Compounds > 4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol

4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol and Edema

4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for 4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol and Edema

Article	Year
Synthesis and biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives as direct 5-lipoxygenase inhibitors. Chemical biology & drug design, 2012, Volume: 80, Issue:1 Biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives was examined for anti-inflammatory activity in in vitro and in vivo assays. The thiazole compounds showed direct inhibition of 5-lipoxygenase (LOX) that is a key enzyme of leukotrienes synthesis and involved in the inflammation-related diseases, including asthma and rheumatoid arthritis. To optimize biological activity, we synthesized 1,3-thiazole-2-amine derivatives and investigated for structure and activity relationship. Especially, N-(3,5-dimethylphenyl)-4-(4-chlorophenyl)-1,3-thiazole-2-amine was shown to have a potent anti-inflammatory activity as a 5-LOX inhibitor. Topics: Administration, Oral; Amines; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Cell Line, Tumor; Edema; Lipoxygenase Inhibitors; Mice; Rats; Structure-Activity Relationship; Thiazoles	2012

Article

Year

Synthesis and biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives as direct 5-lipoxygenase inhibitors.

Chemical biology & drug design, 2012, Volume: 80, Issue:1

Biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives was examined for anti-inflammatory activity in in vitro and in vivo assays. The thiazole compounds showed direct inhibition of 5-lipoxygenase (LOX) that is a key enzyme of leukotrienes synthesis and involved in the inflammation-related diseases, including asthma and rheumatoid arthritis. To optimize biological activity, we synthesized 1,3-thiazole-2-amine derivatives and investigated for structure and activity relationship. Especially, N-(3,5-dimethylphenyl)-4-(4-chlorophenyl)-1,3-thiazole-2-amine was shown to have a potent anti-inflammatory activity as a 5-LOX inhibitor.

Topics: Administration, Oral; Amines; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Cell Line, Tumor; Edema; Lipoxygenase Inhibitors; Mice; Rats; Structure-Activity Relationship; Thiazoles

2012