Compounds > 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
Page last updated: 2024-08-26

4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol and Lung Neoplasms

4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol has been researched along with Lung Neoplasms in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (10.34)18.2507
2000's13 (44.83)29.6817
2010's12 (41.38)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Boo, HJ; Jang, HJ; Kang, YP; Kwon, SW; Lee, HY; Min, HY1
Maser, E; Neumann, KT; Stapelfeld, C1
Balbo, S; Hecht, SS; Johnson, CS; Kovi, RC; O'Sullivan, MG1
Ashmore, JH; Lazarus, P; Luo, S; Watson, CJW1
Brookmeyer, C; Carmella, SG; Hecht, SS; Ming, X; Olvera, N; Yoder, A1
Ding, X; Liu, Z; Megaraj, V; Xie, F; Yang, W; Zhou, X1
Butler, LM; Hecht, SS; Stepanov, I; Yuan, JM1
Balbo, S; Hecht, SS; James-Yi, SA; Johnson, CS; Khariwala, SS; Kovi, RC; Le, CT; O'Sullivan, MG; Upadhyaya, P; Wang, M1
Carmella, SG; Derby, KS; Hatsukami, D; Hecht, SS; Le Marchand, L; Murphy, SE; Tiirikainen, M; Wang, H1
Anderson, KE; Benoit, AR; Caporaso, NE; Carmella, SG; Church, TR; Geisser, MS; Hecht, SS; Le, CT; Zhang, Y1
Carmella, SG; Fan, Y; Gao, YT; Han, S; Hecht, SS; Koh, WP; Murphy, SE; Wang, R; Wickham, K; Yu, MC; Yuan, JM1
Caberto, C; Carmella, S; Cuthrell, K; Derby, KS; Hecht, SS; Le Marchand, L; Murphy, SE1
Bhat, SH; Blair, IA; Gelhaus, SL; Mesaros, C; Vachani, A1
Asomaning, K; Carmella, SG; Chen, F; Christiani, DC; Hecht, SS; Lin, X; Su, L; Ter-Minassian, M; Zhao, Y1
Carmella, SG; Chen, M; Davis, AB; Gao, YT; Han, S; Hecht, SS; Moy, KA; Murphy, SE; Nelson, HH; Tao, L; Wang, R; Yu, MC; Yuan, JM; Zhong, Y1
D'Agostino, J; Ding, X; Xie, F; Zhou, X1
Hecht, SS; Murphy, SE; Nelson, HH; Stepanov, I; Yuan, JM1
Carmella, SG; Fristad, A; Han, S; Hecht, SS; Yang, Y1
Doerge, DR; Fang, JL; Lazarus, P; Upadhyaya, P; Wiener, D1
Carmella, SG; Hatsukami, DK; Hecht, SS; Jensen, J; Kramarczuk, I; Le, C; Li, YS; Losey, L; Murphy, SE; Puumala, SS; Roe, MR; Zimmerman, CL1
Hecht, SS2
Carmella, SG; Hatsukami, DK; Hecht, SS; Lemmonds, C; Murphy, S; Tulunay, OE; Zhang, Y1
Hecht, SS; Kassie, F; Lao, Y; Villalta, PW; Yu, N1
Chase, GA; Dyer, AM; Gallagher, CJ; Hicks, AN; Lazarus, P; Muscat, JE; Richie, J; Zheng, Y1
Behr, M; Ding, X; Fang, C; Kaminsky, LS; Turesky, RJ; Weng, Y1
Akerkar, SA; Borukhova, A; Carmella, SG; Chung, FL; Hecht, SS; Richie, JP; Skowronski, L1
Castonguay, A; Donnelly, PJ; Massey, TE; Petsikas, D; Reid, KR; Smith, GB1
Cole, SP; Deeley, RG; Hecht, SS; Ito , K; Leslie, EM; Upadhyaya, P1

Reviews

3 review(s) available for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol and Lung Neoplasms

ArticleYear
Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer.
    Cancer research, 2014, Jan-15, Volume: 74, Issue:2

    Topics: Biomarkers; Carcinogens; Cotinine; Glucuronides; Humans; Lung Neoplasms; Mass Spectrometry; Multivariate Analysis; Nicotiana; Nicotine; Nitrosamines; Phenanthrenes; Polycyclic Aromatic Hydrocarbons; Prospective Studies; Pyridines; Risk; Risk Assessment; Smoke

2014
Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke.
    Tobacco control, 2004, Volume: 13 Suppl 1

    Topics: Air Pollutants; Benzene; Biomarkers, Tumor; Carcinogens; Environmental Exposure; Female; Humans; Hydrocarbons, Aromatic; Lung Neoplasms; Male; Nitrosamines; Pyridines; Risk Factors; Tobacco Smoke Pollution

