4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone has been researched along with Adenocarcinoma in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.33) | 18.7374 |
| 1990's | 7 (11.67) | 18.2507 |
| 2000's | 27 (45.00) | 29.6817 |
| 2010's | 24 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davies, G; Ehli, E; Ezzeddine, D; Fowler, J; Fujimoto, J; Fukuoka, J; Jakubek, Y; Kadara, H; Kapere Ochieng, J; Lang, W; Liu, Y; McDowell, T; Nunomura-Nakamura, S; Petersen, J; Scheet, P; Wistuba, II | 1 |
| Amin, S; Biddick, L; Desai, D; Lightfoot, S; Patlolla, JM; Qian, L; Rao, CV; Zhang, Y | 1 |
| Amin, S; Brewer, M; Desai, D; Kopelovich, L; Lightfoot, S; Mohammed, A; Patlolla, JM; Qian, L; Rao, CV; Zhang, Y | 1 |
| Imaida, K; Inoue, T; Kishi, S; Kuno, T; Nakano, Y; Ninomiya, F; Yamakawa, K; Yokohira, M | 1 |
| Imaida, K; Kinouch, S; Kishi, S; Nakano, Y; Ninomiya, F; Saoo, K; Tanizawa, J; Yamakawa, K; Yokohira, M | 1 |
| Aizawa, K; Hu, KQ; Liu, C; Smith, DE; Veeramachaneni, S; Wang, XD | 1 |
| Jiang, YG; Li, X; Wu, JJ; Xia, Y; Yang, T; Zhao, Y; Zou, F | 1 |
| Falk, W; Frese, S; Frese-Schaper, M; Keil, A; Schmid, RA; Steiner, SK; Yagita, H | 1 |
| Balbo, S; Hecht, SS; James-Yi, SA; Johnson, CS; Khariwala, SS; Kovi, RC; Le, CT; O'Sullivan, MG; Upadhyaya, P; Wang, M | 1 |
| Chen, L; Gao, W; Keohavong, P; Lu, C | 1 |
| Iyama, S; Kano, J; Kim, Y; Morishita, Y; Noguchi, M; Sakashita, S; Satomi, K; Shiba-Ishii, A; Shiozawa, T | 1 |
| Biddick, L; Kopelovich, L; Kumar, G; Lightfoot, S; Madka, V; Mohammed, A; Patlolla, JM; Qian, L; Rao, CV; Sadeghi, M; Zhang, Y | 1 |
| Imaida, K; Kanie, S; Kishi, S; Nakano, Y; Yamakawa, K; Yokohira, M | 1 |
| Cho, CH; Jin, HC; Leung, WK; Ng, EK; Shin, VY; Sung, JJ; Yu, J | 1 |
| Al-Wadei, HAN; Schuller, HM | 1 |
| Al-Wadei, HA; Schuller, HM | 1 |
| Abe, M; Endo, Y; Igarashi, M; Miyajima, N; Nakae, D; Sugano, S; Sugaya, K; Watanabe, M; Yoshida, M | 1 |
| Blake, DC; Freeman, WM; Herzog, CR; Mikse, OR | 1 |
| An, J; Chang, YJ; Ho, YS; Lee, CH; Lin, SY; Wei, PL; Yang, YY | 1 |
| Aliaga, C; Bortner, JD; Das, A; El-Bayoumy, K; Freeman, WM; Phelps, DS; Somiari, R; Umstead, TM | 1 |
| Blake, DC; Grigoryeva, LS; Gundermann, EL; Herzog, CR; Mikse, OR | 1 |
| Baldi, A; Beleford, D; Boccellino, M; Liu, Z; Maguire, J; Molina, J; Quagliuolo, L; Rattan, R; Shridhar, V; Staub, J | 1 |
| Hashimoto, N; Imaida, K; Kuno, T; Yokohira, M | 1 |
| Fujimoto, J; Kadara, H; Lotan, D; Lotan, R; Men, T; van Pelt, C | 1 |
| Dagne, A; Kassie, F; Luo, X; Melkamu, T; Qian, X; Schutten, MM; Upadhyaya, P | 1 |
| Hecht, SS; Hermanson, D; Johnson, TE; Kassie, F; Lu, J; O'Sullivan, MG; Upadhyaya, P; Wang, L; Xing, C | 1 |
| Kassie, F; Melkamu, T; Qian, X; Upadhyaya, P | 1 |
| Chang, YJ; Chin-Sheng, H; Ho, YS; Kuo, LJ; Lien, YC; Lin, FY; Liu, HH; Wang, W; Wei, PL; Wu, CH | 1 |
