4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide has been researched along with Disease Models, Animal in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (40.00) | 29.6817 |
| 2010's | 14 (46.67) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Boulet, J; Brown, W; Butterworth, J; Coupal, M; Delorme, D; Gawell, L; Griffin, AM; Hodzic, L; Jones, P; Labarre, M; Lavoie, R; Roberts, E; Salois, D; St-Onge, S; Walpole, C; Xiao, W | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Liu, J; Ning, K; Wang, Y; Wu, S; Zhang, L | 1 |
| Connelly, KL; Unterwald, EM | 1 |
| Baca, SM; Bertels, Z; Dripps, IJ; Kieffer, BL; Moye, LS; Pradhan, AA; Siegersma, K; Tipton, AF | 1 |
| Boyer, BT; Dripps, IJ; Jutkiewicz, EM; Neubig, RR; Rice, KC; Traynor, JR | 1 |
| Begum M, ET; Sen, D | 1 |
| Crombie, A; Dripps, I; Moye, LS; Pradhan, AA; Sheets, Z; Tipton, AF; Violin, JD | 1 |
| Chandra, R; Cheer, JF; Dias, C; Francis, TC; Lobo, MK; Nam, H | 1 |
| Kouchek, M; Takasusuki, T; Terashima, T; Xu, Q; Yaksh, TL | 1 |
| Ko, MC; Lee, H; Rice, KC; Sukhtankar, DD | 1 |
| Doyle, AP; Gomez, R; Henry, MA; Jeske, NA; Rowan, MP; Szteyn, K | 1 |
| Befort, K; Boehrer, A; Chung, PC; Darcq, E; Kieffer, BL; Matifas, A; Scherrer, G; Stephan, A | 1 |
| Hirose, N; Kamei, J; Maruyama, Y; Saitoh, A; Takahashi, K; Yamada, M | 1 |
| Mabrouk, OS; Marti, M; Morari, M; Volta, M | 1 |
| Bolte, C; Newman, G; Schultz, Jel J | 1 |
| Ambrose-Lanci, LM; Sterling, RC; Van Bockstaele, EJ | 1 |
| da Silva, LFS; DeSantana, JM; Sluka, KA | 1 |
| Erbs, E; Evans, C; Filliol, D; Kieffer, BL; Matifas, A; Nozaki, C; Pradhan, AA; Walwyn, W | 1 |
| Filliol, D; Gaveriaux-Ruff, C; Hever, XC; Kieffer, BL; Maldonado, R; Matifas, A; Nadal, X; Nassar, MA; Nozaki, C; Reiss, D; Weibel, R; Wood, JN | 1 |
| Altarifi, AA; Folk, JE; Negus, SS; O'Connell, RH; Rice, KC; Rosenberg, MB | 1 |
| Dolle, RE; Gavériaux-Ruff, C; Kieffer, BL; Le Bourdonnec, B; Little, PJ; Nozaki, C; Reiss, D; Windh, RT | 1 |
| Planas, E; Pol, O; Poveda, R; Puig, MM; Romero, A; Sánchez, S | 1 |
| Bausch, SB; Garland, JP; Yamada, J | 1 |
| Kaneko, C; Kuzumaki, N; Matsuzawa, K; Miyoshi, K; Nagumo, Y; Nakajima, M; Nanjo, K; Narita, M; Suzuki, T; Yamazaki, M | 1 |
| Ducharme, J; Ducharme, MP; Lessard, E; Projean, D | 1 |
| Hingne, PM; Sluka, KA | 1 |
| Furuya, H; Horiuchi, T; Inoue, S; Kawaguchi, M; Konishi, N; Kurita, N; Nakamura, M; Sakamoto, T | 1 |
| Hirose, N; Kamei, J; Murasawa, H; Nakatani, A; Saitoh, A; Takahashi, K; Tatsumi, Y; Yamada, M; Yamaguchi, K | 1 |
| da Fonseca Pacheco, CM; da Fonseca Pacheco, D; de Castro Perez, A; de Francischi, JN; Duarte, ID; Klein, A | 1 |
30 other study(ies) available for 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide and Disease Models, Animal
| Article | Year |
|---|---|
N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: the development of diaryl amino piperidines as potent delta opioid receptor agonists with in vivo anti-nociceptive activity in rodent models.
