamino)-1-(3-pyridyl) -1-butanone induces circulating microRNA deregulation in early lung carcinogenesis.
Topics: Adenocarcinoma; Animals; Carcinogenesis; Cell Line, Tumor; Gene Expression Regulation; Humans; Lung; Lung Neoplasms; Male; MicroRNAs; Nitrosamines; Rats; Rats, Inbred F344 | 2014 |
Formation and stability of 4-(hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide, a stable form of reactive intermediate produced from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in mice.
Topics: Animals; Carcinogenesis; Disease Susceptibility; Hydrogen-Ion Concentration; Liver; Male; Mice, Inbred C57BL; Mice, Inbred Strains; Nitrosamines; Tissue Distribution | 2014 |
Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse.
Topics: Animals; Carcinogenesis; Carcinogens; Cytochrome P-450 Enzyme System; DNA Adducts; Lung Neoplasms; Mice; Microsomes, Liver; Multigene Family; Nicotiana; Nitrosamines | 2014 |
Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties.
Topics: Benzo(a)pyrene; Breast Neoplasms; Carcinogenesis; Carcinogens; DNA Damage; Drug Synergism; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; MCF-7 Cells; NADPH Oxidases; Nitrosamines; ras Proteins; Reactive Oxygen Species; Signal Transduction | 2014 |
NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Bronchi; Carcinogenesis; Carcinogens; Catechin; Dietary Supplements; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Lung; Lung Neoplasms; Mice, Inbred A; Neoplasm Proteins; Nitrosamines; Promoter Regions, Genetic; Respiratory Mucosa | 2015 |
Suppression of pulmonary CYP2A13 expression by carcinogen-induced lung tumorigenesis in a CYP2A13-humanized mouse model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogenesis; Carcinogens; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Female; Inflammation; Interferon-gamma; Interleukin-6; Lung; Lung Neoplasms; Mice; Nitrosamines; RNA, Messenger; Steroid Hydroxylases; Tumor Necrosis Factor-alpha | 2015 |
Effects of 8-methoxypsoralen on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogenesis; Carcinogens; Catalysis; Coumarins; Cytochrome P450 Family 2; Female; Hydroxylation; Imidazoles; Methoxsalen; Mice; Mice, Inbred C57BL; Nitrosamines | 2015 |
Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.
Topics: Animals; Carcinogenesis; Chemoprevention; Diet; DNA Adducts; DNA Damage; Female; Inactivation, Metabolic; Lung; Lung Neoplasms; Mice; Microsomes, Liver; Nitrosamines; Pyrones | 2016 |
Identification of a long non-coding RNA NR_026689 associated with lung carcinogenesis induced by NNK.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Nitrosamines; Rats; RNA, Long Noncoding; Tumor Cells, Cultured | 2016 |
Polymeric black tea polyphenols (PBPs) inhibit benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung carcinogenesis potentially through down-regulation of p38 and Akt phosphorylation in A/J mice.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Proliferation; Humans; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polyphenols; Proto-Oncogene Proteins c-akt; Tea | 2017 |
Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Assay; Biphenyl Compounds; Bronchi; Carcinogenesis; Cell Cycle; Cell Proliferation; Cell Survival; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Female; Lignans; Lung Neoplasms; Magnolia; Mice; Molecular Docking Simulation; Nitrosamines; Plant Extracts; RNA, Small Interfering | 2016 |
Smoking-associated lung cancer prevention by blockade of the beta-adrenergic receptor-mediated insulin-like growth factor receptor activation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Insulin-Like Growth Factor II; Lung Neoplasms; Mice; Neoplasms, Experimental; NF-kappa B; Nitrosamines; Phosphorylation; Receptor, IGF Type 1; Receptors, Adrenergic, beta; Receptors, Somatomedin; Signal Transduction; Smoking; STAT3 Transcription Factor; Tumor Burden | 2016 |
Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice.
Topics: Administration, Inhalation; Aerosols; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogenesis; Carcinogens; Female; Glycerol; In Situ Nick-End Labeling; Lung Neoplasms; Mice; Nicotiana; Nitrosamines; Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Spermine | 2017 |
Dietary 5-demethylnobiletin inhibits cigarette carcinogen NNK-induced lung tumorigenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinogenesis; Carcinogens; Citrus; Female; Flavones; Humans; Lung; Lung Neoplasms; Mice; Nitrosamines; Tobacco Products | 2017 |
Lipopolysaccharide enhances mouse lung tumorigenesis: a model for inflammation-driven lung cancer.
Topics: Administration, Intranasal; Animals; Blotting, Western; Carcinogenesis; Disease Models, Animal; Immunohistochemistry; Linear Models; Lipopolysaccharides; Lung Neoplasms; Mice; Nitrosamines | 2013 |