4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with Cancer of Pancreas in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balbo, S; Hecht, SS; Johnson, CS; Kovi, RC; O'Sullivan, MG | 1 |
| Balbo, S; Hecht, SS; James-Yi, SA; Johnson, CS; Khariwala, SS; Kovi, RC; Le, CT; O'Sullivan, MG; Upadhyaya, P; Wang, M | 1 |
| Chen, X; Duan, W; Huo, X; Jiang, Z; Lei, J; Li, X; Ma, J; Ma, Q; Nan, L; Sheng, L; Wang, Z; Wu, E; Wu, Z; Xu, Q; Zhang, D | 1 |
| Al-Wadei, HA; Schuller, HM | 1 |
| Al-Wadei, HA; Al-Wadei, MH; Schuller, HM | 1 |
| Kathman, S; Naufal, Z; Wilson, C | 1 |
| Batra, SK; Kaur, S; Kumar, S; Momi, N; Ponnusamy, MP; Wittel, UA | 1 |
| Chen, M; Eibl, G; Hines, OJ; King, J; Pandol, S; Pham, H; Reber, HA; Takahashi, H | 1 |
| Edderkaoui, M; Grippo, P; Gukovskaya, AS; Lee, IS; Pandol, SJ; Park, CH | 1 |
| Castonguay, A; Miller, MS; Schuller, HM; Walker, K; Weddle, DL; Zhang, L | 1 |
| Akerkar, S; Beger, HG; Cunningham, AJ; El-Bayoumy, K; Henne-Bruns, D; Leder, G; Pittman, B; Prokopczyk, B; Ramadani, M; Straeter, J; Trushin, N | 1 |
| Talamini, G | 1 |
| Askari, MD; Schuller, HM; Tsao, MS | 1 |
| Eguchi, H; Nakachi, K | 1 |
| Beger, HG; El-Bayoumy, K; Henne-Bruns, D; Hoffmann, D; Leder, G; Prokopczyk, B; Ramadani, M; Trushin, N | 1 |
| Baskaran, K; Laconi, S; Reddy, MK | 1 |
| Abbi, R; Hoffmann, D; Rivenson, A; Wynder, EL | 1 |
| Castonguay, A; Jorquera, R; Reichert, A; Schüller, HM | 1 |
| Choi, CI; Chung, FL; Jiao, D; Kelloff, G; Pittman, B; Rigotty, J; Rivenson, A; Steele, V; Zang, E | 1 |
| Akerkar, S; Amin, S; Borukhova, A; Carmella, SG; Desai, D; Hecht, SS; Rigotty, J; Rivenson, A; Trushin, N | 1 |
| Castonguay, A; Miller, MS; Schuller, HM; Thomas, PE; Weddle, DL; Zhang, L; Zheng, B | 1 |
| Hecht, SS; Hoffmann, D | 1 |
| Amin, SG; Chung, FL; Hecht, SS; Morse, MA; Wang, CX | 1 |
| Amin, S; Hecht, SS; Hoffmann, D; Prokopczyk, B; Rivenson, A | 1 |
2 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Cancer of Pancreas
| Article | Year |
|---|---|
Interplay between smoking-induced genotoxicity and altered signaling in pancreatic carcinogenesis.
Topics: Humans; Inflammation; Mutation; Nitrosamines; Pancreatic Neoplasms; Polymorphism, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyridines; ras Proteins; Receptors, Nicotinic; Signal Transduction; Smoking | 2012 |
[Smoking as a risk factor for pancreatic cancer].
Topics: Benzo(a)pyrene; Carcinogens; Cohort Studies; Cytochrome P-450 CYP1A1; Glutathione Transferase; Humans; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Polymorphism, Genetic; Risk Factors; Smoking; Tobacco Smoke Pollution | 2006 |
22 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Cancer of Pancreas
| Article | Year |
|---|---|
Metastasis to the F344 Rat Pancreas from Lung Cancer Induced by 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)- 1-butanol, Constituents of Tobacco Products.
Topics: Animals; Carcinogens; Carcinoma; Lung Neoplasms; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Rats; Rats, Inbred F344; Stereoisomerism | 2018 |
Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.
Topics: Adenocarcinoma; Adenoma; Animals; Apoptosis; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; Humans; Lung Neoplasms; Male; Nitrosamines; Pancreatic Neoplasms; Prohibitins; Pyridines; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2014 |
β2-adrenogenic signaling regulates NNK-induced pancreatic cancer progression via upregulation of HIF-1α.
Topics: Aged; Animals; Carcinogens; Cell Line, Tumor; Cell Proliferation; Disease Progression; Female; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Middle Aged; Nitrosamines; Pancreatic Neoplasms; Receptors, Adrenergic, beta-2; Signal Transduction; Smoking; Transcriptional Activation; Up-Regulation | 2016 |
Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas.
Topics: Adenocarcinoma; Animals; Blotting, Western; Carcinoma, Pancreatic Ductal; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Epinephrine; Female; gamma-Aminobutyric Acid; Lung Neoplasms; Male; Mesocricetus; Models, Animal; Neurotransmitter Agents; Nitrosamines; Norepinephrine; Pancreatic Neoplasms; Pregnancy; Receptors, Nicotinic; Signal Transduction; Smoking | 2009 |
Prevention of pancreatic cancer by the beta-blocker propranolol.
Topics: Adrenergic beta-Antagonists; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticarcinogenic Agents; Carcinoma, Pancreatic Ductal; Cricetinae; Cyclic AMP; Ethanol; Female; Male; Mesocricetus; Nitrosamines; Pancreatic Neoplasms; Pancreatitis; Pregnancy; Prenatal Exposure Delayed Effects; Propranolol; Receptors, Adrenergic, beta; Receptors, Nicotinic | 2009 |
Bayesian derivation of an oral cancer slope factor distribution for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Topics: Animals; Bayes Theorem; Carcinogenicity Tests; Carcinogens; Decision Support Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Environmental Exposure; Female; Humans; Lung Neoplasms; Male; Mice; Models, Biological; Monte Carlo Method; Mouth Neoplasms; Neoplasms, Experimental; Nitrosamines; Pancreatic Neoplasms; Rats; Risk Assessment; United States; United States Environmental Protection Agency | 2009 |
Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells.
Topics: Antineoplastic Agents; Apigenin; Carcinogens; Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Nitrosamines; Pancreatic Neoplasms; Propranolol; Receptors, Adrenergic, beta; Signal Transduction | 2012 |
Akt kinase mediates the prosurvival effect of smoking compounds in pancreatic ductal cells.
Topics: Adenylate Kinase; Animals; Apoptosis; Autophagy; bcl-X Protein; Carcinogens; Cell Line; Cell Survival; Cells, Cultured; DNA Fragmentation; Humans; Mice; Nicotiana; Nitrosamines; Pancreatic Ducts; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Risk Factors; Smoke; Smoking | 2013 |
The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK.
Topics: Adenocarcinoma; Animals; Arachidonic Acid; Cricetinae; Cyclooxygenase Inhibitors; DNA Primers; Ethanol; Female; Genes, p53; Genes, ras; Ibuprofen; Indoles; Lipoxygenase Inhibitors; Male; Maternal-Fetal Exchange; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Pregnancy | 2002 |
4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue.
Topics: Butanones; DNA Adducts; DNA Damage; Humans; Nitrosamines; Pancreas; Pancreatic Neoplasms; Pyridines; Smoking | 2005 |
Duodenal acidity may increase the risk of pancreatic cancer in the course of chronic pancreatitis: an etiopathogenetic hypothesis.
Topics: Alcohol Drinking; Bicarbonates; Duodenum; Exocrine Pancreatic Insufficiency; Gastric Acid; Humans; Hydrogen-Ion Concentration; Inflammation; Nitrosamines; Pancreas; Pancreatic Neoplasms; Pancreatitis, Chronic; Postprandial Period; Proton Pump Inhibitors; Proton Pumps; Risk Factors; Secretin; Smoking; Water | 2005 |
The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors.
Topics: Adrenergic beta-Agonists; Blotting, Western; Carcinogens; Carcinoma, Pancreatic Ductal; Cell Line, Transformed; Cell Proliferation; Cyclic AMP; Epithelium; ErbB Receptors; Humans; Isoproterenol; Mitogen-Activated Protein Kinase Kinases; Nicotiana; Nitrosamines; Pancreatic Ducts; Pancreatic Neoplasms; Phosphorylation; Receptors, Adrenergic, beta-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcriptional Activation | 2005 |
The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols.
Topics: Carcinogens; Chromatography, High Pressure Liquid; Cytosol; Female; Humans; Male; Microsomes; Nitrosamines; Oxidation-Reduction; Pancreas; Pancreatic Neoplasms; Smoking; Stereoisomerism | 2008 |
Transformation of hamster pancreatic duct cells by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in vitro.
Topics: Animals; Base Sequence; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Genes, ras; Mesocricetus; Mice; Molecular Sequence Data; Mutation; Nitrosamines; Pancreatic Ducts; Pancreatic Neoplasms | 1994 |
A study of tobacco carcinogenesis: effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
Topics: Adenoma, Islet Cell; Animals; Body Weight; Carcinogenicity Tests; Corn Oil; Drinking; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; Pancreatic Neoplasms; Rats; Rats, Inbred F344 | 1993 |
Transplacental induction of pancreas tumors in hamsters by ethanol and the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Cricetinae; Drug Synergism; Ethanol; Female; Male; Maternal-Fetal Exchange; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Pregnancy; Sex Factors | 1993 |
Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats.
Topics: Acetylcysteine; Analysis of Variance; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Chi-Square Distribution; Diet; Free Radical Scavengers; Incidence; Isothiocyanates; Leukemia, Experimental; Leydig Cell Tumor; Lung Neoplasms; Lymphoma; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Survival Rate; Testicular Neoplasms | 1996 |
Inhibitory effects of 6-phenylhexyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation and lung tumorigenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Biotransformation; Carcinogens; Drinking Behavior; Feeding Behavior; Glucuronates; Hemoglobins; Isothiocyanates; Lung Neoplasms; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344 | 1996 |
Low levels of expression of cytochromes P-450 in normal and cancerous fetal pancreatic tissues of hamsters treated with NNK and/or ethanol.
Topics: Animals; Blotting, Western; Carcinogens; Cricetinae; Cytochrome P-450 Enzyme System; DNA Adducts; Ethanol; Female; Fetal Diseases; Liver; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Pregnancy | 2000 |
N-nitroso compounds and tobacco-induced cancers in man.
Topics: Carcinogens; Esophageal Neoplasms; Humans; Lung Neoplasms; Mouth Neoplasms; Nitrosamines; Pancreatic Neoplasms; Smoking | 1991 |
Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats.
Topics: Animals; Carcinogens; Diet; DNA; Glucosinolates; Indoles; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Methyltransferases; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Rats; Rats, Inbred F344; Thioglycosides | 1988 |
Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines.
Topics: Animals; Areca; Carcinogens; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Nicotiana; Nitrosamines; Nitroso Compounds; Nose Neoplasms; Pancreatic Neoplasms; Plants, Medicinal; Plants, Toxic; Rats; Rats, Inbred F344 | 1988 |