| Dennis, PA; Dogan, I; Hobbs, EA; Hollander, MC; Linnoila, RI; Maier, CR | 1 |
| Shields, PG | 1 |
| Lam, DC; Minna, JD | 1 |
| Castonguay, A; Miller, MS; Schuller, HM; Walker, K; Weddle, DL; Zhang, L | 1 |
| Rom, WN; Tchou-Wong, KM | 1 |
| Devereux, TR; Herzog, CR; Pittman, B; You, M | 1 |
| Belinsky, SA; Tesfaigzi, Y; Wright, PS | 1 |
| Hao, B; He, F; Lin, D; Miao, X; Tan, W; Wang, H; Zhou, G | 1 |
| Kim, Y; Liu, C; Liu, XS; Russell, RM; Smith, DE; Wang, XD | 1 |
| Becker, JM; Bernert, H; Cekanova, M; Majidi, M; Masi, T; Schuller, HM; Walker, K | 1 |
| Cekanova, M; Schuller, HM | 1 |
| Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM | 1 |
| Duca, G; Hecht, SS; Mardari, I; Stepanov, I | 1 |
| Amin, S; Desai, D; Herzog, CR | 1 |
| Cekanova, M; Laag, E; Majidi, M; Masi, T; Schuller, HM; Takahashi, T | 1 |
| Hao, X; Liao, J; Lu, G; Reuhl, KR; Yang, CS; Yang, G | 1 |
| Guo, Z; Qiao, Y; Shi, Q; Spitz, MR; Wang, L; Wei, Q | 1 |
| Hisamoto, A; Hosokawa, S; Kiura, K; Kondo, E; Mimoto, J; Okada, T; Tabata, M; Takigawa, N; Tanimoto, M | 1 |
| Al-Wadei, HA; Majidi, M; Schuller, HM; Takahashi, T | 1 |
| Abdel-Aziz, HO; Hiraga, K; Hsu, DK; Kato, I; Liu, FT; Murai, Y; Nomoto, K; Tabuchi, Y; Takahashi, H; Takano, Y; Takasaki, I; Tsuneyama, K; Zheng, HC | 1 |
| Al-Wadei, HA; Majidi, M; Schuller, HM | 1 |
| Hoffmann, D; Wynder, EL | 1 |
| Furukawa, F; Kleihues, P; Ohgaki, H; Takahashi, M | 1 |
| Anderson, MW; Belinsky, SA; Stefanski, SA | 1 |
| Amin, S; Cox, JE; Desai, D; el-Bayoumy, K; Hoffmann, D; Prokopczyk, B; Upadhyaya, P | 1 |
| Hecht, SS; Hoffmann, D; Rivenson, A | 1 |
| Orloff, M; Schuller, HM | 1 |
| Plummer, H; Schuller, HM; Tithof, PK; Williams, M | 1 |
| Porter, B; Riechert, A; Schuller, HM | 1 |
| Boyle, P; Gray, N | 1 |
| Schuller, HM | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; Maronpot, RR; Stoner, GD | 1 |
1 review(s) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Adenocarcinoma
| Article | Year |
|---|---|
The biological significance of tobacco-specific N-nitrosamines: smoking and adenocarcinoma of the lung.
Topics: Adenocarcinoma; Animals; Black People; Carcinogenicity Tests; Carcinogens; Cricetinae; Female; Humans; Lung Neoplasms; Male; Mice; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Smoking; Tars; United States; White People | 1996 |
59 other study(ies) available for 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone and Adenocarcinoma
| Article | Year |
|---|---|
Development of Kras mutant lung adenocarcinoma in mice with knockout of the airway lineage-specific gene Gprc5a.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Carcinogens; Cell Lineage; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Mice; Mice, Knockout; Mutation; Nitrosamines; Proto-Oncogene Proteins p21(ras); Receptors, G-Protein-Coupled | 2017 |
β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells.
Topics: Adenocarcinoma; Adenoma; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Carcinogenesis; Cell Line, Tumor; Disease Progression; Escin; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Neoplasm Transplantation; Nicotiana; Nitrosamines; Plant Extracts; Real-Time Polymerase Chain Reaction; Retinal Dehydrogenase; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein | 2013 |
Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Transformation, Neoplastic; Chemoprevention; Cyclin-Dependent Kinase Inhibitor p21; Female; Lung Neoplasms; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Pyrimidines; Random Allocation; Tumor Suppressor Protein p53 | 2013 |
Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenesis; Estradiol; Female; Humans; Hyperplasia; Lung; Lung Neoplasms; Male; Mice; Neoplasms, Hormone-Dependent; Nitrosamines; Orchiectomy; Ovariectomy; Sex Characteristics; Testosterone | 2013 |
Napsin A is possibly useful marker to predict the tumorigenic potential of lung bronchiolo-alveolar hyperplasia in F344 rats.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenoma; Animals; Aspartic Acid Endopeptidases; Biomarkers, Tumor; Bronchioles; Hyperplasia; Immunohistochemistry; Lung; Lung Neoplasms; Nitrosamines; Prognosis; Pulmonary Alveoli; Rats; Rats, Inbred F344 | 2014 |
Development of ferret as a human lung cancer model by injecting 4-(Nmethyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Topics: Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Animals; Carcinogens; Cells, Cultured; Disease Models, Animal; Epithelial Cells; Ferrets; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Metaplasia; Neoplasms, Squamous Cell; Nitrosamines | 2013 |
4-(Methylnitrosamino)-1-(3-pyridyl) -1-butanone induces circulating microRNA deregulation in early lung carcinogenesis.
Topics: Adenocarcinoma; Animals; Carcinogenesis; Cell Line, Tumor; Gene Expression Regulation; Humans; Lung; Lung Neoplasms; Male; MicroRNAs; Nitrosamines; Rats; Rats, Inbred F344 | 2014 |
Influence of natural killer cells and perforin‑mediated cytolysis on the development of chemically induced lung cancer in A/J mice.
Topics: Adenocarcinoma; Animals; Apoptosis; Carcinogens; Cytotoxicity, Immunologic; Female; Forkhead Transcription Factors; Killer Cells, Natural; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Pore Forming Cytotoxic Proteins; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2014 |
Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.
Topics: Adenocarcinoma; Adenoma; Animals; Apoptosis; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; Humans; Lung Neoplasms; Male; Nitrosamines; Pancreatic Neoplasms; Prohibitins; Pyridines; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2014 |
Overexpression of CRM1: A Characteristic Feature in a Transformed Phenotype of Lung Carcinogenesis and a Molecular Target for Lung Cancer Adjuvant Therapy.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Exportin 1 Protein; Fatty Acids, Unsaturated; Female; Gene Expression; Gene Silencing; Humans; Inhibitor of Apoptosis Proteins; Karyopherins; Lung; Lung Neoplasms; Male; Mice; Mice, Nude; Middle Aged; Nitrosamines; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Smoking; Survivin; Transfection; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2015 |
Stratifin accelerates progression of lung adenocarcinoma at an early stage.
Topics: 14-3-3 Proteins; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Disease Progression; Exoribonucleases; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Transgenic; Neoplasm Metastasis; Neoplasm Staging; Nitrosamines; Xenograft Model Antitumor Assays | 2015 |
Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; bcl-X Protein; Carcinogens; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Nicotiana; Nicotine; Nitrosamines; Proliferating Cell Nuclear Antigen; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenoma; Animals; Cell Transformation, Neoplastic; Enzyme Activation; Female; Lung Neoplasms; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Signaling System; Mice, Inbred A; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nitrosamines; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins p21(ras) | 2016 |
Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways.
Topics: Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclooxygenase 2; Dinoprostone; Gene Expression Regulation; Humans; Nicotine; Nitrosamines; p38 Mitogen-Activated Protein Kinases; Propranolol; Receptors, Adrenergic, beta; Receptors, Nicotinic; Signal Transduction; Stomach Neoplasms | 2008 |
beta-Carotene promotes the development of NNK-induced small airway-derived lung adenocarcinoma.
Topics: Adenocarcinoma; Animals; beta Carotene; Biological Assay; Blotting, Western; Cricetinae; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Lung Neoplasms; Male; Mesocricetus; Models, Animal; Nitrosamines; Phosphorylation; Random Allocation; Retinoids; Signal Transduction; Time Factors | 2009 |
Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas.
Topics: Adenocarcinoma; Animals; Blotting, Western; Carcinoma, Pancreatic Ductal; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Epinephrine; Female; gamma-Aminobutyric Acid; Lung Neoplasms; Male; Mesocricetus; Models, Animal; Neurotransmitter Agents; Nitrosamines; Norepinephrine; Pancreatic Neoplasms; Pregnancy; Receptors, Nicotinic; Signal Transduction; Smoking | 2009 |
Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice.
Topics: Adenocarcinoma; Adenoma; Administration, Oral; Animals; Antioxidants; Carcinogens; DNA Glycosylases; Drug Antagonism; Female; Genes, erbB-1; Genes, ras; Humans; Infusions, Subcutaneous; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nitrosamines; Precancerous Conditions; Sex Factors | 2009 |
FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK).
Topics: Adenocarcinoma; Apoptosis; Carcinogens; Cell Line, Tumor; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Nicotine; Nitrosamines; Transcription, Genetic; Tumor Suppressor Proteins | 2010 |
Tobacco-specific carcinogen enhances colon cancer cell migration through alpha7-nicotinic acetylcholine receptor.
Topics: Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Cadherins; Carcinogens; Cell Culture Techniques; Cell Movement; Colonic Neoplasms; Homeodomain Proteins; HT29 Cells; Humans; Nitrosamines; Receptors, Nicotinic; Snail Family Transcription Factors; Transcription Factors; Zinc Finger E-box-Binding Homeobox 1 | 2009 |
Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis.
Topics: 14-3-3 Proteins; Adenocarcinoma; Animals; Annexin A5; Carcinogens; Cluster Analysis; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Female; Histocytochemistry; Immunoblotting; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Organoselenium Compounds; Protein Interaction Mapping; Protein Isoforms; Proteomics; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2009 |
FoxO3a gene is a target of deletion in mouse lung adenocarcinoma.
Topics: Adenocarcinoma; Aflatoxin B1; Animals; Carcinogens; Disease Models, Animal; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Deletion; Loss of Heterozygosity; Lung Neoplasms; Mice; Nitrosamines; Polymerase Chain Reaction; Smoking; Urethane | 2009 |
Methylation induced gene silencing of HtrA3 in smoking-related lung cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Large Cell; Carcinoma, Squamous Cell; Cell Line, Tumor; Cells, Cultured; Cisplatin; DNA Methylation; Drug Resistance, Neoplasm; Etoposide; Gene Silencing; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Nitrosamines; Serine Endopeptidases; Smoking | 2010 |
Risk analysis of environmental chemicals on lung carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cattle; Disease Models, Animal; Female; Humans; Lactoferrin; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred ICR; Nitrosamines; Risk Assessment | 2010 |
Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.
Topics: Adenocarcinoma; Animals; Blotting, Western; Carcinogens; Cyclin D1; Flap Endonucleases; Genomics; Humans; Immunohistochemistry; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Knockout; Nitrosamines; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Receptors, G-Protein-Coupled; Ubiquitin-Conjugating Enzymes | 2010 |
Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Indoles; Lung Neoplasms; Mice; Nitrosamines; Proto-Oncogene Proteins c-akt; Silybin; Silymarin | 2011 |
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Carcinogens; Cell Death; Cell Proliferation; Chalcone; Dose-Response Relationship, Drug; Female; Kava; Liver; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines; Phytotherapy; Plant Extracts | 2011 |
Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anticarcinogenic Agents; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Female; Humans; Indoles; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptor Protein-Tyrosine Kinases | 2011 |
NNK enhances cell migration through α7-nicotinic acetylcholine receptor accompanied by increased of fibronectin expression in gastric cancer.
Topics: Aconitine; Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Carcinogens; Cell Line, Tumor; Cell Movement; Fibronectins; Genetic Vectors; Humans; Nitrosamines; Plasmids; Receptors, Nicotinic; RNA Interference; Stomach Neoplasms; Transfection; Up-Regulation | 2012 |
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
Topics: Adenocarcinoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Drinking Water; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras) | 2011 |
Long-term nicotine replacement therapy: cancer risk in context.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras) | 2011 |
How do we safely get people to stop smoking?
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Lung Neoplasms; Male; Mutation; Nicotine; Nitrosamines; Proto-Oncogene Proteins p21(ras) | 2011 |
The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK.
Topics: Adenocarcinoma; Animals; Arachidonic Acid; Cricetinae; Cyclooxygenase Inhibitors; DNA Primers; Ethanol; Female; Genes, p53; Genes, ras; Ibuprofen; Indoles; Lipoxygenase Inhibitors; Male; Maternal-Fetal Exchange; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Pregnancy | 2002 |
Lung-specific expression of mutant p53 as mouse model for lung cancer.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Genes, p53; Humans; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Transgenic; Mutation; Nitrosamines; Proliferating Cell Nuclear Antigen; Promoter Regions, Genetic; Proteins; Uteroglobin | 2003 |
Carcinogenic induction directs the selection of allelic losses in mouse lung tumorigenesis.
Topics: Adenocarcinoma; Animals; Carcinogens; Loss of Heterozygosity; Lung Neoplasms; Mice; Mice, Inbred A; Mice, Inbred C3H; Nitrosamines; Urethane | 2002 |
SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle.
Topics: Adenocarcinoma; Animals; Beryllium; Carcinogens; CHO Cells; Cornified Envelope Proline-Rich Proteins; Cricetinae; Humans; Lung; Lung Neoplasms; Membrane Proteins; Mice; Mice, Inbred Strains; Mice, Nude; Nitrosamines; Ploidies; Proteins; Rats; Rats, Inbred F344; Resting Phase, Cell Cycle; Transfection | 2003 |
Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
Topics: Adenocarcinoma; Alleles; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Carcinoma, Squamous Cell; Case-Control Studies; Cytochrome P-450 CYP2A6; Female; Gene Deletion; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Male; Middle Aged; Mixed Function Oxygenases; Nitrosamines; Polymorphism, Genetic; Smoking | 2003 |
Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Ferrets; Humans; Immunohistochemistry; Lung Neoplasms; Male; Nitrosamines; Precancerous Conditions; Smoking | 2006 |
Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta 2-adrenergic receptor single-nucleotide polymorphisms.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Carcinogens; Cricetinae; Lung Neoplasms; Mesocricetus; Molecular Sequence Data; Nitrosamines; Polymorphism, Single Nucleotide; Receptors, Adrenergic, beta-2 | 2005 |
NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cricetinae; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; ErbB Receptors; Gene Expression Profiling; Immunohistochemistry; Lung Neoplasms; Male; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Protein Serine-Threonine Kinases; Receptors, Adrenergic, beta-2; Signal Transduction | 2005 |
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Caspase 3; Caspases; Cell Growth Processes; Disease Progression; Female; In Situ Nick-End Labeling; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Smoking; Sulfoxides; Thiocyanates | 2005 |
Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan children.
Topics: Adenocarcinoma; Biomarkers; Carcinogens; Child; Child, Preschool; Cotinine; Environmental Exposure; Female; Humans; Lung Neoplasms; Male; Moldova; Nitrosamines; Rural Population; Tobacco Smoke Pollution; Urban Population | 2006 |
Array CGH analysis reveals chromosomal aberrations in mouse lung adenocarcinomas induced by the human lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Adenocarcinoma; Animals; Carcinogens; Cell Line, Tumor; Chromosome Aberrations; DNA; Gene Dosage; Humans; Karyotyping; Lung Neoplasms; Mice; Nitrosamines; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis | 2006 |
NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells.
Topics: Activating Transcription Factor 1; Adenocarcinoma; Cell Line; Cyclic AMP Response Element-Binding Protein; DNA; DNA-Binding Proteins; Enzyme Activation; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Lung; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nitrosamines; Nuclear Proteins; Phosphorylation; Receptors, Adrenergic, beta-1; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors | 2006 |
Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine.
Topics: Adenocarcinoma; Adenoma; Analysis of Variance; Animals; Caffeine; Catechin; Cell Proliferation; Disease Progression; Female; Flavonoids; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitrosamines; Phenols; Phosphorylation; Polyphenols; Proliferating Cell Nuclear Antigen; Tea; Time Factors | 2006 |
A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adult; Aged; Alkylating Agents; Alkylation; Biological Assay; Carcinogens; Case-Control Studies; Cells, Cultured; DNA Damage; DNA Repair; Female; Humans; In Vitro Techniques; Lung Neoplasms; Lymphocyte Activation; Lymphocytes; Male; Middle Aged; Nitrosamines; Phytohemagglutinins; Pilot Projects; Plasmids; Risk Factors; Sulfuric Acid Esters | 2007 |
Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cisplatin; Codon; Female; Genes, ras; Lung Neoplasms; Mice; Neoplasms, Experimental; Neoplasms, Second Primary; Nitrosamines; Point Mutation | 2007 |
Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells.