2004
Chemoprevention by isothiocyanates.
    Journal of cellular biochemistry. Supplement, 1995, Volume: 22

    Topics: Animals; Anticarcinogenic Agents; Biotransformation; Carcinogens; Humans; Inactivation, Metabolic; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Rats

1995

Trials

1 trial(s) available for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol and Lung Neoplasms

ArticleYear
Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen.
    Journal of the National Cancer Institute, 2004, Jan-21, Volume: 96, Issue:2

    Topics: Adult; Aged; Alkaloids; Biomarkers, Tumor; Carcinogens; Cotinine; Female; Glucuronates; Humans; Lung Neoplasms; Male; Middle Aged; Nitrosamines; Pyridines; Research Design; Smoking; Smoking Cessation; Treatment Outcome

2004

Other Studies

25 other study(ies) available for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol and Lung Neoplasms

ArticleYear
Effect of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and benzo[a]pyrene exposure on the development of metabolic syndrome in mice.
    Life sciences, 2023, Sep-15, Volume: 329

    Topics: 1-Butanol; Animals; Benzo(a)pyrene; Blood Glucose; Carcinogens; Humans; Lung Neoplasms; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Nitrosamines

2023
Different inhibitory potential of sex hormones on NNK detoxification in vitro: A possible explanation for gender-specific lung cancer risk.
    Cancer letters, 2017, 10-01, Volume: 405

    Topics: Carcinogens; Female; Gonadal Steroid Hormones; Humans; Liver; Lung Neoplasms; Male; Nicotiana; Nitrosamines; Pyridines; Sex Factors; Smoking; Tumor Cells, Cultured

2017
Metastasis to the F344 Rat Pancreas from Lung Cancer Induced by 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)- 1-butanol, Constituents of Tobacco Products.
    Toxicologic pathology, 2018, Volume: 46, Issue:2

    Topics: Animals; Carcinogens; Carcinoma; Lung Neoplasms; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Rats; Rats, Inbred F344; Stereoisomerism

2018
Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung.
    Carcinogenesis, 2018, 07-30, Volume: 39, Issue:8

    Topics: 17-Hydroxysteroid Dehydrogenases; Carcinogenesis; Carcinogens; Cytosol; Enzyme Assays; Gene Knockdown Techniques; HEK293 Cells; Humans; Lung; Lung Neoplasms; Microsomes; Nicotiana; Nitrosamines; Oxidation-Reduction; Recombinant Proteins; RNA, Small Interfering; Smoking; Stereoisomerism

2018
High throughput liquid and gas chromatography-tandem mass spectrometry assays for tobacco-specific nitrosamine and polycyclic aromatic hydrocarbon metabolites associated with lung cancer in smokers.
    Chemical research in toxicology, 2013, Aug-19, Volume: 26, Issue:8

    Topics: Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Glucuronides; Humans; Lung Neoplasms; Nicotiana; Nitrosamines; Phenanthrenes; Polycyclic Aromatic Hydrocarbons; Pyridines; Smoke; Solid Phase Extraction; Tandem Mass Spectrometry

2013
Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
    Carcinogenesis, 2014, Volume: 35, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; DNA Adducts; Guanine; Humans; Lung Neoplasms; Mice, Transgenic; Microsomes; Nicotiana; Nitrosamines; Pyridines

2014
Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.
    Carcinogenesis, 2014, Volume: 35, Issue:12

    Topics: Adenocarcinoma; Adenoma; Animals; Apoptosis; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; Humans; Lung Neoplasms; Male; Nitrosamines; Pancreatic Neoplasms; Prohibitins; Pyridines; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism

2014
Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine.
    Cancer research, 2008, Nov-15, Volume: 68, Issue:22

    Topics: Adult; Aged; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nerve Tissue Proteins; Nicotine; Nitrosamines; Polymorphism, Single Nucleotide; Pyridines; Receptors, Nicotinic; Smoking

2008
A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009, Volume: 18, Issue:1

    Topics: Aged; Biomarkers, Tumor; Case-Control Studies; Chi-Square Distribution; Female; Glucuronates; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Nicotiana; Nitrosamines; Prospective Studies; Pyridines; Risk Factors

2009
Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers.
    Cancer research, 2009, Apr-01, Volume: 69, Issue:7

    Topics: Age Factors; Aged; Body Mass Index; Case-Control Studies; Cohort Studies; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitrosamines; Prospective Studies; Pyridines; Smoking

2009
Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer.
    International journal of cancer, 2009, Nov-15, Volume: 125, Issue:10

    Topics: Aged; Asian; Carcinogens; Cross-Sectional Studies; Ethnicity; Female; Follow-Up Studies; Glucuronates; Hawaii; Humans; Inactivation, Metabolic; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Prognosis; Pyridines; Risk Factors; Smoking; Survival Rate; White People