Topics: Analgesics; Animals; Benzamides; Diphenylamine; Disease Models, Animal; Mice; Piperidines; Rats; Receptors, Opioid, delta; Structure-Activity Relationship | 2009 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Hippocampus; Mice; Receptors, Opioid, delta; Signal Transduction; Stress, Psychological; Up-Regulation | 2023 |
Regulation of CRF mRNA in the Rat Extended Amygdala Following Chronic Cocaine: Sex Differences and Effect of Delta Opioid Receptor Agonism.
Topics: Amygdala; Animals; Benzamides; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Disease Models, Animal; Female; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Septal Nuclei; Sex Characteristics; Substance Withdrawal Syndrome; Up-Regulation | 2020 |
Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Benzamides; Cortical Spreading Depression; Disease Models, Animal; GABAergic Neurons; Hyperalgesia; Mice; Mice, Knockout; Migraine Disorders; Nitroglycerin; Piperazines; Prosencephalon; Receptors, Opioid, delta | 2020 |
Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Arrestins; Behavior, Animal; Benzamides; Disease Models, Animal; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Piperazines; Receptors, Opioid, delta; Seizures; Signal Transduction; Swimming | 2018 |
DOR agonist (SNC-80) exhibits anti-parkinsonian effect via downregulating UPR/oxidative stress signals and inflammatory response in vivo.
Topics: Animals; Antiparkinson Agents; Benzamides; Disease Models, Animal; DNA Damage; Down-Regulation; Encephalitis; Male; Mice; Motor Activity; Oxidative Stress; Parkinson Disease; Piperazines; Receptors, Opioid, delta; Unfolded Protein Response | 2018 |
Delta opioid receptor agonists are effective for multiple types of headache disorders.
Topics: Animals; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Headache Disorders; Hyperalgesia; Male; Mice; Morphine; Nitroglycerin; Piperazines; Receptors, Opioid, delta; Sumatriptan | 2019 |
Reduced nucleus accumbens enkephalins underlie vulnerability to social defeat stress.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzamides; Depression; Disease Models, Animal; Dominance-Subordination; Enkephalins; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Piperazines; Receptors, Opioid, delta; Stress, Psychological | 2019 |
Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release.
Topics: Animals; Benzamides; Disease Models, Animal; Injections, Spinal; Ligands; Male; Pain; Pain Threshold; Piperazines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, delta; Substance P | 2013 |
Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fentanyl; Hyperalgesia; Imidazoles; Inflammation; Macaca; Male; Nociceptive Pain; Pain Measurement; Piperazines; Receptors, Opioid; Spiro Compounds | 2014 |
β-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons.
Topics: Animals; Arrestins; Benzamides; beta-Arrestin 2; beta-Arrestins; Capsaicin; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Lectins; Male; Mice; Mice, Inbred C57BL; Pain Threshold; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sensory Receptor Cells; Sensory System Agents; Species Specificity; Time Factors; Trigeminal Ganglion; TRPV Cation Channels | 2014 |
Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures.
Topics: Analgesics, Opioid; Animals; Benzamides; Benzopyrans; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; GABAergic Neurons; Gene Expression Regulation; Mice; Mice, Knockout; Piperazines; Prosencephalon; Reaction Time; Receptors, Opioid, delta; Seizures | 2015 |
Gene expression profiling reveals complex changes in the olfactory bulbectomy model of depression after chronic treatment with antidepressants.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Cerebral Cortex; Cluster Analysis; Depression; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Imipramine; Male; Olfactory Bulb; Oligonucleotide Array Sequence Analysis; Piperazines; Rats; Rats, Wistar | 2008 |
Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hindlimb Suspension; Male; Microdialysis; Motor Activity; Oxidopamine; Parkinsonian Disorders; Piperazines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substantia Nigra; Thiophenes; Time Factors | 2008 |
Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Benzamides; beta-Endorphin; Blood Pressure; Cricetinae; Cyclic AMP; Disease Models, Animal; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypertension; Hypertrophy, Left Ventricular; Myocardial Contraction; Myocardium; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Systole; Ventricular Remodeling | 2009 |
Cocaine withdrawal-induced anxiety in females: impact of circulating estrogen and potential use of delta-opioid receptor agonists for treatment.
Topics: Analysis of Variance; Animals; Anxiety; Benzamides; Body Weight; Cocaine; Disease Models, Animal; Estrogens; Female; Maze Learning; Motor Activity; Ovariectomy; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substance Withdrawal Syndrome | 2010 |
Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.
Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Benzamides; Biophysics; Carrageenan; Cholecystokinin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Kaolin; Knee Joint; Male; Pain Measurement; Pain Threshold; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Statistics, Nonparametric; Transcutaneous Electric Nerve Stimulation | 2010 |
Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.
Topics: Analgesics; Animals; Benzamides; Brain; Calcium; Cell Membrane; Disease Models, Animal; Drug Interactions; Drug Tolerance; Female; Freund's Adjuvant; Ganglia, Spinal; Green Fluorescent Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Inflammation; Ligands; Locomotion; Male; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pain; Pain Threshold; Patch-Clamp Techniques; Piperazines; Piperidines; Protein Binding; Protein Transport; Receptors, Opioid, delta; Sensory Receptor Cells; Spinal Cord; Statistics, Nonparametric; Sulfur Isotopes; Time Factors | 2010 |
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Guanosine 5'-O-(3-Thiotriphosphate); Inflammation; Mice; Mice, Inbred C57BL; Motor Activity; NAV1.8 Voltage-Gated Sodium Channel; Nociceptors; Pain; Pain Measurement; Piperazines; Protein Binding; Receptors, Opioid, delta; Sodium Channels; Sulfur Isotopes | 2011 |
Effects of the δ opioid receptor agonist SNC80 on pain-related depression of intracranial self-stimulation (ICSS) in rats.
Topics: Analgesics, Opioid; Animals; Benzamides; Depression; Disease Models, Animal; Electrodes, Implanted; Male; Nociceptors; Pain; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Self Stimulation | 2012 |
δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization.
Topics: Analgesia; Analgesics, Opioid; Animals; Benzamides; Benzopyrans; Disease Models, Animal; Gene Knock-In Techniques; Humans; Inflammation; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NAV1.8 Voltage-Gated Sodium Channel; Neuralgia; Neurons; Pain Measurement; Piperazines; Receptors, Opioid, delta; Spiro Compounds | 2012 |
Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzamides; Capsaicin; Carrageenan; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Enkephalin, D-Penicillamine (2,5)-; Extravasation of Diagnostic and Therapeutic Materials; Fentanyl; Hindlimb; Histamine Antagonists; Inflammation; Male; Morphine; Narcotic Antagonists; Oxidopamine; p-Methoxy-N-methylphenethylamine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats.
Topics: Animals; Anticonvulsants; Benzamides; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy, Temporal Lobe; Hippocampus; Male; Mossy Fibers, Hippocampal; Muscarinic Agonists; Narcotics; Pilocarpine; Piperazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Seizures | 2005 |
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides; Chronic Disease; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Piperazines; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatica; Somatostatin; Sulfur Isotopes; Time Factors; Tranquilizing Agents | 2006 |
Use of Freund's Complete Adjuvant (FCA) in inflammatory pain models: consequences on the metabolism and pharmacokinetics of the non-peptidic delta receptor agonist SNC80 in the rat.
Topics: Animals; Benzamides; Biological Availability; Blood Proteins; Cytochrome P-450 Enzyme System; Disease Models, Animal; Freund's Adjuvant; Glycoproteins; Humans; Inflammation; Male; Microsomes, Liver; Orosomucoid; Pain; Piperazines; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Recombinant Proteins; Solutions | 2007 |
Blockade of NMDA receptors prevents analgesic tolerance to repeated transcutaneous electrical nerve stimulation (TENS) in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzamides; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Inflammation; Knee Joint; Male; Pain Measurement; Pain Threshold; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Time Factors; Transcutaneous Electric Nerve Stimulation | 2008 |
Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats.
Topics: Animals; Benzamides; Body Temperature; Disease Models, Animal; Hindlimb; Hypothermia, Induced; Injections, Spinal; Male; Motor Activity; Neurons; Piperazines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Single-Blind Method; Spinal Cord Ischemia; Treatment Outcome | 2008 |
Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Brain; Depression; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Olfactory Bulb; Piperazines; Rats; Rats, Wistar; Serotonin; Time Factors; Tryptophan Hydroxylase | 2008 |
The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.
Topics: Amidohydrolases; Analgesics, Opioid; Animals; Arachidonic Acids; Benzamides; Benzomorphans; Cannabinoid Receptor Modulators; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Indoles; Male; Morphine; Organophosphonates; Pain; Pain Measurement; Piperazines; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |