Compounds > 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone
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4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Adenoma

4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with Adenoma in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19903 (5.66)18.7374
1990's21 (39.62)18.2507
2000's16 (30.19)29.6817
2010's13 (24.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hecht, SS; Leitzman, P; Narayanapillai, SC; O'Sullivan, MG; Puppala, M; Sun, H; Upadhyaya, P; Xing, C1
Amin, S; Biddick, L; Desai, D; Lightfoot, S; Patlolla, JM; Qian, L; Rao, CV; Zhang, Y1
Imaida, K; Inoue, T; Kishi, S; Kuno, T; Nakano, Y; Ninomiya, F; Yamakawa, K; Yokohira, M1
Imaida, K; Kinouch, S; Kishi, S; Nakano, Y; Ninomiya, F; Saoo, K; Tanizawa, J; Yamakawa, K; Yokohira, M1
Balbo, S; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B1
Balbo, S; Hecht, SS; James-Yi, SA; Johnson, CS; Khariwala, SS; Kovi, RC; Le, CT; O'Sullivan, MG; Upadhyaya, P; Wang, M1
Imaida, K; Kanie, S; Kishi, S; Nakano, Y; Yamakawa, K; Yokohira, M1
Hosokawa, K; Imaida, K; Kuno, T; Matsuda, Y; Saoo, K; Takeuchi, H; Yamakawa, K; Yokohira, M1
Hanson, TE; Hecht, SS; Johnson, TE; Kassie, F; Negia, M; O'Sullivan, MG; Ruvolo, PP; Upadhyaya, P; Xing, C1
Abe, M; Endo, Y; Igarashi, M; Miyajima, N; Nakae, D; Sugano, S; Sugaya, K; Watanabe, M; Yoshida, M1
Hashimoto, N; Imaida, K; Kuno, T; Yokohira, M1
Kassie, F; Modiano, JF; Murphy, SE; Schutten, MM; von Weymarn, LB1
Shields, PG1
Lam, DC; Minna, JD1
Kido, T; Kimura, S; Paiz, J; Vinson, C; Ward, JM; Yoneda, M1
Jensen-Taubman, SM; Keefe, KM; Linnoila, RI; Wang, XY; Yang, D1
Linnoila, RI; Mukherjee, AB; Yang, Y; Zhang, Z1
Jia, D; Liao, J; Meng, X; Park, ES; Seril, DN; Sun, Y; Yang, CS; Yang, GY1
Iijima, T; Ishiyama, T; Kano, J; Minami, Y; Morishita, Y; Noguchi, M; Okubo, C1
Aebischer, CP; Bachmann, H; Buchwald Hunziker, P; Geatrix, B; Goralczyk, R; Lenz, B; Riss, G; Wertz, K1
Funae, Y; Imaida, K; Kamataki, T; Masumura, K; Miyazaki, M; Nohmi, T; Saoo, K; Takeuchi, H; Yamazaki, H; Yokohira, M1
Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM1
Hosokawa, K; Imaida, K; Matsuda, Y; Saoo, K; Takeuchi, H; Yamakawa, K; Yokohira, M; Zeng, Y1
Aebischer, CP; Bachmann, H; Buchwald Hunziker, P; Goralczyk, R; Greatrix, B; Lenz, B; Riss, G; Wertz, K1
Hao, X; Liao, J; Lu, G; Reuhl, KR; Yang, CS; Yang, G1
Mernitz, H; Russell, RM; Smith, DE; Wang, XD; Wood, RJ1
Castonguay, A; Gunning, WT; Matzinger, SA; You, M1
Hecht, SS; Isaacs, S; Trushin, N1
Amin, S; Desai, D; Djordjevic, MV; Hoffmann, D; Rivenson, A; Zang, E1
Chung, FL; Eklind, KI; Morse, MA; Xu, Y1
Castonguay, A1
Amin, S; Chung, FL; Desai, D; Jiao, D; Kim, S; Smith, TJ; Yang, CS1
Morse, MA; Stoner, GD1
Castonguay, A; Duperron, C1
Baylin, SB; Belinsky, SA; Gabrielson, E; Herman, JG; Michels, R; Nikula, KJ; Palmisano, WA; Saccomanno, G1
Gerson, SL; Liu, L; Qin, X1
Kawabata, K; Matsunaga, K; Mori, H; Nishikawa, A; Sugie, S; Tanakamaru, Y; Yamada, Y1
Chung, FL1
Crist, KA; Hamilton, AD; Lantry, LE; Lubet, RA; Ohkanda, J; Sebti, SM; Wang, Y; Yao, R; You, M; Zhang, Z1
Carlton, PS; Kresty, LA; Stoner, GD1
Castonguay, A; Rioux, N; Yao, R; You, M1
Chen, CB; Hecht, SS; Hirota, N; Hoffmann, D; Ornaf, RM; Tso, TC1
Amin, SG; Chung, FL; Eklind, KI; Morse, MA1
Bouchard, L; Castonguay, A; Nicole, P; Pepin, P1
Chung, FL; Eklind, KI; Morse, MA1
Anderson, MW; Belinsky, SA; Devereux, TR; Foley, JF; Maronpot, RR1
Castonguay, A; Goldblatt, PJ; Gunning, WT; Stoner, GD1
Coccia, JB; Wattenberg, LW1
Becker, KL; Correa, E; Joshi, PA; Nylen, E; Schuller, HM; Witschi, HP1
Amin, SG; Chung, FL; LaGreca, SD; Morse, MA1
Choi, CI; Hecht, SS; Jordan, KG; Trushin, N1
Amin, SG; Chung, FL; Eklind, KI; Hecht, SS; Morse, MA1
Amin, S; Choi, CI; Chung, FL; Hecht, SS; Jordan, KG; Morse, MA; Stoner, GD1

Reviews

2 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Adenoma

ArticleYear
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis by compounds derived from cruciferous vegetables and green tea.
    Annals of the New York Academy of Sciences, 1993, May-28, Volume: 686

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catechin; DNA; DNA Damage; Indoles; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Rats; Rats, Inbred F344; Tea; Thiocyanates; Vegetables

1993
The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black Tea.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1999, Volume: 220, Issue:4

    Topics: Adenoma; Animals; Carcinogens; Disease Models, Animal; Lung Neoplasms; Nitrosamines; Phytotherapy; Plant Extracts; Rats; Rats, Inbred F344; Tea

1999

Other Studies

51 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Adenoma

ArticleYear
Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O
    Journal of medicinal chemistry, 2017, 09-28, Volume: 60, Issue:18

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Female; Guanine; Lung; Lung Neoplasms; Mice; Nitrosamines; Pyrones; Structure-Activity Relationship

2017
β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells.
    Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:10

    Topics: Adenocarcinoma; Adenoma; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Carcinogenesis; Cell Line, Tumor; Disease Progression; Escin; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Neoplasm Transplantation; Nicotiana; Nitrosamines; Plant Extracts; Real-Time Polymerase Chain Reaction; Retinal Dehydrogenase; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein

2013
Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice.
    Oncology reports, 2013, Volume: 30, Issue:6

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenesis; Estradiol; Female; Humans; Hyperplasia; Lung; Lung Neoplasms; Male; Mice; Neoplasms, Hormone-Dependent; Nitrosamines; Orchiectomy; Ovariectomy; Sex Characteristics; Testosterone

2013
Napsin A is possibly useful marker to predict the tumorigenic potential of lung bronchiolo-alveolar hyperplasia in F344 rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2014, Volume: 66, Issue:2-3

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenoma; Animals; Aspartic Acid Endopeptidases; Biomarkers, Tumor; Bronchioles; Hyperplasia; Immunohistochemistry; Lung; Lung Neoplasms; Nitrosamines; Prognosis; Pulmonary Alveoli; Rats; Rats, Inbred F344

2014
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice.
    Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:1

    Topics: Adenoma; Animal Feed; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; DNA Adducts; DNA Damage; Female; Guanine; Kava; Lung; Lung Neoplasms; Mice; Nitrosamines

2014
Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.
    Carcinogenesis, 2014, Volume: 35, Issue:12

    Topics: Adenocarcinoma; Adenoma; Animals; Apoptosis; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; Humans; Lung Neoplasms; Male; Nitrosamines; Pancreatic Neoplasms; Prohibitins; Pyridines; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism

2014
Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice.
    Cancer medicine, 2016, Volume: 5, Issue:5

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenoma; Animals; Cell Transformation, Neoplastic; Enzyme Activation; Female; Lung Neoplasms; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Signaling System; Mice, Inbred A; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nitrosamines; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins p21(ras)

2016
Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2008, Volume: 60, Issue:6

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Hyperplasia; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Time Factors

2008
Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice.
    Cancer prevention research (Philadelphia, Pa.), 2008, Volume: 1, Issue:6

    Topics: Adenoma; Algorithms; Animals; Antineoplastic Agents; Apoptosis; Benzo(a)pyrene; Body Weight; Cell Proliferation; Chemoprevention; Drug Evaluation, Preclinical; Eating; Female; Kava; Lung Neoplasms; Mice; Neoplasms, Multiple Primary; Nitrosamines; Plant Extracts

2008
Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice.
    The Journal of toxicological sciences, 2009, Volume: 34, Issue:2

    Topics: Adenocarcinoma; Adenoma; Administration, Oral; Animals; Antioxidants; Carcinogens; DNA Glycosylases; Drug Antagonism; Female; Genes, erbB-1; Genes, ras; Humans; Infusions, Subcutaneous; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nitrosamines; Precancerous Conditions; Sex Factors

2009
Risk analysis of environmental chemicals on lung carcinogenesis.
    Asian Pacific journal of cancer prevention : APJCP, 2010, Volume: 11, Issue:1

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cattle; Disease Models, Animal; Female; Humans; Lactoferrin; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred ICR; Nitrosamines; Risk Assessment

2010
Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11

    Topics: Adenoma; Animals; Carcinogens; Cells, Cultured; Drinking Water; Female; Guanine; Humans; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nicotine; Nitrosamines

2011
Long-term nicotine replacement therapy: cancer risk in context.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)

2011
How do we safely get people to stop smoking?
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras)

2011
Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse.
    Molecular cancer, 2012, Dec-12, Volume: 11

    Topics: Adenoma; Animals; Biomarkers, Tumor; Carcinoma; CCAAT-Enhancer-Binding Proteins; Cell Transformation, Neoplastic; In Situ Nick-End Labeling; Incidence; Ki-67 Antigen; Lung Neoplasms; Male; Mice; Mice, Transgenic; Nitrosamines; Pulmonary Alveoli

2012
Achaete-scute complex homolog-1 promotes DNA repair in the lung carcinogenesis through matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Adenoma; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Transformation, Neoplastic; Cisplatin; DNA Damage; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Enzyme Induction; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Lung Neoplasms; Matrix Metalloproteinase 7; Mice; Mice, Transgenic; Nitrosamines; Promoter Regions, Genetic; Protein Binding; RNA, Small Interfering; Small Cell Lung Carcinoma; Tumor Suppressor Proteins; Up-Regulation

2012
Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke.
    The Journal of biological chemistry, 2004, Jul-09, Volume: 279, Issue:28

    Topics: Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Susceptibility; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Fas Ligand Protein; Humans; Lung; Lung Neoplasms; MAP Kinase Signaling System; Membrane Glycoproteins; Mice; Mice, Knockout; Nitrosamines; Smoking; Tobacco Smoke Pollution; Uteroglobin

2004
Inhibition of lung carcinogenesis and effects on angiogenesis and apoptosis in A/J mice by oral administration of green tea.
    Nutrition and cancer, 2004, Volume: 48, Issue:1