Topics: Adenocarcinoma; Carcinogens; Epithelial Cells; Estrogen Receptor beta; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Nicotine; Nitrosamines; Receptors, Adrenergic, beta-1; Smoking; Trachea | 2007 |
Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study.
Topics: Adenocarcinoma; Animals; Carcinogens; Galectin 3; Gene Expression; Genetic Predisposition to Disease; Lung Neoplasms; Mice; Mice, Knockout; Nitrosamines; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2008 |
Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma.
Topics: Adenocarcinoma; Animals; Cell Line; Cell Line, Tumor; Cricetinae; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; gamma-Aminobutyric Acid; Humans; Immunohistochemistry; Lung Neoplasms; Nitrosamines; Phosphorylation; Receptors, Adrenergic, beta-1; Receptors, GABA-B; Smoking | 2008 |
Smoking and lung cancer: scientific challenges and opportunities.
Topics: Adenocarcinoma; Black or African American; Black People; Carcinoma, Squamous Cell; Disease Susceptibility; Female; Humans; Incidence; Japan; Lung Neoplasms; Male; Nitrosamines; Risk Factors; Sex Factors; Smoking; Tobacco Smoke Pollution; United Kingdom; United States; White People | 1994 |
K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine.
Topics: Adenocarcinoma; Animals; Base Sequence; Carcinoma, Squamous Cell; DNA, Single-Stranded; Genes, ras; Lung Neoplasms; Male; Molecular Sequence Data; Nitrosamines; Point Mutation; Rats | 1993 |
The A/J mouse lung as a model for developing new chemointervention strategies.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinogens; Disease Models, Animal; Female; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines | 1993 |
Effects of dietary 1,4-phenylenebis(methylene)selenocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation in lung and liver of A/J mice and F344 rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Carcinogens; Diet; DNA Adducts; Female; Liver; Lung; Lung Neoplasms; Male; Mice; Nitrosamines; Organoselenium Compounds; Rats; Rats, Inbred F344 | 1996 |
Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells.
Topics: Adenocarcinoma; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Carcinogens; Carcinoma, Small Cell; Cell Division; Humans; Kinetics; Ligands; Lung Neoplasms; Nicotiana; Nitrosamines; Plants, Toxic; Pyridines; Receptors, Nicotinic; Tumor Cells, Cultured | 1998 |
The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid.
Topics: Adenocarcinoma; Adrenergic beta-Agonists; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carcinogens; CHO Cells; Cricetinae; DNA Replication; DNA, Neoplasm; Humans; Indoles; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Nitrosamines; Radioligand Assay; Receptors, Adrenergic, beta; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tumor Cells, Cultured | 1999 |
Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters.
Topics: Adenocarcinoma; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carcinogens; Cricetinae; Drug Synergism; Epinephrine; Lung Neoplasms; Male; Mesocricetus; Nitrosamines; Propranolol; Receptors, Adrenergic, beta; Theophylline | 2000 |
Tobacco industry must not dump its high nitrosamine tobacco on poor countries.
Topics: Adenocarcinoma; Carcinogens; Developing Countries; Humans; Lung Neoplasms; Nitrosamines; Smoking; Tobacco Industry; United States | 2001 |
Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines.
Topics: Adenocarcinoma; Carcinogens; Cell Division; Diethylnitrosamine; Hexamethonium; Hexamethonium Compounds; Humans; Lung Neoplasms; Nicotine; Nitrosamines; Receptors, Nicotinic; Tumor Cells, Cultured | 1989 |
Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines.
Topics: Adenocarcinoma; Animals; Blotting, Southern; Codon; Dimethylnitrosamine; DNA Mutational Analysis; Female; Gene Expression Regulation; Genes, ras; Lung Neoplasms; Mice; Mice, Inbred Strains; Mutation; Neoplasms, Experimental; Nitrosamines; Transfection | 1989 |