2009
A new liquid chromatography/mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine.
    Rapid communications in mass spectrometry : RCM, 2011, Jan-15, Volume: 25, Issue:1

    Topics: Biomarkers, Tumor; Case-Control Studies; Chromatography, Liquid; Creatinine; DNA Adducts; Drug Stability; Humans; Isotope Labeling; Lung Neoplasms; Mass Spectrometry; Nitrosamines; Phenotype; Pyridines; Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Smoking

2011
Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).
    International journal of cancer, 2012, Mar-15, Volume: 130, Issue:6

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adult; Aged; Case-Control Studies; Creatinine; Female; Humans; Individuality; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Oxidoreductases; Polymorphism, Single Nucleotide; Pyridines; Smoking; Tobacco Smoke Pollution

2012
Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers.
    Cancer research, 2011, Nov-01, Volume: 71, Issue:21

    Topics: Aged; China; Cotinine; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Phenanthrenes; Prospective Studies; Pyridines; Smoke; Smoking

2011
Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:1

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Female; Lung; Lung Neoplasms; Mice; Mice, Knockout; Microsomes, Liver; Nitrosamines; Pyridines; Tissue Distribution

2012
Tobacco smoke biomarkers and cancer risk among male smokers in the Shanghai cohort study.
    Cancer letters, 2013, Jun-28, Volume: 334, Issue:1

    Topics: Biomarkers; Cohort Studies; Cotinine; Esophageal Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Nicotiana; Nitrosamines; Odds Ratio; Pyridines; Risk Factors; Smoking

2013
Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003, Volume: 12, Issue:11 Pt 1

    Topics: Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Lung Neoplasms; Nitrosamines; Pyridines; Sensitivity and Specificity; Smoking; Urinalysis

2003
Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:1

    Topics: Carcinogens; Cell Line; Chromatography, High Pressure Liquid; Glucuronides; Glucuronosyltransferase; Humans; In Vitro Techniques; Liver; Lung Neoplasms; Nitrosamines; Palatine Tonsil; Pyridines; Smoking; Tobacco, Smokeless

2004
Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2005, Volume: 14, Issue:5

    Topics: Adolescent; Adult; Air Pollutants, Occupational; Biomarkers; Carcinogens; Cotinine; Creatinine; Female; Glucuronates; Humans; Interviews as Topic; Lung Neoplasms; Male; Middle Aged; Nicotine; Nitrosamines; Pyridines; Restaurants; Tobacco Smoke Pollution; Workforce

2005
Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Chemical research in toxicology, 2007, Volume: 20, Issue:2

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; DNA Adducts; Dose-Response Relationship, Drug; Lung Neoplasms; Male; Molecular Structure; Nitrosamines; Organ Specificity; Pyridines; Rats; Rats, Inbred F344; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Time Factors

2007
The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:4

    Topics: Adenocarcinoma; Biomarkers, Tumor; Case-Control Studies; Cross-Sectional Studies; Female; Florida; Gene Deletion; Genotype; Glucuronosyltransferase; Humans; Logistic Models; Lung Neoplasms; Male; New York; Nitrosamines; Phenotype; Pyridines; Risk; Smoking

2007
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
    Cancer research, 2007, Aug-15, Volume: 67, Issue:16

    Topics: Animals; Carcinogens; Doxycycline; Female; Guanine; Inbreeding; Liver; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Transgenic; NADPH-Ferrihemoprotein Reductase; Nitrosamines; Pyridines

2007
Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1995, Volume: 4, Issue:8

    Topics: Adult; Anticarcinogenic Agents; Carcinogens; Female; Follow-Up Studies; Glucuronates; Humans; Isothiocyanates; Lung Neoplasms; Male; Nitrosamines; Prognosis; Smoking; Vegetables

1995
Biotransformation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in freshly isolated human lung cells.
    Carcinogenesis, 1999, Volume: 20, Issue:9

    Topics: Aged; Biotransformation; Carcinogens; Female; Humans; Hydroxylation; Inactivation, Metabolic; Lung; Lung Neoplasms; Macrophages, Alveolar; Male; Middle Aged; Nitrosamines; Oxidation-Reduction; Proadifen; Pulmonary Alveoli

1999
Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog.
    The Journal of biological chemistry, 2001, Jul-27, Volume: 276, Issue:30

    Topics: Animals; ATP-Binding Cassette Transporters; Biological Transport; Carcinogens; Cell Line; Cell Membrane; Dose-Response Relationship, Drug; Estradiol; Glutathione; HeLa Cells; Humans; Kinetics; Leukotriene C4; Lung Neoplasms; Mitochondrial Proteins; Models, Chemical; Multidrug Resistance-Associated Proteins; Nitrosamines; Rats; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Transfection

2001