    Topics: Adenoma; Administration, Oral; Animals; Apoptosis; Carcinogens; Dose-Response Relationship, Drug; Female; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Inbred A; Neovascularization, Pathologic; Nitrosamines; Random Allocation; Tea; Vascular Endothelial Growth Factor A; von Willebrand Factor

2004
Phenotypic characteristics of mouse lung adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Molecular carcinogenesis, 2005, Volume: 42, Issue:2

    Topics: Adenoma; Animals; Apoproteins; Carcinogens; DNA-Directed RNA Polymerases; DNA, Complementary; Female; In Situ Hybridization; Lasers; Lung; Mice; Microscopy, Electron, Transmission; Muramidase; Nitrosamines; Phenotype; Promoter Regions, Genetic; Pulmonary Surfactant-Associated Protein A; RNA; RNA, Messenger; Surface-Active Agents; Time Factors; Viral Proteins

2005
Beta-carotene interaction with NNK in the AJ-mouse model: effects on cell proliferation, tumor formation and retinoic acid responsive genes.
    Biochimica et biophysica acta, 2005, May-30, Volume: 1740, Issue:2

    Topics: Adenoma; Animals; beta Carotene; Bronchi; Carcinogens; Cytochrome P-450 Enzyme System; Disease Models, Animal; Down-Regulation; Drug Interactions; Epithelial Cells; Gene Expression Regulation; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Protein Isoforms; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase

2005
Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
    Carcinogenesis, 2005, Volume: 26, Issue:11

    Topics: Adenoma; Animals; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Carcinogens; Chemoprevention; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Escherichia coli Proteins; Female; Humans; Lung Neoplasms; Methoxsalen; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microsomes; Mixed Function Oxygenases; Mutation; Nitrosamines; Pentosyltransferases; Proteins; Salmonella typhimurium; Steroid Hydroxylases

2005
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
    Cancer research, 2005, Sep-15, Volume: 65, Issue:18

    Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Caspase 3; Caspases; Cell Growth Processes; Disease Progression; Female; In Situ Nick-End Labeling; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Smoking; Sulfoxides; Thiocyanates

2005
Post-initiation chemopreventive effects of dietary bovine lactoferrin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice.
    Cancer letters, 2007, Feb-08, Volume: 246, Issue:1-2

    Topics: Adenoma; Animals; Body Weight; Caspase 3; Cattle; Dietary Supplements; Female; Hyperplasia; Lactoferrin; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Organ Size; Proliferating Cell Nuclear Antigen

2007
beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model.
    Nutrition and cancer, 2006, Volume: 54, Issue:2

    Topics: Adenoma; Animals; beta Carotene; Carcinogens; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Protein Isoforms; Random Allocation; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smoking; Vitamins

2006
Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine.
    Cancer research, 2006, Dec-01, Volume: 66, Issue:23

    Topics: Adenocarcinoma; Adenoma; Analysis of Variance; Animals; Caffeine; Catechin; Cell Proliferation; Disease Progression; Female; Flavonoids; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitrosamines; Phenols; Phosphorylation; Polyphenols; Proliferating Cell Nuclear Antigen; Tea; Time Factors

2006
Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity.
    International journal of cancer, 2007, Apr-01, Volume: 120, Issue:7

    Topics: Adenoma; Alitretinoin; Animals; Antineoplastic Agents; Calcitriol; Carcinogens; Cell Transformation, Neoplastic; Dietary Supplements; Disease Models, Animal; Drug Therapy, Combination; Lung Neoplasms; Male; Mice; Mice, Inbred A; Nitrosamines; Retinoid X Receptors; Steroid Hydroxylases; Tretinoin; Vitamin D3 24-Hydroxylase; Vitamins

2007
Ki-ras mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-initiated and butylated hydroxytoluene-promoted lung tumors in A/J mice.
    Molecular carcinogenesis, 1994, Volume: 11, Issue:1

    Topics: Adenoma; Animals; Base Sequence; Butylated Hydroxytoluene; Carcinogens; Female; Genes, ras; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Sequence Data; Mutation; Nitrosamines; Papilloma; Polymerase Chain Reaction; Stomach Neoplasms

1994
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents.
    Carcinogenesis, 1994, Volume: 15, Issue:12

    Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Stomach Neoplasms

1994
A study of tobacco carcinogenesis. LI. Relative potencies of tobacco-specific N-nitrosamines as inducers of lung tumours in A/J mice.
    Cancer letters, 1993, Jul-30, Volume: 71, Issue:1-3

    Topics: Adenoma; Animals; Female; Lung Neoplasms; Mice; N-Nitrosopyrrolidine; Nicotiana; Nitrosamines; Nitroso Compounds; Plants, Toxic; Smoke; Structure-Activity Relationship

1993
Pulmonary carcinogenesis and its prevention by dietary polyphenolic compounds.
    Annals of the New York Academy of Sciences, 1993, May-28, Volume: 686

    Topics: Adenoma; Animals; Carcinogens; Diet; Dose-Response Relationship, Drug; Ellagic Acid; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Plants, Toxic; Smoke; Smoking; Tissue Distribution

1993
The essential role of the functional group in alkyl isothiocyanates for inhibition of tobacco nitrosamine-induced lung tumorigenesis.
    Carcinogenesis, 1996, Volume: 17, Issue:4

    Topics: Adenoma; Animals; Carcinogens; Female; Isothiocyanates; Lung; Lung Neoplasms; Mice; Microsomes; Nicotiana; Nitrosamines; Oxidation-Reduction; Plants, Toxic; Structure-Activity Relationship

1996
Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer.
    Cancer letters, 1997, Mar-19, Volume: 114, Issue:1-2

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Dimethylnitrosamine; DNA Methylation; Dose-Response Relationship, Drug; Ellagic Acid; Esophageal Neoplasms; Female; Guanine; Isothiocyanates; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Rats; Rats, Inbred F344

1997
Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J mice.
    Carcinogenesis, 1997, Volume: 18, Issue:5

    Topics: Adenoma; Animals; Aspirin; Cells, Cultured; Cytochrome P-450 CYP1A2; Enzyme Activation; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Prodrugs; Sulindac

1997
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Sep-29, Volume: 95, Issue:20

    Topics: Adenoma; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma in Situ; Carcinoma, Squamous Cell; DNA Methylation; DNA, Neoplasm; Genes, p16; Humans; Hyperplasia; Lung Neoplasms; Metaplasia; Nitrosamines; Precancerous Conditions; Rats; Rats, Inbred F344; Sputum

1998
Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.
    Carcinogenesis, 1999, Volume: 20, Issue:2

    Topics: Adenoma; Alkyl and Aryl Transferases; Animals; Carcinogens; Crosses, Genetic; DNA Repair; DNA, Neoplasm; Humans; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Transgenic; Nitrosamines; O(6)-Methylguanine-DNA Methyltransferase; Transgenes

1999
Effects of protocatechuic acid, S-methylmethanethiosulfonate or 5-hydroxy-4-(2-phenyl-(E)ethenyl)-2(5H)-furanone(KYN-54) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary carcinogenesis in mice.
    Cancer letters, 1999, Jan-29, Volume: 135, Issue:2

    Topics: 4-Butyrolactone; Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Drug Screening Assays, Antitumor; Female; Hydroxybenzoates; Lung Neoplasms; Methyl Methanesulfonate; Mice; Mice, Inbred A; Nitrosamines; Retinoids

1999
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Carcinogenesis, 2000, Volume: 21, Issue:1

    Topics: Adenoma; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Carcinogens; Enzyme Inhibitors; Genes, ras; Lung Neoplasms; Methionine; Mice; Mutation; Nitrosamines

2000
Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[a]pyrene-induced lung tumorigenesis in strain A/J mice.
    Cancer letters, 2000, Oct-31, Volume: 159, Issue:2

    Topics: Adenoma; Animals; Antineoplastic Agents; Benzo(a)pyrene; Biological Assay; Carcinogens; Diet; Freeze Drying; Fruit; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines

2000
Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis.
    Experimental lung research, 2000, Volume: 26, Issue:8

    Topics: Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Chemoprevention; Cyclooxygenase 1; Cyclooxygenase 2; DNA, Neoplasm; Enzyme Inhibitors; Female; Genes, ras; Immunoenzyme Techniques; Isoenzymes; Lung Neoplasms; Membrane Proteins; Mice; Mice, Inbred A; Mutation; Nitrobenzenes; Nitrosamines; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Sulfonamides

2000
Tobacco-specific nitrosamines: formation from nicotine in vitro and during tobacco curing and carcinogenicity in strain A mice.
    Journal of the National Cancer Institute, 1978, Volume: 60, Issue:4

    Topics: Adenoma; Animals; Female; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Pyridines

1978
Effect of frequency of isothiocyanate administration on inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenoma formation in A/J mice.
    Cancer letters, 1992, Feb-14, Volume: 62, Issue:1

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Drug Administration Schedule; Female; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Thiocyanates

1992
Effects of sulindac and oltipraz on the tumorigenicity of 4-(methylnitrosamino)1-(3-pyridyl)-1-butanone in A/J mouse lung.
    Carcinogenesis, 1992, Volume: 13, Issue:3

    Topics: Adenoma; Animals; Carcinogens; Drug Screening Assays, Antitumor; Female; Intestinal Absorption; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Oxidation-Reduction; Pyrazines; Schistosomicides; Sulindac; Thiones; Thiophenes

1992
New potential chemopreventive agents for lung carcinogenesis of tobacco-specific nitrosamine.
    Cancer research, 1992, May-01, Volume: 52, Issue:9 Suppl

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Humans; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Structure; Nitrosamines; Rats; Rats, Inbred F344; Thiocyanates

1992
Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse.
    Cancer research, 1992, Jun-01, Volume: 52, Issue:11

    Topics: Adenoma; Animals; Carcinogens; Carcinoma; Female; Hyperplasia; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Microscopy, Electron; Nitrosamines; Pulmonary Alveoli; Time Factors

1992
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens.
    Toxicologic pathology, 1991, Volume: 19, Issue:2

    Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylhydrazines; Lung Neoplasms; Methylcholanthrene; Methylnitrosourea; Mice; Mice, Inbred A; Microscopy, Electron; Nitrosamines

1991
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils.
    Carcinogenesis, 1991, Volume: 12, Issue:1

    Topics: Adenoma; Animals; Carcinogens; Citrus; Cyclohexenes; Female; Limonene; Lung Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Plant Oils; Stomach Neoplasms; Terpenes

1991
Pathobiology of lung tumors induced in hamsters by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the modulating effect of hyperoxia.
    Cancer research, 1990, Mar-15, Volume: 50, Issue:6

    Topics: Adenoma; Air; Animals; Bombesin; Carcinogens; Cricetinae; Lung Neoplasms; Male; Mesocricetus; Microscopy, Electron; Neurosecretory Systems; Nitrosamines; Oxygen

1990
Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice.
    Cancer research, 1990, May-01, Volume: 50, Issue:9

    Topics: Adenoma; Animals; Carcinogens; DNA; Female; In Vitro Techniques; Indoles; Liver; Lung; Lung Neoplasms; Methylation; Mice; Nitrosamines

1990
Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice.
    Carcinogenesis, 1990, Volume: 11, Issue:6

    Topics: Adenoma; Animals; Carcinogens; Deuterium; DNA; Female; Guanine; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Structure-Activity Relationship

1990
Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates.
    Carcinogenesis, 1989, Volume: 10, Issue:9

    Topics: Adenoma; Animals; Carcinogens; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Structure-Activity Relationship; Thiocyanates

1989
Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet.
    Carcinogenesis, 1989, Volume: 10, Issue:10

    Topics: Adenoma; Animals; Carcinogens; Diet; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Reference Values

1989